Assessment of human parabens exposure and health risk based on global biomonitoring data.

Parabens are among the most prevalent preservatives utilized in daily life. According to studies, parabens are endocrine disruptors that may be harmful to human health. This study used urine (N = 370,460) and blood (N = 19,521) data from 203 publications from 29 countries to calculate the global estimated daily intakes (EDIs) and grouped EDIs (EDIs) of parabens in different countries and populations, assess the global exposure trends of parabens from 2000 to 2024, and determine the potential health risks of parabens exposure.

Thermally Induced Topological Isomers of Metal-Organic Frameworks for Enhanced CH Separation from CO and CH.

Although isomerism is a fundamental and well-explored phenomenon in organic chemistry, its occurrence in metal-organic frameworks (MOFs) remains rare. Here, we present a novel class of MOF topological isomers that share identical molecular formulas and secondary building units (SBUs), yet exhibit distinct network architectures. These isomers, differentiated by their and topologies, arise from variations in ligand conformation due to steric constraints.

DSNet enables feature fusion and detail restoration for accurate object detection in foggy conditions.

In real-world scenarios, adverse weather conditions can significantly degrade the performance of deep learning-based object detection models. Specifically, fog reduces visibility, complicating feature extraction and leading to detail loss, which impairs object localization and classification. Traditional approaches often apply image dehazing techniques before detection to enhance degraded images; however, these processed images often retain a rough appearance with a loss of detail.

Short-wave infrared (SWIR) polarization imaging using division-of-focal-plane imaging polarimeter.

This study investigates the polarization properties of materials in the short-wave infrared (SWIR) spectrum using a compact division-of-focal-plane imaging polarimeter. The polarimeter is constructed by packaging a micro-polarizer array on top of an InGaAs sensor. Experiments conducted in both indoor and outdoor environments revealed unique transparency, absorption, and polarization behaviors across various materials.

Study on the Motion Trajectory of Abrasives and Surface Improvement Mechanism in Ultrasonic-Assisted Diamond Wire Sawing Monocrystalline Silicon.

The surface quality of diamond wire sawing (DWS) wafers directly affects the efficiency and yield of subsequent processing steps. This paper investigates the motion trajectory of abrasives in ultrasonic-assisted diamond wire sawing (UADWS) and its mechanism for improving surface quality. The influence of ultrasonic vibration on the cutting arc length, cutting depth, and interference of multi-abrasive trajectories was analyzed through the establishment of an abrasive motion trajectory model.

Influence of Grinding Parameters on Surface Roughness and Subsurface Crack Damage Depth of Sapphire Crystal.

Single sapphire crystals has been widely used in technology such as light emitting diodes, lasers, high-temperature and high-voltage devices, special windows, and optical systems, and grinding is an important process of their machining. In order to reveal the influence of the grinding wheel speed, grinding depth, and feed rate on the ground surface quality of sapphire crystals, a three-factor and five-level orthogonal experiment was designed and completed. Variance and range analysis was conducted on the experimental results using the surface roughness and subsurface crack damage depth (SSD) as evaluation indicators, and optimized parameter combinations were explored.

Accelerated tetracycline hydrochloride mineralisation by Fe@CeO/MgO complex metal oxides via ozone-catalysed interfacial reactions: The role of oxygen vacancies and multivalent metal cycling.

Heterogeneous catalytic ozonation (HCO) shows promising potential for degrading emerging contaminants, but its mineralisation rate needs further improvement due to insufficient electron transfer. To address this limitation, an efficient HCO system was developed by synthesising a Fe@CeO/MgO multi-metal catalyst via an isomorphous substitution strategy, which was then coupled with ozone (O) for efficient tetracycline hydrochloride (TCH) mineralisation. The results indicated that TCH mineralisation rate reached 0.

PointFormer: Keypoint-Guided Transformer for Simultaneous Nuclei Segmentation and Classification in Multi-Tissue Histology Images.

