Plant-derived hydrogel and photosynthetic nano-units for myocardial infarction therapy.

Ischemic injury and reperfusion injury collectively determine the total infarct size, a major prognostic factor following myocardial infarction (MI). Therefore, addressing both ischemic and reperfusion stages could substantially reduce infarct size and improve clinical outcomes. In this study, we develop a two-component therapeutic system from different parts of Glycyrrhiza: a functional hydrogel made from glycyrrhizic acid extracted from the stem and root, and nanosized chloroplast units (NCUs) derived from leaves.

Association between different response patterns during oral glucose tolerance test and postpartum glucose intolerance in women with gestational diabetes.

Purpose: Our study aimed to assess the associations of the response patterns during gestational oral glucose tolerance test (OGTT) with postpartum glucose intolerance (PGI) in women with gestational diabetes mellitus (GDM).

Methods: This cohort study included 5348 GDM women who underwent the OGTT both 24-28 weeks during pregnancy and 4-12 weeks postpartum from January 2017 to June 2022. Gestational OGTT response patterns included individual time-point glucose values, glucose response trajectories, and GDM subtypes.

Treatment of Erythematotelangiectatic Rosacea With Collateral Puncture Therapy: Protocol for a Randomized Controlled Trial.

Background: Erythematotelangiectatic rosacea (ETR) is the most common subtype of rosacea, characterized by persistent facial erythema and telangiectasia of varying calibers. It causes significant aesthetic impairment and is often accompanied by uncomfortable symptoms, such as burning, stinging, dryness, and itching, profoundly affecting patients' quality of life. Intense pulsed light (IPL) therapy demonstrates notable improvement in persistent erythema and telangiectasia; however, it is associated with issues such as a prolonged treatment course and high costs.

The long-term effects of adverse childhood experiences on adult health and behaviors: mediating role of socioeconomic inequality.

Background: Despite extensive research into the health effects of adverse childhood experiences (ACEs), there remains a need for nationally representative data to assess the associations between ACEs and both adult health and behaviors, focusing on the mediating role of socioeconomic inequality.

Method: Using data from the 2019-2022 Behavioral Risk Factor Surveillance System (BRFSS) (N = 249,186 adults), ACE exposure was categorized into five groups (0, 1, 2, 3, and 4 or more ACEs). Socioeconomic inequality was assessed based on income levels.

Exposure to multiple metals and leukocyte telomere length in children and adolescents: The mediating effect of thyroid hormones.

Exposure to metals has been related to alterations in leukocyte telomere length (LTL), an aging marker. However, the evidence regarding this relationship in children and adolescents, as well as the underlying mechanisms, remains unclear. Therefore, we aimed to explore the individual and mixture effects of metals on LTL in children and adolescents and to assess the mediating role of thyroid hormones and the modifying effect of a healthy lifestyle.

Association between multiple metals exposure and metabolic dysfunction-associated fatty liver disease among Chinese adults.

Background: Previous research has investigated the hepatotoxicity of single metal exposure. However, there is limited evidence about metal mixture and their association with metabolic dysfunction-associated fatty liver disease (MAFLD), particularly in the Chinese population.

Objective: To investigate the individual and combine effects of 20 metals on MAFLD in a large population in China.

Reproductive factors and biological aging: the association with all-cause and cause-specific premature mortality.

Study Question: Are reproductive factors associated with biological aging, and does biological aging mediate the associations of reproductive factors with premature mortality?

Summary Answer: Multiple reproductive factors are related to phenotypic age acceleration (PhenoAge-Accel), while adherence to a healthy lifestyle mitigates these harmful effects; PhenoAge-Accel mediated the associations between reproductive factors and premature mortality.

What Is Known Already: Accelerated aging is a key contributor to mortality, but knowledge about the effect of reproductive factors on aging is limited.

Study Design, Size, Duration: This prospective cohort study included 223 729 women aged 40-69 years from the UK biobank in 2006-2010 and followed up until 12 November 2021.

Association between multiple metal exposure and bone mineral density among Chinese adults.

Previous studies about metal exposures and bone mineral density (BMD) have mainly focused on individual metals. The objective of this study was to explore the association of single and multiple metal exposures with BMD among Chinese adults. We recruited 2922 participants from Tongji Hospital in Wuhan, China.

Reproductive factors, genetic susceptibility and risk of type 2 diabetes: A prospective cohort study.

Aim: To explore the relationships of multiple reproductive factors with type 2 diabetes mellitus (T2DM) risk and the joint effects of reproductive factors and genetic susceptibility.

Methods: We included 262,368 women without prevalent T2DM from the UK biobank. Cox proportional hazards regression models were employed to estimate the relationships of reproductive factors with T2DM risk and the joint effects of reproductive factors and genetic susceptibility.

Association of exposure to multiple metals with hemoglobin levels in Chinese children and adolescents.

Background: Previous studies have linked single metal to hemoglobin levels in children and adolescents; however, studies with regards to metal mixtures are still limited.

Objective: We aimed to investigate the associations of single metal and metal mixtures with hemoglobin levels in children and adolescents.

Methods: We conducted a cross-sectional study of 2064 children and adolescents aged 6 to 19 years in Liuzhou, China in 2018.

FGF1 attenuates sepsis-induced coagulation dysfunction and hepatic injury via IL6/STAT3 pathway inhibition.

Background & Aims: Sepsis, a globally prevalent and highly lethal condition, remains a critical medical challenge. This investigation aims to assess the relevance of FGF1 as a potential therapeutic target for sepsis.

