Development and validation of an interpretable multi-task model to predict outcomes in patients with rhabdomyolysis: a multicenter retrospective cohort study.

Background: Rhabdomyolysis (RM) is a complex clinical syndrome with heterogeneous progression patterns among patients of varying severity. Early and accurate prediction of acute kidney injury (AKI), disease severity, renal replacement therapy (RRT) requirements, and mortality risk is essential for timely identification of high-risk individuals, personalized treatment planning, and optimal allocation of healthcare resources. We aimed to develop and externally validate an interpretable multi-task machine learning (ML) model to predict four clinical outcomes in patients with rhabdomyolysis: AKI, disease severity, the need for RRT, and in-hospital mortality.

Jasminum sambac: Progress in research on ethnopharmacology, phytochemistry, pharmacological actions and other applications.

Aim Of The Study: This paper reviews the progress of research on the botany, traditional uses, phytochemistry, pharmacology, modern uses and toxicity of Jasminum sambac (L.) Aiton (JS).

Materials And Methods: Literature for this paper on JS was obtained from databases such as Web of Science, PubMed, ACS Publications, Google Scholar, Baidu Scholar, and CNKI.

Corydalis rhizoma attenuates primary dysmenorrhea in rats by inhibiting the FAK/PI3K-AKT/NF-κB signaling pathway.

Ethnopharmacological Relevance: Primary dysmenorrhea (PD) is a prevalent condition affecting women globally. Corydalis rhizoma (known as Yanhusuo in Chinese, YHS) is commonly used to treat PD. However, the mechanisms by which raw-YHS (YHS-R) and vinegar-processed YHS (YHS-V) exert the therapeutic effects on PD remain unclear.

Optimal planning with multiple collaborative processing analysis in atmospheric pressure plasma processing for imprinting continuous phase plates.

Large-aperture continuous phase plate (CPP) plays a crucial role in high-power laser systems, spawning a substantial demand for high-volume manufacturing. Given the intricate surface topographies of CPPs, the utilization of multiple tool influence functions (TIFs) during fabrication has been widely recognized as an efficacious means to strike a more favorable balance between machining efficiency and precision. However, it should be noted that even with the same set of multiple TIFs, the collaborative performance can exhibit variations across different designed CPP surfaces, thereby introducing ambiguity into the determination of the optimal processing strategy.

Understanding the Nanoindentation Edge Effect of Single-Crystal Silicon Using Molecular Dynamics Simulations.

The edge effect refers to what occurs when an object undergoes elastic contact with the edge of a material. This is common in practical applications, but the understanding of this phenomenon is not yet mature enough, and understanding the microscopic characteristics of the material regarding this phenomenon is necessary. This article investigates the edge effects of single-crystal silicon at different indentation positions through molecular dynamics simulations.

Effects of Black Garlic Polyphenols on the Physicochemical Characteristics, Antioxidant Activity, and Sensory Evaluation of Yogurt.

Yogurt fortified with polyphenols, as a new type of functional yogurt, exhibits high quality and good antioxidant activity. However, the effects of black garlic polyphenols (BGP) on the quality of solidified yogurt have been scarcely reported. Therefore, the effects of different levels (0.

Rosmarinic acid potentiates gefitinib in lung adenocarcinoma by modulating interactions between cancer cells and cancer-associated fibroblasts.

While cancer-associated fibroblasts (CAFs) significantly influence tumor progression, their temporal dynamics remain poorly understood. We investigated time-dependent interactions between non-small cell lung cancer (NSCLC) cells and CAFs, and evaluated rosmarinic acid (RA)'s potential to modulate these interactions. HCC827 lung adenocarcinoma cells and MRC-5 fibroblasts were co-cultured in vitro.

Screening and identification of HLA-A2-restricted neoepitopes for immunotherapy in endocrine therapy-resistant breast cancer.

Endocrine therapy has shown significant clinical efficacy in estrogen receptor alpha (ERα)-positive breast cancer management, but the emergence of therapy-resistant mutations significantly undermines treatment outcomes, frequently leading to disease progression and metastasis. Among these resistance mechanisms, mutations in the ESR1 gene are particularly prevalent, detectable in 76% of endocrine therapy-resistant tumor specimens. The identification of immunogenic neoepitopes derived from mutant ESR1 offers a promising therapeutic avenue for patients with endocrine therapy-resistant breast cancer.

A chromosome-level genome assembly of the Bullacta exarata (Cephalaspidea: Haminoeidae).

