Adverse Childhood Experiences, Genetic Susceptibility, and the Risk of Osteoporosis: A Cohort Study.

Emerging evidence indicates that individuals exposed to adverse childhood experiences (ACEs) face elevated risks for various chronic illnesses. However, the association between ACEs and osteoporosis risk remains underexplored, particularly regarding potential modifications by genetic susceptibility. This prospective cohort study aims to examine the relationship of ACEs with incident osteoporosis and investigate interactions with polygenic risk score (PRS).

CrispHunter-enabled systematic crRNA design and structure-optimized hairpin probes for enhanced CRISPR-Cas12a detection of Burkholderia pseudomallei.

Effective control of genetically diverse pathogens necessitates rapid and accurate diagnostics, as their genomic variability undermines assay reliability and complicates public health interventions. Herein, we introduce a CRISPR-Cas12a-based molecular diagnostic platform integrating robust in silico crRNA design via our CrispHunter pipeline with a high-performance detection module featuring structure-optimized hairpin probes. We validated this approach using Burkholderia pseudomallei, whose high pathogenicity, genetic diversity, and diagnostic evasion exemplify the challenges of detecting heterogeneous pathogens.

Adverse childhood experiences, childhood socioeconomic status, and subsequent high myopia: Results from six universities in China.

Background: High myopia is a critical public health problem. The relationships of adverse childhood experiences (ACEs) and childhood socioeconomic status (SES) with later high myopia remain under explored.

Methods: A total of 17,237 college students from six universities were recruited through a multistage, random cluster sampling method in Shaanxi province, China.

Sleep deprivation exacerbates experimental colitis via down-regulating the clock gene Per2.

Intestinal bowel disease (IBD), prevalent among sleep-deprived populations, is closely associated with circadian rhythm disruptions. Evidence suggests that sleep deprivation (SD) exacerbates colitis; however, the mechanisms remain poorly understood. We subjected mice with Dextran sulfate sodium (DSS) induced acute and chronic colitis to 6 h-SD per day.

Heavy metals, epigenetic aging, and mortality: A cohort study.

Background: Aging is a multifaceted biological process modulated by interplay of genetic determinants and environmental influences. However, the role of epigenetic aging in the association between environmental exposures and mortality risk in human populations remains incompletely understood.

Objective: Investigate the associations between urinary metal exposure, epigenetic-age acceleration markers (EAMs), and mortality risk.

The association between per- and polyfluoroalkyl substances and biological aging among middle and older age adults: The moderating effect of caffeine.

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are pervasive environmental pollutants associated with aging-related diseases and mortality risks, yet their relationship with biological aging remains underexplored. Notably, dietary antioxidants like caffeine have been shown to alleviate oxidative stress and inflammation, and these pathways are closely related to PFAS-induced toxicity and aging processes. However, whether dietary caffeine intake could mitigate the adverse effect of PFAS on biological aging is still unknown.

Reducing tilt errors in chromatic confocal measurement: a peak extraction algorithm based on the pseudo-Voigt function.

In chromatic confocal measurement (CCM), peak extraction is a critical step in converting spectral signals into physical position information, which directly affects the measurement accuracy and reliability. However, when measuring inclined surfaces with CCM techniques, the spectral confocal signal (SCS) becomes distorted and loses its symmetry. Existing peak extraction methods, when applied to asymmetric SCS, introduce high-frequency random errors, significantly reducing measurement accuracy.

Adverse childhood experiences are associated with job burnout in nursing interns: the mediation role of sleep duration.

Background: Adverse childhood experiences (ACEs) have been linked to a higher probability of adverse physical and emotional conditions. Yet, there remains limited understanding regarding the correlation between ACEs and job burnout, and the role of sleep duration as a potential mediator in this relationship remains largely understudied.

Methods: From December 2023 to February 2024, a convenience sampling method was used to recruit nursing interns from multiple hospitals in Hunan Province, China.

Development and application of an ion sensitive probe for helicon plasma diagnostics.

This study focuses on the design and application of an Ion Sensitive Probe (ISP) for the PKU Plasma Test (PPT) device, marking the first implementation of the ISP in a large-diameter helicon plasma device with a single-loop antenna discharge. The strong influence of electrode material on ISP diagnostic performance is also observed for the first time, and tungsten is proven to be the optimal choice. Experimental results demonstrate that both ion and electron temperatures are at the order of 1 eV.

Multifunctional Infrared Polarizer Based on Aligned Growth of High-Density Boron Nitride Nanotubes.

Boron nitride nanotubes (BNNTs) are an emerging mid-infrared optical material that exhibits significant potential in nanoscale resonators, lasers, detectors, and sensors due to the strong light-matter interactions induced by phonon polaritons (PhPs). However, the large-scale controllable synthesis and device applications of BNNTs still face huge challenges. In this study, a substrate-pretreated and boron source dual-catalyst infiltrated growth method, and a damage-free purification method toward the high-density and aligned BNNT (ABNNT) thin films is developed.

The long-term effects of adverse childhood experiences on adult health and behaviors: mediating role of socioeconomic inequality.