Methods: Sepsis was induced in C57BL/6 mice through LPS administration to establish an in vivo animal model.

Association between essential metals, adherence to healthy lifestyle behavior, and ankle-brachial index.

Background: Ankle-brachial index (ABI) is a noninvasive diagnostic method for peripheral arterial disease (PAD) and a predictor of cardiovascular events.

Objective: The present study aimed to evaluate the association between individual or combined essential metals and ABI, as well as assess the collective impact of essential metals when coupled with healthy lifestyle on ABI.

Methods: A total of 2865 participants were recruited in Wuhan Tongji Hospital between August 2018 and March 2019.

Microwave-Assisted Synthesis of SnO@ZnInS Composites for Highly Efficient Photocatalytic Hydrogen Evolution.

This research successfully synthesized SnO@ZnInS composites for photocatalytic tap water splitting using a rapid two-step microwave-assisted synthesis method. This study investigated the impact of incorporating a fixed quantity of SnO nanoparticles and combining them with various materials to form composites, aiming to enhance photocatalytic hydrogen production. Additionally, different weights of SnO nanoparticles were added to the ZnInS reaction precursor to prepare SnO@ZnInS composites for photocatalytic hydrogen production.

Association between hemoglobin A1c trajectory during pregnancy and adverse birth outcomes among non-gestational diabetic women.

Aims: Previous studies have shown that higher hemoglobin A1c (HbA1c) levels within the normal range during pregnancy can increase the risk of adverse birth outcomes. However, the effects of the longitudinal HbA1c trajectory during pregnancy on adverse birth outcomes among non-gestational diabetic women are poorly characterized. We aimed to identify HbA1c trajectory during pregnancy among non-gestational diabetic women and to estimate their associations with adverse birth outcomes.

Exposure to organochlorine pesticides and polychlorinated biphenyls, adherence to an ideal cardiovascular health, and arterial stiffness among Chinese adults.

This study aimed to assess the relationships between exposure to individual organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), and their mixture and arterial stiffness and explore whether adherence to an ideal cardiovascular health (CVH) could mitigate these associations. The cross-sectional study enrolled 1437 Chinese adults between March and May 2019 in Wuhan, China. OCPs and PCBs concentrations were measured using solid phase extraction coupled with gas chromatography-tandem mass spectrometry.

Association of prenatal essential metal exposure with newborn mitochondrial DNA copy number: Results from a birth cohort study.

Imbalance or deficiencies of essential metals can lead to oxidative stress, that can damage mitochondrial DNA (mtDNA) molecule. Knowledge on effects of exposure to essential metals and their mixture remains limited. We aimed to evaluate individual and joint associations of prenatal essential metals with neonatal mtDNA copy number.

Associations of polychlorinated biphenyls and organochlorine pesticides with metabolic dysfunction-associated fatty liver disease among Chinese adults: Effect modification by lifestyle.

Exposure to environmental pollutants and unhealthy lifestyles are key risk factors for metabolic dysfunction-associated fatty liver disease (MAFLD). While previous studies have suggested links between exposure to organochlorine pesticides (PCBs) and organochlorine pesticides (OCPs) and MAFLD, the results have been inconsistent. Furthermore, the combined effects of PCBs and OCPs on MAFLD and whether lifestyle factors can modify the associations remain unknown.

Associations of polychlorinated biphenyl and organochlorine pesticide exposure with hyperuricemia: modification by lifestyle factors.

Recent research has reported positive associations of exposure to polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) with hyperuricemia. However, most of these studies have primarily focused on the individual effects of PCB/OCP exposure. We aimed to explore the associations of both individual and combined PCB/OCP exposure with hyperuricemia and examine whether such associations could be modified by lifestyle factors.

Association between female-specific reproductive factors and leukocyte telomere length.

Study Question: What are the associations between female-specific reproductive factors and leukocyte telomere length (LTL)?

Summary Answer: Early menarche, early menopause, short reproductive lifespan, early age at first birth, multiparity, and use of oral contraceptives (OCs) and hormone replacement therapy (HRT) were associated with shorter LTL.

What Is Known Already: Reproductive factors have been associated with age-related diseases, but their associations with cellular aging, as indicated by LTL, are unclear.

Study Design, Size, Duration: This population-based study included 224 965 women aged 40-69 years from the UK Biobank between 2006 and 2010.

Toxicokinetics of recombinant human fibroblast growth factor 21 for injection in cynomolgus monkey for 3 months.

Recombinant human fibroblast growth factor 21 (FGF-21) is a potential therapeutic agent for multiple metabolic diseases. However, little is known about the toxicokinetic characteristics of FGF-21. In the present study, we investigated the toxicokinetics of FGF-21 delivered via subcutaneous injection .

Associations of self-reported sleep duration and sleep quality during pregnancy with newborn telomere length.

Background: Telomere length (TL) at birth is considered a potential biomarker for lifelong health. Although maternal sleep disturbance has been linked to a series of adverse pregnancy outcomes, evidence on the effect of maternal sleep on newborn TL remains scarce. Therefore, we aim to investigate the association of maternal sleep duration and sleep quality with newborn TL.

Sex-specific associations of single metal and metal mixture with handgrip strength: a cross-sectional study among Chinese adults.

Metallic elements are ubiquitous in the natural environment and always collaborate to affect human health. The relationship of handgrip strength, a marker of functional ability or disability, with metal co-exposure remains vague. In this study, we aimed to investigate the effect of metal co-exposure on sex-specific handgrip strength.