Case Report: Diagnosis, treatment and follow-up of venous thrombosis in adolescent diabetic patients with SARS-CoV-2.

The highest risk of diabetes mellitus (DM)-related complications, collectively known as venous thromboembolism (VTE), is observed in the age group of 20-39 years. However, this observation sharply contrasts with the increased incidence of superficial venous thrombosis observed among adolescent patients during the coronavirus disease 2019 (COVID-19) outbreak in Hebei Province in December 2022. Moreover, it contradicts the absence of venous thrombosis observed in pediatric diabetic patients who were treated prior to the COVID-19 outbreak.

A telomere-to-telomere genome of wild soybean with resistance to soybean cyst nematode X12.

The soybean cyst nematode (SCN) is one of the most destructive pests affecting soybean production worldwide. Wild soybean (Glycine soja) germplasm offers valuable genetic resources for developing SCN-resistant cultivars. Here, we present a telomere-to-telomere assembly of the wild soybean Glycine soja accession YSD56, which is resistant to the highly virulent SCN race X12.

Cascaded strapdown line-of-sight stabilization for Risley prisms on motion platforms.

A cascaded strapdown line-of-sight (LOS) stabilization and tracking method based on Risley prisms is proposed to address the challenge of maintaining image closed-loop stability in the presence of platform attitude disturbances. First, this paper introduces the Risley-prism coordinate system and the inertial space coordinate system, and then analyzes the disturbance coupling between LOS and the platform, superimposing the platform's attitude disturbance onto the target position motion. By utilizing an inverse calculation model, the system achieves suppression of platform disturbance.

The GmGDPD family regulates phosphorus efficiency in soybean and enables precision breeding with domestication-lost alleles.

Phosphorus (P) deficiency severely limits soybean productivity, yet the genetic basis of P efficiency remains underexplored. Here, we systematically identified 27 GmGDPD genes in soybean (Glycine max), revealing that family expansion was driven by segmental/tandem duplication events, accompanied by functional diversification through acquisition of protein kinases, catalytic domain-like kinase and GUB_WAK_bind domains. Transcriptome and reverse transcription quantitative PCR analyses demonstrated that genes, including GmGDPD2/9/12/14, were significantly induced under low Pi stress, correlating with enhanced root apical meristem activity.

Photo-Fenton Degradation of Tetracycline Boosted by Charge Redistribution in g-CN with Fe-N Configuration and O/P Dual Doping.

The persistent contamination of aquatic environments by tetracycline (TC) necessitates advanced remediation strategies. Herein, a ternary Fe-O-P-co-modified graphitic carbon nitride (FOPCN) was synthesized via structural integration of Fe-N configurations with O/P dual doping for efficient TC degradation in a solar-driven photo-Fenton system. This study pioneers the synergistic coupling of Fe-N coordination and heteroatomic O/P substitution to optimize charge dynamics.

The Characteristics and Outcomes of Adult Acute Myeloid Leukemia Patients With KMT2A-Partial Tandem Duplication.

Introduction: KMT2A-Partial Tandem Duplication (KMT2A-PTD) is a recurrent gene mutation present in acute myeloid leukemia (AML) and its prognostic significance needs to be clarified.

Methods: Three hundred and eighty-seven consecutive adult newly diagnosed AML patients with non-favorable cytogenetic risk were tested for KMT2A-PTD by real-time quantitative PCR. All patients were screened for AML-related gene fusions and mutations.

CD137 might be a pivotal regulator of Th1/Th17-driven autoimmunity and B-cell hyperactivity in hyperthyroidism.

Objective: This study aims to investigate the impact of antithyroid drug (ATD) intervention on the expression levels of CD137, IFN-γ, and IL-17 in plasma cytokines, chemokines, and peripheral blood mononuclear cells (PBMCs) of hyperthyroid patients, compared to healthy controls. The goal is to elucidate the involvement of Th cell immune balance, as well as cellular and humoral immunity, in the pathogenesis of hyperthyroidism.

Methods: Eighty-one hyperthyroidism patients diagnosed between April 2021 and April 2022 were initially included in the study.

Effects of Potassium Fulvic Acid on Soil Physical and Chemical Properties and Soil Microenvironment of Blueberry ( L.) Under Salt Stress.

These days, one of the main issues preventing agricultural development is salinized soils. Potassium fulvic acid (PFA) not only regulates plant growth, but also improves the soil nutrient content and physical structure, which makes it a soil conditioner worth promoting. Nevertheless, the research conducted thus far on the subject of PFA with regard to plant growth and inter-root microbial communities remains somewhat limited in scope.

Novel Z-scheme CuO@Ag/g-CN heterojunctions: integrating ultrasensitive SERS detection with superior visible-light photocatalysis for tetracycline elimination.

Tetracycline (TC), a widely used broad-spectrum antibiotic for treating bacterial infections, poses significant risks to human health and ecological environments caused by extensive abuse. Hence, sensitive detection and efficient degradation of TC are crucial for protecting both human health and ecological environment. In this work, a multifunctional Z-scheme CuO@Ag/g-CN heterojunction was designed and constructed in order to achieve both ultrasensitive surface-enhanced Raman scattering (SERS) detection and efficient photocatalytic degradation of TC.

Fabrication of TiO/CuFeO composites for oxytetracycline degradation through heterogeneous photo-Fenton-like process under visible light.

The heterogeneous photo-Fenton-like (HPF-like) catalyst TiO/CuFeO was prepared by ball-milling and calcination for oxytetracycline (OTC) degradation. The systematic characterization indicated that the dispersion of TiO nanoparticles onto CuFeO improved visible light absorption and promoted electron transfer through heterojunction structure, benefitting photocatalytic activity. The optimum conditions were specified as 0.

