Efficacy and safety of intranasal corticosteroids combined with mucoactive drugs for chronic rhinosinusitis.

Background: Chronic rhinosinusitis (CRS) leads to a burden in life and economy. Better therapies need to be explored.

Objective: This stage I study aims to explore the efficacy and safety of intranasal corticosteroids combined with mucoactive drugs for CRS.

Comparative analysis of endplate volumetric bone mineral density and endplate vertebral bone quality for predicting cage subsidence in lateral lumbar interbody fusion.

Objective: The aim of this study was to compare the predictive efficacy of quantitative CT (QCT)-based endplate volumetric bone mineral density (EP-vBMD) and MRI-based endplate vertebral bone quality (EBQ) score for cage subsidence (CS) after lateral lumbar interbody fusion (LLIF).

Methods: A retrospective study was conducted on patients who underwent single-level LLIF in conjunction with pedicle screw fixation at the authors' institution between January 2019 and April 2023. The volumetric bone mineral density (vBMD) was measured based on preoperative CT using phantom-less QCT software.

Rare primary anorectal malignant melanoma presenting with painless hematochezia: a case report.

Background: Anorectal malignant melanoma (ARMM) is an exceedingly rare and highly aggressive malignancy characterized by low prevalence, high misdiagnosis rates, and frequent recurrence/metastasis.

Case Report: This report details the case of a 51-year-old woman presenting with persistent bright red blood in her stool. Digital rectal examination revealed a firm, spherical mass approximately 4 cm from the anal verge.

The evolution of concomitant mitral regurgitation in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement: a prospective multi-center China-DVD2 cohort study.

Background: Severe aortic stenosis (AS) often coexists with mitral regurgitation (MR). This study evaluated the significant evolution of MR in patients undergoing transcatheter aortic valve replacement (TAVR) for AS.

Methods: This multi-center China Degenerative Valve Disease II Cohort (China-DVD2) Study enrolled patients undergoing TAVR for AS from January 2020 to October 2023.

Engineered hollow CuO@ZnO p-n heterojunction nanocomposites for synergistic photocatalytic disinfection and tissue regeneration.

Photocatalytic antibacterial therapy is a promising method for wound disinfection and treatment. However, the weak photocatalytic antibacterial activity of ZnO stimulated by visible light limits its applications. In this study, porous CuO@ZnO heterojunctions with enhanced visible light response are successfully synthesized by coupling ZnO and CuO using a one-pot water bath method.

Nano-enabled repurposing of Benproperine phosphate enhances pancreatic Cancer chemotherapy through lethal autophagy arrest and immune activation.

Gemcitabine-based chemotherapy remains a cornerstone in pancreatic cancer treatment, yet its efficacy is hindered by poor bioavailability and adaptive resistance mechanisms, such as autophagy. In this study, we developed a hyaluronic acid (HA) modified zeolitic imidazolate framework-8 (ZIF-8) drug-repurposing nanoplatform (HA/ZIF-8@BPP/Gem) against pancreatic cancer through the co-delivery of the antitussive benproperine phosphate (BPP) and gemcitabine (Gem). Using cell lines, patient-derived xenograft models, and orthotopic tumor models, we demonstrated that BPP and Gem, rapidly released from the nanoplatform in the acidic tumor microenvironment, exhibited synergistic cytotoxicity without causing significant biochemical abnormalities or organ toxicity.

[Observation of morphological and molecular biological changes of nasal mucosa in patients with type 2 inflammation chronic rhinosinusitis with nasal polyps after Reboot surgery].

To explore the effect, postoperative mucosal pathological changes and molecular biological changes of reboot operation for type 2 inflammation chronic rhinosinusitis with nasal polyps（CRSwNP） patients, and to provide theoretical basis for the clinical application of this kind of operation. We collected 29 patients who were diagnosed with CRSwNP with type 2 inflammatino response and underwent Reboot surgery from June 2022 to August 2023, and 27 patients who were diagnosed with deviated septum and underwent simple submucosal resection of the septum as the control group. We conducted nasal symptom scoring, endoscopic sinusitis scoring, and CT scanning of the sinuses before and after surgery, as well as HE staining, immunohistochemical staining, and detection of inflammatory factors using Elisa kits at the time of surgery, 1, 3, and 6 months postoperatively.

Case report: Secondary neck mass infection in a patient with multiple osteomyelitis caused by Corynebacterium striatum.

