Season of Blood Pressure Measurement Screening and All-Cause Mortality: A Community-Based Prospective Cohort Study.

Background: The association between season of screening blood pressure (BP) measurement and adverse outcomes has not been examined among populations without prior physician-diagnosed hypertension. We aimed to investigate the association between the season of screening clinic BP measurement and the risk of all-cause mortality.

Methods: This was a prospective cohort study, and data were analyzed from an ongoing community hypertension screening program in Shanghai between 2018 and 2024.

Environmental impact analysis of the synergistic recycling process of waste three-way catalysts and waste LiCoO batteries.

Waste three-way catalysts (TWCs) and waste LiCoO batteries represent critical environmental challenges due to hazardous components yet contain high-value resources, and their recycling has garnered widespread attention. We propose a novel 'waste-to-waste' synergistic recycling where spent LiCoO batteries reconstruct mineral phases of waste TWCs, enabling co-recovery of platinum group metals and Li/Co without traditional oxidants. However, the environmental performance of this process still requires further analysis.

perspectives on surface photocatalysis: advances, challenges, and opportunities.

Surface photocatalysis holds significant promise for converting solar energy into chemical fuels and addressing environmental challenges. While calculations provide critical insights into the thermodynamic and kinetic aspects of catalytic reactions, applying these methods to surface photocatalysis remains challenging. In this work, we discuss the key challenges that need to be addressed when using calculations to understand surface photocatalytic processes, the reasons behind these challenges, and the potential directions and opportunities for overcoming them in the future.

Mechanically Heterogeneous Architecture Enables Robust and Ultrathin Bioelectronics for High-Fidelity Biosignal Monitoring.

High-fidelity biosignal monitoring is essential for daily health tracking and the diagnosis of chronic diseases. However, developing bioelectrodes capable of withstanding repeated use and mechanical deformation on wet tissue surfaces remains a significant challenge. Here, we present a robust and ultrathin bioelectrode (RUB), featuring a mechanically heterogeneous architecture and a thickness of ∼3 μm.

In Situ Construction of Optical Resonators from MXene Inks for Highly Modifiable and Scalable Structural Colors.

Structural colors offer distinct advantages over traditional chemical colors (such as pigments and dyes), including high saturation, resistance to fading, and environmental friendliness. However, unlike traditional dyes or pigments that allow for Structural colors offer distinct advantages over traditional chemical colors (such as pigments and dyes), including high saturation, resistance to fading, and environmental friendliness. However, unlike traditional dyes or pigments that allow for arbitrary color adjustments during the coloring process, current structural color surfaces lack flexibility in control, as their colors are difficult to reprocess or adjust once formed.

Mitochondrial ClpX Inhibition Induces Ferroptosis and Blocks Pancreatic Cancer Cell Proliferation.

The ATPase caseinolytic protease X (ClpX), forming the ClpXP complex with caseinolytic protease P (ClpP), is essential for mitochondrial protein homeostasis. While ClpP targeting is a recognized anticancer strategy, the role of ClpX in cancer remains underexplored. In pancreatic ductal adenocarcinoma (PDAC), elevated CLPX expression correlates with poor prognosis, suggesting its oncogenic function.

Copper-Catalyzed Coupling of -Acyl-'-Substituted Hydrazines with (Hetero)aryl Chlorides/Bromides.

The coupling of -acyl-'-substituted hydrazines with (hetero)aryl bromides and chlorides is efficiently catalyzed by CuI/4-hydroxy picolinamide and Cu(OAc)/6-hydroxy picolinohydrazide, respectively. Under these conditions, a broad range of (hetero)aryl halides and -acyl-'-substituted hydrazines react smoothly at 80-120 °C, affording the corresponding products in good to excellent yields in most cases.

Brain Microstructural Alteration and Its Implications for Postoperative Delirium in Elderly Surgical Patients: A Narrative Review.

Purpose: Postoperative delirium (POD) remains poorly understood in terms of predictors and underlying mechanisms. This review summarized emerging evidence on the association between brain microstructural alterations and POD.

Method: This is a narrative review, describing the microstructural changes in aging brain, microstructural MRI findings, relationship among microstructural alterations, cognitive reserve and POD, and potential interventions targeting microstructure.

