Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Ethnopharmacological Relevance: Curcuma kwangsiensis radix (CKR) is one of the most important herbs in traditional Chinese medicine. It effectively enhances blood circulation and eliminates stasis, which is highly associated with thrombosis. Furthermore, CKR is primarily produced in the Guangxi and Yunnan provinces of China. However, the quality control indicators of CKR in different production regions remain controversial.
Aim: To explore the quality marker (Q-Marker) of CKR in different production regions.
Materials And Methods: First, we determined the UPLC fingerprints of CKR from different production regions. Second, in vitro, antiplatelet aggregation biopotency (AAB) was measured using a parallel-line assay based on the quantitative response method of the bioassay. We identified CKR components and their serum metabolism using UPLC-Q-TOF-MS. Subsequently, molecular docking technology was used for Q-Marker analysis. Finally, we established a method for the quantitative analysis of Q-Marker.
Results: We observed significant differences of CKR between the Guangxi and Yunnan provinces according to the UPLC fingerprint and AAB results. Eight quality control-relevant components were screened using orthogonal partial least squares based on the spectrum-effect relationship. UPLC-Q-TOF-MS identified 57 CKR components, and 10 prototype components and 11 metabolites, respectively, were detected during serum metabolism. Ultimately, curcumenone was screened as a Q-Marker using the spectrum-effect relationship integrated with serum metabolism, which positively correlated with the quality. The AAB results of the Q-Marker indicated that curcumenone exhibited significant anti-platelet aggregation activity. The results of the Q-Marker molecular docking revealed the strongest binding effect between curcumenone and the GP-IIb/IIIa receptor, whereas that between the P2Y12 receptor and the P2Y1 receptor was the weakest. In addition, quantitative analysis of the Q-Marker indicated that there were significant differences in the contents of the Q-Marker from different production regions.
Conclusions: We identified a Q-Marker for CKR that can provide a foundation for quality evaluation research from different production regions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jep.2025.119652 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Using Theory-Based Frameworks to Identify Barriers and Enablers of Physicians' Telemedicine Adoption and Develop Intervention Strategies in China: Multicenter Qualitative Study.
J Med Internet Res
September 2025
Institute of Hospital Management, Peking University Third Hospital, Beijing, China.
Background: Telemedicine is developing rapidly, presenting new opportunities and challenges for physicians and patients. Limited research has examined physicians' behavior during the process of adopting telemedicine and related factors.
Objective: This study aimed to identify perceived barriers and enablers of physicians' adoption of telemedicine and to develop intervention strategies.
Fermented Food Consumption Across European Regions: Protocol for the Development and Validation of the Web-Based Fermented Foods Frequency Questionnaire (3FQ).
JMIR Res Protoc
September 2025
Department of Food Science and Technology, Kaunas University of Technology, Kaunas, Lithuania.
Background: Fermented foods vary significantly by food substrate and regional consumption patterns. Although they are consumed worldwide, their intake and potential health benefits remain understudied. Europe, in particular, lacks specific consumption recommendations for most fermented foods.
View Article and Find Full Text PDFCost-Effectiveness of In-Bed Cycling and Routine Physiotherapy for Patients Receiving Mechanical Ventilation.
JAMA Netw Open
September 2025
School of Rehabilitation Science, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Importance: The cost-effectiveness of adding early in-bed cycling to usual physiotherapy among adults receiving mechanical ventilation in the intensive care unit (ICU) compared with usual physiotherapy alone is unknown.
Objective: To evaluate the cost-effectiveness of in-bed cycling plus usual physiotherapy compared with usual therapy alone in the Critical Care Cycling to Improve Lower Extremity Strength (CYCLE) randomized clinical trial.
Design, Setting, And Participants: This trial-based economic evaluation with a 90-day time horizon compared early cycling plus usual physiotherapy vs usual physiotherapy alone from a societal perspective.
State-Level Variation in and Barriers to Medicaid Abortion Coverage.
JAMA Netw Open
September 2025
Yale School of Medicine, New Haven, Connecticut.
Importance: Approximately 35% of individuals seeking abortion care use Medicaid for health insurance. Although the Hyde Amendment restricts use of federal funds for most abortions, states can supplement coverage using state funds. Understanding the scope of abortion coverage across states and potential barriers to access may help address health care inequities and inform interventions.
View Article and Find Full Text PDFAssociation of work-family conflict with turnover intention among hospital ophthalmologists in Japan: a cross-sectional study.
Jpn J Ophthalmol
September 2025
Department of Medical Education Studies, International Research Center for Medical Education, Graduate School of Medicine, The University of Tokyo, Bunkyō, Tokyo, Japan.
Purpose: To examine the associations between work-family conflict, implicit gender bias, and turnover intention among hospital ophthalmologists.
Study Design: Cross-sectional study.
Methods: We conducted a web-based questionnaire survey between January and February 2024.