Fluorinated solvent coupled anions-derived hybrid interphase enabled highly reversible and cryogenic silicon anode.

Silicon (Si) has emerged as a prominent candidate for high-energy batteries due to its exceptionally high theoretical capacity and favorable lithiation potential. However, its electrochemical performance at subzero temperatures is significantly hampered by slow ion transport and sluggish ion diffusion processes. Here, we present a weakly solvating electrolyte formulated with 1 M lithium bis(fluorosulfonyl)imide (LiFSI) in a mixture of fluoroethylene carbonate (FEC) / methyl trifluoroacetate (MTFA).

Role of gut-brain axis dysregulation in the pathogenesis of non-alcoholic fatty liver disease: mechanisms and therapeutic implications.

Non-alcoholic fatty liver disease (NAFLD) has emerged as a global health challenge due to its rising prevalence and strong association with metabolic syndrome. Recent studies highlight the critical role of the gut-brain axis (GBA)-a bidirectional communication system between the gut, brain, and liver-in NAFLD pathogenesis. Dysregulation of this axis can worsen metabolic dysfunction, inflammation, and liver injury.

Immunosuppressive nitrogen-containing triterpenoid saponins from Mussaenda erosa and the therapeutic efficacy of heinsiagenin A in a murine lupus erythematosus model.

Eight novel nitrogen-containing triterpenoid saponins, designated mussaerosides A-H (1-8), and ten known ones (9-18) were obtained from the aerial parts of Mussaenda erosa Champ (Rubiaceae). Structural characterization was achieved through spectroscopic techniques and chemical derivatization. Immunosuppressive screening of the saponins and sapogenin heinsiagenin A revealed potent inhibition of T- and B-lymphocytes proliferation, and the latter exhibited potent inhibitory activities against the proliferation of ConA-induced T lymphocyte (CC = 22.

Comparative Chloroplast Genomics of Cultivars: Insights into Positive Selection and Population Evolution.

The chloroplast genome, as an important evolutionary marker, can provide a new breakthrough direction for the population evolution of plant species. represents one of the most economically significant and widely cultivated fruit species in the genus In this study, we sequenced and analyzed the complete chloroplast genomes of seven cultivars of to detect the structural variation and population evolutionary characteristics. The total genome size ranged from 156,404 bp ( cv.

Chlorogenic acid alleviates deoxynivalenol-induced damage in porcine trophectoderm cells by regulating the PI3K/AKT signaling pathway†.

The proliferation and migration of porcine trophectoderm (pTr) cells are crucial processes during the early stages of embryo implantation in sows. The effects of deoxynivalenol (DON) and chlorogenic acid (CGA), a plant-derived compound, on pTr cells are currently unclear. In this study, pTr cells were treated with DON at different times (24, 48, and 72 h) and different concentrations (0.

The association between magnesium depletion score (MDS) and overactive bladder (OAB) among the U.S. population.

Objective: This study aimed to assess the relationship between magnesium depletion score (MDS) and overactive bladder (OAB) prevalence.

Methods: This study utilized data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. Multivariate logistic regression was employed to investigate the association between MDS and OAB.

The Erk1/2-EGR1 signaling pathway is involved in lipopolysaccharide-induced transforming growth factor-beta 1 expression in mouse macrophages.

Numerous studies have demonstrated that lipopolysaccharide (LPS) stimulates TGF-β1 expression. Although studies have implicated the NF-κB/METTL3/METTL14 transactivation/m6A-dependent and AMPK-dependent signaling pathways are engaged in this process in a variety of cell types, the underlying regulatory mechanism in murine macrophages is still not fully understood. To address this issue, in vitro studies were performed using the murine macrophage cell line, RAW264.

Immunological landscape of periodontitis and rheumatoid arthritis and their molecular crosstalk.

Background: The association between periodontitis (PT) and rheumatoid arthritis (RA) is well-established; however, the molecular mechanisms underlying this relationship remain poorly understood. This study aims to delineate shared genetic and molecular features between PT and RA to uncover potential common pathways involved in their pathogenesis.

