Engineered hollow CuO@ZnO p-n heterojunction nanocomposites for synergistic photocatalytic disinfection and tissue regeneration.

Photocatalytic antibacterial therapy is a promising method for wound disinfection and treatment. However, the weak photocatalytic antibacterial activity of ZnO stimulated by visible light limits its applications. In this study, porous CuO@ZnO heterojunctions with enhanced visible light response are successfully synthesized by coupling ZnO and CuO using a one-pot water bath method.

Development of a transtheoretical model for the prevention and treatment of skin disease through ultraviolet protection based on 14,681 samples of outpatient clinics and a cross-sectional survey.

Background: Little is known about the association between types of skin and subcutaneous diseases and UV protection literacy.

Objective: To assess the burden and treatment of skin diseases in Ninger County, Yunnan Province, and establish a transtheoretical model for optimizing public perceptions and behaviors regarding UV radiation.

Methods: Electronic medical records of outpatients from the dermatology department were collected from January 2022 to July 2024, and a self-administered questionnaire assessed the public knowledge about UV exposure risks and behaviors.

Clinical and pathological features of 209 cases of pilomatricoma in children: a retrospective study.

Background: Pilomatricoma, albeit benign, may have a potential impact on children's appearance and health. Clinical practice has revealed variations in the clinical manifestations, anatomical locations, and sizes of pilomatricoma among different pediatric patients. However, few studies have comprehensively summarized the correlations between these features and treatment efficacy, which is crucial for enhancing clinicians' understanding and diagnostic accuracy of the disease.

Development of a polydopamine‑graphene nanocomposite electrochemical aptasensor for sensitive detection of lung cancer biomarker VEGF165.

This study presents a novel electrochemical aptasensor utilizing polydopamine-graphene (PDA-G) nanocomposite for VEGF165 detection. The PDA-G nanocomposite was synthesized through a one-step self-polymerization process and characterized by SEM, XPS, and FTIR, confirming successful PDA coating on graphene sheets with 22.3% C-N bond incorporation.

Oncogenic GOPC-ROS1 fusion promotes the formation of lymphatic malformations by impairing tight junction and its crizotinib resistance through repressing ferroptosis.

The complicacy of genetic abnormalities in lymphatic malformations (LMs) limits their treatment in clinical practice. In this study, we identified a complex LM with Golgi-associated PDZ and coiled-coil motif containing (GOPC)-proto-oncogene ROS 1 (ROS1) fusion that responds to crizotinib. The oncogenic roles of GOPC-ROS1 fusion in the formation of LMs remain unknown.

IFN γ and the IFN γ Signaling Pathways in Merkel Cell Carcinoma.

Recent preclinical and clinical studies have confirmed the essential role of interferons in the host's immune response against malignant cells. Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer strongly associated with Merkel cell polyomavirus (MCPyV). Despite progress in understanding MCC pathogenesis, the role of innate immune signaling, particularly interferon-γ (IFN γ) and its downstream pathways, remains underexplored.

Lactylation: A new direction for tumor-targeted therapy.

Lactate, a central metabolite generated during glycolysis, functions not only as a by-product but also as a critical signalling mediator, profoundly influencing tumor progression and cellular destiny. Among the post-translational modifications, lactylation-a novel modification driven by lactate-has emerged as a transformative discovery, reshaping our understanding of lactate's role within the tumor microenvironment (TME). This modification bridges metabolic reprogramming and epigenetic regulation, unveiling previously unexplored dimensions of tumor biology.

Global, regional, and national burden of gout among older adults (≥65) from 1990 to 2021 and projections for 2050.

Background: Gout, a common and treatable type of inflammatory arthritis, is caused by the buildup of monosodium urate crystals in the synovial fluid and other tissues. This study uses epidemiological modeling to analyze the global impact of gout among older adults (≥65) from 1990 to 2021, with projections extending to 2050, using the most recent data from the Global Burden of Disease (GBD) 2021.

Method: Data from the GBD 2021 database were used to evaluate the global burden of gout in adults aged 65 and older from 1990 to 2021.

Exploring supply and demand imbalance of community-based older adult care: an observational study in Chongqing, China.

Objective: Using an urban area in southwest China as a case study, this research investigates and analyzes the supply and demand of community-based older adult care services to provide a basis for optimizing the older adult care service system.

