Protection against stroke-induced blood-brain barrier disruption by Guanxinning injection and its active-component combination via TLR4/NF-κB/MMP9-mediated neuroinflammation.

Background: The blood-brain barrier (BBB) is essential for central nervous system (CNS) homeostasis, yet neuroinflammatory mechanisms driving BBB disruption remain poorly understood.

Purpose: To explore the oxygen-glucose deprivation/reoxygenation (OGD/R)-induced BBB dysfunction and evaluate the therapeutic effects of Guanxinning injection (GXNI), a Danshen-Chuanxiong herbal combination, targeting neuroinflammatory pathways.

Methods: A 3D-BBB organoid composed of human brain microvascular endothelial cells, human astrocytes, and primary human brain microvascular pericytes was constructed, and conditions for OGD/R that simulate ischemic stroke were established.

TCA cycle mode switch determines the fate of pirtobrutinib-tolerant persister cells in mantle cell lymphoma.

Bruton's tyrosine kinase inhibitors (BTKi) and cell therapy have successfully been used to treat mantle cell lymphoma (MCL); however, therapy resistance inevitably emerges. Cancer cells can progressively develop stable resistance by traversing through a transient drug-tolerant persister (DTP) state. The mechanisms enabling DTP cells to reversibly adapt to therapies and evolve to acquire heterogeneity remain poorly understood, and characterizing DTP cells in MCL continues to pose a challenge for clinic translation.

Heterostructured ZnAl-LDH/BiOBr photocatalyst with enhanced surface molecular adsorption for efficient bisphenol A removal.

A novel dual-function ZnAl-LDH/BiOBr nanocomposite photocatalyst was synthesized using a self-assembly process and optimized by response surface methodology for the advanced treatment of wastewater micropollutants. A series of characterizations revealed that ZnAl-LDH/BiOBr exhibits suitable heterojunction structure and excellent optoelectronic properties. As a result, ZnAl-LDH/BiOBr achieved the near-complete removal of bisphenol A (BPA) after 120 min through a synergistic process of adsorption and visible-light photocatalysis.

Context-modulating effect on processing scientific metaphors: Evidence from ERPs.

Previous event-related potential (ERP) studies have demonstrated the neural specificity of cognitive processing mechanisms in scientific metaphors. This property makes semantic retrieval and extraction more difficult compared to conventional metaphors. However, the role of context in modulating the comprehension of scientific metaphors remains unclear, and there has been no analysis or categorization of abstract and difficult scientific metaphors.

Selection and Validation of Reference Genes in Under Abiotic Stresses, MeJA Treatment, and in Different Tissues.

is a valuable traditional medicinal plant that contains enriched active compounds such as triterpenoids and flavonoids. Understanding the accuulation process of these secondary metabolites in requires exploring gene expression regulation under abiotic stresses and hormonal stimuli. qRT-PCR is a powerful method for gene expression analysis, with the selection of suitable reference genes being paramount.

Exploring the quality marker of Curcumae kwangsiensis radix from different production regions using the spectrum-effect relationship, serum metabolism, and molecular docking integrated with chemometrics.

Ethnopharmacological Relevance: Curcuma kwangsiensis radix (CKR) is one of the most important herbs in traditional Chinese medicine. It effectively enhances blood circulation and eliminates stasis, which is highly associated with thrombosis. Furthermore, CKR is primarily produced in the Guangxi and Yunnan provinces of China.

Hemodynamic effects of stenosis with varying severity in different segments of the carotid artery using computational fluid dynamics.

Carotid atherosclerosis is a leading cause of ischemic stroke. As a result of atherosclerotic plaque formation, the carotid artery lumen narrows, leading to significant hemodynamic alterations. These changes can further contribute to the development of subsequent lesions.

Investigations of modulation method and stress mechanism for the growth of AlGaN channel heterostructures.

In this work, the strong connection between the channel and the barrier layer of AlGaN channel heterostructures has been investigated in detail. Unlike GaN as a channel material, AlGaN channel layers significantly influence the transport characteristics and quality of AlGaN barrier layers with increasing Al composition. Furthermore, the stress mechanism in the growth of the AlGaN layer has been thoroughly discussed.

 (Rosaceae), a new species from Fujian, China.

C.An & G.C.

Hemodynamic effects of bifurcation and stenosis geometry on carotid arteries with different degrees of stenosis.

Carotid artery stenosis (CAS) is a key factor in pathological conditions, such as thrombosis, which is closely linked to hemodynamic parameters. Existing research often focuses on analyzing the influence of geometric characteristics at the stenosis site, making it difficult to predict the effects of overall vascular geometry on hemodynamic parameters. The objective of this study is to comprehensively examine the influence of geometric morphology at different degrees of CAS and at bifurcation sites on hemodynamic parameters.

Regulation of NLRP3 inflammasome and Caspase-3/4/11 by 2',4'-dihydroxychalcone contributes to anti-colorectal cancer.

Background: Chronic inflammation is closely related to the occurrence and progression of many cancers, especially colorectal cancer (CRC), which can be triggered by repeated and sustained induction of colitis in mice. CRC is a typical type of cancer that can be caused by inflammation and NLRP3 inflammasome dysregulation plays a certain role in the pathogenesis of CRC.

