DBN1‑mediated upregulation of GAB2 facilitates the migration and invasion of T‑cell acute lymphoblastic leukemia cells.

T-cell acute lymphoblastic leukemia (T‑ALL) is an aggressive hematological malignancy. The poor prognosis of T‑ALL is closely associated with extensive leukemic infiltration into critical organs. Therefore, the mechanism underlying T‑ALL infiltration is worth investigating.

Clinical features of high myopia with optic nerve head prelaminar schisis: Wuhan high myopia study.

Background: The global prevalence of high myopia is rising, posing a significant public health concern. Limited research exists on risk factors for prelaminar schisis (PLS) and its impact on visual field changes in highly myopic eyes. Herein, we investigated clinical features of prelaminar schisis (PLS) in highly myopic eyes.

Preliminary assessment of the therapeutic potential of staphylococcal enterotoxin-like W via biological activity and TCR binding sites analysis.

Staphylococcal enterotoxin-like W (SElW) is a novel, widely prevalent enterotoxin-like protein that functions as a classical staphylococcal superantigen (SAg) and has been shown to exacerbate infections caused by the epidemic clone CC398. However, the genetic distribution and amino acid polymorphisms, biological and antitumor activity, and T cell receptor (TCR) binding sites of SElW in strains prevalent in China have not been investigated. The carrier rate and distribution of were determined by PCR, the stability and antitumor activity of recombinant SElW (rSElW) protein were evaluated.

Evaluation and Experiment of High-Strength Temperature- and Salt-Resistant Gel System.

To address the issues of poor thermal stability, inadequate salt tolerance, and environmental risks in conventional gel systems for the development of high-temperature, high-salinity heterogeneous reservoirs, a triple-synergy gel system comprising anionic polyacrylamide (APAM), polyethyleneimine (PEI), and phenolic resin (SMP) was developed in this study. The optimal synthesis parameters-APAM of 180 mg/L, PEI:SMP = 3:1, salinity of 150,000 ppm, and temperature of 110 °C-were determined via response surface methodology, and a time-viscosity model was established. Compared with existing binary systems, the proposed gel exhibited a mass retention rate of 93.

Spatial stratified heterogeneity of mumps incidence in China: a Geodetector-based analysis of driving factors.

Background: China reports the highest number of mumps cases globally, with the disease demonstrating distinct spatial clustering and variability characteristics.

Methods: This study employed descriptive statistics and spatial autocorrelation analysis to examine the spatial distribution characteristic and patterns of mumps across 31 Chinese provinces in 2020. Furthermore, based on the principle of spatial stratified heterogeneity, the Geodetector method was systematically applied to assess the influence intensity and interaction effects of economic development, population structure, education level, environmental conditions, and healthcare resource allocation on mumps incidence rate.

The Observation of Peripapillary Hyperreflective Ovoid Mass-Like Structures in Adolescents by Swept-Source Optical Coherence Tomography Angiography.

Purpose: To present the swept-source optical coherence tomography angiography (SS-OCTA) characteristics of peripapillary hyperreflective ovoid mass-like structures (PHOMS) in healthy adolescents and evaluate the effects of PHOMS on peripapillary structural and microvascular parameters.

Methods: A total of 218 eyes of 117 healthy adolescents were included. SS-OCTA images centered on the optic nerve head (ONH) were captured on eyes included.

Comprehensive genome-wide identification and expression analysis of phenylalanine ammonia-lyase (PAL) gene family in Populus simonii × Populus nigra, and functional study in tobacco under abiotic stress.

Background: Phenylalanine ammonia-lyase (PAL) is a crucial rate-limiting enzyme in the phenylpropanoid biosynthesis pathway, playing a vital role in plant growth, development, and response to abiotic stresses. Populus simonii × P. nigra is a widely recognized fast-growing species in Northeast China, characterized by strong drought resistance, and saline-alkaline tolerance.

Flux-Controlled Two-Site Kitaev Chain.

In semiconducting-superconducting hybrid devices, Andreev bound states (ABSs) can mediate the coupling between quantum dots, allowing for the realization of artificial Kitaev chains. In order to engineer Majorana bound states (MBSs) in these systems, one must control the energy of the ABSs. In this Letter, we show how extended ABSs in a flux-tunable Josephson junction can be used to control the coupling between distant quantum dots separated by ≃1  μm.

Correlation between dual-time-point F-FDG PET/CT imaging and pathological grade in hepatocellular carcinoma.

Background: Dual-time-point (DTP) F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) imaging has been associated with an enhanced diagnostic yield in various malignancies. Nevertheless, there is a lack of data on the use of delayed imaging in patients with hepatocellular carcinoma (HCC). The aim of this study was to investigate the correlation between the semiquantitative parameters of DTP F-FDG PET/CT scan and histological grades of HCC.

Live Pulse-Echo Speed-of-Sound Estimation for Quality Assessment of Large Muscles in Humans.

Objective: Muscle quality is broadly regarded as an indicator of physical health. Conventionally, ultrasound metrics such as echogenicity have been derived to assess muscle quality, but these measures are prone to changes in ultrasound hardware and operator skill. In contrast, tissue speed-of-sound (SoS) is an intrinsic property that can potentially act as a more robust biomarker for muscle quality.

Intestinal metabolomic profiling provides insights into the molecular mechanisms for hyperuricemia-induced intestinal barrier dysfunctions in a hyperuricemia mouse model.