Methods: A two-stage sampling method was employed to select older participants. Questionnaires, designed based on the Kano model, were administered to participants, and semi-structured interviews were conducted with community senior center managers and services users.

Hyperconjugated linker design in giant dimeric donors enabled superior short-circuit current in organic solar cells.

Giant dimeric donors possess definite chemical structures and regulatable molecular skeletons and are expected to become alternative photovoltaic materials for polymer donors with batch differences. However, the design of giant dimeric donors is still at an early stage and needs to be further explored. Here, through creative semi-flexible and flexible linker design, we synthesized three interesting giant dimeric donors with relative monomer positions ranging from parallel to staircase to perpendicular in their optimized conformation.

Small Molecule Donor/Polymer Acceptor Organic Solar Cells with Efficiency of 13.65% Enabled by Film Formation Kinetics and Phase Separation Control.

Organic solar cells (OSCs) based on small molecular donor and polymer acceptor (S/P-type) show low photovoltaic performance due to the unideal morphology. However, previous work mainly focused on the aspects of donors, but how the polymer acceptor influences its morphology and device performances is lacking in study. In this work, we apply three polymerized nonfullerene small molecules as acceptors, combining film-forming kinetics and microstructure characterization to investigate the efficient S/P-type OSCs requirements on polymers.

The intervention effect of comprehensive precision nursing in elderly patients with type 2 diabetes.

Objective: This study evaluated the impact of precision nursing on blood sugar levels, psychological health and quality of life in ageing type 2 diabetes patients.

Methods: A prospective cohort study involving 100 older patients was carried out at a tertiary hospital located in Sichuan Province, China. The patients were categorised into two groups: a control group that received standard nursing care and an observation group that received tailored nursing interventions.

Novel LBR pathogenic variants with loss of sterol reductase activity participate in the pathogenesis of skeletal dysplasia via dysregulating canonical Wnt pathway.

Biallelic pathogenic variants in the lamin B receptor (LBR) with impaired sterol reductase function are associated with the development of perinatal lethal Greenberg dysplasia (GRBGD) and mild nonfatal skeletal dysplasia with or without Pelger-Huet anomaly (PHASK), as well as other related hereditary skeletal dysplasia. However, the underlying molecular mechanism remains unclear. In this study, we found two novel pathogenic variants of LBR, namely missense mutation (c.

Thioredoxin-loaded nanocomposite wound dressing for the delivery of adipose derived stem cells for wound healing applications.

In the current research, Thioredoxin was loaded into chitosan nanoparticles and then loaded into the matrix of collagen hydrogel containing adipose-derived stem cells (ASCs). In vitro studies including Scanning electron microscopy imaging, cell viability assay, cell migration assay, swelling assay, release assay, radical scavenging assay were performed in order to characterize the dressings. Then, the wound healing activity of these scaffolds were studied in a rat model of wound healing.

Targeting kinases that regulate programmed cell death: a new therapeutic strategy for breast cancer.

Breast cancer is one of the most prevalent malignant tumors among women and ranks as the second leading cause of cancer-related deaths in females, primarily due to delays in diagnosis and shortcomings in treatment strategies. Consequently, there is a pressing need to identify reliable therapeutic targets and strategies. In recent years, the identification of effective biomarkers-particularly novel molecular therapeutic targets-has become a focal point in breast cancer research, aimed at predicting disease aggressiveness and monitoring treatment responses.

Fire cupping inspired negative-pressure microneedle syringes loaded with herb berberine-based nano composite for psoriasis therapy.

Psoriasis, an immune-mediated chronic inflammatory skin disorder, poses challenges for topical treatment due to the thickening of the stratum corneum, hindering drug penetration. Furthermore, long-term use of chemical drugs may lead to immunosuppression and abnormal hepatic or renal dysfunction. Inspired by traditional Chinese fire cupping (Ba Huo Guan), a negative-pressure microneedle syringe therapy has been proposed here for psoriasis treatment.

Microenvironment-responsive NIR-IIb multifunctional nanozyme platform for bacterial imaging and specialized anti-anaerobic bacteria periodontal therapy.

