Vitamin A and vitamin B12 levels and coronary artery atherosclerosis: Univariate and multivariate Mendelian randomization analysis.

Coronary artery atherosclerosis (CAA) stands as a prominent etiological contributor to global cardiovascular morbidity and mortality. Its pathogenesis entails intricate interplays among genetic predisposition, environmental factors, and lifestyle determinants. Trace elements, though necessitated in minuscule quantities, have emerged as potential modulators of CAA progression, yet their exact impact remains unclear.

[ Granule improves motor deficits in mouse models of Parkinson's disease by regulating the necroptosis pathway].

Objectives: To investigate the effects of formulated granules of (TGY) on motor deficits in a mouse model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced subacute Parkinson's disease (PD) and explore the possible molecular mechanisms.

Methods: Ninety C57BL/6 mice were randomized equally into 6 groups, including a control group, a PD model group, a NEC-1 (6.5 mg/kg) treatment group, two TGY treatment groups at 5 and 2.

Consensus statement on the multidisciplinary treatment of nasopharyngeal carcinoma with immune checkpoint inhibitors in China.

Introduction: This study aims to establish a multidisciplinary consensus on the treatment of nasopharyngeal carcinoma (NPC) in China, with a particular focus on the guidelines for the use of immune checkpoint inhibitors (ICIs) to ensure scientific and rational treatment protocols.

Methods: The consensus was formulated based on the 'guidelines for the diagnosis and treatment of NPC (2024 edition)' issued by the Chinese Society of Clinical Oncology. The Delphi method was used to collect and consolidate expert opinions.

Application of nanobody‑based CAR‑T in tumor immunotherapy (Review).

Chimeric antigen receptor (CAR) T cell therapy is a type of cellular immunotherapy showing promising clinical effectiveness and high precision. CAR‑T cells express membrane receptors with high specificity, which enable them to identify certain target antigens generated by cancerous cells. The three primary structural elements of the CAR are the extracellular domain, transmembrane domain and cytoplasmic domain.

Efficient separation of impurities from pyrolusite and the enhancement of its products for improving the performance of lithium-ion batteries.

Manganese sulfate is a derivative of manganese resources with multiple applications. In addition to its traditional uses, it plays a critical role in various environmental and energy sectors. Manganese sulfate not only contributes to water treatment but also plays a significant role in the production of lithium-ion battery materials.

When digital-AI transformation sparks adaptation: job crafting and AI knowledge in job insecurity contexts.

Introduction: As AI technology continues to rise, numerous studies have explored its impact on employee behavior. However, little is known about employees' responses to the integration of AI in the digital transformation process. Drawing on Conservation of Resources Theory, this study aims to examine the impact of digital-AI transformation on employees' job crafting behaviors, focusing on the mediating role of job insecurity and the moderating effect of AI knowledge.

Ultrasound-Optimized Extraction and Multi-Target Mechanistic Analysis of Antioxidant and Hypoglycemic Effects of Essential Oil.

, a medicinal and edible plant, has shown promise in improving digestive health; however, the mechanisms underlying its antioxidant and hypoglycemic effects remain unclear. This study aimed to optimize the extraction of essential oil (AVEO) and elucidate its bioactive potential. Ultrasound-assisted extraction yielded 3.

Effects of Aging on Motor Unit Properties in Isometric Elbow Flexion.

This study investigates age-related differences in motor unit (MU) properties and neuromuscular control during isometric elbow flexion across the human lifespan. High-density surface electromyography (sEMG) was recorded from the biceps brachii of 44 participants, divided into three groups: Child (8-14 years), Adult (20-40 years), and Elder (65-80 years). MU spike trains were extracted noninvasively by sEMG decomposition.

Synthesis of Indole-Fused Bicyclo[3.1.1]heptanes through (3+3) Cycloaddition of 2-Indolylmethanols with Bicyclo[1.1.0]butanes.

A variety of indole-fused bicyclo[3.1.1]heptanes were prepared in good yields with high regioselectivity through organocatalyzed umpolung (3+3) cycloaddition of 2-indolylmethanols and bicyclo[1.

Combined transcriptome and metabolome analysis of tilapia response to hypoxia and Streptococcus agalactiae co-exposure.

