sp. nov., a novel halotolerant, flexirubin-type pigment-producing bacterium of the family .

A Gram-staining-negative, non-motile, aerobic, rod-shaped bacterium, designated 14752, was isolated from a saline lake in Xinjiang Uygur Autonomous Region, China. The strain was subjected to a taxonomic study using a polyphasic approach. Strain 14752 was able to grow at 4-40 ℃ (optimum 28 ℃), pH 6.

sp. nov., isolated from the upper respiratory tract of duck.

Five bacterial strains, designated as RCAD1438, RCAD1439, RCAD1670, RCAD1671 and RCAD1672, were isolated from the upper respiratory tract of ducks in Anhui, Shaanxi and Sichuan, China. All strains are Gram-stain-negative, rod-shaped, non-motile, non-spore-forming, aerobic and capsulated. They grow optimally at 37 °C and pH 7.

Asymmetric Total Synthesis of 5,10-seco-Neoansamycin A.

The first asymmetric total synthesis of 5,10-seco-neoansamycin A, a 19-membered cyclic octaketide, was achieved in 20 steps (with several steps being telescoped) and 6.7% overall yield starting from the reported compound, thus leading to the assignment of its absolute configuration. This convergent synthetic approach features late-stage macrolactamization, a judicious application of an asymmetric aldol reaction.

Brucine Inhibits Gastric Cancer via Activation of Ferroptosis Through Regulating the NF-κB Signaling Pathway.

Gastric cancer (GC) is the third leading cause of cancer mortality globally, often presenting with insidious symptoms that lead to late-stage diagnoses, underscoring the critical need for innovative diagnostic and therapeutic strategies. One such avenue is the exploration of ferroptosis, a regulated form of cell death implicated in various pathological conditions and malignancies. In this study, we demonstrate that brucine, an alkaloid derived from Strychnos nux-vomica, exerts significant antitumor effects on GC cells both in vitro and in vivo.

Jinggangmycin-induced NlPR-L and NlABD4-L genes regulate fecundity in the brown planthopper, Nilaparvata lugens (Stål) (Hemiptera: Delphacidae).

The brown planthopper (BPH), Nilaparvata lugens (Stål), is a typical insecticide-induced resurgence rice pest that causes severe damage to rice in Asian countries. Previous studies have shown that the fungicide Jinggangmycin (JGM), used to control rice sheath blight disease, can stimulate BPH fecundity; however, the molecular mechanism remains to be further explored. In this study, based on transcriptomic analysis, we found that the PI3K-Akt signaling pathway was significantly enriched in BPH after feeding on JGM-treated rice, where the NlPR-L and NlABD4-L genes were significantly upregulated.

CYP72A15 confers resistance against penoxsulam to Echinochloa phyllopogon.

As the weed Echinochloa phyllopogon has rapidly developed multi- and cross-resistance to several herbicides, we aimed to determine the mechanism underlying penoxsulam resistance in weeds. There was no target mutation in the tested population, and P450 enzyme activity was significantly higher in the penoxsulam-treated resistant population, confirming that non-target-site resistance was dominant. The antioxidant enzyme activity of the resistant population was higher than that of the sensitive population following the application of the penoxsulam and cleared HO faster.

Mn-doped carbon dots-based fluorescent-colorimetric dual-mode probes for selective and sensitive detection of Cr(VI) ions and l-ascorbic acid via smartphone-integrated analytical platform.

Background: Hexavalent chromium ions (Cr(VI)), a notorious toxic heavy metal pollutant with proven carcinogenicity, endangers human health and the environment. Meanwhile, l-ascorbic acid (L-AA), a vital biological antioxidant, has abnormal levels closely tied to various diseases. Developing efficient synchronous detection methods for these two key analytes is of great value in clinical and environmental monitoring.

An injectable nanosuspension based on orthoester and biomimetic carboxymethyl chitosan nanoparticles for chemo/thermo-synergistic tumor therapy.

The primary objective of this study was to develop a nanosuspension based on orthoester compounds (OE) and carboxymethyl chitosan (CMCS) for the combined treatment of tumors. Initially, OE was synthesized as a liquid pharmaceutical excipient. Subsequently, nanoparticles were formulated using CMCS and loaded with mitoxantrone (MIT).

Preliminary evaluation of pectoralis major fascia use in robotic nipple sparing mastectomy and immediate breast reconstruction with gel implant: a retrospective comparative cohort study.

Objective: To demonstrate that the feasibility of using the da Vinci robotic XI surgical system for breast reconstruction with pectoralis major fascia instead of latissimus dorsi flaps.