Periodontitis is a chronic inflammatory disease caused by plaque. In order to remove pathogens and promote tissue repair, the following steps need to be taken simultaneously: localizing the diseased area, improving the anaerobic microenvironment, as well as addressing the anti-inflammatory and osteogenic needs. This study aims to address these issues by developing a responsive near-infrared-IIb nanozyme system (DMUP), assembled from lanthanide-doped down-converted nanoparticles and multi-enzymatically active nanozyme.

Diagnosis-related groups study of uterine leiomyoma patients based on E-CHAID.

Diagnosis-related groups (DRG) is emerging as an effective tool for measuring the quality and efficiency of medical services. This study aims to explore a DRG combination scheme for control the hospitalization costs in patients with uterine leiomyoma (UL). This study enrolled a total of 3087 UL patients from a tertiary hospital in Chongqing between year 2017 and 2021.

A Fluorescence/Colorimetric Synergistic-Enhanced Type-I Heterostructured MOF@QDs for Both Multi-Depth Food-Freshness Prediction and Extra Preservation.

Spoiled food has significantly impacted the global economy and public health, which increases worldwide concern about monitoring and preserving food freshness. Herein, a multi-functional type-I heterojunction (Eu@ZMC) is designed by europium metal-organic framework (EuMOF), zinc oxide quantum dots (ZnO QDs), and chlorogenic acid (CGA). Eu@ZMC achieves ratiometric fluorescent/colorimetric sensing of pH and biogenic amines to detect freshness.

MXene-Derived Multifunctional Biomaterials: New Opportunities for Wound Healing.

The process of wound healing is frequently impeded by metabolic imbalances within the wound microenvironment. MXenes exhibit exceptional biocompatibility, biodegradability, photothermal conversion efficiency, conductivity, and adaptable surface functionalization, demonstrating marked potential in the development of multifunctional platforms for wound healing. Moreover, the integration of MXenes with other bioactive nanomaterials has been shown to enhance their therapeutic efficacy, paving the way for innovative approaches to wound healing.

Integrated degradation of bacteria, organic pollutants, total phosphorus, and antibiotics in food wastewater through immobilization of Bacillus velezensis on polyethylene glycol-polyvinyl alcohol/sodium alginate/nano-TiO microspheres.

Food wastewater is characterized by complex composition and a wide range of pollutants. Existing treatment methods are often inefficient for single pollutants and new, environmentally friendly, and integrated treatment methods are needed. This study aimed to construct a novel polyethylene glycol (PEG)-polyvinyl alcohol (PVA)/sodium alginate (SA)/nano-TiO hydrogel microsphere-immobilized Bacillus velezensis system for the integrated degradation of complex pollutant components in food wastewater.

Peritoneal adipose stem cell-derived extracellular vesicles mediate the regulation of ovarian cancer cell proliferation and migration through EGFR-NF-κB signaling.

Peritoneal dissemination frequently develops in patients with ovarian cancer (OC) and is associated with recurrence and metastasis. However, the cellular components and mechanisms supporting OC peritoneal metastasis are poorly understood. To elucidate these, we utilized RNA sequencing to investigate the cellular composition and function.

SIGIRR plays a dual role in zebrafish infected with Edwardsiella piscicida: Boosting digestive system wellness and mitigating inflammation.

Single immunoglobulin interleukin-1 receptor-associated protein (SIGIRR) negatively regulates the inflammatory response induced by bacterial infection by inhibiting the excessive synthesis of inflammatory mediators and overactivation. This inhibitory mechanism reduces the fish's susceptibility to pathogens and enhances survival rates. Zebrafish lacking the SIGIRR gene were generated using CRISPR/Cas9 gene knockout technology.

Advances in Drug Delivery Systems for Atopic Dermatitis Treatment.

Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by pruritus and impaired skin barrier function. Advances in drug delivery systems have transformed AD treatment by enhancing drug stability, bioavailability, and targeted delivery. Drug delivery systems such as liposomes, hydrogels, and microneedles enable deeper skin penetration, prolonged drug retention, and controlled release, reducing side effects and treatment frequency.

Worldwide prevalence of atopic dermatitis in children between 2000 and 2021: A systematic analysis.

Background: Atopic dermatitis (AD) is a prevalent allergic disease that significantly impacts pediatric health.

Objective: To comprehensively describe the global, regional, and national AD prevalence trends among children aged 0 to 14 years between 2000 and 2021.

Methods: Data from the Global Burden of Disease Study 2021 were used to analyze AD prevalence and case numbers.