Single Te Nanoribbon for Disrupting Conventional Sensitivity-Power Limits of Flexible Strain Sensors.

Flexible strain sensors are pivotal for the advancement of robotics, wearable healthcare, and human-machine interaction in the post-Moore era. However, conventional materials struggle to simultaneously achieve high sensitivity, a broad strain range, and low power consumption for cutting-edge applications. In this work, the issue is addressed through single crystal 1D tellurium nanoribbons (NRs), which are synthesized on SiO/Si substrate by hydrogen-assisted chemical vapor deposition (CVD) method.

Oyster farming acts as a marine carbon dioxide removal (mCDR) hotspot for climate change mitigation.

Bivalve farming, a vital component of global aquaculture, has been proposed as a potential marine carbon dioxide removal (mCDR) strategy, yet its role remains contentious. Using field mesocosms, we demonstrate that oyster filter-feeding enhances mCDR by accelerating the formation of particulate and dissolved organic carbon in the water column and promoting organic carbon deposition in sediments. This process shifts the water column toward a more autotrophic and alkaline state, effectively sequestering CO from the atmosphere.

Ecosystem health assessment and ecological restoration strategies for Guangzhou City, China.

As the central city of the Guangdong-Hong Kong-Macao Greater Bay Area, Guangzhou's ecosystem health forms the foundation for the city's future sustainable development.To accurately assess and forecast future ecosystem health under different scenarios, based on land use data and the dynamic evolution characteristics of ecosystem health in Guangzhou from 2000 to 2020, we utilized a coupling of polynomial models, InVEST model, PLUS model and vigor-organization-resilience model to forecast and assess future ecosystem health under three scenarios: natural development, urban development, and ecological protection. Additionally based on the existing policies, ecological restoration zones were delineated.

Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution.

Performing total RNA profiling on formalin-fixed, paraffin-embedded (FFPE) samples, the predominant sample conservation method in clinical practice, remains challenging for current spatial transcriptomics techniques. Here, we introduce Stereo-seq V2, which employs random primers to capture and sequence RNAs in situ on FFPE sections and provides single-cell resolution. The random-priming-based strategy offers unbiased transcript capturing and uniform gene body coverage, which increase the sensitivity to marker genes, the efficiency of non-polyadenylation (poly(A)) RNA profiling, and immune repertoire coverage.

Variability in NO emissions at the sediment-water interface in coastal aquaculture: The role of stocking densities and feeding strategies.

Mariculture systems are an important source of nitrous oxide (NO). To develop effective NO reduction technologies for these systems, it is essential to understand how different farming activities affect NO flux, a topic that remains inadequately explored. This study investigated how different mariculture activities, including non-fed low-density (OL) and high-density (OH) oyster farms, artificially-fed sea cucumber farms (AM), and control sites (CN), impact diffusive NO fluxes at the sediment-water interface.

Single-cell eQTL mapping of human endogenous retroviruses reveals cell type-specific genetic regulation in autoimmune diseases.

Human endogenous retroviruses constitute a significant portion of the human genome and play complex roles in gene regulation and disease processes. However, the expression pattern and disease associations of specific retroviral loci remain pooly understood. This study examines the expression and regulatory mechanisms of these retroviral elements in immune cells.

Simultaneous detection of five shrimp pathogens using a single-tube EvaGreen real-time PCR assay with differential melting temperature.

The World Organisation for Animal Health (WOAH) has assessed crustacean diseases, such as infections with white spot syndrome virus (WSSV), infectious hypodermal and hematopoietic necrosis virus (IHHNV), decapod iridescent virus 1 (DIV1), and acute hepatopancreatic necrosis disease (AHPND), as listed diseases, and infection with (EHP) as an emerging disease, all of which significantly threaten the shrimp industry. This study developed a quintuplex EvaGreen-based melting curve real-time PCR method for the simultaneous detection of WSSV, IHHNV, DIV1, AHPND-causing (), and EHP. In the specific assay, only the target pathogen demonstrated efficient and detectable amplification, thereby indicating that the method exhibits high specificity.

Video Demoireing using Focused-Defocused Dual-Camera System.