Methods: Gene expression data sets for PT and RA were retrieved from the Gene Expression Omnibus (GEO) database.

Uncovering potential molecular markers and pathological mechanisms of Parkinson's disease and myocardial infarction based on bioinformatics analysis.

BackgroundThe direct association between Parkinson's disease (PD) and Myocardial infarction (MI) has been the subject of relatively limited research.ObjectiveThe purpose of this study was to identify the genes most associated with PD and MI to explore their common pathogenesis.MethodsThe gene expression profiles of PD and MI were downloaded from GEO database.

Lights and shadows of clozapine on the immune system in schizophrenia: a narrative literature review.

Schizophrenia is a chronic mental disorder and one of the main causes of disability in the world. Approximately 1% of the general population suffers from this disorder, and almost 30% of cases are unresponsive to antipsychotic therapies. Clozapine is a Food and Drug Administration (FDA)-approved antipsychotic drug for treatment-resistant schizophrenia (TRS).

Rubiadin Mediates the Upregulation of Hepatic Hepcidin and Alleviates Iron Overload via BMP6/SMAD1/5/9-Signaling Pathway.

Iron overload disease is characterized by the excessive accumulation of iron in the body. To better alleviate iron overload, there is an urgent need for safe and effective small molecule compounds. Rubiadin, the active ingredient derived from the Chinese herb Prismatomeris tetrandra, possesses notable anti-inflammatory and hepatoprotective properties.

Kynurenine, a derivative of tryptophan, inhibits progesterone biosynthesis in porcine granulosa luteal cells through Aryl hydrocarbon receptor-mediated downregulation of GATA-binding protein 4, 6, and CCAAT/enhancer-binding protein beta†.

Kynurenine (KYN) is a primary tryptophan derivative found in the human body and fermented foods. Previous studies have shown that KYN is an aryl hydrocarbon receptor (AHR) agonist and is important in regulating various physiological activities, including female reproduction. Progesterone is a vital steroid hormone that facilitates embryo implantation and maintains pregnancy.

Dissolving microneedle synergistic rocaglamide-loaded liposome to regulate abnormal neutrophils for anti-psoriasis.

Psoriasis seriously affects the physical and mental health of patients. Rocaglamide (RocA), derived from Aglaia odorata, exhibits potent pharmacological activities. Although its efficacy in psoriasis is unclear, RocA could be a promising therapeutic drug.

Periplosides Extract from Improve Collagen Antibody-Induced Arthritis by Regulating Macrophage Polarization.

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized primarily by the synovial infiltration of inflammatory cells. Macrophage infiltration in the joint synovium is one of the early hallmarks of RA disease activity. , which has been widely employed in traditional Chinese medicine (TCM) to alleviate RA, harbors a bioactive compound known as periplosides (PePs).

UV-B irradiation promotes anthocyanin biosynthesis in the leaves of .

Anthocyanins are the most valuable pigments in (). Although ultraviolet-B (UV-B) irradiation is a key environmental factor influencing anthocyanin biosynthesis in , the deep molecular mechanism remains unclear. Herein, we examined the changes in the total anthocyanin content and transcriptomic characteristics of leaves following UV-B irradiation treatment.

Exploring resveratrol against Alzheimer's disease and Parkinson's disease through integrating network pharmacology, bioinformatics, and experimental validation strategy in vitro.

Background: The study aims to investigate the pharmacological basis and molecular mechanisms of resveratrol in the treatment of Alzheimer's disease (AD) and Parkinson's disease (PD) through the approach of treating different diseases with the same method, guided by traditional Chinese medicine theory. Utilizing network pharmacology and bioinformatics methods, this research aims to provide modern medical evidence for the theory of treating different diseases with the same method in traditional Chinese medicine.

Methods: Omnibus from Swiss Target Prediction, TCMSP, SuperPred, SEA, HIT, CTD, TCMIP and Gene Expression Disease datasets for resveratrol related genes, Alzheimer's disease, and Parkinson's disease were obtained from the GEO database.

Research Note: Study on the in-situ preservation of pigeons based on the level of endangerment of genetic resources.