Methods: A retrospective analysis was conducted on the clinical data of 33 female patients with breast cancer who were treated with robotic nipple sparing mastectomy and immediate breast reconstruction with gel implant (RNSMIBR) between September 2022 and June 2024 and met the selection criteria. The surgical techniques employed included the use of a latissimus dorsi muscle flap (LDMF) in seven cases (Group A), a LDMF without skin island in nine cases (Group B) and a pectoralis major fascia in 17 cases (Group C).

Regulating cell stress responses by nitric oxide to enhance calcium overload-mediated tumor therapy.

Amino acid (AA)-based nanoparticles (NPs) hold promise in cancer therapy due to their excellent biocompatibility and the various therapeutic functions derived from AA monomers. Here, we developed a universal one-step method to synthesize AA-based NPs. We then constructed L-Arginine (L-Arg)/calcium phosphate (CaP) NPs to enhance cancer therapy through synergistic calcium overload to induce apoptosis and immunogenic cell death.

Synthesis and Preclinical Evaluation of Novel Tc-Labeled Glucose Derivatives Containing Different Proline Analogs as Linker Moieties for Tumor Imaging.

2-[F]Fluoro-2-deoxy-d-glucose ([F]FDG) is the most extensively utilized tumor imaging agent in clinical positron emission tomography (PET) applications. Nevertheless, no radiolabeled glucose derivatives for single-photon emission computed tomography (SPECT) imaging have achieved clinical usage comparable to that of [F]FDG. Technetium-99m is a common single-photon-emitting radionuclide used in clinical practice and has potential for the development of novel radiopharmaceuticals.

Substituting Superhalogens for the Fluorine Atom of 5-Fluorouracil: A New Approach to Modulate its Structure, Electronic Properties, and Chemical Reactivity.

The development of 5-fluorouracil (5-FU) analogs contributes to overcome its side effects and drug resistance. To explore more 5-FU analogs, the substituent effect of BO, NO, and PO on the geometric structure, electronic properties, and reactivity of 5-FU has been systematically studied by density functional theory calculations and molecular docking in this article. It is revealed that the introduced superhalogens can not only form stable covalent bonds with the pyrimidine ring, like the original F atom in 5-FU, but also pose significant effect on the geometric and electronic structures of 5-FU.

Exploring the causal relationship between 25-hydroxyvitamin D and asthma: A bidirectional Mendelian randomization study.

The role of 25-hydroxyvitamin D (25(OH)D) in disease has attracted much attention. However current research findings on the relationship between 25(OH)D and asthma are not completely consistent. This study aims to explore the potential causal relationship between 25(OH)D levels and asthma using a bidirectional Mendelian randomization (MR) approach.

[The role and mechanisms of N,N-dimethylglycine sodium in promoting wound healing in mice].

N,N-Dimethylglycine (DMG) is a glycine derivative, and its sodium salt (DMG-Na) has been demonstrated to possess various biological activities, including immunomodulation, free radical scavenging, and antioxidation, collectively contributing to the stability of tissue and cellular functions. However, its direct effects and underlying mechanisms in wound healing remain unclear. In this study, a full-thickness excisional wound model was established on the dorsal skin of mice, and wounds were treated locally with DMG-Na.

Facile synthesis of a near-infrared fluorophore based on Dibenzo[def,mno]chrysene-6,12-dione acceptor for dual applications in organic light-emitting diode and cellular imaging.

Near-infrared (NIR) fluorophores, characterized by emission wavelengths exceeding 650 nm, have garnered significant attention due to their diverse and advanced applications in fields such as organic light-emitting diodes (OLEDs), photomicrography, anti-counterfeiting, in vivo/vitro bioimaging, as well as theranostics. In this study, we report the rational design and facile synthesis of a novel NIR fluorescent molecule, AA-TPA, strategically constructed by integrating two twisted triphenylamine (TPA) electron-donating groups with a dibenzo[def,mno]chrysene-6,12-dione (AA) electron-accepting unit. The pronounced donor-acceptor interaction within the non-planar and rigid molecular architecture facilitates NIR emission with a peak at 667 nm, while preserving efficient luminescence with a photoluminescence quantum yield of 46 % in a doped film.

Determination of the standardized ileal amino acid digestibility of corn in 13-day-old broilers and establishment of the prediction equations.

This study was conducted to evaluate apparent ileal amino acid digestibility (AID AA) and standardized ileal amino acid digestibility (SID AA) in corn with different sources fed to broilers and to establish prediction equations of SID AA based on the chemical composition of corn. Ten different sources of corn were evaluated. A total of 660 1-day-old male broilers (Arbor Acres) were randomly divided into 11 treatments (6 replicates, 10 birds per replicate).

CSF total tau as a proxy of synaptic degeneration.

