Real time wire rope detection method based on Rockchip RK3588.

In the era of fully mechanized and automated coal mine production, the need for autonomous fault detection and intelligent identification of wire ropes has become increasingly critical. Conventional model training and algorithmic computations rely on server-based systems, requiring significant computational resources. This study proposes a real-time wire rope detection system utilizing the Rockchip RK3588 platform.

Sustainable and Direct Upcycling of Waste Graphite Anodes via Deep Eutectic Solvents.

Lithium-ion batteries (LIBs) have flourished in power and energy storage, followed by the waste batteries that are pouring into the market. For waste graphite anode, how to deal with high efficiency, high economic efficiency, and low environmental pollution has become a huge challenge. In the work, a deep eutectic solvent (DES), with a low melting point, low cost, and natural environmental protection, is applied as a green reagent to realize the sustainable and direct upcycling of waste graphite.

Coptisine Improves Liver Inflammation in Sepsis by Regulating STAT1/IRF1/GPX4 Signaling-Mediated Kupffer Cells Ferroptosis.

Sepsis is a life-threatening condition characterized by organ dysfunction, with the liver being particularly vulnerable due to inflammation triggered by Kupffer cell activation. Ferroptosis, an iron-dependent form of regulated cell death associated with macrophages, has emerged as a key pathogenic mechanism. This study aimed to investigate the protective effects of coptisine (COP), a natural alkaloid, against sepsis-induced hepatic ferroptosis and injury using in vivo and in vitro models.

Spatiotemporal variations and risk assessment of fungicides in the Dongjiang River Basin: Tributaries as contamination hotspots.

Although considerable research has explored fungicide patterns in major rivers, the role of tributaries remains overlooked. This study investigated the spatiotemporal distribution, and ecological risks of seven target fungicides in the Dongjiang River Basin of southeastern China, focusing on both the main stream and tributaries. All fungicides were detected in 100 % of water samples, with total concentrations ranging from 7.

PLAUR Neutrophils Drive Anti-PD-1 Therapy Resistance in Patients with Hepatocellular Carcinoma by Shaping an Immunosuppressive Microenvironment.

Hepatocellular carcinoma (HCC) is characterized by an immunosuppressive tumor microenvironment (TME) that limits the efficacy of immune checkpoint inhibitors. However, the role of distinct neutrophil subsets within the TME in mediating tumor resistance to immunotherapy remains poorly understood. Here, the present study reveals that the urokinase-type plasminogen activator receptor (PLAUR) neutrophils are enriched in immunotherapy non-responders and correlate with poor prognosis.

An Interpretability Method for Broken Wire Detection.

As an indispensable piece of production equipment in the industrial field, wire rope is directly related to personnel safety and the normal operation of equipment. Therefore, it is necessary to perform broken wire detection. Deep learning has powerful feature-learning capabilities and is characterized by high accuracy and efficiency, and the YOLOv8 object detection model has been adopted to detect wire breaks in electromagnetic signal images of wire rope, achieving better results.

Constructing Uniform and Robust LiN Interface by Methacrylamide Additive Achieves High Performance of LiNiMnO Battery.

Because the traditional electrolyte is unstable at high voltage, the commercial use of LiNiMnO in power batteries still faces huge challenges. Regarding this, the introduction of additives directly into the electrolyte is one of the easiest ways. Herein, an amide compound, methacrylamide (MAA), is proposed as a novel additive into the conventional electrolyte in our work.

Manipulation of Hydrogen Transfer Behaviors by RhCu Alloying Enables an All-in-one Sustainable "Furfural-Nitrate" System.

Nitrate and furfural are typical wastes mainly from industrialization and agriculturalization progresses, and their clean conversions are still very challenging for a sustainable future. Nevertheless, scant attention has been devoted to the core issues: the rational integration of two wastes recycling and the targeted manipulation of hydrogen (H*) transfer behaviors to address their sluggish reaction kinetics. Herein, we report an all-in-one electrochemical energy system that is thermodynamically designed by coupling nitrate reduction (NORR) and furfural oxidation reactions (FORs) together.

FMO2 cancer-associated fibroblasts sensitize anti-PD-1 therapy in patients with hepatocellular carcinoma.

