Combined transcriptomics and metabolomics analyses reveal the molecular mechanism of heat tolerance in .

Introduction: is a prevalent non- yeast in brewing. The aim of this study was to isolate a high temperature resistant strain from the of strong flavor and to elucidate its molecular mechanism.

Methods: Growth activity was assessed at temperatures of 37°C, 40°C, 45°C, and 50°C.

Integrated trade-offs/synergies and interactions approach to quantifying the direct and indirect effects of environmental factors on ecosystem services.

The driving mechanisms of ecosystem services (ESs) involve two aspects: the effects of environmental factors (e.g., precipitation and slope) on ESs and the effects of trade-offs/synergies on ESs.

Transcriptome profiling unravels improved ethanol production and acetic acid tolerance in yeast by preculture of wheat gluten hydrolysates.

The effects of wheat gluten hydrolysates (WGH) preculture on yeast acetic acid tolerance and fermentation performances were investigated. Results showed that WGH preculture significantly increased yeast growth and viability under acetic acid stress. Particularly, the WGH fraction precipitated with 90 % (v/v) gradient ethanol (WGH-C) preculture significantly improved yeast cell membrane integrity and H-ATPase activity, thereby decreasing the intracellular accumulation of ROS and acetic acid.

Exploring the Influence of Pottery Jar Formula Variables on Flavor Substances Through Feature Ranking and Machine Learning: Case Study of Maotai-Flavored Baijiu.

The advantages of pottery jars in the aging process of Baijiu are evident, but the impact of their material composition and pore structure on the flavor of Baijiu has not been widely studied. This study systematically analyzed the effects of six types of pottery jars on metal ions and flavor substances during the storage process of Maotai-flavored Baijiu. It was found that changes in the content of Fe and Zn metals, as well as pore parameters in the jars, significantly affected the content of AL, Mg, K, Na, and Ca ions in Baijiu.

Electrospun ZIF-67/PVDF composite membranes for efficient ciprofloxacin removal from wastewater.

Cobalt 2-methylimidazole (ZIF-67) has been broadly explored for its applications in the treatment of antibiotics in wastewater. However, ZIF-67 in powder form is difficult to recover. In the study, ZIF-67 and Polyvinylidene Fluoride (PVDF) were blended electrospinning to prepare ZIF-67/PVDF membrane for adsorption of ciprofloxacin (CIP).

Polymer Brush-Grafted Metal-Organic Framework Nanoplates for Enhanced Catalysis of CO Cycloaddition with Epoxides.

The catalytic performance of 2D nanostructure-based heterogeneous catalysts is highly dependent on their dispersibility and stability. This work presents the grafting of polymer brushes onto 2D Cu-based metal-organic framework (MOF) nanoplates via a versatile UV-induced radical polymerization approach for CO fixation through the cycloaddition reaction with epoxides. The polymer brushes are selectively anchored to the external surfaces of the nanoplates, which greatly improves the long-term dispersibility and stability in solvents while preserving their intrinsic porosity and crystalline structures.

Rh(III)-Catalyzed Indole Dearomative 1,2-Alkoxyl Shift Rearrangement.

A Rh(III)-catalyzed dearomative C3 alkoxylation of indoles via cascade C(sp)-H activation and 1,2-alkoxyl shift rearrangement has been developed. This method provides an efficient strategy to rapidly assemble 3-alkoxyindolin-2-one scaffolds using alcohols as alkoxyl sources. Mechanistic studies indicate that indolyl C2 alkoxylation followed by Ag(I)/Cu(II)-mediated 1,2-alkoxyl migration is involved in this transformation.

Novel heterogeneous Fenton catalysts prepared using electrolytic manganese residue for efficient degradation of acetaminophen.

Electrolytic manganese residue (EMR) was used as a support to prepare novel EMR-supported catalysts for the heterogeneous Fenton degradation of acetaminophen. Among the five supported catalysts, Co/EMR showed the highest catalytic activity. Several important factors influencing the decay of acetaminophen, including Co loading content, catalyst dosage, HO concentration and initial solution pH, were investigated.

Reprogrammable soft actuators based on a photochromic organic-inorganic hybrid membrane with modulatable NIR photothermal conversion.

