Efficacy and safety of Belimumab, Rituximab and Voclosporin in the treatment of lupus nephritis based on registered clinical trials: A systematic review and network meta-analysis.

ObjectiveTo systematically compare the clinical effectiveness and safety of Belimumab, Rituximab and Voclosporin in the treatment of lupus nephritis based on network meta-analysis method.MethodsSystematic search of registered clinical trials in four major databases (Pubmed, Embase, Web of Science, The Cochrane Register of Clinical Trials) and ClinicalTrials.gov.

Correlation between neurogenic injury and lumbar disc degeneration in tethered cord syndrome: a retrospective MRI study based on somatosensory evoked potentials.

Purpose: This study examines the association between neurogenic injury and lumbar intervertebral disc degeneration (LDD) in tethered cord syndrome (TCS) by comparing lumbar sagittal parameters and disc degeneration between patients with normal and abnormal somatosensory evoked potential (SSEP) findings.

Methods: We retrospectively analyzed clinical data from 43 patients diagnosed with TCS between July 2018 and July 2024. Based on tibial nerve somatosensory evoked potential (SSEP) examination results, patients were categorized into SSEP-normal and SSEP-abnormal groups.

Diagnosis methods for pancreatic cancer with the technique of deep learning: a review and a meta-analysis.

Background: Early diagnosis can significantly improve survival rate of Pancreatic ductal adenocarcinoma (PDAC), but due to the insidious and non-specific early symptoms, most patients are not suitable for surgery when diagnosed. Traditional imaging techniques and an increasing number of non-imaging diagnostic methods have been used for the early diagnosis of pancreatic cancer (PC) through deep learning (DL).

Objective: This review summarizes diagnosis methods for pancreatic cancer with the technique of deep learning and looks forward to the future development directions of deep learning for early diagnosis of pancreatic cancer.

Prevalence of radiographic knee osteoarthritis in China: a national survey of thirty thousand, four hundred and fifty five individuals cross-sectional study.

Background: Knee osteoarthritis (KOA) is a major health burden for adults and the elderly globally; however, national radiological and epidemiological data and predictive models for KOA are lacking in China. Most of the existing studies are limited to regional samples, which cannot accurately reflect disease burden and risk factors.

Objectives: This study aimed to systematically analyze the prevalence and risk factors of adult radiology KOA in China for the first time using a national representative sample and to develop a prediction model to provide a basis for public health strategies.

Effect of microscope-assisted modified lateral lumbar interbody fusion and impact on lumbar lordosis and intervertebral height.

Purpose: This study aimed to evaluate the effectiveness of microscope-assisted modified lateral lumbar interbody fusion (micro-XOLIF) and to compare its impact on lumbar sagittal plane imaging parameters with extreme lateral interbody fusion (XLIF).

Methods: We retrospectively collected the data of patients who underwent XLIF and micro-XOLIF in our hospital. We compared general data, medical records, and imaging parameters of both groups, including lumbar sagittal balance and postoperative intervertebral height.

Shear wave elastography for noninvasive assessment of intracompartmental pressure in tibial plateau fractures: a cross-sectional study.

Background: This study aimed to investigate the utility of shear wave elastography (SWE) as a noninvasive diagnostic tool for assessing anterior compartment intracompartmental pressure (ICP) in patients with tibial plateau fractures, facilitating early detection of high compartment pressure (HCP) to mitigate acute compartment syndrome (ACS) risks.

Methods: In this cross-sectional study conducted from January 2024 to March 2025 at a tertiary hospital in China, 170 patients aged 18-65 years with tibial plateau fractures diagnosed within 48 h were enrolled. Demographic data, injury mechanisms, Schatzker classification, and laboratory parameters were collected.

Advances in corneal preservation: A comparative narrative review of active and non-active methods.

Corneal transplantation, a critical treatment for corneal blindness, depends on effective preservation of donor corneal tissue. Preservation techniques are broadly classified into active and non-active methods based on the viability of endothelial cells. Active preservation-such as hypothermic storage and organ culture-maintains endothelial cell viability and is primarily used in penetrating keratoplasty.

COL4A1 as a potential prognostic biomarker with functional roles in colon cancer progression.