Background: The efficacy of immune checkpoint inhibitors (ICIs) for hepatocellular carcinoma (HCC) is limited by heterogeneity in individual responses to therapy. The heterogeneous phenotypes and crucial roles of cancer-associated fibroblasts (CAFs) in immunotherapy resistance remain largely unclear.

Methods: A specific CAF subset was identified by integrating comprehensive single-cell RNA sequencing, spatial transcriptomics and transcriptome profiling of patients with HCC with different responses to antiprogrammed cell death protein 1 (anti-PD-1) therapy.

Cobalt-copper dual-atom catalyst boosts electrocatalytic nitrate reduction from water.

Electrochemical nitrate reduction reaction (NORR) presents a promising approach for sustainable water denitrification. Yet its practical implementation is hindered by sluggish reaction kinetics. Herein, we develop a nitrogen-doped carbon supported cobalt-copper dual-atom catalyst (CoCu-NC DAC) to significantly enhance the electro-catalytic NORR performance.

Environmental drivers of spatial variation in tropical forest canopy height: Insights from NASA's GEDI spaceborne LiDAR.

Forest canopy height is a fundamental ecosystem property-influencing patterns of forest carbon storage and forest ecosystem responses to climate variability and change. Previous studies have analyzed environmental drivers influencing spatial variation in canopy height at landscape-to-regional scales; however, far less is known about the environmental determinants underlying regional and global scale variation in forest canopy height. Using the canopy height metrics products from Global Ecosystem Dynamics Investigation (GEDI), a space-borne Light Detection and Ranging (LiDAR) instrument specifically designed to characterize forest structure, we analyze the environmental correlates of spatial variation of global tropical forest canopy height.

Lattice Oxygen-Driven Co-Adsorption of Carbon Dioxide and Nitrate on Copper: A Pathway to Efficient Urea Electrosynthesis.

The electrochemical coupling of CO and NO on copper-based catalysts presents a sustainable strategy for urea production while simultaneously addressing wastewater denitrification. However, the inefficient random adsorption of CO and NO on the copper surface limits the interaction of the key carbon and nitrogen intermediates, thereby impeding efficient C-N coupling. In this study, we demonstrate that the residual lattice oxygen in oxide-derived copper nanosheets (O-Cu) can effectively tune the electron distribution, thus activating neighboring copper atoms and generating electron-deficient copper (Cu) sites.

LCAT deficiency promotes hepatocellular carcinoma progression and lenvatinib resistance by promoting triglyceride catabolism and fatty acid oxidation.

Lecithin cholesterol acyltransferase (LCAT), a crucial enzyme in lipid metabolism, plays important yet poorly understood roles in tumours, especially in hepatocellular carcinoma (HCC). In this study, our investigation revealed that LCAT is a key downregulated metabolic gene and an independent risk factor for poor prognosis in patients with HCC. Functional experiments showed that LCAT inhibited HCC cell proliferation, migration and invasion.

A Unique Expression Profile Responding to Powdery Mildew in Wild Emmer Wheat D430.

Powdery mildew, caused by f. sp. (), is a disease that seriously harms wheat production and occurs in all wheat-producing areas around the world.

Challenges and Opportunities of Uranium Extraction From Seawater: a Systematic Roadmap From Laboratory to Industry.

Uranium extraction from seawater (UES) is crucial for ensuring the sustainable development of nuclear power and has seen significant advancements in recent years. However, natural seawater is a highly complex biogeochemical system, characterized by an extremely low uranium (U) concentration (≈3.3 µg L), abundant competitive ions, and significant marine biological pollution, making UES a formidable challenge.

Deciphering the pharmacological mechanism of Radix astragali for allergic rhinitis through network pharmacology and experimental validation.

Radix Astragali (RA) has been recognized for its therapeutic potential in allergic rhinitis (AR), yet its potential pharmacological mechanisms remain elusive. This study systematically investigated the physicochemical properties and biological activities of RA's phytochemicals, aiming to elucidate their targets and mechanisms in AR treatment. We identified 775 potential targets of RA's key phytochemicals and intersected these with 29,544 AR-related disease targets, pinpointing 747 shared therapeutic targets.

WWOX tuning of oleic acid signaling orchestrates immunosuppressive macrophage polarization and sensitizes hepatocellular carcinoma to immunotherapy.

Background: Immune checkpoint inhibitors (ICIs) are therapeutically effective for hepatocellular carcinoma (HCC) but are individually selective. This study examined the role of specific common fragile sites (CFSs) related gene in HCC immunotherapy.

