TaGW2-TaVOZ1 module regulates wheat salt tolerance via both E3 ligase-dependent and -independent pathways.

Wheat production is limited by the rapid expansion of salinized arable land worldwide. Identification of the molecular mechanisms that underlie the salt stress response is of great importance. Here, we uncovered the NAC-type transcription factor, TaVOZ1, as a positive regulator of wheat salt tolerance.

A Small-Diameter Artificial Vascular Graft: Biocompatibility Evaluation and Regulatory Mechanisms of Vascular Remodeling at the Cellular and Molecular Levels.

The increasing prevalence of cardiovascular diseases highlights the urgent demand for small-diameter artificial vascular grafts (SD-AVGs). However, the clinical application of current SD-AVGs is limited by complications such as thrombosis and proliferative stenosis. We first designed and fabricated a triple-layered SD-AVG (TL-SD-AVG) composed of polycarbonate polyurethane and polyethylene terephthalate using electrospinning and mixed weaving techniques.

Neuroplasticity and brain health: insights from natural torpor.

Natural torpor is a seasonal adaptation that ensures very low energy expenditure to survive periods of harsh conditions. The brains of hibernating mammals can survive prolonged periods with a low body temperature and low energy supply. Moreover, they exhibit marked changes in neuronal morphology, function, and network connectivity during the torpor-arousal transition.

Impact of two-dimensional dosimetric leaf gap on SRS-VMAT for single-isocenter multi-target brain metastases.

To explore the effects of two-dimensional dosimetric leaf gap (DLG) on the gamma pass rate (GPR) for single-isocenter multi-target (SIMT) stereotactic radiosurgery for patients with brain metastases. Two-dimensional DLG data were measured by an electronic portal imaging device (EPID) with the sweeping gap methods provided by Varian. A total of 56 arc fields from 28 SIMT patients were analyzed, including 19 with multiple targets and 9 with single targets.

Regional citrate anticoagulation algorithm and management protocol aimed at ensuring blood calcium stability: a prospective single-arm study.

Background: Although several regional citrate anticoagulation (RCA) algorithms have been reported, clinical data confirming their effectiveness and safety are limited. We have developed a novel RCA algorithm applicable to extensive continuous renal replacement therapy (CRRT) settings. The aims of this study were to evaluate the incidence of calcium and citrate abnormalities that necessitated human intervention when using this algorithm during RCA and to identify the optimal values of the coefficients and in the equations.

Durable Lithium Metal Anodes Enabled by {110}-Textured Epitaxy on a LiF@Ag Commensurate Heterostructure.

Lithium metal anodes (LMAs) hold great promise for high-energy storage, but their practical application is hindered by challenges such as Li dendrite growth and unstable solid electrolyte interphase. Designing heteroepitaxial substrates to guide {110}-textured Li growth is a promising strategy to suppress dendrite formation and parasitic reactions. LiF and Ag are potential candidates owing to their low lattice mismatch with Li, whilst the former lacks sufficient lithiophilicity and the latter suffers from Li-Ag alloying.

Study on the synthesis of nano-hydroxyapatite assisted by sodium dodecyl sulfate significantly enhances the adsorption performance of rhodamine B.

In this study, we synthesized sodium dodecyl sulfate modified hydroxyapatite (SDS-HAP) to enhance the removal efficiency of rhodamine B (RhB) dye. The SDS-HAP prepared using the sol-gel method exhibited a significantly higher adsorption capacity compared to pristine HAP. Various characterization techniques, including X-ray diffraction (XRD), N adsorption-desorption isotherms, Fourier-transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM), were utilized to systematically investigate the morphological and structural changes.

Independent Effects of Hypothyroidism and Obesity on Endometrial Cancer Risk Revealed by Mendelian Randomisation.

: Thyroid dysfunction, particularly hypothyroidism, has been associated with endometrial cancer in observational studies; however, these findings may be confounded by obesity, an endometrial cancer risk factor. To clarify these associations, we performed Mendelian randomisation analysis, a genetic approach that mitigates confounding and reverse causation analyses. : We accessed European-ancestry GWAS summary statistics for endometrial cancer (12,270 cases; 46,126 controls), endometrioid (8758 cases), and non-endometrioid (1230 cases) subtypes.