Moire patterns, unwanted color artifacts in images and videos, arise from the interference between spatially high-frequency scene contents and the spatial discrete sampling of digital cameras. Existing demoireing methods primarily rely on single-camera image/video processing, which faces two critical challenges: 1) distinguishing moire patterns from visually similar real textures, and 2) preserving tonal consistency and temporal coherence while removing moire artifacts. To address these issues, we propose a dual-camera framework that captures synchronized videos of the same scene: one in focus (retaining high-quality textures but may exhibit moire patterns) and one defocused (with significantly reduced moire patterns but blurred textures).

Research on Companion-Based Forest Therapy and Its Physiological and Psychological Benefits to College Students.

With the growing pressures of modern society, physical and mental health issues have emerged as critical global concerns. Forest therapy (FT), a novel health management model that integrates natural environments with physical and mental healing, has gained increasing attention in recent years. However, mainstream FT approaches often overlook the psychological value of interpersonal interaction.

The regulatory role of immune microenvironment-related cells and pathways in the pathogenesis of keloids.

Keloids are skin lesions caused by excessive fibrotic reactions, and their pathogenesis is not yet fully understood. Recent studies have shown that the immune microenvironment plays a significant role in the development of keloids. This article reviews the distribution and functions of immune microenvironment-related cells in keloids, including keratinocytes, fibroblasts, mast cells, macrophages, T cells, and stem cells, as well as the interactions between these cells and local cells.

Developing angiogenesis-related prognostic biomarkers and therapeutic strategies in bladder cancer using deep learning and machine learning.

Bladder cancer (BLCA) is a prevalent urological malignancy that exhibits a high degree of tumor heterogeneity and morbidity. Tumor angiogenesis, a vital hallmark of cancer, greatly influences the tumor microenvironment (TME). The emergence of anti-angiogenic drugs has provided a new turning point in cancer treatment.

Feature variable selection for identifying salmonids cultured in freshwater and seawater based on chemometrics analysis and data fusion strategies.

The selection of feature variables to distinguish between freshwater- and seawater-farmed salmonids is crucial for building reliable traceability methods. Here, salmonids were cultured for 94 days under three different salinity change regimes. Their stable isotopes, elements, and phospholipid fatty acids were characterized.

SpatialSNV: A novel method for identifying and analyzing spatially resolved SNVs in tumor microenvironments.

Background: The dynamics of single-nucleotide variants (SNVs) play a critical role in understanding tumor development, yet their influence on shaping tumor microenvironments remains largely unexplored. Spatial transcriptomics offers an opportunity to map SNVs within the tumor context, potentially uncovering new insights into tumor microenvironment dynamics.

Results: This study developed SpatialSNV for identifying effective SNVs across tumor sections using multiple spatial transcriptomics platforms.

The effect of dual inflammation on the acute phase clinical outcomes of schizophrenia patients with comorbid COVID-19.

Background And Hypothesis: Inflammation plays a crucial role in pathological mechanisms in schizophrenia (SZ) and the coronavirus disease 2019 (COVID-19), but the impact of dual inflammation on SZs' clinical outcomes is poorly understood. This study aimed to investigate whether dual inflammation impacts acute phase outcomes in patients with schizophrenia comorbid with COVID-19 (COVID-SZs).

Study Design: A total of 114 SZs and 49 COVID-SZs were recruited for this study.

EBBA-detector: An effective detector for defect detection in solar panel EL images with unbalanced data.

Solar panel defect detection, a crucial quality control task in the manufacturing process, often faces challenges such as varying defect sizes, severe image background interference, and imbalanced data sample distribution. To address these issues, this paper proposes the EBBA-Detector. The core of the model lies in an enhanced balanced attention framework, which includes an Enhanced Bidirectional Feature Pyramid Network (EBFPN) and a Balanced-Attention Module (B-A Module).

Dual inflammation in schizophrenia infected with COVID-19: Impact on cognitive function.

Background: Accumulating evidence has shown that cognitive function among schizophrenia is pervasively impaired and has a connection between immune-inflammatory markers. COVID-19 elicited a series of inflammatory cascades. However, in the context of dual inflammation, fluctuations in cognitive function of schizophrenia in the long-term remain unknown.

Alkylaluminium-catalyzed regioselective hydrophosphinylation of α,β-unsaturated ketones into γ-ketophosphine oxides.

A green method for regioselective hydrophosphinylation of α,β-unsaturated ketones using alkylaluminium compounds has been developed. It proceeds without acids, bases, or additives, yielding γ-ketophosphine oxides efficiently. This process offers excellent atom economy, functional group tolerance, and high yields in a short time.

