Synthesis and Evaluation of Novel C-X-C Chemokine Receptor 4-Targeted Radiotracers for Oncological Imaging.

C-X-C chemokine receptor 4 (CXCR4), which is overexpressed in various cancers, has been considered as an important target for cancer theranostics. In this study, a series of small molecule radiotracers targeting CXCR4 were developed and obtained with high radiochemical purity (>95%). Among seven radiotracers, [Ga]Ga-SDNUM04 showed favorable binding affinity ( = 32.

Zeolite synthesis from coal gangue: a response surface methodology approach for optimal conditions.

The formation process of zeolites is influenced by multiple factors, and the traditional single-variable approach lacks sufficient explanatory power in elucidating the principles governing crystal synthesis. In this study, the response surface methodology (RSM) is employed to optimize the synthesis conditions for zeolites derived from secondary coal gangue utilization. Based on the four-factor modeling approach, a six-stage experimental design was established to investigate the effects of both individual factors and multi-factor interactions on the response value.

Multiple roles of ALDH1 in health and disease.

Aldehyde dehydrogenase 1 (ALDH1) is an important aldehyde-metabolizing enzyme that plays a key role in various biological processes, such as regulating cellular growth, modulating retinoic acid (RA) signaling pathways, and contributing to stem cell function. It is recognized as a crucial biomarker not only because of its significant involvement in the occurrence and development of various cancers but also because it is an important prognostic indicator for cancer progression. Furthermore, recent research has provided substantial evidence that the multiple roles of ALDH1 extend beyond cancer, with significant progress in understanding its mechanisms in other diseases and its clinical applications.

Associations of absolute and relative grip strength with cognitive performance in Chinese middle-aged and older populations.

BackgroundRecent meta-analyses indicate that the relationship between grip strength (GS) and cognition is more complex than that was previously assumed. Multiple studies have established a significant correlation between body composition and GS.ObjectiveTo assess longitudinal relationships between absolute and relative GS trajectories and cognitive function.

Chemical Energy-Driven Lithiation Preparation of Co@Mo Core-Shell Heterostructures for Highly Efficient Hydrogen Evolution.

Developing efficient transition metal-based catalysts through interface and defect engineering is crucial for enhancing hydrogen production via water electrolysis at high current densities, though it remains a significant challenge. In this study, Co@Mo heterostructures are designed and synthesized using a chemical-energy-driven lithiation (CEDL) process on CoS@MoS. By taking advantage of the slow crystallization kinetics at room temperature, the original core-shell structure is preserved during the lithiation of CoS@MoS heterostructures.

Comparative Analysis of Transposable Element Evolution in Crustaceans.

Transposable elements (TEs) are pivotal in driving genome evolution, playing a significant role in generating genetic diversity, modulating genome size, and inducing chromosome structural changes. Despite extensive research in model species, studies on TE evolution and structure in crustaceans are notably limited. This study offers an in-depth analysis of TEs diversity and its impact on representative crustacean genomes' genome structure and function.

Relationship between pediatric asthma and respiratory microbiota, intestinal microbiota: a narrative review.

Pediatric asthma is a common chronic airway inflammatory disease that begins in childhood and its impact persists throughout all age stages of patients. With the continuous progress of detection technologies, numerous studies have firmly demonstrated that gut microbiota and respiratory microbiota are closely related to the occurrence and development of asthma, and related research is increasing day by day. This article elaborates in detail on the characteristics, composition of normal gut microbiota and lung microbiota at different ages and in different sites, as well as the connection of the gut-lung axis.

Structural engineering on keratin to tailor porous structure of biochar for high-efficiency tetracycline removal.

The inherent complexity of biomass poses challenges in designing or controlling the porous structure of biochar after intense activation reactions. Here, structural engineering on keratin was developed to modulate the porous structure of bovine-horn-derived biochar via the controllable coupled oxidation and pyrolysis reactions. The possible chemical reaction pathways of the coupled oxidation and pyrolysis reactions were proposed.