Non-specific phospholipase Cs and their potential for crop improvement.

Non-specific phospholipase C (NPC), a family of enzymes found in plants and microbes but not yet in animals, plays important roles in various biological processes in plants. NPCs hydrolyze different glycerophospholipids to generate diacylglycerol (DAG) and phosphate-containing head groups, and some NPCs are shown to use other membrane lipids, including sphingophospholipids and galactolipids. The structure resolution of NPC4 provides mechanistic insights into the broad substrate uses of NPCs.

A cross-sectional analysis of remnant cholesterol-diabetes association in US adults.

The relationship between remnant cholesterol and diabetes is a critical issue in the fields of health and public health. Currently, the relationship between remnant cholesterol (RC) and diabetes is a highly researched and trending topic. The aim of this study was to investigate association between RC and diabetes in US individuals.

GWAS meta-analysis identifies five susceptibility loci for endometrial cancer.

Background: Endometrial cancer is the most common gynaecological cancer in high-income countries. In addition to environmental risk factors, genetic predisposition contributes towards endometrial cancer development but is still incompletely defined.

Methods: Building on genome-wide association studies (GWASs) by the Endometrial Cancer Association Consortium, we conducted a GWAS meta-analysis of 17,278 endometrial cancer cases and 289,180 controls, incorporating biobank samples from the UK, Finland, Estonia and Japan.

Genome-wide identification of the mA gene family and analysis of mA methylome in alfalfa under drought stress.

Crops frequently endure diverse environmental stresses that negatively impact their growth and yield. Understanding the mechanisms underlying stress responses is crucial for developing stress-tolerant crop varieties, thereby improving their adaptability and productivity. N-methyladenosine (mA) is the most prevalent and reversible internal modification found in eukaryotic mRNA, and is installed, removed, and recognized by methyltransferases (writers), demethylases (erasers), and mA-binding proteins (readers), playing crucial roles in regulating plant growth, development, and environmental stress response.

Treatment of Erythematotelangiectatic Rosacea With Collateral Puncture Therapy: Protocol for a Randomized Controlled Trial.

Background: Erythematotelangiectatic rosacea (ETR) is the most common subtype of rosacea, characterized by persistent facial erythema and telangiectasia of varying calibers. It causes significant aesthetic impairment and is often accompanied by uncomfortable symptoms, such as burning, stinging, dryness, and itching, profoundly affecting patients' quality of life. Intense pulsed light (IPL) therapy demonstrates notable improvement in persistent erythema and telangiectasia; however, it is associated with issues such as a prolonged treatment course and high costs.

Sheng-ji Hua-yu Formula promotes diabetic ulcer healing via regulating the cAMP/PKA/CREB signaling pathway.

Ethnopharmacological Relevance: Diabetic Ulcers (DUs) represent a common and severely debilitating complication associated with diabetes. Chinese Herbal Medicine (CHM) provides advantages in the treatment and healing of DUs. Sheng-ji Hua-yu Formula (SJHY), a topical CHM prescription with a long history of clinical application, has been proven to effectively accelerate healing processes in patients with DUs and exhibits a definite therapeutic effect while ensuring safety.

Regulation of glucosylceramide synthase and sphingolipid remodeling in the plant response to phosphate deficiency.

Sphingolipids are important and abundant lipids in the plasma membrane, and their homeostasis plays a key role in plant growth, development, and stress responses. We previously found that nonspecific phospholipase C4 (NPC4) hydrolyzes sphingophospholipids upon phosphate starvation. Here, we defined the downstream steps of sphingolipid remodeling by identifying glucosylceramide synthase (GCS) and its regulatory mechanisms in Arabidopsis thaliana.

Comprehensive genome-wide identification and expression analysis of the EPF/EPFL gene family in oat.

