Preparation and Properties of Magnetically Responsive Graphene/Boron Nitride/Iron Oxide Filler Composite Epoxy Resin Materials.

In this paper, magnetically responsive graphene/boron nitride/iron oxide fillers were prepared by growing iron oxide on the surface of graphene/boron nitride fillers via liquid-phase reaction. By adding the composite filler into the epoxy resin and utilising magnetic field-assisted curing, the composites were prepared to effectively improve the thermal conductivity of the composites while maintaining the insulating properties. The thermal conductivity of the composite filler is 2.

Copper-Catalyzed Chan-Lam Reaction and Sequential Oxidative Fischer Indole Synthesis to Prepare Indole Derivatives.

A variety of α-quinazolin-4-yloxy ketones were prepared in moderate to excellent yields through a copper-catalyzed Chan-Lam reaction/[3,3]-rearrangement of -hydroxyquinazolinones and alkenyl boronic acids. More importantly, α-quinazolin-4-yloxy ketones could serve as indole precursors through the Fischer indole synthesis procedure by reacting with arylhydrazines in air, which involved nucleophilic substitution, oxidation, and [3,3]-rearrangement in a one-pot. The present cascade reaction highlights a broad substrate scope, good functional group compatibility, and high rearrangement selectivity, and the obtained α-quinazolin-4-yloxy ketones served as high site-marked indole precursors.

Efficacy and safety of sinus balloon catheter dilation versus functional endoscopic sinus surgery in the treatment of chronic sinusitis: A meta-analysis.

Background: This meta-analysis aimed to evaluate the efficacy and safety of sinus balloon catheter dilation (SBCD) versus functional endoscopic sinus surgery (FESS) in the treatment of chronic sinusitis (CRS).

Methods: Four databases (PubMed, Embase, Web of Science, and Cochrane Library) were searched from the establishment of the databases to October 7, 2024, for randomized controlled trials comparing SBCD versus FESS in the treatment of CRS. Meta-analyses of Lund-Mackay score, sinonasal outcome test-20 score, complications, operating time and revision surgery were performed.

SERS hydrogel designed using a microfluidic droplet platform for label-free therapeutic drug monitoring of doxorubicin in human serum.

Background: Doxorubicin (DOX) is an anthracycline anticancer drug that is commonly employed in the treatment of acute leukemia, malignant lymphoma, breast cancer and prostate cancer. Given the narrow safe dosage range and the strong toxic reaction associated with the drug, prolonged or excessive use can result in serious adverse reactions, which greatly limits its clinical application. It is therefore necessary to develop a rapid, sensitive and reproducible therapeutic drug monitoring (TDM) method for DOX in order to create an individualised dosing regimen based on the patient's specific situation, thus facilitating the precise treatment of the disease.

Exploring the impact of platform leadership on employee innovative behavior: a sequential explanatory mixed method.

This study uses the Ability-Motivation-Opportunity framework to explore the influence mechanism of platform leadership on employees' innovation behavior. This study examines organizational learning, knowledge sharing, coworker support, and psychological empowerment as mediating variables, employee innovation behavior as the dependent variable. This study constructs a multi-mediated model to analyze the impact of platform leadership on employee innovative behavior, which includes 13 hypotheses.

Variation of healthcare associated infections at a tertiary hospital in Southwest China over a 5-year period (2019-2023): a retrospective observational study.

Background: Healthcare-associated infections (HAIs), which are associated with prolonged hospitalization and increased mortality, remain a global challenge. The COVID-19 pandemic paradoxically reduced some HAIs through enhanced hygiene measures but exacerbated others due to resource diversion, with effects after policy changes remaining unclear. Therefore, this study analyzed HAIs distribution, pathogenic microorganisms distribution, and antibiotic susceptibility capturing the period surrounding strict COVID-19 control measures in a southwest China tertiary hospital.

Efficacy and safety of neoadjuvant PD-1 inhibitors or PD-L1 inhibitors combined with chemoradiotherapy for locally advanced rectal cancer: a systematic review and meta-analysis.