Green Synthesis of Coal Gangue-Derived NaX Zeolite for Enhanced Adsorption of Cu and CO.

The accumulation of coal gangue (CG), a byproduct of coal mining, poses severe environmental challenges. This study presents a green strategy to convert CG into high-value NaX zeolite via an alkali fusion-hydrothermal method. Through orthogonal experiments, the optimal synthesis conditions (solid-liquid ratio 1:8, crystallization temperature 110 °C, time 12 h) were identified, yielding NaX zeolite with exceptional crystallinity (98%), specific surface area (703.

Intelligent identification method of origin for Alismatis Rhizoma based on image and machine learning.

Alismatis Rhizoma (AR) is widely utilized as a natural medicine across many Asian countries. However, in China, due to its complex origins, AR quality varies, which can affect clinical efficacy. Therefore, there is a need for a method that is both fast and objective to determine the source of AR.

Cobalt-catalyzed organic nano carbon source for hybrid hard carbon/graphite nanoribbon anode in high-potential potassium-ion batteries.

Potassium-ion batteries (PIBs) have attracted intense interest because of the abundance and low cost of potassium carbonate as a raw material. Hard carbon has shown high potential as the anode in PIBs at high fluorosulfonimide-based electrolytes concentration due to large d-space giving the dominated capacitive-controlled process. However, high discharge slope and high concentration electrolytes are harmful to the cathode and hinder the hard carbon-based PIBs in practice.

The clinical antiprotozoal drug halofuginone promotes weight loss by elevating GDF15 and FGF21.

Obesity is a debilitating global pandemic with a huge cost on health care due to it being a major underlying risk factor for several diseases. Therefore, there is an unmet medical need for pharmacological interventions to curb obesity. Here, we report that halofuginone, a Food and Drug Administration-approved anti-scleroderma and antiprotozoal drug, is a promising anti-obesity agent in preclinical mouse and pig models.

Immune repertoire sequencing reveals differences in treatment response to camrelizumab plus platinum-based chemotherapy in advanced ESCC.

This study evaluated the efficacy and safety of camrelizumab combined with platinum-based chemotherapy (taxanes [T] or fluorouracil agents [F] plus platinum [P] drugs) as the first-line treatment in advanced esophageal squamous cell carcinoma (ESCC), using immune repertoire sequencing (IRS) to explore treatment response mechanism. In this multi-center, prospective cohort study, 88 patients received camrelizumab plus TP or FP, achieving a 1-year progression-free survival of 56.8% and overall survival of 68.

Postoperative radiotherapy improves survival in completely resected non-small cell lung cancer with pathologic N2 stage IIIA and positive lymph node count greater than one: a SEER-based retrospective cohort study.

Objective: Non-small cell lung cancer (NSCLC) constitutes approximately 85% of lung cancer cases, with 20%-30% of patients diagnosed at stage III. While multimodal therapy is the standard for treating locally advanced NSCLC, the role of PORT remains controversial. This study seeks to evaluate the effect of postoperative radiotherapy (PORT) on overall survival (OS) and cancer-specific survival (CSS) in patients with resected pathologic N2 (pN2) stage IIIA NSCLC.

Crystalline/amorphous heterostructure CoNi/MoO electrocatalyst for alkaline seawater hydrogen evolution at ultra-high current density of 4000 mA/cm.

Designing highly efficient nonprecious metal electrocatalyst for the hydrogen evolution reaction (HER) in seawater electrolyte, particularly under ultra-high current density conditions, remains a formidable challenge. In this study, we successfully synthesized a crystalline/amorphous heterostructured CoNi/MoO electrocatalyst through a facile hydrothermal method followed by a calcination-reduction process. The as-prepared CoNi/MoO catalyst exhibited remarkable HER catalytic performance in both alkaline water and seawater electrolytes.

Inhibition of complement system-related gene ITGB2 attenuates epithelial-mesenchymal transition and inflammation in diabetic nephropathy.

Purpose: Emerging evidences have indicated a role of the complement system in the pathogenesis of diabetic nephropathy (DN). Thus, this study was conducted to explore the complement system-related key biomarkers for patients with DN.