Extracellular vesicles in age-related diseases: disease pathogenesis, intervention, and biomarker.

Aging is a multifactorial biological process characterized by the irreversible accumulation of molecular damage, leading to an increased risk of age-related diseases. With the global prominent rise in aging populations, elucidating the mechanisms underlying the aging process and developing strategies to combat age-related diseases have become a pressing priority. Extracellular vesicles (EVs) have gained significant attention due to their role in intercellular communication.

[A pan-cancer analysis of PYCR1 and its predictive value for chemotherapy and immunotherapy responses in bladder cancer].

Objectives: To explore the potential of pyrroline-5-carboxylate reductase 1 (PYCR1) as a pan-cancer biomarker and investigate its expression, function, and clinical significance in bladder cancer (BLCA).

Methods: Bioinformatics analysis was conducted to evaluate the associations of PYCR1 with prognosis, immune microenvironment remodeling, tumor mutation burden (TMB), and microsatellite instability (MSI) in cancer patients. Using the TCGA-BLCA dataset, univariate and multivariate regression analyses were performed to assess the potential of PYCR1 as an independent prognostic risk factor for BLCA, and a clinical decision model was constructed.

Infection with infectious precocious virus (IPV) suppresses infection with decapod iridescent virus 1 (DIV1) in Macrobrachium rosenbergii.

In recent years, diseases caused by infectious precocious virus (IPV) or decapod iridescent virus 1 (DIV1) have resulted in significant losses to the giant freshwater prawn (Macrobrachium rosenbergii) industry, threatening sustainable aquaculture development of this species. Co-infection with these two viruses was found in farmed prawns. This study investigated the biological characteristics of co-infection in M.

A positive-sense single-stranded RNA virus acquired a negative-sense open reading frame through recombination.

Although positive- and negative-sense single-stranded RNA viruses are ubiquitous in nature, there is currently no evidence of recombination or reassortment between viruses with these two major forms of genome organization. Here, we describe the discovery of brine shrimp virga-like virus 1 (BSVV1), a novel positive-sense single-stranded RNA virus with a recombinant genome structure derived from two viral phyla with differing genome organizations. The genome of BSVV1 comprises three open reading frames (ORFs).

Surveillance and Genomic Evolution of Infectious Precocity Virus (IPV) from 2011 to 2024.

Infectious precocity virus (IPV) poses a significant economic threat to the aquaculture industry by causing sexual precocity and slow growth in . In this study, we conducted an in-depth investigation into the genetic evolution of IPV from 2011 to 2024 by collecting 31 IPV variants through epidemiological surveys and public databases, including 29 variants with complete genomic sequences. The phylogenetic analysis revealed that these complete genomic sequences clustered into two distinct phylogenetic clades as follows: the Southeast Asian clade and the Chinese clade.

Polydopamine Nanocomposite Hydrogel for Drug Slow-Release in Bone Defect Repair: A Review of Research Advances.

In recent years, hydrogels have emerged as promising candidates for bone defect repair due to their excellent biocompatibility, high porosity, and water-retentive properties. However, conventional hydrogels face significant challenges in clinical translation, including brittleness, low mechanical strength, and poorly controlled drug degradation rates. To address these limitations, as a multifunctional polymer, polydopamine (PDA) has shown great potential in both bone regeneration and drug delivery systems.

Intersubject neural similarity reveals the development trajectory of recognition memory in children.

Recognition memory improves with child development, but the neural mechanisms underlying such improvement and the developmental variation remain poorly understood. Herein, we investigated how the neural representations during the encoding and retrieval phases of recognition memory change with age, using representational similarity analysis in a sample of children aged 6-13 years (n = 137). Our results indicated that the encoding and retrieval phases have distinct neural patterns of development.

Integrated physiological, transcriptomic and metabolomic analyses reveal ROS regulatory mechanisms in two castor bean varieties under alkaline stress.

Saline-alkaline stress has caused severe ecological and environmental problems. Castor bean is a potential alkali-tolerant plant, however, its reactive oxygen species (ROS) regulatory mechanisms under alkaline stress remain unclear. This study investigated the physiological, transcriptomic, and metabolomic characteristics of two varieties (ZB8, alkaline-sensitive; JX22, alkaline-resistant) under alkaline stress.