Unraveling molecular characteristics and functional exploration of panoptosis for prognosis stratification in lung adenocarcinoma: a tumor marker prognostic study.

Background: As a unique cell death modality mediated by multifaceted PANoptosome complexes, PANoptosis plays a crucial role in the development, invasion, and drug resistance of cancers. However, there is a lack of mechanisms for the PANoptosis in lung adenocarcinoma (LUAD).

Methods: More than 1500 biopsy samples of LUAD and other cancers were collected from diversified cohorts in various databases.

An Efficient Electrochemiluminescence Biosensor Based on Ru(bpy)@AuNPs@SWCNTs for miRNAs Detection Using a Dual Engine-Triggered DNA Walker.

The diagnosis and treatment of acute pancreatitis remain challenging due to the limitations of diagnostic methods, which often result in delayed treatment and suboptimal outcomes. This underscores the need for innovative diagnostic strategies to enable early detection and improve therapeutic interventions. Electrochemiluminescence (ECL)-based biosensors have emerged as a promising solution, offering advantages such as cost-effectiveness, ease of use, and high sensitivity.

Ethyl acetate extract from Herpetospermun cardigerum wall. Ameliorated concanavalin A-induced autoimmune hepatitis in mice by reprofiling gut microenvironment to modulate IDO1/KYN and PI3K/AKT/NF-κB pathways.

Background: Autoimmune hepatitis (AIH) is an immunoinflammatory chronic liver disease with increasing prevalence worldwidely, lacking of effective medicine. Herpetospermum caudigerum Wall. (HC) is a traditional Tibetan medicine used to treat liver diseases for thousands of years.

Research progress of non-coding RNA regulating the role of PANoptosis in diabetes mellitus and its complications.

Diabetes is a chronic metabolic disease that is endemic worldwide and is characterized by persistent hyperglycemia accompanied by multiple severe complications, including cardiovascular disease, kidney dysfunction, neuropathy, and retinopathy. The pathogenesis of diabetes mellitus and its complications is multifactorial, involving various molecular and cellular pathways. In recent years, research has indicated that mechanisms of cell death play a significant role in the advancement of diabetes and its complications.

Kinsenoside from Anoectochilus roxburghii (Wall.) Lindl. suppressed oxidative stress to attenuate aging-related learning and memory impairment via ERK/Nrf2 pathway.

Ethnopharmacological Relevance: Anoectochilusroxburghii (Wall.) Lindl. (AR), as an exceptionally valuable traditional Chinese medicine, has been widely used to treat hepatitis, cancer, diabetes, etc.