Purpose: As an edible Chinese medicine, Abrus cantoniensis Hance (ACH) has both anti-inflammatory and anti-tumor activities.

Cytological analysis of flower development, insights into suitable growth area and genomic background: implications for Glehnia littoralis conservation and sustainable utilization.

Background: Glehnia littoralis F. Schmidt ex Miq., an endangered plant species with significant medicinal, edible, and ecological value, is now a central concern for conservation and sustainable utilization.

High-efficiency removal of microcystis aeruginosa using Z-scheme AgBr/NH2-MIL-125(Ti) photocatalyst with superior visible-light absorption: Performance insights and mechanisms.

Algal blooms have become a widespread concern for drinking water production, threatening ecosystems and human health. Photocatalysis, a promising advanced oxidation process (AOP) technology for wastewater treatment, is considered a potential measure for in situ remediation of algal blooms. However, conventional photocatalysts often suffer from limited visible-light response and rapid recombination of photogenerated electron-hole pairs.

The HSP90-MYC-CDK9 network drives therapeutic resistance in mantle cell lymphoma.

Brexucabtagene autoleucel CAR-T therapy is highly efficacious in overcoming resistance to Bruton's tyrosine kinase inhibitors (BTKi) in mantle cell lymphoma. However, many patients relapse post CAR-T therapy with dismal outcomes. To dissect the underlying mechanisms of sequential resistance to BTKi and CAR-T therapy, we performed single-cell RNA sequencing analysis for 66 samples from 25 patients treated with BTKi and/or CAR-T therapy and conducted in-depth bioinformatics™ analysis.

Frequency-domain terahertz optoacoustics for non-contact quantitative detection of gas, liquid, and solid samples.

Terahertz optoacoustics (THz-OA) combines the advantages of abundant molecular characteristic absorptions in a terahertz band and the low attenuation through ultrasonic detection. Frequency-domain THz-OA, benefiting from the compact and the low cost of a continuous-wave THz source, has been used in gas detection and sensing. However, liquid and solid detections are hard to achieve due to the sensitivity limitation of existing technologies.

Potentiation of apoptosis in drug-resistant mantle cell lymphoma cells by MCL-1 inhibitor involves downregulation of inhibitor of apoptosis proteins.

Bruton's tyrosine kinase inhibitors (BTKi) and CAR T-cell therapy have demonstrated tremendous clinical benefits in mantle cell lymphoma (MCL) patients, but intrinsic or acquired resistance inevitably develops. In this study, we assessed the efficacy of the highly potent and selective MCL-1 inhibitor AZD5991 in various therapy-resistant MCL cell models. AZD5991 markedly induced apoptosis in these cells.

Longitudinal and vertical distribution of microplastics in various pipe scales in an operating drinking water distribution system.

Microplastics (MPs) are ingested by humans through the daily consumption of drinking water. Pipe scales are recognized as important sites of MPs occurrence in the drinking water distribution system (DWDS). Despite extensive research on drinking water, no study has been conducted to investigate the distribution of MPs in pipe scales within an operational DWDS.

Exploiting PRMT5 as a target for combination therapy in mantle cell lymphoma characterized by frequent ATM and TP53 mutations.

Constant challenges for the treatment of mantle cell lymphoma (MCL) remain to be recurrent relapses and therapy resistance, especially in patients harboring somatic mutations in the tumor suppressors ATM and TP53, which are accumulated as therapy resistance emerges and the disease progresses, consistent with our OncoPrint results that ATM and TP53 alterations were most frequent in relapsed/refractory (R/R) MCL. We demonstrated that protein arginine methyltransferase-5 (PRMT5) was upregulated in R/R MCL, which predicted a poor prognosis. PRMT5 inhibitors displayed profound antitumor effects in the mouse models of MCL with mutated ATM and/or TP53, or refractory to CD19-targeted CAR T-cell therapy.

Targeting glutaminase is therapeutically effective in ibrutinib-resistant mantle cell lymphoma.

Mantle cell lymphoma (MCL) is an incurable B-cell non-Hodgkin lymphoma characterized by frequent relapses. The development of resistance to ibrutinib therapy remains a major challenge in MCL. We previously showed that glutaminolysis is associated with resistance to ibrutinib.

TIGIT is the central player in T-cell suppression associated with CAR T-cell relapse in mantle cell lymphoma.

Background: Chimeric antigen receptor (CAR) T-cell therapy using brexucabtagene autoleucel (BA) induces remission in many patients with mantle cell lymphoma (MCL), and BA is the only CAR T-cell therapy approved by the FDA for MCL. However, development of relapses to BA is recognized with poor patient outcomes. Multiple CAR T-cell therapies have been approved for other lymphomas and the resistance mechanisms have been investigated.

Terahertz optoacoustic detection of aqueous salt solutions.

Terahertz radiation has been used to detect aqueous salt solutions; however, strong absorption of water in terahertz regime limits the application of traditional terahertz techniques. Here, we present a novel method in analyzing aqueous salt solutions via terahertz optoacoustics. Terahertz optoacoustic signals can be manipulated by temperature control, which allows the dampening of water background and providing more information of solute.