Cerebrospinal fluid (CSF) total tau (t-tau) is considered a biomarker of neuronal degeneration alongside brain atrophy and fluid neurofilament light chain protein (NfL) in biomarker models of Alzheimer's disease (AD). However, previous studies show that CSF t-tau correlates strongly with synaptic dysfunction/degeneration biomarkers like neurogranin (Ng) and synaptosomal-associated protein 25 (SNAP25). Here, we compare the association between CSF t-tau and synaptic degeneration and axonal/neuronal degeneration biomarkers in cognitively unimpaired and impaired groups from two independent cohorts.

sp. nov., sp. nov., sp. nov., sp. nov., sp. nov., sp. nov., sp. nov. and sp. nov., isolated from ginseng rhizosphere.

Thirteen novel strains - J2L1-78, J2P1-59, J22R24, J22R133, J22P168, J22P271, J22R187, J22R193, J2L1-63, J2R1-6, J22G21, J22G47, and J31P216 - were isolated from the rhizosphere of 20-year-old ginseng in Jilin Province, P.R. China.

Quasi-Solid-State ECL Immunosensor Based on Adenine-Incorporated MOFs Adsorption and Electrochemical Release of Ru(bpy) for Signal Enhancement.

Electrochemiluminescence (ECL) immunosensors are widely used for cancer marker detection due to their high selectivity, but their reuse is limited by the need for electrode reconditioning after each assay, hindering large-scale application. In our work, a novel quasi-solid-state ECL immunosensor is designed. A gel-cast cellulose membrane is used as our sensor platform, providing a new location for biomolecular-specific identification.

Associations between trajectories of plasma biomarkers for Alzheimer's disease, brain structures, and cognitive function: a prospective cohort study in the UK Biobank.

Plasma amyloid-β(Aβ)42/40 ratio, glial fibrillary acidic protein (GFAP), neurofilament light (NfL), and phosphorylated tau181(p-tau181) are promising biomarkers for Alzheimer's disease (AD)-related pathology. We aimed to explore the longitudinal trajectories of these biomarkers in association with changes in structural brain markers and cognition, and the impact of cognitive reserve on their associations with cognitive function. This cohort study included 1270 individuals (mean age 59.

Long-lasting ultraviolet-A persistent luminescence in SrMg(PO):Ce,A (A = Li, Na, K) phosphors by X-rays rapid charging.

UVA persistent luminescent materials have potential applications in energy-saving catalysis and photodynamic therapy. However, the charging time required for existing materials is too long, which restricts their efficiency. We developed novel UVA persistent luminescent phosphors SrMg(PO):Ce and SrMg(PO):Ce,A (A = Li, Na, K) which can be charged rapidly by X-rays.

Reduction-responsive RNAi nanoplatform for enhanced cancer sonoimmunotherapy via dual inhibition of mitophagy and Nrf2 pathways.

Sonodynamic therapy (SDT) has emerged as a promising non-invasive modality with deeper tissue penetration than photodynamic or chemodynamic therapies. However, its therapeutic efficacy remains limited due to inadequate reactive oxygen species (ROS) generation, largely attributed to tumor-intrinsic antioxidant systems and mitophagy. Existing combinations of SDT with immunotherapy are primarily additive and fail to address the mechanistic interplay between ROS suppression and immune evasion.

Autophagy dictates PHGDH-mediated serine metabolism in a timely manner to support oocyte development.

The metabolic co-dependence of the oocyte and surrounding granulosa cells is crucial for oocyte developmental competence. Previous research has shown that serine-glycine and its key downstream metabolites are significantly involved in the process of oocyte maturation. However, the mechanism of serine metabolism and its influence on oocyte maturation remain unclear.

LRRC75A-AS1 facilitates breast cancer cell proliferation and invasion via functioning as a CeRNA to modulate miR489-3p/ARD1.

This study aimed to elucidate the molecular mechanism through which ARD1 regulates breast cancer (BC) progression via the LRRC75A-AS1/miR-489-3p axis. The expression levels of ARD1, miR-489-3p, and LRRC75A-AS1 in BC cells were quantified using reverse transcription-polymerase chain reaction (RT-PCR). The interaction between miR-489-3p and ARD1 was validated through dual-luciferase reporter assays and RNA-binding protein immunoprecipitation (RIP).

Self-healing and adhesive eutectogels with dual conductive networks for multimodal health monitoring and human-computer interaction.

Flexible sensors exhibit transformative potential across diverse applications ranging from continuous health monitoring to advanced human-machine interaction. However, conventional unimodal sensors are limited in their ability to capture multidimensional signals in complex scenarios. To address this issue, this study synthesized a polymerizable deep eutectic solvent (pDES) from choline chloride (Chcl) and acrylic acid (AA).