Epidermal pattern factor-like (EPF/EPFL) genes are a unique class of small, secreted peptides found in plants that play crucial roles in plant stress responses. A genome-wide analysis revealed 33 AsEPF/EPFL genes in oats (Avena sativa), with 28 containing the conserved EPF domain and 5 harbouring the stomagen domain. These proteins share 2-6 conserved motifs, reflecting functional modularity.

Multi-tissue expression and splicing data prioritise anatomical subsite- and sex-specific colorectal cancer susceptibility genes.

Genome-wide association studies have suggested numerous colorectal cancer (CRC) susceptibility genes, but their causality and therapeutic potential remain unclear. To prioritise causal associations between gene expression/splicing and CRC risk (52,775 cases; 45,940 controls), we perform a transcriptome-wide association study (TWAS) across six tissues with Mendelian randomisation and colocalisation, integrating sex- and anatomical subsite-specific analyses. Here we reveal 37 genes with robust causal links to CRC risk, ten of which have not previously been reported by TWAS.

Chlorogenic acid alleviates deoxynivalenol-induced damage in porcine trophectoderm cells by regulating the PI3K/AKT signaling pathway†.

The proliferation and migration of porcine trophectoderm (pTr) cells are crucial processes during the early stages of embryo implantation in sows. The effects of deoxynivalenol (DON) and chlorogenic acid (CGA), a plant-derived compound, on pTr cells are currently unclear. In this study, pTr cells were treated with DON at different times (24, 48, and 72 h) and different concentrations (0.

Proteomic analysis of oat (Avena sativa L.) under drought stress using tandem mass tag labeling.

Drought is a major abiotic stress that limits oat growth. This study investigated the phenotypic, physiological, and proteomic differences between drought-resistant (Grain King [G]) and drought-susceptible (XiYue [X]) oat varieties under drought stress (soil water content of 15% ± 5% of field water-holding capacity) and normal conditions (soil water content of 75% ± 5% of field water-holding capacity). Phenotypic analysis showed that plant height, aboveground biomass, and underground biomass decreased under drought stress in both varieties, with variety X exhibiting a greater reduction.

Effects of Different Proportions of DHA and ARA on Cognitive Development in Infants: A Meta-Analysis.

Objectives: Previous studies have assessed the effect of docosahexaenoic acid (DHA, 22:6-3) and arachidonic acid (ARA, 20:4-6)-supplemented infant formula on brain development and cognitive function in infants. However, the results have been inconsistent. The aim of this systematic review and meta-analysis was to assess the effect of DHA and ARA supplementation on cognitive function in infants from randomized controlled trials (RCTs).

Tracking neural activity patterns during rapid high-altitude transitions.

Rapid adaptation to dynamic changes in the environment is critical for human survival. Extensive studies have observed human behavior and brain activity in a stable environment, but there is still a lack of understanding of how our brain's functional activity drives behavioral changes when the natural environment changes. Here, we used a virtual environment platform named the hypobaric hypoxia chamber to investigate how human neural oscillations and related behaviors are affected by changes in barometric pressure and oxygen levels at different altitudes.

Genome-Wide Identification and Expression Profile Analysis of the NADPH Oxidase Gene Family in L.

The plant respiratory burst oxidase homologs () are crucial enzymes responsible for the production of reactive oxygen species (ROS) in plants, playing a pivotal role in regulating various aspects of plant growth, development, and stress responses. While family members have been identified across a wide range of plant species, the functions and characteristics of the gene family in oats remain poorly understood. In this study, 35 members of the gene family in the oat genome were identified using bioinformatics approaches.

A Swedish genome-wide haplotype association analysis identifies novel candidate loci associated with endometrial cancer risk.

Genome-wide association studies [GWAS] have identified a limited number of endometrial cancer risk loci by analyzing single nucleotide polymorphisms [SNPs]. We hypothesized that analyzing haplotypes rather than SNPs could provide novel and more detailed information on genetic cancer susceptibility loci. To examine the association of a SNP or haplotype with endometrial cancer risk we performed a two-stage haplotype GWAS.