The mudsnail, Bullacta exarata, is an important marine food mollusk for both economic and aquaculture purposes. However, the scarcity of genomic information has hindered genetic research and breeding efforts. To address this gap, we developed a chromosome-level genome assembly utilizing short reads, HiFi long reads, and Hi-C sequencing data.

Collagen peptides promote skin collagen synthesis by modulating the gut microbiota and activating the TGF-β pathway.

Collagen peptides have shown potential in improving skin conditions. Based on this, we hypothesized that the protease-resistant portion of these peptides might act as a prebiotic to enhance collagen synthesis by modulating the gut microbiota and activating the TGF-β pathway. rat models and everted gut sac experiments demonstrated that hydroxyproline-containing tripeptide-rich collagen peptides (CTP) exhibited superior absorption compared to high molecular weight collagen peptides.

Clinicopathological and prognostic study of idiopathic membranous nephropathy with tip or non-tip variant focal segmental glomerulosclerosis: a single-center cohort study.

Idiopathic membranous nephropathy (IMN) complicated with focal segmental glomerulosclerosis (FSGS) is not rare, but the impact of variant pathological manifestations of FSGS (tip variant vs non-tip variant) on the clinical and prognosis of IMN patients remains to be further studied. A total of 536 eligible IMN patients were enrolled in the study and divided into three groups based on the variant histopathological presence of FSGS: 387 patients without FSGS (IMN group), 67 patients with tip variant FSGS (tpFSGS group), and 82 patients with non-tip variant FSGS (ntpFSGS group). IMN patients with FSGS had significantly lower serum albumin (IMN vs.

Deep Learning-Based Automated Detection of Oral Leukoplakia in Clinical Imaging.

Objective:  This study aims to develop and validate a deep learning-based system for automated identification of oral leukoplakia (OLK), addressing diagnostic challenges in clinical practice.

Methods:  We conducted a comparative analysis of 19 convolutional neural network (CNN) architectures using 446 clinical images of histopathologically confirmed oral leukoplakia cases. The dataset was augmented with 1,041 normal oral mucosa images for comparison.

The history of nutritional sciences.

Human history began with the understanding of food, including what can be eaten, what cannot be eaten, and what is beneficial for health. This is the earliest and simplest form of food nutrition for humans. The history of nutrition, from ancient dietary habits to modern nutritional science as we know it today, is a fascinating journey spanning thousands of years.

n-3 polyunsaturated fatty acids-enriched fish oil attenuates chronic alcohol-induced liver injury via a mechanism involving the upregulation of Retsat.

This study aimed to delineate the protective role of fish oil against alcoholic liver disease (ALD), identify the principal active component between eicosapentaenoic acid (EPA, C20:5 n-3) and docosahexaenoic acid (DHA, C22:6 n-3), and elucidate the molecular mechanisms. C57BL/6J mice were randomly assigned to receive either an alcohol-fed (AF) or pair-fed control (PF) diet, enriched with fish oil (FO) or corn oil (CO) for four weeks. Additionally, a series of in vitro experiments were performed using AML-12 cells to further investigate potential mechanisms.

Effects of Different Proportions of DHA and ARA on Cognitive Development in Infants: A Meta-Analysis.

Objectives: Previous studies have assessed the effect of docosahexaenoic acid (DHA, 22:6-3) and arachidonic acid (ARA, 20:4-6)-supplemented infant formula on brain development and cognitive function in infants. However, the results have been inconsistent. The aim of this systematic review and meta-analysis was to assess the effect of DHA and ARA supplementation on cognitive function in infants from randomized controlled trials (RCTs).

High pathogenicity of emerging porcine G9P[23] and G11P[7] rotavirus for newborn piglets in China.

In order to better understand the pathogenicity of the current porcine A group rotavirus (PoRVA) field strains, AHBZ2304 (G9P[23]) and AHBZ2303 (G11P[7]) isolated from diarrhea suckling piglets were selected for pathogenicity analysis in the present study. Experimental inoculation of colostrum-deprived 2-day-old piglets revealed that both isolates caused severe clinical sings, high level of virus shedding and significant damage to the small intestinal villi. Additionally, both gross and microscopic lung lesions were identified at 72 h post infection (HPI) compared to control.

Investigation into the Influence of Polishing Depth and Speed on the Nano-Polishing Process of Nickel-Phosphorus Alloys via Molecular Dynamics.

Nickel-phosphorus (NiP) alloys have been widely used in many engineering fields such as aerospace, automotive, and optics; however, it is difficult to study the material removal mechanism and microscopic size changes in the polishing process of nickel-phosphorus alloys through simple experiments. In light of these difficulties, there is a need to improve our understanding of the surface friction and wear mechanisms of NiP materials. In the present study, molecular dynamics simulations are employed for the first time to investigate the material removal mechanism, mechanical response, phase transformation, and stress distribution of two NiP alloys with different phosphorus contents during the nano-polishing process by adjusting the polishing depth and speed.

