Efficacy and Safety of Guben Kechuan Granules in the Treatment of Chronic Bronchitis: A Multi-Center and Randomized Controlled Trial.

Background: Chronic bronchitis (CB) is an inflammatory respiratory disease characterized by high prevalence and treatment challenges. In recent years, the integration of traditional Chinese medicine (TCM) with conventional therapies has gained widespread application in CB management, showing promising clinical benefits.

Methods: This multicenter, randomized controlled trial, led by China-Japan Friendship Hospital in Beijing, China, enrolled 300 CB patients aged 18-75 years.

FFT-RDNet: A Time-Frequency-Domain-Based Intrusion Detection Model for IoT Security.

Resource-constrained Internet of Things (IoT) devices demand efficient and robust intrusion detection systems (IDSs) to counter evolving cyber threats. The traditional IDS models, however, struggle with high computational complexity and inadequate feature extraction, limiting their accuracy and generalizability in IoT environments. To address this, we propose FFT-RDNet, a lightweight IDS framework leveraging depthwise separable convolution and frequency-domain feature fusion.

Novel microbial fuel cell integrating anoxic/oxic-membrane bioreactor design for simultaneous energy recovery and carbon-nitrogen removal from shale oil and gas wastewater.

Shale oil and gas wastewater (SOGW), rich in pollutants, poses an environmental threat. A novel microbial fuel cell (MFC) resembling an anoxic/oxic-membrane bioreactor (A/O-MBR), called AOMM, was developed to treat SOGW and recover energy. AOMM required no expensive ion-exchange membrane and incorporated a custom suspended-rotating biocathode, reducing the reliance on high-cost and hard-to-scale components.

The pharmacogenomic landscape in the Chinese: An analytics of pharmacogenetic variants in 206,640 individuals.

Pharmacogenomic landscapes and related databases are important for identifying the biomarkers of drug response and toxicity. However, these data are still lacking for the Chinese population. In this study, we constructed a pharmacogenomic landscape and an associated database using whole-genome sequencing data generated by non-invasive prenatal testing in 206,640 Chinese individuals.

Pd/Cu Catalyzed Asymmetric Allylation for Stereodivergent Synthesis of Glutamic Acid Derivatives.

A synergistic Pd/Cu catalyst system has been developed for stereodivergent transformation of Morita-Baylis-Hillman (MBH) carbonates and Schiff bases derived from simple amino acids to afford a series of optically active β-branched γ-methyleneglutamic acid derivatives with adjacent tertiary/tertiary and quaternary/tertiary stereocenters in high yields (up to 96 %) with excellent diastereo- and enantioselectivities (>20/1 dr and >99 % ee in most cases) under mild conditions. The use of SKP ligand is disclosed to be crucial for the success of the transformation, and in particular allowing the reaction to proceed at low catalyst loading (0.02 mol % for Pd and 0.

HLA-B*35:01-mediated activation of emodin-specific T cells contributes to Polygonum multiflorum thunb. -induced liver injury in mice.

Ethnopharmacological Relevance: HLA-B*35:01 has been identified as a risk allele for Polygonum multiflorum Thunb.-induced liver injury (PMLI). However, the immune mechanism underlying HLA-B*35:01-mediated PMLI remains unknown.

Improvement of UCVA, BCVA, and Intraocular Pressure after Phakic Posterior Chamber Intraocular Lens Implantation for Myopia.

Objective: The purpose of this study is to explore the artificial lens planting of the back room shape of the crystal eye eyes and The clinical effect of ICL in patients with myopia.

Methods: A Retrospective Study Spanning from 2021 to 2023 within Huai'an First People's Hospital. This study involves the comparative analysis of 100 eyes subjected to 'Crystalline Lens Extraction + IOL' and 100 eyes undergoing 'ICL' treatment.

CCDN-DETR: A Detection Transformer Based on Constrained Contrast Denoising for Multi-Class Synthetic Aperture Radar Object Detection.

The effectiveness of the SAR object detection technique based on Convolutional Neural Networks (CNNs) has been widely proven, and it is increasingly used in the recognition of ship targets. Recently, efforts have been made to integrate transformer structures into SAR detectors to achieve improved target localization. However, existing methods rarely design the transformer itself as a detector, failing to fully leverage the long-range modeling advantages of self-attention.

Efficacy and Safety of Biosimilar QL1207 vs. the Reference Aflibercept for Patients with Neovascular Age-Related Macular Degeneration: A Randomized Phase 3 Trial.

Introduction: This trial aimed to compare the efficacy and safety between biosimilar QL1207 and the reference aflibercept for the treatment of neovascular age-related macular degeneration (nAMD).

Methods: This randomized, double-blind, phase 3 trial was conducted at 35 centers in China. Patients aged ≥ 50 years old with untreated subfoveal choroidal neovascularization secondary to nAMD and best-corrected visual acuity (BCVA) letter score of 73-34 were eligible.

WGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis.

Background: Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a major impediment to its clinical application. It is indispensable to explore alternative treatment molecules or drugs for mitigating DIC. WGX50, an organic extract derived from Zanthoxylum bungeanum Maxim, has anti-inflammatory and antioxidant biological activity, however, its function and mechanism in DIC remain unclear.

Targeting circular RNA-Glra2 alleviates retinal neurodegeneration induced by ocular hypertension.

Glaucoma is a leading cause of irreversible vision loss characterized by retinal neurodegeneration. Circular RNAs (circRNAs) have emerged as the potential biomarkers and therapeutic targets for neurodegenerative diseases. However, the expression profiling of circRNAs in glaucomatous neurodegeneration has not been fully understood.

Geotechnical Deformation Distributed Measuring Technology Research Based on Parallel Spiral Sensing Line.

