Transcoronary Sinus Therapy for Coronary Microvascular Dysfunction.

Coronary microvascular disease has been found to increase the incidence of the composite endpoint for cardiovascular events and affect coronary revascularization. Coronary microvascular disease is often accompanied by epicardial disease, and despite successful revascularization and optimal medications, coronary microvascular disease may lead to reduced exercise tolerance and worsening clinical symptoms. Moreover, despite advances in percutaneous coronary intervention for coronary revascularization, the management of microvascular obstruction in reperfused myocardial tissue remains challenging and is a high-risk procedure.

Development of an MRI-Based Comprehensive Model Fusing Clinical, Habitat Radiomics, and Deep Learning Models for Preoperative Identification of Tumor Deposits in Rectal Cancer.

Background: Tumor deposits (TDs) are an important prognostic factor in rectal cancer. However, integrated models combining clinical, habitat radiomics, and deep learning (DL) features for preoperative TDs detection remain unexplored.

Purpose: To investigate fusion models based on MRI for preoperative TDs identification and prognosis in rectal cancer.

WGCNA and LASSO regression-based selection and validation of microRNA biomarkers of β-thalassemia.

Objective: In patients with severe β-thalassemia, fetal hemoglobin (HbF) upregulation may provide an avenue to better therapeutic outcomes. The mechanisms that regulate the expression of HbF, however, are currently unclear. This study was developed with the goal of exploring biomarkers and molecular mechanisms associated with HbF expression to help inform the development of novel therapeutic strategies.

Regulation of Oomycete Autophagy, Lipid Droplet Accumulation and Pathogenesis by Three Rab GTPases.

Among eukaryotes, Rab GTPases are critical for intracellular membrane trafficking and possess various functions. Oomycetes, responsible for many devastating plant diseases, pose a significant threat to global agriculture. However, the functions of Rab GTPases in oomycetes are largely uncharted.

Tissue-specific distribution and trophic transfer of PCBs in marine organisms from the Beibu Gulf, South China Sea: Probabilistic health risk assessment via Monte Carlo simulation.

Despite global phase-out initiatives, legacy polychlorinated biphenyls (PCBs) remobilize in marine ecosystems as secondary emission sources, posing ecotoxicological and human health risks emerge through cross-trophic dietary exposure pathways. This study aimed to systematically examined the distribution, trophic transfer properties, and health risks of PCBs in six fish and eight invertebrate species from the Beibu Gulf in southern China, by stable isotope analysis, hierarchical cluster analysis, and Monte Carlo simulation. The ΣPCBs concentrations ranged from 0.

Efficacy and mechanism of high-purity HAMCC combined with CGF in promoting the repair of radiation-induced skin and soft tissue damage.

Radiotherapy, a prevalent and effective treatment for various malignancies, often causes collateral damage to normal skin and soft tissues in the irradiated area. To address this, we developed a novel approach combining SVFG-modified adipose-derived high-activity matrix cell clusters (HAMCC) with concentrated growth factors (CGF) to enhance regeneration and repair of radiation-induced skin and soft tissue injuries. Our study included cellular assays, wound healing evaluations, and histological analyses.

Cathayanon E induces apoptosis and enhances oxaliplatin sensitivity in colorectal cancer through suppression of MCL1.

Colorectal cancer (CRC) is one of the most common and lethal malignancies worldwide, with treatment failure often attributed to chemoresistance and evasion of apoptosis. Cathayanon E (CE), a natural chalcone derivative isolated from Morus alba, has shown anticancer potential, but its role and mechanism in CRC remain largely unexplored. In this study, CE significantly inhibited CRC cell proliferation and induced apoptosis both in vitro and in vivo.

The inhibitory effect of antiplatelet drugs on spontaneous platelet aggregation on glass surfaces: an analysis based on microscopic three-dimensional topography.

In vitro assessment of the inhibitory effect of antiplatelet drugs on platelet aggregation is frequently employed to guide personalized antiplatelet therapy in clinical practice. However, existing methods for detecting platelet aggregation rely heavily on high concentrations of exogenous agonists, which may obscure part of the inhibitory effect of antiplatelet drugs and lead to an underestimation of their effects. This study validates a novel analytical strategy for evaluating the effects of antiplatelet drugs by quantifying the microscopic three-dimensional morphological parameters of platelet aggregates formed through spontaneous aggregation on a glass surface.