Targeting tsRNA-1797 Alleviates Diabetes-Induced Vascular Dysfunction Through Modulating Purine Metabolism.

Unlabelled: Diabetes is a metabolic disorder associated with an increased risk of systemic vascular complications. Notably, diabetic retinopathy (DR) represents a major microvascular complication and a leading cause of blindness and vision impairment. Despite its clinical significance, the precise molecular mechanisms underlying vascular dysfunction and the associated metabolic disturbances in DR remain incompletely understood.

A heterogeneous nanocomposite architecture with contrasting thermal conductivity and hydrophilicity for synergistic solar-thermal storage and evaporation.

Solar-driven evaporation is an eco-friendly and cost-effective freshwater production technique. It is essential to maintain continuous evaporation under intermittent sunlight for practical application. Integrating solar-thermal storage with evaporation is a promising solution.

Rabeprazole- and vonoprazan-based dual therapies for H pylori eradication: effective with low side effects, rabeprazole being more cost-effective.

Objective: To evaluate the eradication effect of dual therapy based on rabeprazole or vonoprazan for (Hp) infection.

Methods: Data from 300 Hp-positive patients were retrospectively analyzed. Patients who received rabeprazole and amoxicillin were assigned to the rabeprazole group, those who received vonoprazan and amoxicillin were placed in the vonoprazan group, and those who underwent conventional quadruple therapy (omeprazole + amoxicillin + clarithromycin + bismuth potassium citrate) were included in the control group.

A compact on-chip microsensor for dual-channel measurement of potassium and creatinine in whole blood.

Blood potassium and creatinine levels are critical indicators for managing chronic kidney disease (CKD). In response to the need for home monitoring and emergency care, point-of-care diagnostic technologies based on microsystems have emerged, nevertheless they remain limited in portability and speed for direct in whole blood samples measurement. To enable direct blood detection of potassium and creatinine for effective CKD management, this study presents a novel on-chip self-driven dual-channel optical microsensor designed for real-time monitoring of potassium and creatinine levels in whole blood.

Clinical Features of Antiphospholipid Syndrome with Intracardiac Mass.

Antiphospholipid syndrome (APS), a disorder characterized by the presence of antiphospholipid antibodies, is commonly associated with thrombotic events and pregnancy complications. Although cardiac involvement of APS is very common, intracardiac thrombus is rare and easily misdiagnosed. In order to reduce missed diagnosis and misdiagnosis, we investigated the clinical features of APS with intracardiac mass by summarizing 50 cases (1 newly presented case and 49 additional cases collected from PubMed from 1985 to the present).

Flow Mode-Dependent Regulation of von Willebrand Factor Degradation in Mechanical Circulatory Support.

Background: Among patients reliant on continuous-flow (CF) mechanical circulatory support devices, bleeding is primarily caused by an acquired von Willebrand factor (vWF) deficiency, precipitated by the high shear stress and diminished pulsatility inherent to these systems. However, despite its clinical significance, the relationship between these devices' flow modes and the development of vWF defects remains poorly investigated. Herein, we conducted molecular dynamic (MD) simulations and in vivo validation to investigate this relationship.

Leveraging AAV1-Rac1T17N to prevent experimental proliferative vitreoretinopathy.

Background: Platelet-derived growth factor receptor β (PDGFRβ) is the principal PDGFR isoform in retinal pigment epithelial (RPE) cells from the epiretinal membranes of patients with proliferative vitreoretinopathy (PVR). Ras-related C3 Botulinum toxin substrate 1 (Rac1), a member of the Rho family, is a crucial factor in the cell migration and contraction processes that are inherent to the pathogenesis of PVR. The mutants Rac1T17N and Rac1Q61L can block and promote Rac1 activation, respectively.

Coffee peel polyphenols ameliorate nonalcoholic fatty liver disease by modulating cannabinoid receptor type-1-ceramide axis.

Cannabinoid receptor type-1 (CB1) signaling plays an important part in maintenance of energy homeostasis, and CB1 blockers have shown promise in the treatment of obesity-related metabolic dysfunction. Coffee peel contains abundant phytochemicals and possesses hypolipidemic and anti-inflammatory activities. The present study aimed to elucidate the preventive effect of coffee peel polyphenols (CPPs) on nonalcoholic fatty liver disease (NAFLD) from the perspective of CB1 signaling.