The precursors that appear when geological disasters occur are geotechnical deformations. This paper studies the TDR (Time Domain Reflection) measurement technology for the distributed measurement of geotechnical deformation using parallel spiral wire as a sensor, which is used for monitoring and early warning detection of geological disasters. Based on the mechanism of the electromagnetic field distribution parameters of the parallel spiral sensing wire, the relationship between the stretching amount of the parallel spiral wire and the change in its characteristic impedance is analyzed.

Analysis of the Macular Region Following Panretinal Photocoagulation for the Treatment of Diabetic Retinopathy Using Optical Coherence Tomography.

Background: Diabetic retinopathy (DR) is the most prevalent microvascular complication of diabetes. Panretinal photocoagulation (PRP) is the established treatment for mitigating severe visual impairment resulting from proliferative DR.

Objective: This study aims to investigate the impact of PRP on the macular region in patients with DR, utilizing optical coherence tomography (OCT) for assessment.

Circ_0047835 Combines with miR-144-3p to Promote the Proliferation, Invasion, Migration, and Fibrosis of TGF-β1-Treated Human Tenon's Capsule Fibroblasts by Upregulating SP1.

Purpose: Glaucoma is the leading cause of blindness worldwide with complex pathogenesis. Circular RNAs (circRNAs) play critical roles in various diseases, including glaucoma. The purpose of this study was to investigate the role of circ_0047835 and underlying mechanisms in the development of fibrosis after glaucoma filtration surgery.

Down-Regulation of circCOL1A2 Suppresses the Dysfunction of Diabetes-Related Retinal Microvascular Endothelial Cells via miR-646/FGF7 Axis.

Purpose: Diabetic retinopathy (DR), the major complication of diabetes, is the leading cause of vision loss and blindness globally. Altered circular RNAs (circRNAs) expression has been found to be involved in DR process. Hence, this work aimed to explore the role and mechanism of circCOL1A2 in DR.

GATA binding protein 5-mediated transcriptional activation of transmembrane protein 100 suppresses cell proliferation, migration and epithelial-to-mesenchymal transition in prostate cancer DU145 cells.

It has been reported that transmembrane protein 100 (TMEM100) acts as a tumor regulator in several types of cancers. However, whether the expression of TMEM100 is associated with the development and prognosis of prostate cancer (PCa) remains elusive. Therefore, the present study aimed to uncover the role of GATA binding protein 5 (GATA5)-mediated activation of TMEM100 in the proliferation, migration and epithelial-to-mesenchymal transition (EMT) of PCa cells.

Circular RNA circZNF532 facilitates angiogenesis and inflammation in diabetic retinopathy via regulating miR-1243/CARM1 axis.

Background: Diabetic retinopathy (DR) is a serious complication of diabetes. Numerous reports have validated that circular RNAs (circRNAs) participate in DR progression. This study aimed to elucidate the role and potential mechanism of circRNA zinc finger protein 532 (circZNF532) in DR.

The Immunological Mechanisms and Immune-Based Biomarkers of Drug-Induced Liver Injury.

Drug-induced liver injury (DILI) has become one of the major challenges of drug safety all over the word. So far, about 1,100 commonly used drugs including the medications used regularly, herbal and/or dietary supplements, have been reported to induce liver injury. Moreover, DILI is the main cause of the interruption of new drugs development and drugs withdrawn from the pharmaceutical market.

CYP2C19 Genotyping May Provide a Better Treatment Strategy when Administering Escitalopram in Chinese Population.

Depression disorder is one of the most serious mental illnesses in the world. Escitalopram is the essential first-line medication for depression disorder. It is the substrate of hepatic cytochrome P450 (CYP) enzyme with high polymorphism.

Automated segmentation of macular edema for the diagnosis of ocular disease using deep learning method.

Macular edema is considered as a major cause of visual loss and blindness in patients with ocular fundus diseases. Optical coherence tomography (OCT) is a non-invasive imaging technique, which has been widely applied for diagnosing macular edema due to its non-invasive and high resolution properties. However, the practical applications remain challenges due to the distorted retinal morphology and blurred boundaries near macular edema.

Identification of urban land use efficiency by indicator-SDG 11.3.1.

Inefficiency in urban land use is one of the problems caused by rapid urbanization. The UN Sustainable Development Goals (SDGs) indicator 11.3.

Sound Radiation of Orthogonal Antisymmetric Composite Laminates Embedded with Pre-Strained SMA Wires in Thermal Environment.

The interest of this article lies in the sound radiation of shape memory alloy (SMA) composite laminates. Different from the traditional method of avoiding resonance sound radiation of composite laminates by means of structural parameter design, this paper explores the potential of adjusting the modal peak of the resonant acoustic radiation by using material characteristics of shape memory alloys (SMA), and provides a new idea for avoiding resonance sound radiation of composite laminates. For composite laminates embedded with pre-strained SMA, an innovation of vibration-acoustic modeling of SMA composite laminates considering pre-stain of SMA and thermal expansion force of graphite-epoxy resin is proposed.

miR-133a-3p promotes apoptosis and induces cell cycle arrest by targeting CREB1 in retinoblastoma.

Introduction: Retinoblastoma (RB) is a malignant tumor that is derived from photoreceptors. It is common in children under 3 years old with a family genetic predisposition. MicroRNA-133a-3p (miR-133a-3p) is one of the tumor-related miRNAs that interprets a critical function in the genesis and development of various tumors.

Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction.

Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults. Vascular pericyte degeneration is the predominant clinical manifestation of DR, yet the mechanism governing pericyte degeneration is poorly understood. Circular RNAs (circRNAs) play important roles in multiple biological processes and disease progression.