Worldwide research on 3D printing for cancer: a dual-method analysis of bibliometrics and stratified focused thematic.

Aim: This study investigates the application of three-dimensional (3D) printing in cancer research and treatment, highlighting the current advancements, key areas of interest, and emerging trends in the field.

Methods: Literature records and cited references were retrieved from the Web of Science Core Collection (WOSCC) database and analyzed using Excel 2019, Bibliometrix, VOSviewer, and CiteSpace. Based on the scientometric results, a stratified and focused thematic analysis was performed by cancer type to enhance clinical relevance and investigate tumor-specific applications.

Emerging molecular targets in deep vein thrombosis: from inflammation to coagulation.

Deep vein thrombosis (DVT), a prevalent vascular disorder driven by venous stasis, endothelial injury, and hypercoagulability, imposes a significant global health burden due to life-threatening complications like pulmonary embolism. Recent advances highlight inflammation as a pivotal contributor to DVT pathogenesis, intricately linked with coagulation through immunothrombosis. This review synthesizes emerging molecular targets bridging these pathways, focusing on neutrophil extracellular traps (NETs), peptidylarginine deiminase 4 (PAD4), P-selectin, high-mobility group box 1 (HMGB1), tissue factor (TF), complement C3, and the NLRP3 inflammasome.

Fabrication of flexibility-rigidity alternately assembled solid-state luminescence covalent organic frameworks: application to rifampicin antibiotics detection and latent fingerprint recognition.

To enhance the fluorescence properties of covalent organic frameworks (COFs) for broader applications, we introduce flexibility-rigidity alternately assembled red fluorescent COFs, named COF-MA. Its uniquely wide layer spacing (7.054 Å) significantly reduces π-π stacking interactions, suppressing fluorescence self-quenching and boosting solid-state emission.

Identification of multi-omic pleiotropy factors for peripheral artery disease.

Background: Peripheral artery disease (PAD) is prevalent and frequently co-occurs with type 2 diabetes (T2D) and coronary artery disease (CAD). Although shared genetic factors may contribute to these comorbidities, few studies have examined pleiotropy at the transcriptomic and proteomic levels.

Methods: We generated summary statistics for transcriptome-wide (TWAS) and proteome-wide (PWAS) association analyses across PAD, T2D, and CAD.

Exploiting an evolutionary constraint: Targeting TatD nuclease with chrysosplenol D disrupts Mycoplasma gallisepticum infection.

Mycoplasma gallisepticum (MG) poses a substantial constraint on global poultry production as a prevalent avian pathogen. Nucleases exhibit critical regulatory functions in metabolic homeostasis and virulence mechanisms of MG. Targeting these enzymatic mediators may represent a novel therapeutic approach to overcome the limitations in current treatment modalities.

Targeting Programmed Cell Death in Flap Ischemia/Reperfusion Injury.

A skin flap is a composite tissue unit comprising skin and subcutaneous fat with an intact vascular supply. Skin flaps are commonly employed for wound reconstruction, transplantation of damaged tissues, and cosmetic procedures. However, flap necrosis resulting from ischemia/reperfusion injury (IRI) is a frequent complication, leading to surgical failure.

Effect of myeloid-derived suppressor cells on retinal epithelial cells in retinopathy of prematurity model.

Background: Retinopathy of prematurity (ROP) is a proliferative vascular disease with a high incidence rate. Myeloid-derived suppressor cells (MDSCs) are a type of stem cell that possesses remarkable regenerative and reparative capabilities. However, the role of MDSCs as a stem cell therapy in the treatment of ROP remains unclear.

Risk assessment and interventions for malignant ground-glass lung nodules.

Pulmonary ground-glass nodules (GGNs) have become a major problem owing to their high frequency, limited diagnostic differentiation, complex pathogenesis, and lack of effective intervention strategies. With the ongoing increase in the frequency of pulmonary nodules and improved control of smoking, GGNs may become the predominant manifestation of early-stage lung cancer (LC) in the future. However, current diagnostic approaches are limited in terms of both accuracy and specificity, leading to a dual challenge of overtreatment and delayed intervention.

Real-time Monitoring Unveils Three Distinct Neuronal Response Patterns to SAW Ultrasound via L-type Calcium Channels.

