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Neodymium iron boron (NdFeB) magnetic materials are widely used in fields such as electronics, medical devices, power machinery, and hardware machinery. This paper conducted a three-factor and five-level orthogonal experiment on diamond wire saw cutting NdFeB to determine the influence degree of key factors such as workpiece feed rate, diamond wire speed, and workpiece processed size on the surface roughness a and waviness a of NdFeB slices. Further analysis was conducted on the influence of various parameters on the PV value (peak valley difference) of the waviness profile curve of the sawed surface. Finally, slicing processing was carried out under optimized process parameter combinations. The research results indicate that the primary and secondary order of process parameters affecting surface roughness a and waviness a is workpiece feed rate, wire speed, and sawed workpiece size, and the influence on the waviness PV value also shows a consistent trend. The optimal combination of processing parameters is workpiece feed rate of 0.1 mm·min, wire speed of 1600 m·min, and workpiece size of 10 mm. The obtained surface roughness a is 0.433 μm and the waviness a is 0.037 μm, respectively. The regression mathematical model for the waviness PV value is PV = 0.747 × × × . The research results of this paper provide an experimental basis and guidance for optimizing process parameters of sawing NdFeB.
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http://dx.doi.org/10.3390/ma18051173 | DOI Listing |
Environ Monit Assess
September 2025
Department of Civil Engineering, Faculty of Engineering, Karpagam Academy of Higher Education, Pollachi Main Road, Eachanari Post, Coimbatore, Tamil Nadu, 641021, India.
Synthetic dyes, such as Congo red (CR), pose serious threats to human health and aquatic ecosystems because of their carcinogenicity and resistance to degradation, necessitating the development of efficient and eco-friendly remediation strategies. In this study, silver nanoparticles (AgNPs) were synthesized via a green method using Ocimum sanctum (holy basil) leaf extract and applied for CR dye removal from aqueous solutions. The adsorption process was optimized using response surface methodology (RSM) based on Box-Behnken design (BBD), evaluating the influence of key parameters including pH, AgNP dosage, initial dye concentration, contact time, and temperature.
View Article and Find Full Text PDFCancer Immunol Immunother
September 2025
Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Whole blood (WB) transcriptomics offers a minimal-invasive method to assess patients' immune system. This study aimed to identify transcriptional patterns in WB associated with clinical outcomes in patients treated with immune checkpoint inhibitors (ICIs). We performed RNA-sequencing on pre-treatment WB samples from 145 patients with advanced cancer.
View Article and Find Full Text PDFAnal Bioanal Chem
September 2025
School of Artificial Intelligence, Hangzhou Dianzi University, Hangzhou, 310018, China.
The prompt and accurate identification of pathogenic bacteria is crucial for mitigating the transmission of infections. Conventional detection methods face limitations, including lengthy processing, complex sample pretreatment, high instrumentation costs, and insufficient sensitivity for rapid on-site screening. To address these challenges, an aptamer (Apt)-sensor based on functionalized magnetic nanoparticles (MNPs) was developed for detecting Escherichia coli.
View Article and Find Full Text PDFNat Commun
September 2025
Life-Like Materials and Systems, University of Mainz, Mainz, Germany.
Nuclear biomolecular condensates are essential sub-compartments within the cell nucleus and play key roles in transcription and RNA processing. Bottom-up construction of nuclear architectures in synthetic settings is non-trivial but vital for understanding the mechanisms of condensates in real cellular systems. Here, we present a facile and versatile synthetic DNA protonucleus (PN) platform that facilitates localized transcription of branched RNA motifs with kissing loops (KLs) for subsequent condensation into complex condensate architectures.
View Article and Find Full Text PDFBMJ Health Care Inform
September 2025
Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China
Objectives: The objectives were to examine the associations between accelerometer-measured circadian rest-activity rhythm (CRAR), the most prominent circadian rhythm in humans and the risk of mortality from all-cause, cancer and cardiovascular disease (CVD) in patients with cancer.
Methods: 7456 cancer participants from the UK Biobank were included. All participants wore accelerometers from 2013 to 2015 and were followed up until 24 January 2024, with a median follow-up of 9.