Background: Despite extensive research into the health effects of adverse childhood experiences (ACEs), there remains a need for nationally representative data to assess the associations between ACEs and both adult health and behaviors, focusing on the mediating role of socioeconomic inequality.

Method: Using data from the 2019-2022 Behavioral Risk Factor Surveillance System (BRFSS) (N = 249,186 adults), ACE exposure was categorized into five groups (0, 1, 2, 3, and 4 or more ACEs). Socioeconomic inequality was assessed based on income levels.

Prenatal thallium exposure and child neurodevelopment at 2 years: a birth cohort study in China.

Background: Thallium, a highly toxic heavy metal, is well-documented for causing neurodevelopmental toxicity in animal models. However, epidemiological evidence regarding the effects of early-life thallium exposure on human neurodevelopment remains limited.

Objective: To investigate the trimester-specific associations of maternal thallium exposure with early childhood neurodevelopment.

Graph-Based Prediction of miRNA-Drug Associations with Multisource Information and Metapath Enhancement Matrices.

Recent studies have demonstrated that miRNA expression dysregulation is closely related to the occurrence of various diseases; thus, miRNA-based drug development strategies have received increasing research interest. Most existing computational methods focus on the attribute information of individual nodes and are limited to the direct associations between nodes, thereby ignoring the complex associations inherent in the network. This limitation may lead to the loss of key potential information, which impacts the prediction accuracy.

Current status of elevated blood pressure and hypertension among adolescents in Asia: a systematic review.

Background: Hypertension among adolescents in Asia is an emerging public health concern that is directly associated with early onset cardiovascular risks. As such, it can also lead to further health issues and challenges for health care in the future. As existing studies have predominantly focussed on adult populations, we sought to provide targeted insights into adolescent hypertension across Asia, elucidating the impact of rapid lifestyle and environmental changes on this younger population.

The mediating effects of sleep quality in the relationship between loneliness and depression among middle-aged and older adults.

Loneliness has long been recognized as a key predictor of depression in older adults, and both are related to sleep quality. However, to this day, less is known about whether sleep quality mediates their relationship. This study aimed to examine the relationship between loneliness, sleep quality, and depressive symptoms, and to further explore whether sleep quality mediates the relationship between loneliness and depressive symptoms.

Metabolically healthy across body mass index categories in relation to serum Klotho levels: a population-based study.

Background: Metabolic health status and body mass index (BMI) are both key predictors of aging-related diseases and premature mortality. However, the relationship between metabolically distinct phenotypes, classified by BMI categories, and serum Klotho levels-a biomarker of aging-remains poorly understood. This study aimed to investigate the association between metabolically healthy phenotypes and serum Klotho levels among middle and aged adults.

Association of thallium exposure in early life with gut microbiota in neonates.

Previous research has found a correlation between heavy metals and gut microbiota in humans. However, there are few population-based studies examining the impact of early life thallium (Tl) exposure on neonatal microbiome. 342 newborns were recruited from Hunan Children's Hospital and subsequently divided into three groups (low, medium, and high) based on the 25th and 75th percentiles of serum Tl concentration.

Ultrasensitive Recognition of Trace Nerve Agents Enabled via a Thermally Activated Delayed Fluorescence-Based Fluorescent Probe.

The development of fluorescent probes for the detection of nerve agents has been a significant focus of research due to their lethal toxicity to humans. Inspired by the excited state properties of thermally activated delayed fluorescence (TADF), we designed two visualized fluorescence probes, PT and PPT, that exhibit characteristics of delayed fluorescence and aggregation-induced emission. These probes are intended for the rapid and highly sensitive detection of diethyl chlorophosphate (DCP).

Current trends in household food insecurity, dietary diversity, and stunting among children under five in Asia: a systematic review.

Background: Household food insecurity (HFI) and poor dietary diversity (DD) are major public health challenges in Asia, greatly contributing to stunting among children under five. While previous research has focussed primarily on African regions, this systematic review provides novel insights into the association between HFI, DD, and stunting within the Asian context.

Methods: We searched across six major databases for studies published between 2019 and 2023 exploring the association between HFI, DD, and stunting in children under five across Asia.

Sex-specific associations between exclusive breastfeeding and postpartum depression in Chinese women.

Background: Studies on the association of exclusive breastfeeding and postpartum depression (PPD) are inconsistent and no prior study has investigated whether this association was influenced by other factors. This study aimed to investigate the correlation between exclusive breastfeeding and PPD in Chinese population, as well as to determine whether other factors influence this association.

Methods: A cross-sectional survey was carried out on 7685 postpartum women from a hospital of Shenzhen, China, utilizing the Edinburgh Postnatal Depression Scale (EPDS) to evaluate PPD.

Association between multiple metals exposure and metabolic dysfunction-associated fatty liver disease among Chinese adults.

Background: Previous research has investigated the hepatotoxicity of single metal exposure. However, there is limited evidence about metal mixture and their association with metabolic dysfunction-associated fatty liver disease (MAFLD), particularly in the Chinese population.

Objective: To investigate the individual and combine effects of 20 metals on MAFLD in a large population in China.