Multi-Target Repetitive Transcranial Magnetic Stimulation Improves Freezing of Gait in Parkinson's Disease: A Randomized Controlled Trial.

Objective: In this randomized, double-blind, sham-controlled trial, we investigated the efficacy of multi-target 10-Hz rTMS targeting both M1 and SMA in alleviating freezing of gait (FOG) in Parkinson's disease (PD) patients.

Methods: Eighty-four PD-FOG patients were randomly assigned (1:1:1:1) to four groups: M1 and SMA group, M1 group, SMA group, and sham group. rTMS was administered once daily for 10 consecutive days.

SNTA1-deficient human cardiomyocytes show shorter field potential duration and slower conduction velocity.

In clinical settings, patients with α-1-syntrophin point mutations are often associated with rare arrhythmias, including Long QT syndrome, Brugada syndrome, and sudden infant death syndrome. Previous studies on α-1-syntrophin have predominantly utilized nonhuman cardiomyocyte models. This study aims to elucidate the phenotype of α-1-syntrophin deficiency using human cardiomyocytes.

Temperature-insensitive liquid level sensor based on a U-shaped cascade core-offset structure.

A sensor based on a U-shaped cascade core-offset structure is proposed for liquid level measurement. The cladding modes are more easily excited by the core-offset structures. The U-shaped structure leads to more energy leakage into the cladding, making the sensor more sensitive to changes in the external environment.

CCR1/CCL5 macrophage-mediated CCL5 T cell chemotaxis in salivary gland aggravates Sjögren's syndrome.

Introduction: CCR1 upregulation in macrophages promotes sequential T/B-cell infiltration via CCL5-mediated crosstalk, aggravating salivary gland damage in Sjögren's syndrome (SS), implicating CCR1/CCL5 as potential therapeutic targets.

Objectives: To investigate the role of CCR1/CCL5 in salivary gland lymphocytic infiltration and SS progression.

Methods: Functional enrichment analysis was performed on four bulk RNA-seq datasets to identify common immune pathways, highlighting CCR1 as a key factor.

Kinetic modelling and reactivity of liquid nitromethane under detonation conditions.

Liquid nitromethane (NM) may undergo detonation under accidental stimuli, making kinetic modeling crucial for assessing the safety risks associated with its detonation. This study employs first-principles molecular dynamics to investigate chemical behavior of nitromethane under high temperature (>2000 K) and pressure (>1 GPa) conditions, revealing five previously unidentified intermediates (CHNOH, CHNOH, CHNOH, CHONO, NOCHNO) and establishing a nitromethane chemical kinetic model which include 543 elementary reactions and 79 species, which is successfully applied in the prediction of nitromethane detonation characteristics. The calculated detonation pressure (13.

Recent advances in small molecular inhibitors of pyruvate carboxylase for human diseases.

Pyruvate carboxylase (PC) is an important biotin-dependent regulatory metabolic enzyme in the tricarboxylic acid cycle that is responsible for catalyzing the conversion of pyruvate to oxaloacetate. In many organisms, such as animals, bacteria and plants, PC is widely involved in the regulation of cellular metabolic pathways, and abnormal PC activity leads to metabolic disorders that may take critical parts in cancer, type II diabetes, inflammation, and other diseases. Thus, targeting PC may be a promising treatment option for cancer and other human diseases.

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi-Omics and Multi-Modal Data Analysis.

Osteoporosis is a common metabolic bone disease with aging, characterized by low bone mineral density (BMD) and higher fragility fracture risk. Although current pharmacological interventions provide therapeutic benefits, long-term use is limited by side effects and comorbidities. In this study, we employed driver signaling network identification (DSNI) and drug functional networks (DFN) to identify repurposable drugs from the Library of Integrated Network-Based Cellular Signatures.

Comparison of Phosphonium and Sulfoxonium Ylides in Ru(II)-Catalyzed Dehydrogenative Annulations: A Density Functional Theory Study.

Density functional theory calculations have been performed to explore the detailed mechanism of a ruthenium-catalyzed dehydrogenative annulation between α-carbonyl phosphonium ylide () and sulfoxonium ylide (). The proposed catalytic cycles consist of several elementary steps in succession, namely the C-H activation of ylide , the insertion of ylide , reductive elimination, protodemetallation, and an intramolecular Wittig reaction, in which C-H activation is rate-limiting, with a free energy barrier of 31.7 kcal/mol.

First-principles calculations of solid-phase enthalpy of formation of energetic materials.

The solid-phase enthalpy of formation (∆H) of energetic materials was generally predicted from the gas-phase enthalpy of formation (∆H) and sublimation enthalpy (∆H). Here, the standard ∆H of energetic materials is directly obtained from density functional theory (DFT) calculations by computing the enthalpy difference between the solid-phase energetic material and its constituent elements in their reference states. To reduce the errors in DFT calculations, a concept of isocoordinated reaction is introduced, i.

Dysfunction of subthalamic dopaminergic circuitry contributes to anxiety- and depression-like behaviors in 6-OHDA lesion-induced hemiparkinsonian mice.