Ultrasound neuromodulation shows promise for treating neurological disorders, but the underlying mechanisms remain unclear. Here, we developed an integrated surface acoustic wave (SAW) ultrasound chip enabling simultaneous electrophysiological recording and Ca imaging of cultured hippocampal neurons to investigate neuronal excitability and synaptic transmission during ultrasound stimulation. This study revealed, for the first time, three distinct neuronal response patterns induced by SAW ultrasound: an immediate response showing rapid activation, a delayed response exhibiting facilitation after several minutes, and a non-response maintaining baseline activity.

Disruption of gut microbiome and metabolome in treatment-naïve children with attention deficit hyperactivity disorder.

Background: Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with an increasing prevalence in children. Recent studies have suggested that the gut microbiota may play a significant role in the development of ADHD. However, the specific relationship between changes in intestinal bacteria and related metabolites in children with ADHD remains poorly understood.

Leveraging pleiotropy to improve genetic risk prediction across diseases.

Background: Polygenic scores (PGSs) have shown promise in predicting disease risk, but their predictive accuracy remains limited for many complex diseases. Leveraging the shared genetic architecture among correlated traits may improve prediction performance.

Methods: We developed a flexible framework for constructing multi-trait PGSs by integrating candidate PGSs (N=2,651) derived from publicly available GWAS summary statistics (N=51)-using single-trait, MTAG-all, and MTAG-pairwise approaches.

Robust pleiotropy-decomposed polygenic scores identify distinct contributions to elevated coronary artery disease polygenic risk.

Background: Polygenic risk score (PRS) have proved to offer robust risk prediction for coronary artery disease (CAD). However, the global CAD PRS summarizes the joint effects of all the markers in the genome, masking potential genetic heterogeneity that may be important for disease interpretation and targeted interventions.

Methods: Using summary-level data, we identified 43 significant CAD-related traits based on genetic correlations, and further classified them into eight pleiotropy clusters based on their biological functions.

Ginger-processed Magnoliae Officinalis Cortex ameliorates ovalbumin-induced asthma by alleviating inflammation via the gut-lung axis.

Background: The complex pathophysiology of asthma and the lack of effective therapies have driven research into natural product remedies. Ginger-processed Magnoliae Officinalis Cortex (GMOC), a traditional Chinese medicine, has been used for asthma treatment, but the lack of its potential mechanism of action limits the clinical application of GMOC.

Purpose: To investigate the mechanism of action of GMOC in asthmatic mice based on the gut-lung axis.

Soybean Cultivar Breeding Has Increased Yields Through Extended Reproductive Growth Periods and Elevated Photosynthesis.

Despite being one of China's largest soybean ( L. Merr.) production areas, the Huanghuaihai Farming Region (HFR) has long been plagued by suboptimal yields.

Unraveling the effects of allelopathic algicide on Microcystis population: microcystin pollution risk assessment and proteomic-metabolomic insights into the sensitivity of toxigenic and non-toxigenic strains.

The global expansion of Microcystis-dominated cyanobacterial blooms (MCBs) threatens aquatic ecosystems health, where Microcystis population comprises coexisting microcystin (MC)-producing (MC) and MC-free (MC) strains. Luteolin, an allelopathic algicide, has shown potential in inhibiting MCMicrocystis growth and MC-production/-release. This study investigated luteolin's effects on co-cultured MC and MCMicrocystis (i.

Exploring microbial natural products through NMR-based metabolomics.

Covering: 2000. 01 to 2025. 03The soaring demand for novel drugs has led to an increase in the requirement for smart methods to aid in the exploration of microbial natural products (NPs).

Scalable Multifunctional Fabrics with Boosted Intrinsic Photothermal Efficiency for Salt-Resistant Solar-Driven Janus Evaporators.

Global population growth and climate change are causing freshwater scarcity, which necessitates creative solutions like solar-driven desalination. This technology's widespread adoption is hampered by cost and efficiency issues. Intrinsic photothermal conversion efficiency has gotten less attention than light trapping and thermal management, which have been the main focuses of efforts to increase photo-to-vapor efficiencies.

Performance Evaluation of Image Segmentation Using Dual-Energy Spectral CT Images with Deep Learning Image Reconstruction: A Phantom Study.