Paddle-like self-stirring nanoreactors with multi-chambered mesoporous branches for enhanced dual-dynamic cascade reactions.

Developing artificial nanomaterial systems that can convert external stimuli to achieve nanoscale self-sustainable motion (for example, self-rotation), and simultaneously integrate and deploy the spatial localization of multiple active sites to unravel the intraparticle diffusion patterns of molecules, is of great importance for green synthetic chemistry. Here we show a paddle-like self-stirring mesoporous silica nanoreactor system with separated chambers and controllable proximity of active sites. The nanoreactors are designed by encapsulating magnetic FeO (~20 nm) in the first chamber, and meantime, Au and Pd nanocrystals are spatially isolated in different domains.

Ecological Risk and Early Warning of PCBs in Central Jilin Province's Black Soil Zone, China.

To investigate the levels of polychlorinated biphenyls (PCBs) in the black soils of Northeast China, we collected 59 surface soil samples from the central black soil region of Jilin Province. We analyzed the concentrations and sources of seven PCBs in the black soil, assessed the ecological risks associated with PCB contamination, and provided a risk assessment for PCBs in this soil type. The mean concentrations of the seven PCBs (PCB28, PCB52, PCB101, PCB118, PCB138, PCB153, and PCB180) were as follows: 1.

Serum FGF23 and DPP4 Levels as Biomarkers for Coronary Artery Disease Severity in Type 2 Diabetic Patients with Coronary Heart Disease.

Objective: This study aimed to evaluate the relationship between serum fibroblast growth factor 23 (FGF23) and dipeptidyl peptidase 4 (DPP4) levels, and the severity and prognosis of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD).

Methods: A total of 113 patients with both T2DM and CHD (T2DM+CHD group) and 74 patients with T2DM without CHD (T2DM-only group) who underwent coronary angiography between January 2021 and June 2023 were enrolled. Based on Gensini scores, the T2DM+CHD group was further divided into three subgroups: mild (n=38), moderate (n=46), and severe (n=29) lesions.

Relationship of corneal percent tissue altered with visual outcome in small incision lenticule extraction surgery.

Background: We observed the effect of different modified percentage of tissue alteration (mPTA) on corneal higher-order aberrations in small incision lenticule extraction (SMILE), and explored safe threshold values of mPTA for SMILE surgery.

Methods: 148 patients (270 eyes) was retrospectively analyzed and grouped into two groups based on mPTA between 24%. Mixed linear model analysis was used for preoperative and postoperative 1 week (W1), 1 month (M1), 3 months (M3), and 6 months (M6) follow-ups to compare the differences and changes in visual acuity, and corneal higher order aberrations between groups.

Causal effect analysis of the relationship between Alzheimer's diseas (AD) and wet age-related macular degeneration (wAMD).

PurposeAlzheimer's disease (AD) and wet age-related macular degeneration (wAMD) are both prevalent degenerative diseases in the elderly population. However, whether AD is causally related to wAMD is unclear. A Mendelian randomization(MR) analysis was conducted to investigate the association between them.

Enhancing efficacy and mitigating toxicity of Semen Strychni: From traditional practices to modern pharmaceutical innovations.

Ethnopharmacological Relevance: Semen Strychni (Maqianzi), the seeds of Strychnos nux-vomica L. (family Loganiaceae), is a traditional Chinese herbal medicine known for its anti-inflammatory, analgesic, and anti-tumor properties. However, the clinical application of Semen Strychni has been seriously limited due to its severe central nervous system toxicity and narrow therapeutic window.

Long-Term Trends and Ecological Risks of Heavy Metal Accumulation in Cultivated Land of Songnen Plain, China.

Heavy metal pollution in agricultural soils poses a serious threat to food security. Therefore, it is crucial to conduct risk assessments and issue early warnings about high levels of metal contamination for the sustained prosperity of agriculture. To assess the risks, identify the sources, quantify the amounts, and determine the extent of pollution from seven heavy metals, as well as to provide early warnings, 78 soil samples were collected from farmed lands in the Songnen Plain of Jilin Province.

TRIM47 promotes head and neck squamous cell carcinoma malignant progression by degrading XAF1 through ubiquitination.

Tripartite motif-containing 47 (TRIM47) is a member of the TRIM family, which has E3 ligase activity and has been demonstrated to be involved in tumor development. In this work, we found that TRIM47 is highly expressed in head and neck squamous cell carcinomas (HNSCC) tissues. TRIM47 overexpression promoted HNSCC cell proliferation.

Crystal-Facet Engineering of Mesoporous CuS Cascade Nanoreactors Enhances Photocatalytic C-C Coupling of CO-to-CH.

Crystal-facet heterojunction engineering of mesoporous nanoreactors with highly redox-active represents an efficacious strategy for the transformation of CO into valuable C products (e.g., CH).

Hyperspectral inversion of heavy metal content in farmland soil under conservation tillage of black soils.

Globally, heavy metal (HM) soil pollution is becoming an increasingly serious concern. Heavy metals in soils pose significant environmental and health risks due to their persistence, toxicity, and potential for bioaccumulation. These metals often originate from anthropogenic activities such as industrial emissions, agricultural practices, and improper waste disposal.

Investigating ocular biomarkers and differential diagnosis of Alzheimer's disease and vascular cognitive impairment based on multimodal imaging.

Significance: The eye can be used as a potential monitoring window for screening, diagnosis, and monitoring of neurological diseases. Alzheimer's disease (AD) and vascular cognitive impairment (VCI) are common causes of cognitive impairment and may share many similarities in ocular signs. Multimodal ophthalmic imaging is a technology to quantify pupillary light reaction, retinal reflectance spectrum, and hemodynamics.