Deterioration of water quality, especially low dissolved oxygen, has contributed to outbreaks of streptococcal disease in tilapia. It has been reported that hypoxia increases the mortality of tilapia during Streptococcus agalactiae infection. However, the underlying mechanism of the increased susceptibility of tilapia to S.

Joint Extraction of Cyber Threat Intelligence Entity Relationships Based on a Parallel Ensemble Prediction Model.

The construction of knowledge graphs in cyber threat intelligence (CTI) critically relies on automated entity-relation extraction. However, sequence tagging-based methods for joint entity-relation extraction are affected by the order-dependency problem. As a result, overlapping relations are handled ineffectively.

Bioinformatics mining and experimental validation of prognostic biomarkers in colorectal cancer.

Colorectal cancer (CRC) is a prevalent condition with increasing incidence and mortality rates. The identification of robust prognostic gene signatures remains an unmet clinical need in CRC treatment. In this study, data from the GEO and TCGA databases were utilized to identify 2,779 upregulated and 2,629 downregulated genes in CRC tissues compared to adjacent normal tissues.

Integrated multi-omics analysis reveals diagnostic biomarkers and therapeutic targets for systemic lupus erythematosus.

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder with poorly understood molecular mechanisms. This study investigated causal relationships between plasma proteins and SLE using two-sample Mendelian randomization analysis based on genome-wide association study data. Functional enrichment analyses Gene Ontology and Kyoto Encyclopedia of Genes and Genomes and protein-protein interaction network analysis identified apolipoprotein A2, MANSC domain-containing protein 1, and proteasome subunit beta 5 as key genes involved in glycoprotein metabolism and immune responses.

A novel network for resolving subjective masking differences and accurate thyroid nodule diagnosis.

Background: Over the past three decades, there has been a significant increase in the incidence of thyroid cancer. Ultrasound serves as a non-invasive tool in differentiating between benign and malignant thyroid nodules. However, its reliance on manual input can often lead to subjective bias.

A Streamlined One-Step Bioprocess for Isomaltulose Production in Bacillus subtilis Through Multicopy Genomic Integration of Sucrose Isomerase Gene.

Isomaltulose, a sucrose isomer with a low glycemic index and non-cariogenic properties, is extensively used in the food industry. The industrial production of this functional sugar relies on enzymatic biotransformation using sucrose isomerase (SIase). However, conventional bioprocesses involve expressing and isolating the SIase enzyme, followed by using the purified SIase to convert sucrose into isomaltulose, resulting in a multi-step and high-cost process that hindered the broader applications of isomaltulose.

A Clustered Adaptive Exposure Time Selection Methodology for HDR Structured Light 3D Reconstruction.

Fringe projection profilometry (FPP) has been widely applied in industrial 3D measurement due to its high precision and non-contact advantages. However, FPP often encounters measurement problems with high-dynamic-range objects, consequently impacting phase computation. In this paper, an adaptive exposure time selection method is proposed to calculate the optimal number of exposures and exposure time by using an improved clustering method to divide the region with different reflection degrees.

Physico-chemical properties, adsorption capacity and anti-oxidization of lignin and cellulose separated from mung bean skin by deep eutectic solvent treatment.

Background: The health function of mung bean skin is closely related to its physico-chemical and physiological properties. However, current research ignores the interaction of the physico-chemical and physiological properties of mung bean skin lignin, mung bean skin cellulose and homologous mung bean skin.

Results: The extraction of lignin and cellulose from mung bean skin was conducted using a deep eutectic solvent based on choline chloride-lactic acid.

Mendelian randomization investigation: Exploring the relationship between phosphatidylinositol levels and hypertrophic cardiomyopathy risk through interleukin-20 receptor subunit alpha expression.

This Mendelian randomization study investigated the causal relationship between phosphatidylinositol (PI) levels and hypertrophic cardiomyopathy (HCM) risk, while evaluating the potential mediating role of interleukin-20 receptor subunit alpha (IL-20RA). Leveraging genome-wide association study data from Finnish and European populations, our 2-sample Mendelian randomization analysis revealed a significant inverse association between PI levels and HCM risk (odds ratio [OR] = 0.686, 95% confidence interval [CI]: 0.

A holistic genome dataset of bacteria and archaea of mangrove sediments.