Automatic nuclei segmentation and classification (NSC) is a fundamental prerequisite in digital pathology analysis as it enables the quantification of biomarkers and histopathological features for precision medicine. Nuclei appear to be small, however, global spatial distribution and brightness contrast, or color correlation between the nucleus and background, have been recognized as key rationales for accurate nuclei segmentation in actual clinical practice. Although recent great breakthroughs in medical image segmentation have been achieved by Transformer-based methods, the adaptability of segmenting and classifying nuclei from histopathological images is rarely investigated.

Haplotype-specific interactions of Phragmites australis with Spartina alterniflora under salt stress.

Biological invasions present a global environmental challenge, the competitive interactions between native and invasive species constitute a crucial factor in determining the success of invasions. Past research has often treated native species as a monolithic entity when conducting competition experiments with invasive species. In truth, different genotypes may possess substantial differences in functional traits and competitive abilities.

Clinical value and survival analysis of subcutaneous soft tissue metastasis detected by F-FDG PET/CT.

Objective: To retrospectively analyze cases of whole-body F-FDG PET/CT imaging, identify abnormal images of subcutaneous nodules, and explore the clinical application value of PET/CT in detecting subcutaneous soft tissue metastases and its impact on survival.

Method: An analysis was conducted on cases from August 2019 to August 2024, and 57 cases of subcutaneous nodules were found to have positive 18F-FDG imaging, all of which underwent pathological puncture or biopsy. Collect patient histological subtypes, metastasis patterns, treatment, and survival rates.

DRP1, fission and apoptosis.

Mitochondrial fission is a critical physiological process in eukaryotic cells, participating in various vital activities such as mitosis, mitochondria quality control, and mitophagy. Recent studies have revealed a tight connection between mitochondrial fission and the mitochondrial metabolism, as well as apoptosis, which involves multiple cellular events and interactions between organelles. As a pivotal molecule in the process of mitochondrial fission, the function of DRP1 is regulated at multiple levels, including transcription, post-translational modifications.

Gestational and lactational exposure to DEHP triggers ACSL4/TFR-mediated hippocampal neuronal ferroptosis via YAP activation: Implication for the neurocognitive disorders in male offspring.

Di-(2-ethylhexyl) phthalate (DEHP) is one of the most extensively used phthalate and poses a public health concern. Perinatal exposure to DEHP has been shown to cause neurodevelopmental abnormalities and neurobehavioral disorders in offspring. However, the precise molecular mechanism has not yet been fully elucidated.

A modified Müller-Plathe method capable of quickly establishing an expected temperature difference in classical and molecular dynamics simulations for thermal transport calculations.

The Müller-Plathe method [F. Müller-Plathe, , 1997, , 6082] has been widely used to calculate the thermal transport properties of materials, with the advantages of easy implementation and no external thermostat needed. However, the temperature differences of model systems are uncontrollable in the original Müller-Plathe method, which largely depends on the selected time intervals for velocity exchanges in the molecular dynamics simulations, largely affecting the computational efficiency of the Müller-Plathe-method-based molecular dynamics simulations, especially first-principles calculations.

Unlocking the Potential of Nanostructured ZnO on PPC Membranes: High-Throughput Synthesis, Morphology Tailoring, and Enhanced Antibacterial Activity.

The development of nanostructured ZnO (nano-ZnO) with tailored morphologies is critical for creating effective antibacterial materials. This study introduces a high-throughput platform for the in situ synthesis of PPC/nano-ZnO composites, enabling precise control over the morphology of nano-ZnO to optimize antibacterial performance. By leveraging electrospinning, heat treatment, and hydrothermal synthesis, we fabricated diverse nano-ZnO structures, including nanoparticles, nanorods, and nanoflowers, on PPC nanofiber membranes.

Process Parameters Analysis in Diamond Wire Saw Cutting NdFeB Magnet.