Rationale: The opportunistic pathogen Corynebacterium striatum has been generating more clinical infections in recent years, but secondary infections at different parts caused by it have been reported more rarely.

Patient Concerns: This case details a 52-year-old male patient who got an infection that advanced to multiple osteomyelitis and soft tissue abscess after block therapy for external humeral epicondylitis of the right arm. Unexpectedly, the chronic ulcerated region of the patient's neck was infested with Corynebacterium striatum due to inadequate treatment of the main infection, resulting in a secondary infection of the neck mass.

Adropin as a therapeutic candidate for HFpEF: evidence of oxidative stress mitigation via Nrf2/HO-1 signaling.

Background: Heart failure with preserved ejection fraction (HFpEF), which accounts for more than half of all heart failure cases worldwide, has emerged as a major public health challenge characterized by substantial morbidity and mortality rates. As adropin is a key regulator of cardiovascular and metabolic homeostasis, this study investigated its therapeutic effects against HFpEF pathogenesis.

Methods: C57BL/6 mice were fed a high-fat diet (60% fat-derived calories) with NG-nitro-L-arginine methyl ester (L-NAME, 0.

An evaluation of the effectiveness of 3D virtual imaging combined with intraoperative ultrasonography to guide liver staining in anatomic segmental hepatectomy.

Identification of a tumor-bearing portal territory using indocyanine green (ICG) fluorescence imaging (IGFI) facilitates precise laparoscopic anatomic hepatectomy (LAH). However, it is technically challenging to perform a transhepatic portal injection of ICG or to clamp the target portal pedicle and inject ICG during LAH. Herein, we aimed to investigate the feasibility and efficacy of portal territory identification using IGFI under the combined guidance of three-dimensional (3D) virtual imaging and intraoperative ultrasound (IOUS) in LAH.

GLP-1/GIP dual agonist tirzepatide alleviates mice model of Parkinson's disease by promoting mitochondrial homeostasis.

Background: The prevailing treatment of Parkinson's disease (PD) is not yet satisfactory. The present investigate the neuroprotective effect of the GLP-1/GIP dual agonist tirzepatide and examine the potential mechanisms involved.

Methods: Analysis of GLP1 receptor (GLP1R) and GIPR expression alterations in dopaminergic neurons from PD patients in the GSE238129 dataset.

Mutational landscape and tyrosine kinase inhibitor sensitivity in EGFR L833 and H835 mutated non-small cell lung cancer.

Background: Non-small cell lung cancer (NSCLC) patients with EGFR L833 and H835 mutations show potentially satisfying responses to EGFR tyrosine kinase inhibitors (TKI); however, investigations on their molecular and clinical characteristics are limited.

Methods: DNA sequencing data from 240 NSCLC patients with EGFR L833 and H835 mutations were analyzed, including 57 with EGFR-TKI treatment records. An external cohort of 346 EGFR L858R-mutated NSCLC patients was also evaluated for comparative molecular landscape analysis.

Rufy3 Knockdown Induces PANoptosis Through MAP4/CDK1 Axis to Inhibit Colorectal Cancer Growth: Evidence From In Vitro and In Vivo Models.

Colorectal cancer (CRC) has a high morbidity and mortality. PANoptosis is a phenomenon in which metabolism and cell death are closely related. However, the underlying molecular mechanism of PANoptosis in CRC is still unclear.

Geographic Variation in Venom Proteome and Toxicity Profiles of Chinese : Implications for Antivenom Optimization.

Differences in venom within snake species can affect the efficacy of antivenom, but how this variation manifests across broad geographical scales remains poorly understood. envenoming causes severe morbidity in China, yet whether intraspecific venom variation exists across mainland regions is unknown. We collected venom samples from seven biogeographical regions (spanning > 2000 km latitude).

The G-branch off-the-shelf mixed branch endograft for thoracoabdominal aortic aneurysm: 1-year results from a prospective multicenter study.

Background: The use of off-the-shelf multi-branched endografts for thoracoabdominal aortic aneurysm (TAAA) is increasing; however, these commercially available devices have limited anatomical feasibility for treating TAAA. This study aimed to assess the safety and efficacy of a novel G-branch off-the-shelf endograft for TAAA.

Materials And Methods: A total of 73 patients with TAAA were treated using the G-branch endograft at 14 sites across China.

KIFC1 Overexpression Promotes Pancreatic Carcinoma Progression via Stabilising BUB1B.