: To evaluate the medical image segmentation performance of monochromatic images in various energy levels. : The low-density module (25 mm in diameter, 6 Hounsfield Unit (HU) in density difference from background) from the ACR464 phantom was scanned at both 10 mGy and 5 mGy dose levels. Virtual monoenergetic images (VMIs) at different energy levels of 40, 50, 60, 68, 74, and 100 keV were generated.

Deciphering the joint intracellular and extracellular regulatory strategies of toxigenic Microcystis to achieve intraspecific competitive advantage: An integrated multi-omics analysis with novel allelochemicals identified.

Global increase in Microcystis-dominated cyanobacterial blooms (MCBs) severely threatens ecological and human health. Intraspecific interaction between microcystin (MC)-producing (MC) Microcystis and co-existing MC-free (MC) Microcystis influences the relative abundance of MCMicrocystis, ultimately determining the toxicity and hazard of MCBs. However, specific allelochemicals driving this interaction and underlying molecular mechanisms remain unclear.

Accelerated tetracycline hydrochloride mineralisation by Fe@CeO/MgO complex metal oxides via ozone-catalysed interfacial reactions: The role of oxygen vacancies and multivalent metal cycling.

Heterogeneous catalytic ozonation (HCO) shows promising potential for degrading emerging contaminants, but its mineralisation rate needs further improvement due to insufficient electron transfer. To address this limitation, an efficient HCO system was developed by synthesising a Fe@CeO/MgO multi-metal catalyst via an isomorphous substitution strategy, which was then coupled with ozone (O) for efficient tetracycline hydrochloride (TCH) mineralisation. The results indicated that TCH mineralisation rate reached 0.

Promising Response to Pyrotinib in Non-Small-Cell Lung Cancer with the Rare HER2 R456C Mutation: A Case Report.

Background: HER2 exon 20 insertions exhibit relative resistance to chemotherapy and covalent HER2-targeted tyrosine kinase inhibitors (TKIs) in non-small-cell lung cancer (NSCLC). Furthermore, specific missense mutations in the extracellular domain of the HER2 protein have been identified as oncogenic drivers in NSCLC. However, their structural properties and clinical response to HER2-targeted inhibitors remain poorly understood, warranting further investigation.

Research and Prospects of Digital Twin-Based Fault Diagnosis of Electric Machines.

This paper focuses on the application of digital twins in the field of electric motor fault diagnosis. Firstly, it explains the origin, concept, key technology and application areas of digital twins, compares and analyzes the advantages and disadvantages of digital twin technology and traditional methods in the application of electric motor fault diagnosis, discusses in depth the key technology of digital twins in electric motor fault diagnosis, including data acquisition and processing, digital modeling, data analysis and mining, visualization technology, etc., and enumerates digital twin application examples in the fields of induction motors, permanent magnet synchronous motors, wind turbines and other motor fields.

The Impact of Test Device on the Evaluation Cooling Effect of Radiation-Cooling Materials.

Passive radiation cooling technology, as a new zero-energy refrigeration technology method, has received widespread attention in recent years. However, due to differences in the testing devices used by different teams, it becomes difficult to directly compare the cooling performance of the respective prepared materials. This study combines experimental and theoretical methods to explore the impact of testing equipment and sample size on the results of the radiative cooling capacity evaluation.

Unitary Block-Correlated Coupled Cluster Ansatz Based on the Generalized Valence Bond Wave Function for Quantum Simulation.

Strongly correlated (SC) systems present significant challenges for classical quantum chemistry methods. Quantum computing, particularly the variational quantum eigensolver (VQE), offers a promising framework to address these challenges by inherently supporting exponentially large configuration spaces. However, its application to SC systems remains limited due to the single-reference nature of the widely used ansatzes such as unitary coupled cluster (UCC).

A framework for studying multi-omic risk factors and their interplay: application to coronary artery disease.

Background: Transcriptome-wide and proteome-wide association studies (TWAS and PWAS) have identified risk genes across complex diseases. However, the contributions of proximal risk variants and cross-omic interplay remain to be understood.

Methods: We propose an integrative framework to characterize disease-associated transcripts and proteins, and apply it to coronary artery disease (CAD).