The large-scale and intensive development of the meat pigeon breeding industry have resulted in the replacement of a large number of low-performance local breeds by a few breeds with excellent production performance. However, due to the characteristics of pigeon species that are monogamous, for which the W chromosome cannot be recovered and for which semen cannot be cryopreserved, the preservation of pigeon species is still mainly based on in-situ preservation. In this study, pigeons were classified into 6 classes of endangerment based on the criteria of the 100-year inbreeding coefficient of poultry populations in the "Assessment of Endangered Poultry Genetic Resources" (NY/T 2996-2016).

Two new limonoid glycosides from the seeds of and their PDE4D inhibitory activities.

Two new limonoid glycosides, named limonosides A () and B (), along with four known limonoids (-) were obtained from the seeds of . Their structures were deduced based on extensive spectroscopic analysis. Limonoside A () and nomilin () were found to possess moderate phosphodiesterase type 4D (PDE4D) inhibitory effect with values of 89.

Realization of monolayer ZrTe topological insulators with wide band gaps.

Two-dimensional topological insulators hosting the quantum spin Hall effect have application potential in dissipationless electronics. To observe the quantum spin Hall effect at elevated temperatures, a wide band gap is indispensable to efficiently suppress bulk conduction. Yet, most candidate materials exhibit narrow or even negative band gaps.

Association between life's essential 8 and overactive bladder.

Limited research has explored the relationship between overactive bladder (OAB) and cardiovascular health (CVH). We aim to examine the correlation between OAB and CVH in American adults, utilizing the Life's Essential 8 (LE8). We included 70,190 individuals from the National Health and Nutrition Examination Survey spanning from 2005 to 2018.

Rocaglamide regulates iron homeostasis by suppressing hepcidin expression.

The anemia of inflammation (AI) is characterized by the presence of inflammation and abnormal elevation of hepcidin. Accumulating evidence has proved that Rocaglamide (RocA) was involved in inflammation regulation. Nevertheless, the role of RocA in AI, especially in iron metabolism, has not been investigated, and its underlying mechanism remains elusive.

Porous High-Entropy Oxide Anode Materials for Li-Ion Batteries: Preparation, Characterization, and Applications.

High-entropy oxides (HEOs), as a new type of single-phase solid solution with a multi-component design, have shown great potential when they are used as anodes in lithium-ion batteries due to four kinds of effects (thermodynamic high-entropy effect, the structural lattice distortion effect, the kinetic slow diffusion effect, and the electrochemical "cocktail effect"), leading to excellent cycling stability. Although the number of articles on the study of HEO materials has increased significantly, the latest research progress in porous HEO materials in the lithium-ion battery field has not been systematically summarized. This review outlines the progress made in recent years in the design, synthesis, and characterization of porous HEOs and focuses on phase transitions during the cycling process, the role of individual elements, and the lithium storage mechanisms disclosed through some advanced characterization techniques.

N-Containing triterpenoid saponins from Mussaenda densiflora and identification of heinsiagenin A as a potent immunosuppressant.

Eleven triterpenoid saponins, including five new compounds, which were named densiflorasides A - E (1 - 5), were isolated from aerial parts of Mussaenda densiflora (Rubiaceae). Their structures were elucidated based on spectroscopic and single-crystal X-ray diffraction analyses and chemical methods. All the isolated compounds and the aglycone heinsiagenin A were evaluated for their immunosuppressive and antiosteoclastogenic activities in vitro.

Berberine alleviates inflammation in polycystic ovary syndrome by inhibiting hyaluronan synthase 2 expression.

Background: Polycystic ovary syndrome (PCOS) is a heterogeneous metabolic and endocrine disorder that causes anovulatory infertility and abnormal folliculogenesis in women of reproductive age. Several studies have revealed inflammation in PCOS follicles, and recent evidence suggests that Berberine (BBR) effectively reduces inflammatory responses in PCOS, however, the underlying mechanisms remain unclear.

Purpose: To determine the underlying mechanisms by which BBR alleviates inflammation in PCOS.