One-Pot Sequential Coordination-Covalent Construction of Symmetry-Broken MNO Catalytic Sites in Cobalt-Polyimide Polymers for Nitrate Electroreduction.

The metal-nitrogen chelated species, MN, have shown promise as efficient electrocatalysts for nitrate reduction, yet the symmetric arrangement of N atoms results in suboptimal adsorption affinity toward reaction substrates and intermediates. The current approaches to breaking the symmetry of MN suffer from inaccuracy and inhomogeneity because of the lack of strategies stemming from molecular design aspects. Herein, we report the construction of symmetry-broken MNO sites in coordination polymers via sequential coordination-covalent control in a one-pot reaction.

A novel biguanide-derivative promotes NEDD4-mediated FGFR1 ubiquitination through BMI1 to overcome osimertinib resistance in NSCLC.

Objective: Osimertinib (OSI) therapy, a cornerstone in treating non-small cell lung cancer (NSCLC), has been severely limited by rapidly developing acquired resistance. Inhibition of bypass activation using a combination strategy holds promise in overcoming this resistance. Biguanides, with excellent anti-tumor effects, have recently attracted much attention for this potential.

A cross-scale analysis for the determinants of bonding dynamics on the distributions of rolling velocities of cells in microvessels.

The interplay between subcellular adhesion dynamics and cellular-scale deformations under shear flow drives key physiological and pathological processes. While both bond kinetics and fluid-cell interactions have been extensively studied in rolling adhesion, how bond characteristics quantitatively determine cellular velocity distributions remains unclear. In this study, we systematically investigate how force-free bond kinetics and intrinsic mechanical properties govern rolling adhesion dynamics, using macroscopic velocity distributions as a reference.

TOX-induced lnc-SUMF2-8 compromises antitumor function and anti-PD-1 response of CD8 T cells via lysosome-dependent degradation of TCF-1.

The reduction of TCF-1 during CD8 T cell exhaustion leads to attenuated antitumor activity and diminished responsiveness to immune checkpoint inhibitors. However, how TCF-1 is downregulated remains unclear. Here, we showed that during CD8 T cell exhaustion, lnc-SUMF2-8, induced by transcription factor TOX, can bind to cytosolic TCF-1, and direct it to the lysosome for degradation.

Elesclomol-Copper combination synergistically targets mitochondrial metabolism in cancer stem cells to overcome chemoresistance in pancreatic ductal adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis, partly due to cancer stem cells (CSCs) that drive progression and treatment resistance. We explored the therapeutic potential of inducing cuproptosis, a copper-dependent regulated cell death, in CSC-enriched PDAC models. Using human and murine PDAC models, we evaluated elesclomol, a copper transport enhancer.

Chargeable Hydrogels with Dual Modulatory Effects of Bacterial Killing and Immune Remodeling toward Wound Healing.

Wound infections challenge clinical medicine, and developing novel therapies is critically important in overcoming antimicrobial resistance and an off-balanced immune microenvironment. Electrical stimulation as a biocompatible, easy-to-operate, and controllable technique has great potential in eradicating pathogens and modulating the immune system. However, safe and soft platforms that integrate both bactericidal and immunological modulatory effects of electrical stimulation are rarely reported.

Reduced phenological differences under nitrogen enrichment facilitate invasion by a late-growing plant.

Although invasion success is often attributed to the early phenology of the invader, many late-growing invaders also thrive in resource-enriched environments. However, the mechanism behind this paradox remains poorly understood. Here, we tested how nitrogen (N) enrichment influences competition between the late-growing invader Spartina alterniflora and the early-growing native Phragmites australis in a coastal salt marsh.

A Reaction-Diffusion-Coupled Strategy for Ampere-Level Electrocatalytic Nitrate Reduction to Ammonia.

Ampere-level electrocatalytic nitrate reduction to ammonia (eNRA) offers a carbon-neutral alternative to the Haber-Bosch process. However, its energy efficiency is critically hampered by the inherent conflict between the reaction and diffusion. Herein, we propose a reaction-diffusion-coupled strategy implemented on a well-tailored CuCoNiRuPt high-entropy alloy aerogel (HEAA) to simultaneously realize energy barrier homogenization and accelerate mass transport, endowing ampere-level eNRA with a high energy efficiency.