COL4A1, a key component of the basement membrane, has been increasingly implicated in tumor progression, yet its role in colon cancer remains incompletely understood. In this study, we conducted a comprehensive integrative analysis using transcriptomic data from the TCGA-COAD cohort, combined with functional validation in colon cancer cell lines. Gene set enrichment analysis (GSEA) revealed that high COL4A1 expression was associated with oncogenic pathways including epithelial-mesenchymal transition (EMT), KRAS signaling, and inflammatory responses.

Serous and Exosomal LDH-C4 as a Potential Diagnostic and Prognostic Biomarker of Cervical Carcinoma.

Background: Exosomal molecules derived from cancer cells have been recognized as candidate biomarkers for cancer diagnosis and prognosis. This study aimed to evaluate the potential of the LDH-C4 expression level in cervical carcinoma.

Methods: A retrospective study was conducted on patients with cervical carcinoma at the Third Hospital of Hebei Medical University, in Shijiazhuang, China, between July 2021 to September 2023.

Leptin receptor signaling mediates the distinct tendon-bone interface reconstruction in rotator cuff tears and osteoporosis-comorbid rotator cuff tears.

Background: The intact tendon-bone interface (TBI) consists of four histological layers-tendon, fibrocartilage, calcified fibrocartilage, and bone-that gradually merge into each other, making complete structural restoration after injury challenging. Osteoporosis poses a significant risk for rotator cuff tears (RCTs) and re-tears after arthroscopic rotator cuff repair (ARCR). Activating Leptin receptor (Lepr) mediated Stat3 signaling transduction facilitates the transcription of Runx2 and Sox9, respectively, and promotes osteogenesis and chondrogenesis.

Xuebijing alleviates high-voltage electrical burn-induced acute kidney injury by inhibiting neutrophils and inflammation.

This study aimed to investigate the clinical effect of Xuebijing in alleviating acute kidney injury (AKI) after high-voltage electrical burns by inhibiting neutrophils, inflammatory cells, and its potential influence on reactive oxygen species (ROS). Ninety-six patients with AKI following high-voltage electrical burns, admitted to our hospital from February 2023 to December 2024, were included. They were randomized using a computer-generated random number sequence into two groups: a study group (Xuebijing, n = 48) and a control group (n = 48).

Equilibrium Mechanics in Fracture Reduction of Tibial Plateau.

Background: Tibial plateau fracture is one of the common fractures in the lower limb, mostly caused by high-energy injuries, which may be accompanied by different degrees of compression and displacement of the joint surface, affecting the knee joint alignment, stability, and sports function, and improper treatment may cause various complications, which are a more difficult problem in the clinic. The objective of this study was to investigate the biomechanical mechanisms underlying effective closed reduction in the treatment of tibial plateau fractures, particularly focusing on the performance of the homeopathic double reverse traction repositor compared to traditional traction table methods.

Methods: We developed a biomechanical model to analyze the equilibrium mechanics during tibial plateau fracture reduction.

Non-linear association between neutrophil-to-lymphocyte ratio and 90-day mortality in patients with pneumonia receiving glucocorticoids alone or in combination with other immunosuppressants: A retrospective cohort study.

Objective: The relationship between neutrophil-to-lymphocyte ratio (NLR) and 90-day mortality in patients with pneumonia receiving glucocorticoids alone or in combination with other immunosuppressants has not been fully verified. We aimed to explore the influence of NLR on 90-day mortality in this specific population.

Methods: This study utilized the data set from the Dryad database, involving 696 participants diagnosed with pneumonia who were receiving glucocorticoids alone or in combination with other immunosuppressants.

Fatal pneumonia in a patient with Kearns-Sayre syndrome case report and literature review.

Kearns-Sayre syndrome is a mitochondrial DNA deletion disorder, classically characterized by a triad of onset before the age of 20, pigmentary retinopathy, and chronic progressive external ophthalmoplegia (CPEO). The condition is frequently associated with third-degree atrioventricular block, endocrine dysfunction, and short stature. Here, we report a case of KSS presenting with a progressive clinical course that began at birth with ptosis and later developed type 1 diabetes, hypopituitarism, and third-degree atrioventricular block.

Retrospective case-control study of intraoperative EEG correlates in postoperative delirium.

Objectives: This retrospective study investigated the association between perioperative SedLine EEG parameters and the incidence of postoperative delirium (POD) in elderly patients undergoing breast cancer surgery.