Methods: DN microarray datasets were downloaded from the GEO database, followed by differentially expressed genes (DEGs) screening.

VEGFR3 mitigates hypertensive nephropathy by enhancing mitophagy via regulating crotonylation of HSPA1L.

Oxidative stress-associated proximal tubular cells (PTCs) damage is an important pathogenesis of hypertensive renal injury. We previously reported the protective effect of VEGFR3 in salt-sensitive hypertension. However, the specific mechanism underlying the role of VEGFR3 in kidney during the overactivation of the renin-angiotensin-aldosterone system remains unclear.

Investigating the relationship between goal orientation, self-efficacy, positive emotionality, and affective engagement among Chinese students.

This study delved into the complex interplay between self-efficacy, achievement goals, positive emotions, and affective engagement among university students in China. To achieve this, a stratified random sampling technique was employed, resulting in a sample of 391 students from four geographically distinct universities across China. The data collection relied on self-reported questionnaires that measured academic self-efficacy, goal orientation (specifically focusing on mastery versus performance goals), positive emotions, and various aspects of affective engagement, including enjoyment, satisfaction, and interest in learning.

Analysis of nanomedicine applications for inflammatory bowel disease: structural and temporal dynamics, research hotspots, and emerging trends.

Background: The application of nanomedicine in inflammatory bowel disease (IBD) has gained significant attention in the recent years. As the field rapidly evolves, analyzing research trends and identifying research hotpots are essential for guiding future advancements, and a comprehensive bibliometric can provide valuable insights.

Methods: The current research focused on publications from 2001 to 2024, and was sourced from the Web of Science Core Collection (WoSCC).

Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosis.

Beyond dyslipidemia, inflammation contributes to the development of atherosclerosis. However, intrinsic factors that counteract vascular inflammation and atherosclerosis remain scarce. Here we identify insulin-like growth factor binding protein 6 (IGFBP6) as a homeostasis-associated molecule that restrains endothelial inflammation and atherosclerosis.

Comparative evaluation of negative lymph node count, positive lymph node count, and lymph node ratio in prognostication of survival following completely resection for non-small cell lung cancer: a multicenter population-based analysis.

Objective: Lung cancer is the leading cause of cancer-related mortality. Lymph node involvement remains a crucial prognostic factor in non-small cell lung cancer (NSCLC), and the TNM system is the current standard for staging. However, it mainly considers the anatomical location of lymph nodes, neglecting the significance of node count.

SPINK13 acts as a tumor suppressor in hepatocellular carcinoma by inhibiting Akt phosphorylation.

The PI3K/Akt pathway is overexpressed in nearly 50% of hepatocellular carcinomas and inhibits apoptosis by promoting the expression of antiapoptotic genes. Serine protease inhibitors have been shown to induce apoptosis in hepatoma cells by downregulating SPINK13 in the PI3K/Akt pathway. In this study, SPINK13 was expressed in lentiviral vectors.

Plasma Induced Atomic-Scale Soldering Enhanced Efficiency and Stability of Electrocatalysts for Ampere-Level Current Density Water Splitting.

Industrial water electrolysis typically operates at high current densities, the efficiency and stability of catalysts are greatly influenced by mass transport processes and adhesion with substrates. The core scientific issues revolve around reducing transport overpotential losses and enhancing catalyst-substrate binding to ensure long-term performance. Herein, vertical Ni-Co-P is synthesized and employed plasma treatment for dual modification of its surface and interface with the substrate.

Predictive value of near-term prediction models for severe immune-related adverse events in malignant tumor PD-1 inhibitor therapy.

Immune-related adverse events (irAEs) impact outcomes, with most research focusing on early prediction (baseline data), rather than near-term prediction (one cycle before the occurrence of irAEs and the current cycle). We aimed to explore the near-term predictive value of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), absolute eosinophil count (AEC) for severe irAEs induced by PD-1 inhibitors. Data were collected from tumor patients treated with PD-1 inhibitors.