Cadmium exposure could damage the liver, which is suggested to be associated with the hyperuricemia (HUA)-induced intestinal barrier injury. To reveal the mechanism for HUA-induced intestinal barrier injury, the HUA mice constructed by knockout (Ko) of the urate oxidase (Uox) gene and their corresponding controls were used for the metabolomics analysis. Clinical biochemistry from the plasma was assessed, and the histopathological changes of the intestines were evaluated.

Refate identifies chemical compounds to target trans-regulatory networks for cellular conversion.

Identifying chemical compounds that target trans-regulatory networks (TRNs) underlying molecular programs of cells for directed cellular conversion (i.e. differentiation, reprogramming, transdifferentiation, and dedifferentiation) is a key step towards advancing regenerative medicine.

Multiple evanescent white dot syndrome associated with focal scleral nodule: a case report and literature review.

Background: Multiple evanescent white dot syndrome (MEWDS) is a rare transient inflammatory retinopathy characterized by discrete white dots disseminated on the fundus. Focal scleral nodule (FSN) typically presents as a stable, solitary, yellow-white, subretinal lesion arising from the sclera. This article reports a rare case of MEWDS associated with FSN in a young female.

CCR1/CCL5 macrophage-mediated CCL5 T cell chemotaxis in salivary gland aggravates Sjögren's syndrome.

Introduction: CCR1 upregulation in macrophages promotes sequential T/B-cell infiltration via CCL5-mediated crosstalk, aggravating salivary gland damage in Sjögren's syndrome (SS), implicating CCR1/CCL5 as potential therapeutic targets.

Objectives: To investigate the role of CCR1/CCL5 in salivary gland lymphocytic infiltration and SS progression.

Methods: Functional enrichment analysis was performed on four bulk RNA-seq datasets to identify common immune pathways, highlighting CCR1 as a key factor.

Evolution of research trends and emerging hotspots in bioelectrical impedance analysis over the last two decades: a bibliometric analysis.

Background And Objective: Over the last two decades, bioelectrical impedance analysis (BIA) has gained popularity as a method for assessing body compartments in nutrition studies, sports medicine, and evaluating hydration levels, fat mass, and fat-free mass variations in both healthy and diseased individuals. This study aims to offer researchers an overview of the research trends in BIA.

Methods: The data was obtained from the Web of Science Core Collection database.

Will the inclusion of AI anchors enhance the operational performance of live streaming e-commerce supply chains?

With the rapid growth of the live streaming e-commerce market, traditional live streaming models are encountering mounting challenges, whereas the advent of artificial intelligence (AI) technology has breathed new life into live streaming. This paper delves into the role of the AI anchor and model selection in scenarios both with and without the involvement of the Key Opinion Leader (KOL). Specifically, the AI anchor, whether invested in by the brand or the live streaming platform, is integrated into the regular anchor model (Model NN) and the hybrid model combining the KOL and the regular anchor (Model NK).

Characterization of the salivary microbiome in healthy individuals under fatigue status.

Background & Aims: Limited understanding exists regarding the characteristics and biological significance of the salivary microbiome in healthy individuals experiencing physiological fatigue. This study aimed to delineate the structural and functional alterations in the salivary microbiome of healthy individuals undergoing physiological fatigue compared to energetic controls, and to explore its potential as a biomarker for fatigue status.

Methods: A cohort of 7 healthy individuals experiencing acute physiological fatigue (induced by prolonged study and confirmed via electroencephalography; Fatigue group, FTG) and 63 energetic healthy controls (Energetic group, ENG) were enrolled.

Bronchoalveolar lavage cytokine profile and clinical features as risk predictors of plastic bronchitis in children with Mycoplasma pneumoniae pneumonia.

Background: Plastic bronchitis (PB), a condition in which mucus plugs block the bronchial tree, is a serious complication of Mycoplasma pneumoniae pneumonia (MPP). This study investigated whether clinical features and cytokine levels in bronchoalveolar lavage fluid (BALF) distinguish MPP from MPP complicated by PB and sought to identify risk factors for PB in children with MPP.

Methods: A total of 128 children 3-14 years of age with MPP who underwent bronchoscopy at Jingmen Central Hospital, China, between 1 April 2023 and 31 March 2024 were enrolled.

Effects of varied rTMS frequencies on cognitive function in individuals with chronic schizophrenia: A double-blind randomized controlled trial.

Background: Accumulating evidence has indicated the effects of repetitive transcranial magnetic stimulation (rTMS) on cognitive improvements in individuals with schizophrenia. However, the comparative effectiveness of low-frequency rTMS versus high-frequency rTMS on cognitive improvements remains unclear. This study aims to investigate the difference in the efficacy of low and high-frequency rTMS on cognitive function in chronic individuals with schizophrenia.

Adiabatic Pumping of Orbital Magnetization by Spin Precession.

We propose adiabatic pumping of orbital magnetization driven by coherent spin precession, which enables rectification by converting periodic oscillations into a static signal. The orbital magnetization originates from the adiabatic evolution of valence electrons with a topological bulk contribution expressed as a Chern-Simons form. When the precession cone angle of spin S is small, the resulting magnetization is proportional to S×S[over ˙] and contributes to the magnon Zeeman effect, the energy shift induced by a magnetic field.

Peripheral neuropathy associated with immunomodulatory drugs: a pharmacovigilance analysis based on the FDA adverse event reporting system database.

Background: Peripheral neuropathy requires early detection and intervention.

Aim: This study aimed to examine the association between immunomodulatory medications (IMiDs; thalidomide, lenalidomide, and pomalidomide) and peripheral neuropathy.

Method: OpenVigil 2.