Background: Mangroves are one of the most productive marine ecosystems with high ecosystem service value. The sediment microbial communities contribute to pivotal ecological functions in mangrove ecosystems. However, the study of mangrove sediment microbiomes is limited.

Comparative long-term outcomes of first-line CDK4/6 inhibitors plus endocrine therapy versus endocrine therapy in patients with HR+/HER2-metastatic or advanced breast cancer: a meta-analysis.

Introduction: This meta-analysis was designed to compare the long-term outcomes of first-line cyclin-dependent kinase 4/6 (CDK4/6) inhibitors plus endocrine therapy (ET) versus ET in patients with HR+/HER2-metastatic or advanced breast cancer (BC).

Materials And Methods: Four databases (Medline, Embase, Web of Science, and CENTRAL) were searched for literature comparing First-line CDK4/6 inhibitors plus ET to ET in patients with HR+/HER2-metastatic or advanced breast cancer. The search was conducted from the database's establishment to April 3, 2025.

Honeycomb-inspired chitosan-based beads with pore structure and multifunctional groups: Improvement of fluoride ion adsorption efficiency and DFT calculations.

Selective removal of F from industrial wastewater containing multiple anions is a major challenge. Here, we propose a biomimetic chitosan/FeOOH/AlOOH bead (CFeAlB) with a unique honeycomb porous structure and amino and hydroxyl multifunctional groups and AlOOH/FeOOH bimetallic active components for enhanced selective adsorption capacity and enrichment of F. The adsorption of F by CFeAlB (29.

Mechanistic insights and clinical evidence of Helianthus annuus Linn. (Sunflower) seed oil for dermatological applications: A narrative review.

Plant oils play an important role in natural product-based dermatological formulations owing to their multifunctional therapeutic properties. Among these, sunflower seed oil (SSO) has gained prominence due to its dual role as a barrier-restoring emollient and skin penetration enhancer. Rich in unsaturated fatty acids, particularly linoleic acid (LA) and oleic acid (OA), SSO supports skin health by restoring lipid bilayer organization, modulating ceramide synthesis, and activating peroxisome proliferator-activated receptor-alpha (PPAR-α).

Efficacy and safety of lenvatinib plus transarterial chemoembolization with or without programmed death-1 inhibitors in the treatment of intermediate or advanced hepatocellular carcinoma: a systematic review and meta-analysis.

Introduction: This meta-analysis aimed to evaluate the efficacy and safety of Lenvatinib plus transarterial chemoembolization with or without programmed death-1 inhibitors (PD-1 inhibitors) in the treatment of intermediate or advanced hepatocellular carcinoma (HCC).

Materials And Methods: Four databases (Pubmed, Embase, Web of Science, and Cochrane Library) were searched for studies comparing lenvatinib plus transarterial chemoembolization with PD-1 inhibitors (TACE-L-P) versus Lenvatinib plus transarterial chemoembolization (TACE-L) for intermediate or advanced HCC. Meta-analyses were conducted for progression-free survival (PFS), overall survival (OS), objective response rate (ORR), disease control rate (DCR), and Grade ≥ 3 treatment-related adverse events (Grade ≥ 3 AEs).

Dravet syndrome: novel insights into -mediated epileptic neurodevelopmental disorders within the molecular diagnostic-therapeutic framework.

Dravet Syndrome (DS), a rare genetic encephalopathy characterized by severe drug-resistant epilepsy and progressive neurodevelopmental regression in infancy, is caused by mutations in the gene on chromosome 2q24 in over 80% of cases. This review synthesizes current insights into its molecular pathogenesis, precision diagnostics, and therapeutic innovations: mutations disrupt Nav1.1 sodium channel expression and membrane trafficking in GABAergic interneurons through transcriptional dysregulation, pre-mRNA splicing defects, and gating dysfunction, thereby impairing inhibitory synaptic transmission and disrupting brainwide excitatory-inhibitory balance.

Effects of Immunostimulants on Physiological Performances, Immune Gene Expression, Liver, and Intestinal Protection Against Infection in Juvenile Asian Seabass ().

The present study aims to develop a more valuable innovative aquaculture feed for the sustainable aquaculture industry. An experiment with a completely random design was developed with five groups containing 0% immunostimulant and 0.5% ginger, 1.