Methods: We analyzed HCC tissues using next-generation sequencing and flow cytometry via time-of-flight technology.

Changing climate intensifies downstream eutrophication by enhancing nitrogen availability from tropical forests.

The contribution of diffuse nutrient exports from forests to downstream water bodies is significant owing to their extensive spatial distribution across watersheds. However, the intricacies of coupling mechanism between diffuse nutrient exports and meteorological factors driving downstream eutrophication remain poorly understood. Multiple methods involving field sampling, laboratory analysis, and model simulation were utilized to investigate the impact of diffuse nutrient exports from tropical forests on chlorophyll a concentration dynamic in the downstream reservoir.

Integrated "Two-in-One" Strategy for High-Rate Electrocatalytic CO Reduction to Formate.

The electrochemical CO reduction reaction (ECR) is a promising pathway to producing valuable chemicals and fuels. Despite extensive studies reported, improving CO adsorption for local CO enrichment or water dissociation to generate sufficient H* is still not enough to achieve industrial-relevant current densities. Herein, we report a "two-in-one" catalyst, defective Bi nanosheets modified by CrO (Bi-CrO), to simultaneously promote CO adsorption and water dissociation, thereby enhancing the activity and selectivity of ECR to formate.

FGFR2 fusion/rearrangement is associated with favorable prognosis and immunoactivation in patients with intrahepatic cholangiocarcinoma.

Increasing evidence highlights that fibroblast growth factor receptor 2 (FGFR2) fusion/rearrangement shows important therapeutic value for patients with intrahepatic cholangiocarcinoma (ICC). This study aims to explore the association of FGFR2 status with the prognosis and immune cell infiltration profiles of patients with ICC. A total of 226 ICC tissue samples from patients who received surgery at the Department of Liver Surgery at Zhongshan Hospital, Fudan University, were collected retrospectively and assigned to a primary cohort (n = 152) and validation cohort (n = 74) group.

Effect of Orthodontic Treatment on the Outcomes of Endodontically Treated Teeth: A Cone-Beam Computed Tomography Analysis.

Introduction: Often there is the need of moving endodontically treated teeth. Orthodontic movement may have no effect on the prognosis of teeth with root canal treatment (RCT). To verify this subject, we evaluated the effect of orthodontic movement on the prognosis of RCT teeth using cone-beam computed tomography (CBCT) and further explored the influence of orthodontic movement on the prognosis of RCT teeth with and without apical periodontitis (AP).

Repolarization of Immunosuppressive Macrophages by Targeting SLAMF7-Regulated CCL2 Signaling Sensitizes Hepatocellular Carcinoma to Immunotherapy.

Unlabelled: Immune checkpoint inhibitors have limited efficacy in hepatocellular carcinoma (HCC). Macrophages are the most abundant immune cells in HCC, suggesting that a better understanding of the intrinsic processes by which tumor cells regulate macrophages could help identify strategies to improve response to immunotherapy. As signaling lymphocytic activation molecule (SLAM) family members regulate various immune functions, we investigated the role of specific SLAM receptors in the immunobiology of HCC.

Chemokine CCL21 determines immunotherapy response in hepatocellular carcinoma by affecting neutrophil polarization.

Background: The efficacy of immune checkpoint inhibitors (ICIs) in hepatocellular carcinoma (HCC) is poor and great heterogeneity among individuals. Chemokines are highly correlated with tumor immune response. Here, we aimed to identify an effective chemokine for predicting the efficacy of immunotherapy in HCC.

Correction: Highly photoluminescent nitrogen-rich carbon dots from melamine and citric acid for the selective detection of iron(iii) ion.

[This corrects the article DOI: 10.1039/C5RA26521E.].

Efficacy of hemoporfin-PDT on port-wine stains: A retrospective analysis of 2952 cases.

Objective: To conduct a retrospective analysis of Hemoporfin photodynamic therapy (HMME-PDT) in the treatment of port-wine stains (PWS).

Method: A retrospective analysis was conducted based on the clinical data from March 2017 to December 2022, so as to summarize the demographic characteristics, clinical efficacy and adverse reactions. The effectiveness of HMME-PDT was examined with respect to treatment times, age, gender, subtype, and location of PWS lesions.