Methods: A total of 80 elderly patients, aged 60 years or older, who underwent breast cancer surgery between January and December 2024, were included in the analysis. Patients were divided into the POD group and the NPOD group according to whether they developed postoperative delirium.

Suture Bridge Technique for Arthroscopic Repair of Posterior Cruciate Ligament Tibial Avulsion.

Arthroscopy has gradually become the routine method to treat posterior cruciate ligament tibial insertion avulsion. However, arthroscopic surgery possesses the advantages of being minimally invasive, having a good appearance, and having no need for revision surgery for internal fixation. Compared with open surgery, it is limited by disadvantages such as unstable fixation, unsatisfactory reduction, and fracture fragment displacement.

Ultrasound-Assisted Anatomic Posterior Cruciate Ligament Reconstruction With Remnant Preservation by Reference to Distal Reflection of the Posterior Capsule and Posterior Septum.

Compared with anterior cruciate ligament reconstruction, posterior cruciate ligament (PCL) reconstruction has a higher failure rate and revision rate, which is associated with multiple factors such as graft option, fixation method, postoperative rehabilitation, and management of concomitant injuries. Among them, "killer turn" is a key factor in the failure of PCL reconstruction. Although there are various techniques for PCL reconstruction, the ideal surgery remains controversial.

Cost-Effectiveness and Cost-Utility Analysis of Tongxinluo Capsules Compared With Conventional Therapy for the Treatment of Acute Myocardial Infarction.

Aim: Tongxinluo (TXL) capsule, a traditional Chinese medicine compound, has proven effective in acute myocardial infarction (AMI), but its cost-effectiveness is unclear.

Methods: This economic evaluation utilized individual data from clinical trials to compare major adverse cardiac and cerebrovascular events (MACCEs) at 30 days and quality-adjusted life years (QALYs) at 1 year between an intervention group (TXL combined with conventional therapy) and the control group (placebo plus conventional therapy), from a healthcare perspective. A lifetime cost-utility analysis (CUA) was conducted using a Markov model, and sensitivity analyses were performed to evaluate the robustness of the results.

METTL1 drives glioma progression by promoting N7-methylguanosine (m7G) modification of glycolysis-related enzyme PGK1.

Glioma is a common brain malignancy with a poor prognosis. N7-methylguanosine (m7G) modification is involved in cancer progression, and methyltransferase 1 (METTL1) is a m7G methyltransferase. Here, we aimed to study the role of METTL1 in glioma and the potential mechanism.

cGAS-STING axis: A central regulator of neural homeostasis and neuroinflammatory pathogenesis.

An increasing amount of evidence shows that type I interferon response, which is induced by cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) and stimulator of interferon genes (STING) is closely associated with health and neuroinflammatory diseases. Abnormal activation or loss of control of the cGAS-STING axis affects the development of neuroinflammation. Thus, we examined its role in major neurological diseases, including traumatic brain injury, Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, herpes simplex encephalitis, and ataxia-telangiectasia.

HNF4A ameliorates acute liver failure by inhibiting NCOA4-mediated ferritinophagy.

Intracellular iron homeostasis imbalance is linked to cellular ferroptosis and inflammatory injury diseases. NCOA4-mediated ferritin autophagy is vital for regulating intracellular iron homeostasis, but its impact on acute liver failure (ALF) pathogenesis and regulatory mechanisms remain unclear. This study explores the role and regulatory mechanisms of NCOA4 in hepatocyte ferroptosis and ALF progression.

Early nursing interventions for neurogenic bowel dysfunction in acute-phase spinal cord injury patients: A non-concurrent controlled trial.

Background: Traumatic spinal cord injury (SCI) often leads to neurogenic bowel dysfunction (NBD), causing significant gastrointestinal issues that adversely affect patients' quality of life (QoL). The current study evaluates the effectiveness of early nursing interventions in managing NBD among SCI patients.

Methods: A non-concurrent controlled trial design included 125 participants with acute-phase SCI.

Multi-Omics insights into the molecular mechanisms of trochlear dysplasia: A proteomic and metabolomic study in rats.

Introduction: Trochlear dysplasia (TD) is a skeletal deformity that causes abnormal morphology of the trochlear groove, leading to patellar instability and related joint issues. Despite its clinical importance, the molecular mechanisms behind TD are not well understood. This study aims to explore these mechanisms using an integrated proteomic and metabolomic approach in a rat model of TD.