Pancreatic cancer (PC) is a highly lethal tumour of the gastrointestinal tract. New molecular targets are urgently needed for its treatment. Kinesin family member C1 (KIFC1) is implicated in the development and progression of several types of cancer.

Clinical, Microbiological, and Antibiotic Treatment Characteristics of Bacterial Infections in Patients with Liver Cirrhosis in China: A Multicenter Study.

Background And Aims: Epidemiological data on bacterial infections in cirrhosis in China remain limited. Therefore, we aimed to conduct a multicenter study to investigate the characteristics and outcomes of patients with cirrhosis and bacterial infections in China.

Methods: We retrospectively enrolled 1,438 hospitalized adult patients with cirrhosis and bacterial or fungal infections from 24 hospitals across China between January 2018 and September 2024.

Generation of a human PBMC induced pluripotent stem cell line JXEYi001-A-iPSC from a pediatric patient with ventricular arrhythmias.

This study established an iPSC line, JXEYi001-A, from a 7-year-old male with a KCNJ2 mutation linked to ventricular arrhythmias (VA). KCNJ2 encodes Kir2.1, essential for cardiac repolarization; its mutations can cause short QT syndrome, increasing VA risk.

Association of Plasma Aldosterone Concentration With Early Renal Injury Biomarkers in Primary Aldosteronism: A Propensity-Matched Comparative Study.

Primary aldosteronism (PA) independently increases renal impairment risk beyond blood pressure effects. Although hyperaldosteronism is known to mediate renal injury, associations between plasma aldosterone concentration (PAC) and early kidney damage biomarkers such as retinol-binding protein (RBP) and β2-microglobulin (β2-MG) remain insufficiently explored. We investigated the association of PAC with renal function indicators-including RBP, β2-MG, albumin-to-creatinine ratio (ACR), and estimated glomerular filtration rate (eGFR)-comparing matched patients with PA and essential hypertension (EH).

Neuroform EZ stenting for basilar artery atherosclerotic stenosis.

Periprocedural complications, including perforator occlusion, in-stent restenosis, and even death, are frequently encountered in endovascular therapy for basilar artery (BA) lesions. This study sought to evaluate the efficacy of the Neuroform EZ stent in managing atherosclerotic BA stenosis. A retrospective analysis was conducted on clinical data from 71 patients with symptomatic atherosclerotic BA stenosis who underwent Neuroform EZ stent implantation.

Association Between Whole Blood Cell-Derived Inflammatory Markers and All-Cause Mortality in Patients with Sepsis-Associated Acute Kidney Injury: A Retrospective Study Based on the MIMIC-IV Database.

BackgroundSepsis-associated acute kidney injury (SA-AKI) is a serious condition with a high mortality rate. Whole blood-derived inflammatory markers like the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI), are emerging prognostic indicators for various diseases. This study endeavors to unravel the link of these markers to all-cause mortality(ACM) in the SA-AKI population utilizing the MIMIC-IV database.

Mycophenolate mofetil plus methotrexate versus cyclophosphamide with sequential azathioprine for treatment of Takayasu arteritis.

Objectives: Study the efficacy and safety of mycophenolate mofetil (MMF) combined with methotrexate (MTX) compared to cyclophosphamide (CYC) followed by azathioprine (AZA) to treat active Takayasu arteritis (TAK).

Methods: Adults with active TAK were randomised in a 2:1 ratio to receive oral MMF plus MTX or intravenous CYC followed by oral AZA. All subjects also received high-dose oral glucocorticoids with a predefined taper.

Unraveling molecular characteristics and functional exploration of panoptosis for prognosis stratification in lung adenocarcinoma: a tumor marker prognostic study.

Background: As a unique cell death modality mediated by multifaceted PANoptosome complexes, PANoptosis plays a crucial role in the development, invasion, and drug resistance of cancers. However, there is a lack of mechanisms for the PANoptosis in lung adenocarcinoma (LUAD).

Methods: More than 1500 biopsy samples of LUAD and other cancers were collected from diversified cohorts in various databases.

Deep learning-based spatial analysis on tumor and immune cells of pathology images predicts MIBC prognosis.

Objective: Muscle-invasive bladder cancer (MIBC) is a highly aggressive disease with a poor prognosis. This study aims to explore the correlation between the spatial distribution of lymphocyte aggregates and the prognosis of MIBC using deep learning.

Methods: Whole-slide images (WSIs) and clinical information of MIBC patients were collected from The Cancer Genome Atlas (TCGA) and the HBlaU079Su01 microarray.