Brønsted Base-Catalyzed Phosphorylation of Alkynes via Vinylidene -Quinone Methides.

Vinylphosphonates serve as crucial components in synthetic chemistry, medicinal chemistry, and materials science. However, traditional synthetic methods for these compounds typically require the use of noble metal catalysts and hazardous reagents. Herein, we report a metal-free strategy for the divergent synthesis of vinylphosphonates through the P nucleophilic addition of vinylidene -quinone methides (-VQMs).

Taxonomic revision of the critically endangered big-headed turtles (Reptilia: Testudines: Platysternidae Gray, 1869), with description of a new species.

The big-headed turtle ( ), currently the only extant member of the genus and the family Platysternidae, has undergone severe population declines driven by poaching, illegal trade, and habitat loss, leading to its classification as Critically Endangered (CR) by the International Union for Conservation of Nature (IUCN). Despite its conservation status, persistent taxonomic ambiguities and unresolved phylogenetic relationships have hindered effective protection and management. This study integrated evidence from genome-wide single nucleotide polymorphisms (SNPs), mitochondrial DNA sequences ( , ), and morphological data to reconstruct the phylogeny and phylogeography of and revise its taxonomy.

Bionic nanomedicines for microwave-triggered cuproptosis to enhance cancer immunotherapy.

Cuproptosis relies on intracellular copper accumulation and shows great potential in tumor therapy. However, the high content of glutathione (GSH) in tumor cells limits its effectiveness. Furthermore, the mechanism of immune activation mediated by cuproptosis remains unclear.

Potential Causal Relationships Between Circulating Micronutrient Levels and Multiple Neuroimmune Diseases: A Genetic Association Analysis.

Background: Growing evidence suggests a close association between circulating micronutrient levels and neuroimmune diseases. Nevertheless, the causal relationship between them remains unclear. Furthermore, due to confounding factors, many micronutrients implicated in these diseases remain unidentified.

Generic Intravenous Amisulpride (QLG2069) for the Prevention of Postoperative Nausea and Vomiting in Adults: A Phase III, Multicenter, Randomized, Placebo-Controlled Study.

Background: The dopamine D2/D3 antagonist amisulpride has demonstrated its superiority and efficacy in prophylaxis of postoperative nausea and vomiting (PONV). Given the branded intravenous amisulpride (Barhemsys) has not been approved in China, there is unmet clinical need for amisulpride. Our primary objective was to ascertain the efficacy and safety of the generic intravenous amisulpride (QLG2069) in the prophylaxis of PONV.

Vitamin A and vitamin B12 levels and coronary artery atherosclerosis: Univariate and multivariate Mendelian randomization analysis.

Coronary artery atherosclerosis (CAA) stands as a prominent etiological contributor to global cardiovascular morbidity and mortality. Its pathogenesis entails intricate interplays among genetic predisposition, environmental factors, and lifestyle determinants. Trace elements, though necessitated in minuscule quantities, have emerged as potential modulators of CAA progression, yet their exact impact remains unclear.

Observation on the efficacy of moxibustion with fuzi cake combined with auricular point pressing in treating anxiety and depression in newly diagnosed people living with HIV: A randomized controlled trial.

Background: This study investigated the efficacy of moxibustion with aconite cake combined with earlobe acupressure in alleviating anxiety and depression in newly diagnosed human immunodeficiency virus patients.

Methods: Ninety eligible patients from the Affiliated Ruikang Hospital of Guangxi University of Chinese Medicine were randomly divided into an intervention group and a control group of 45 each. The control group received conventional care, while the intervention group received the combined therapy.

Green Synthetic Amide-Modified Hyper-Cross-Linked Adsorption Resin for Efficiently Separating Chlorogenic Acid From Eucommia ulmoides Extracts.

Eucommia ulmoides Oliver leaf is rich in chlorogenic acid, which has antioxidant, antiviral, and anti-inflammatory activities. In this work, a new and green strategy for functional hyper-crosslinked adsorption resin based on Friedel-Crafts reaction of pendant vinyl groups in divinylbenzene with anhydrous ethanol and acrylamide grafting polymerization was developed, and the obtained HCREt-AM resin had excellent performance on chlorogenic acid separation from Eucommia ulmoides Oliver leaf extract. Adsorption isotherm and kinetics study showed the adsorption process fitted by Langmuir adsorption isotherm and pseudo-second-order kinetic equation.