Neodymium iron boron (NdFeB) magnetic materials are widely used in fields such as electronics, medical devices, power machinery, and hardware machinery. This paper conducted a three-factor and five-level orthogonal experiment on diamond wire saw cutting NdFeB to determine the influence degree of key factors such as workpiece feed rate, diamond wire speed, and workpiece processed size on the surface roughness a and waviness a of NdFeB slices. Further analysis was conducted on the influence of various parameters on the PV value (peak valley difference) of the waviness profile curve of the sawed surface.

Ezh2 Regulates Early Astrocyte Morphogenesis and Influences the Coverage of Astrocytic Endfeet on the Vasculature.

Astrocytes are crucial for central nervous system (CNS) development and function, with their differentiation being stringently controlled by epigenetic mechanisms, such as histone modifications. Enhancer of Zeste Homologue 2 (EZH2), a histone methyltransferase, is essential for the suppression of gene expression. However, the role of EZH2 in astrocyte early morphogenesis has remained unclear.

Advances in hydrogel for diagnosis and treatment for Parkinson's disease.

Currently, few symptomatic and palliative care options are available for patients with Parkinson's disease (PD). Interdisciplinary research in materials engineering and regenerative medicine has stimulated the development of innovative therapeutic strategy for patients with PD. Hydrogels, which are versatile and accessible to modify, have garnered considerable interests.

Conflict-based strategy combined integrated optimal conflict avoidance algorithm.

This paper presents a Conflict-Based Strategy - Combined Integrated Optimal Conflict Avoidance (CBS-CIOCA) algorithm for more efficient multi-robot path planning. The algorithm first refines the conflict types in the high-level model of the traditional CBS algorithm and introduces two conflict categories: avoidable conflicts and unavoidable conflicts. Next, the low-level model of the traditional CBS algorithm is improved, transforming the path search process into two distinct algorithms with different focuses.

High expression of nucleotide-binding oligomerization domain protein 1 correlates with poor prognosis and immune cell infiltration in Glioblastoma Multiforme patients.

Nucleotide-binding oligomerization domain protein 1 (NOD1) is one of the innate immune receptors that has been associated with tumorigenesis and abnormally expressed in various cancers. However, the role of NOD1 in Glioblastoma Multiforme (GBM) has not been investigated. We used the Tumor Immune Estimate Resource (TIMER) database to compare the differential expression of NOD1 in various tumors.

Effects of GaN substrates of different polarity on the thermal and electronic properties of monolayer MoS.

Monolayer MoS, a compound in two-dimensional TMDs, exhibits excellent physical and chemical properties due to its sandwich structure, making it widely used in the design of nanodevices. We investigated the impact of GaN substrates on the thermal and electronic properties of monolayer MoS. The results reveal that the polarity of the GaN substrate significantly affects the thermal conductivity of monolayer MoS.

Carbon Nanofiber/Polyaniline Composite Aerogel with Excellent Electromagnetic Interference Shielding, Low Thermal Conductivity, and Extremely Low Heat Release.

The rapid development of communication technology and high-frequency electronic devices has created a need for more advanced electromagnetic interference (EMI) shielding materials. In response to this demand, a study has been conducted to develop multifunctional carbon nanofibers (CNFs)/polyaniline (PANI) aerogels with excellent electromagnetic interference shielding, flame retardancy, and thermal insulation performance. The process involved freeze-drying of electrospun CNFs and PANI nanoparticles followed by in situ growth PANI to coat the CNFs, creating the core-shell structured CNFs/PANI composite fiber and its hybrid aerogels (CP-3@PANI).

A within-subject voxel-wise constant-block partial least squares correlation method to explore MRI-based brain structure-function relationship.

The brain structure-function relationship is crucial to how the human brain works under normal or diseased conditions. Exploring such a relationship is challenging when using the 3-dimensional magnetic resonance imaging (MRI) functional dataset which is temporal dynamic and the structural MRI which is static. Partial Least Squares Correlation (PLSC) is one of the classical methods for exploring the joint spatial and temporal relationship.