Shape-transformation soft actuators that can quickly respond to external stimuli have been potential candidates in biomimetic soft robots and flexible driving devices. However, the lack of shape reprogrammability restricts their complexity of deformation as well as reusability in practical application. Herein, we present a unique reprogrammable actuator based on asymmetric bilayer compounding with UV-modulated photochromic complex (NEU20) through a sequential polymerization process.

An EEG-based analysis of the effects of different music genres on driving stress.

Introduction: Sudden road conditions can trigger drivers' psychological stress, increasing the risk of traffic accidents. Music, as an emotion regulation tool, effectively alleviates stress and enhances psychological health. However, the effects of different genres of music on drivers' stress remain understudied.

Photoinduced Copper-Catalyzed Radical Mizoroki-Heck Reaction with Unactivated Alkyl Iodide.

Herein, we present a method for copper-catalyzed photoinduced radical Mizoroki-Heck (M-H) reactions utilizing unactivated alkyl iodides and styrene. This approach enables the smooth generation of ()-olefin products with a good functional group tolerance, demonstrating broad applicability. The mechanism involves the in situ formation of a copper complex that binds to the alkyl iodide, leading to radical fragmentation under visible-light irradiation.

From discoloration to color enhancement: A novel approach to high-concentration tannic acid detection based on VCo-N-C bimetallic Nanozyme.

The direct and rapid detection of high-concentration tannic acid (TA) was crucial for food quality monitoring. In this study, a TA detection system was developed based on a binary metal V and Co-enclosed carbon substrate (VCo-N-C) nanozyme with laccase-like activity, which innovatively shifted the conventional detection approach from the 3,3',5,5'-tetramethylbenzidine (TMB) discoloration principle to the 4-aminoantipyrine(4-AP) color enhancement principle. In the presence of VCo-N-C, 4-AP specifically bound to the oxidation products of TA, resulting in a brown-red compound.

EEG Microstate Dynamics during Different Physiological Developmental Stages and the Effects of Medication in Schizophrenia.

Background: Schizophrenia (SCZ) is associated with abnormal neural activities and brain connectivity. Electroencephalography (EEG) microstate is a voltage topographical representation of temporary brain network activations. Most research on EEG microstates in SCZ has focused on differences between patients and healthy controls (HC).

Electrochemical Synergistic Ni/Co-Catalyzed Carbonylative Cross-Electrophile Coupling of Aryl and Alkyl Halides with CO.

Accessing unsymmetric ketones and achieving their carbon isotope labeling are crucial yet challenging tasks in both synthetic and medicinal chemistry. We report here an efficient electrochemical nickel-/cobalt-catalyzed carbonylative cross-electrophile coupling reaction. This method allows for the modular synthesis of a library of unsymmetric ketones from simple building blocks, including aryl halides, alkyl halides, and gaseous CO.

Genomic analysis and metabolic pathway mining of Phallus cremeo-ochraceus.

Phallus cremeo-ochraceus is a nutritious edible mushroom. In this study, after tissue isolation, 33 strains were obtained, among which one strain PC7 with rapid mycelial growth and stable passage was obtained. Here, after quality control and assembly, a sequence of 410,647,36 bp was obtained, with 20,218 contigs.

Anisotropic Swelling Behavior of Liquid Crystal Elastomers in Isotropic Solvents.

The chemical response of liquid crystal elastomers (LCEs) offers substantial potential for applications in propulsion systems, micromechanical systems, and active smart surfaces. However, the shape-changing behaviors of LCEs in response to organic (isotropic) solvents remain scarcely explored, with most research focusing on liquid crystal (anisotropic) solvents. Herein, we prepared a series of aligned LCEs with varying crosslink densities using a surface alignment technique combined with an aza-Michael addition reaction, aiming to investigate their swelling behaviors in different isotropic solvents.

Oxygen Vacancy Engineering of BiTiO Piezocatalyst Driving In Situ HO Evolution for Self-Cycled Fenton-Like Degradation of Pollutants.

In this work, we synthesized a BiTiO piezocatalyst with surface oxygen vacancy (BTO-Ov) to facilitate in situ hydrogen peroxide (HO) production and to establish a piezocatalytic self-cycled Fenton-like system for degradation of pollutants. Notably, the HO evolution rate from the BTO-Ov catalyst reaches 558.8 μmol g h when utilizing pure water, significantly exceeding the rate obtained from pure BTO (274.