Hollow polydopamine for the enhanced ultrasensitive dual-modal immunochromatographic detection of Salmonella typhimurium in dairy products via machine learning.

Salmonella typhimurium (S. typhimurium) A dual-mode colorimetric/photothermal immunochromatographic strip (ICS) employing hollow polydopamine nanoparticles (h-PDA) is reported for the ultrasensitive detection of Salmonella typhimurium (S. typhimurium).

[Treatment approaches for affected eyes in hospitalized patients with acute primary angle-closure glaucoma: a multicenter retrospective analysis].

To investigate the treatment approaches for attacking eyes in patients with clinical acute primary angle-closure glaucoma (APACG) and their alignment with the recommendations in the . A cross-sectional study was conducted, including medical records of consecutive inpatients diagnosed with APACG from 22 ophthalmic centers nationwide during three periods: September 7, 2020, to January 6, 2021; September 7, 2021, to January 6, 2022; and September 7, 2022, to January 6, 2023. For patients meeting the inclusion criteria in both eyes, the right eye was uniformly selected for analysis.

EcSnx27 facilitates in vitro release of Singapore grouper iridovirus and interacts with its major capsid protein.

Sorting nexin 27 (Snx27), a member of the sorting nexin (SNX) family, plays crucial roles in cell signaling, organelle motility, protein sorting and membrane remodeling/trafficking. While existing studies have focused on the functions of SNXs in mammalian viral diseases and immune regulation, little is known about fish-encoded SNXs, particularly their regulatory roles in aquatic virus infection. In this study, we characterized the Snx27 from the orange-spotted grouper (Epinephelus coioides) and found that it facilitates the in vitro release of Singapore grouper iridovirus (SGIV), as evidenced by the detection of viable virions in the culture supernatants of SGIV-infected grouper spleen (GS) cells.

Stabilization of delayed stochastic reaction-diffusion Cohen-Grossberg neural networks via variable gain intermittent boundary control.

This study presents a novel variable gain intermittent boundary control (VGIBC) approach for stabilizing delayed stochastic reaction-diffusion Cohen-Grossberg neural networks (SRDCGNN). In contrast to traditional constant gain intermittent boundary control (CGIBC) methods, the proposed VGIBC framework dynamically adjusts the control gain based on the operational duration within each control cycle, thereby improving adaptability to variations in work interval lengths. The time-varying control gain is designed using a piecewise interpolation method across work intervals, defined by a finite set of static gain matrices.

Pay-It-Forward 23-Valent Pneumococcal Polysaccharide Vaccination Among Older Adults: Protocol for a Randomized Controlled Trial.

Background: The 23-valent pneumococcal polysaccharide vaccine reduces the risk of pneumonia among adults by 38% to 46%. However, only a few older adults in resource-limited areas of China have received the pneumococcal vaccination. Pay-it-forward is a social innovation that offers participants free or subsidized health services and a community-engaged message, with an opportunity to donate to support subsequent recipients.

Analysis of flavor formation and metabolite changes during production of Double-Layer Steamed Milk Custard made from buffalo milk.

Double-Layer Steamed Milk Custard (DLSMC) is a famous traditional Chinese dessert. This study aimed to analyze the flavor and the changes in metabolites during different stages of DLSMC preparation, including raw buffalo milk, thermo-processing, first and second-layer milk skin formation. Electronic nose and electronic tongue were employed to preliminarily assess the overall flavor characteristics between these stages.

Electrochemical Biosensors Combined with Nanomaterial Signal Amplification for the Detection of Alzheimer's Disease Biomarkers in Blood.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder primarily characterized by cognitive decline and behavioral impairments, typically manifesting in the elderly and presenile population. With the rapid global aging trend, early diagnosis and treatment of AD have become increasingly urgent research priorities. The primary pathological features of AD include excessive accumulation of β-amyloid (Aβ) plaques, the formation of neurofibrillary tangles, and neuronal loss.

Genomic and stress resistance characterization of GX17, a potential probiotic for animal feed applications.

Unlabelled: Lactobacilli, recognized as beneficial bacteria within the human body, are celebrated for their multifaceted probiotic functions, including the regulation of intestinal flora, enhancement of body immunity, and promotion of nutrient absorption. This study comprehensively analyzed the genotypic and phenotypic characteristics of () strains isolated from the intestines of healthy chicks and assessed their potential as probiotics. The assembled genome consists of 29,521,986 bp, and a total of 1,771 coding sequences (CDSs) were predicted.