Anxiety and depression are common non-motor symptoms severely affecting the quality of life in patients with Parkinson's disease, but the underlying pathophysiological mechanisms remain elusive. As dopaminergic (DA) system and the subthalamic nucleus (STN) are involved in motor control and emotional processing, we herein investigated the role of DA circuitry in the STN in regulating depression in parkinsonian mice. A hemi-parkinsonian mouse model was established by injection of 6-OHDA into the right medial forebrain bundle (MFB), desipramine (20 mg/kg, i.

OAB-14 Attenuated Glymphatic System Disorder, Neuroinflammation and Dyskinesia in Parkinson's Disease Model Mice Induced by Rotenone.

Parkinson's Disease (PD) is a neurodegenerative disorder characterized by the pathological accumulation of alpha-synuclein (α-syn) in the neuronal cell bodies of the substantia nigra. The glymphatic system within the Central Nervous System (CNS) is responsible for clearing metabolic waste and abnormal proteins and its dysfunction may significantly contribute to the pathogenesis of PD. Our previous study showed that OAB-14, the novel small molecular compound, showed a great potential effect in APP/PS1 transgenic mice.

Identification of Acidic Triterpenoid Saponins from Silene vulgaris Using a Methylation-Based Isolation and LC-MS Analysis Strategy.

The Silene genus plants in the Caryophyllaceae family are a large genus with over 850 species. It has been known that Silene genus plants contain triterpenoid saponins. These saponins have glucuronic acid in the sugar chain and are difficult to separate in chromatography.

Macrophage-related inflammatory responses to degradation products of biodegradable molybdenum implants.

Metallic molybdenum (Mo) has been increasingly recognized as a potential biodegradable metal for biomedical implants. However, the macrophage-mediated inflammatory responses to Mo-based implants remain underexplored. This study examined the inflammatory reactions of macrophages to the degradation products of biodegradable Mo implants.

CTA-based deep-learning integrated model for identifying irregular shape and aneurysm size of unruptured intracranial aneurysms.

Background: Artificial intelligence can help to identify irregular shapes and sizes, crucial for managing unruptured intracranial aneurysms (UIAs). However, existing artificial intelligence tools lack reliable classification of UIA shape irregularity and validation against gold-standard three-dimensional rotational angiography (3DRA). This study aimed to develop and validate a deep-learning model using computed tomography angiography (CTA) for classifying irregular shapes and measuring UIA size.

Impressive improvement of zinc-iodine battery performance by doping poly(vinyl alcohol) into the cathode.

Herein, a KB-P60 cathode was synthesized from poly(vinyl alcohol) (PVA) coated Ketjen black (KB). The specific capacity of KB-P60 was increased by 113% from pure KB at 1 A g. In addition, KB-P60 achieved an ultra-long cycle life of 30 000 cycles at 20 A g with minimal degradation, effectively suppressing the shuttle effect.

Enhancing Mixed Traffic Flow with Platoon Control and Lane Management for Connected and Autonomous Vehicles.

As autonomous driving technology advances, connected and autonomous vehicles (CAVs) will coexist with human-driven vehicles (HDVs) for an extended period. The deployment of CAVs will alter traffic flow characteristics, making it crucial to investigate their impacts on mixed traffic. This study develops a hybrid control framework that integrates a platoon control strategy based on the "catch-up" mechanism with lane management for CAVs.

Prediction of Potential Habitat Distributions and Climate Change Impacts on the Rare Species (Magnoliaceae) in China Based on MaxEnt.

Changes in species' habitats provide important insights into the effects of climate change. , a critically endangered species endemic to karst ecosystems, has a highly restricted distribution and is a key biological resource. Despite its ecological importance, the factors influencing its habitat suitability and distribution remain poorly understood.

OAB-14 alleviates mitochondrial impairment through the SIRT3-dependent mechanism in APP/PS1 transgenic mice and N2a/APP cells.

Alzheimer's disease (AD) is a progressive degenerative disease that affects a growing number of elderly individuals worldwide. OAB-14, a novel chemical compound developed by our research group, has been approved by the China Food and Drug Administration (FDA) for clinical trials in patients with AD (approval no. YD-OAB-220210).

Role of Radiomics-based Multiomics Panel in the Microenvironment and Prognosis of Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is the most prevalent form of liver tumor, characterized by restricted therapeutic options and typically low long-term survival rates. Recently, immunotherapy has revolutionized HCC treatment, making the tumor microenvironment (TME) a research focus. Radiomics is increasingly crucial in HCC clinical decisions, offering advanced tools for TME characterization and prognosis assessment.

Early Oxidation Kinetics of N-Dodecane under High-Temperature Conditions.

n-Dodecane(CH) is a typical surrogate fuel for aviation kerosene used in high-performance aero engines. The combustion kinetics of n-dodecane at temperatures above the critical point condition is the focus of attention in the aerospace field. In this paper, the first-principles molecular dynamics method is used to study the high-temperature oxidation of CH.