The underlying neurobiological basis of gray matter volume alterations in schizophrenia with auditory verbal hallucinations: A meta-analytic investigation.

Schizophrenia patients with auditory verbal hallucinations (AVH) frequently exhibit brain structural alterations, particularly reductions in gray matter volume (GMV).Understanding the neurobiological mechanisms underlying the changes is essential for advancing treatment strategies. To address this, a meta-analysis was conducted to identify GMV changes in schizophrenia patients with AVH and their associations with gene expression and neurotransmitter receptor profiles.

Effects of Dietary Pretreatment with All- Lycopene on Lipopolysaccharide-Induced Jejunal Inflammation: A Multi-Pathway Phenomenon.

This study was conducted to investigate the effects and mechanisms of all- lycopene on intestinal health by establishing lipopolysaccharide-induced (LPS-induced) jejunal inflammation model. Dietary lycopene supplementation enhanced serum and jejunum antioxidant capacity. Lycopene significantly reduced LPS-induced upregulation of toll-like receptor-4 (TLR-4) and nuclear factor kappa-B (NF-κB), suggesting that lycopene reduced the activation of TLR-4/NF-κB signaling pathway induced by LPS challenge, and further protected mice from LPS induced jejunal inflammation.

Facile Synthesis of MoP and Its Composite Structure with Ru as an Efficient Electrocatalyst for Hydrogen Evolution Reaction in Both Acidic and Alkaline Conditions.

Developing low-cost electrocatalysts for efficient hydrogen evolution in both acidic and alkaline conditions is crucial for water-electrolytic hydrogen applications. Herein, MoP was synthesized via a simple, low-cost, and green phosphorization route. More importantly, the Ru/MoP composite prepared using the as-synthesized MoP as a reactant, which exhibited excellent catalytic activity for the hydrogen evolution reaction.

Extension of mindful safety practices through safety knowledge and safety motivation: a study of the aviation industry.

This article attempts to extend the mindful safety practices adopted by pilots in the aviation industry. There is still a lack of discussion about how these factors (individual, group and organizational levels) influence the adoption of mindful safety practices among commercial pilots in the aviation industry. Data were collected from a sample of commercial pilots in China within 8 months.

New insights into the role of cellular states, cell-secreted metabolites, and essential nutrients in biofilm formation and menaquinone-7 biosynthesis in Bacillus subtilis natto.

Menaquinone-7 (MK-7), known for its health benefits, is in high demand across the health and medical fields. Two-stage fermentation strategy can efficiently enhance MK-7 production by Bacillus subtilis natto (B. subtilis natto).

Directed synthesis of N1/N3-histidine modified by 2-hydroxyethylthioethyl and identification in sulfur mustard-exposed plasma.

Sulfur mustard (HD) alkylates biomolecules such as proteins, generating specific biomarkers. This study employs steric hindrance, electronic effects, and solvent effects through an occupancy-removal strategy to synthesize regioisomers [N1-HETE]-His and [N3-HETE]-His, overcoming isomer separation challenges in conventional methods. Density functional theory (DFT) calculations revealed hexafluoroisopropanol (HFIP)'s critical role in directing HD's regioselective alkylation: HFIP modulates steric and electronic environments to preferentially target N1 or N3 sites of histidine imidazole rings, with predictions validated experimentally.

Synthesis of α-N-Heteroaryl Ketones by Nickel-Catalyzed Chemo-, Regio- and Enantioselective Carbonylation of Alkenes and N-Alkenyl Heteroarenes.

Enantioenriched α-aminoketones serve as important substructures in life science and precursors for the synthesis of diverse value-added targets in organic and biochemistry. However, direct access to enantioenriched α-aminoketones from simple and readily available starting materials remains a formidable challenge. Herein, we report an unprecedented nickel-catalyzed asymmetric cross-coupling protocol for the synthesis of enantioenriched α-N-heteroaryl ketones from alkenes and enamines in the presence of a carbon monoxide surrogate.

A public opinion propagation model for technological disasters.

Public opinion on technological disasters is influenced by unique factors and characteristics. Based on the infectious disease model, this paper develops a public opinion dissemination model for technological disasters, considering factors such as disaster severity, government response, accountability, and the impact of both positive and negative media content. Using differential equation stability theory, we analyze the existence and stability of both the free propagation equilibrium point and the propagation equilibrium point.