Highly Sensitive Determination of Bacillus subtilis by Microchip Electrophoresis Combining With A Dual Nucleic Acid Recycling Amplification.

In dairy products, Bacillus subtilis (B. subtilis) is considered a harmful spoilage bacterium. Consequently, it is imperative to establish highly sensitive and selective approaches for detecting B.

The Protective Effects of TLR2/NOD2 Combined Agonist CL429 on 14.1 MeV Neutron-Radiation Damage.

High-energy neutron radiation (HENR) induces severe cellular and tissue damage, yet effective prophylactic agents remain limited. In this study, the TLR2/NOD2 co-agonist CL429 was evaluated for its radioprotective potential against 14.1 MeV neutron exposure.

Adoptive transfer of third-party donor CMV-specific T cells for refractory cytomegalovirus infection following umbilical cord blood transplantation.

Refractory cytomegalovirus (CMV) infection is a severe complication following umbilical cord blood transplantation (UCBT). Antiviral agents, the standard first-line therapy, are limited by toxicity and resistance without robust T-cell immunity. We evaluated third-party donor (TPD)-derived CMV-specific T cells (CMVSTs) as a treatment option.

Sequential intrathoracic injection and intravenous infusion of BCMA CAR-T cells in a patient with relapsed/refractory primary plasma cell leukemia.

Patients with primary plasma cell leukemia (pPCL), particularly those with extramedullary disease (EMD), face a poor prognosis even with chimeric antigen receptor (CAR)-T cell therapy. This case report describes a patient with relapsed/refractory pPCL and life-threatening malignant pleural effusion (PE) treated with intrapleural CAR-T cells targeting B-cell maturation antigens. CAR-T cell expansion within the PE was observed, along with a rapid reduction in leukemia cell count and PE volume.

Transition behavior of the waiting time distribution in a stochastic model with the internal state.

It has been noticed that when the waiting time distribution exhibits a transition from an intermediate time power-law decay to a long-time exponential decay in the continuous time random walk model, a transition from anomalous diffusion to normal diffusion can be observed at the population level. However, the mechanism behind the transition of waiting time distribution is rarely studied. In this paper, we provide one possible mechanism to explain the origin of such a transition.

A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2.

Targeted protein degraders hold potential as therapeutic agents to target conventionally 'undruggable' proteins. Here, we develop a high-throughput screen, DEath FUSion Escaper (DEFUSE), to identify small-molecule protein degraders. By conjugating the protein of interest to a fast-acting triggerable death protein, this approach translates target protein degradation into a cell survival phenotype to illustrate the presence of degraders.

Amplifying antigen-induced cellular responses with proximity labelling.

Antigen-induced clustering of cell surface receptors, including T cell receptors and Fc receptors, represents a widespread mechanism in cell signalling activation. However, most naturally occurring antigens, such as tumour-associated antigens, stimulate limited receptor clustering and on-target responses owing to insufficient density. Here we repurpose proximity labelling, a method used to biotinylate and identify spatially proximal proteins, to amplify designed probes as synthetic antigen clusters on the cell surface.

Probing the heterogeneous nature of LiF in solid-electrolyte interphases.

The electrolyte-electrode interface serves as the foundation for a myriad of chemical and physical processes. In battery chemistry, the formation of a well-known solid-electrolyte interphase (SEI) plays a pivotal role in ensuring the reversible operations of rechargeable lithium-ion batteries (LIBs). However, characterizing the precise chemical composition of the low crystallinity and highly sensitive SEI presents a formidable challenge.

EMC2 promotes triple negative breast cancer growth by protecting FDFT1 from endoplasmic reticulum associated degradation to impair ferroptosis susceptibility.

Cholesterol biosynthesis is more activated in triple negative breast cancer (TNBC) than in other subtype breast cancer and plays essential role in facilitating TNBC. However, the regulatory network and how cholesterol biosynthesis contribute to TNBC development and progression are not well elucidated. Here, we found that reticulum membrane protein complex 2 (EMC2) is highly expressed in TNBC and predicts short survival of patients.