Background: The objective of this meta-analysis was to assess the effectiveness and safety of neoadjuvant PD-1/L1 inhibitors plus chemoradiotherapy(CRT) for locally advanced rectal cancer (LARC).

Materials And Methods: Databases including PubMed, Embase, Cochrane Library and Web of Science were examined for pertinent studies. Meta-analyses were conducted on pathological complete response (pCR), clinical complete response (cCR), major pathologic response (MPR), sphincter-sparing surgery (SSS), R0 resection, surgery rate, Grade≥3 adverse events (AEs), and 3-year disease-free survival (DFS).

Epigenetic age acceleration mediates the association between low-grade systemic inflammation and cardiovascular diseases: insight from the NHANES 1999-2002.

Background: Currently, with the global aging of the population, inflammation, recognized as a hallmark in age-related diseases, has been studied and linked to cardiovascular diseases (CVD). However, limited evidence on whether inflammation modifies epigenetic aging and affects CVD risk.

Methods: This study included 404 CVD patients and 1941 non-CVD individuals from the 1999-2002 National Health and Nutrition Examination Survey cross-sectional data.

Identification of key genes and diagnostic biomarkers for peripheral atherosclerosis: A multi-omics approach.

Peripheral atherosclerosis (PAS), characterized by lipid plaque accumulation in arterial walls, significantly increases cardiovascular risk. This study aimed to identify molecular biomarkers and elucidate underlying mechanisms of PAS progression. We analyzed 2 gene expression omnibus datasets (GSE28829, GSE100927) to identify differentially expressed genes (P < .

-C-H Amidation of Phenols through Intramolecular Rearrangement of -Phenoxyarylamides.

This study presents an efficient and concise methodology devised for effectuating the -C-H amidation of phenols through the rearrangement of -phenoxybenzamide derivatives. A variety of substrates, equipped with different electron-withdrawing and electron-donating functional groups, react smoothly under mild basic conditions or even without a base, eliminating the need for excessive use of strong acids, Lewis acids, or costly transition-metal catalysts (e.g.

Anomalous thermodiffusion, absolute negative mobility, and reverse heat transport in a single quantum dot.

We investigate the steady-state transport characteristics of a quantum dot system consisting of a single energy level embedded between two reservoirs under the influence of both the temperature gradient and bias voltage. Within tailored parameter regimes, the system can exhibit three counterintuitive transport phenomena of anomalous thermodiffusion, absolute negative mobility, and reverse heat transport respectively. These counterintuitive phenomena do not violate the second law of thermodynamics.

Deep Learning-Based Multimodal Feature Interaction-Guided Fusion: Enhancing the Evaluation of EGFR in Advanced Lung Adenocarcinoma.

Rationale And Objectives: The aim of this study is to develop a deep learning-based multimodal feature interaction-guided fusion (DL-MFIF) framework that integrates macroscopic information from computed tomography (CT) images with microscopic information from whole-slide images (WSIs) to predict the epidermal growth factor receptor (EGFR) mutations of primary lung adenocarcinoma in patients with advanced-stage disease.

Materials And Methods: Data from 396 patients with lung adenocarcinoma across two medical institutions were analyzed. The data from 243 cases were divided into a training set (n=145) and an internal validation set (n=98) in a 6:4 ratio, and data from an additional 153 cases from another medical institution were included as an external validation set.

Inverse reinforcement learning for discrete-time linear systems based on inverse optimal control.

This paper mainly deals with inverse reinforcement learning (IRL) for discrete-time linear time-invariant systems. Based on input and state measurement data from expert agent, several algorithms are proposed to reconstruct cost function in optimal control problem. The algorithms mainly consist of three steps, namely updating control gain via algebraic Riccati equation (ARE), gradient descent to correct cost matrix, and updating weight matrix based on inverse optimal control (IOC).

Inner-Sphere Electron Transfer Enabling Highly Reversible Mn/MnO Conversion toward Energy-Dense Electrolytic Zinc-Manganese Batteries.

High-voltage electrolytic Zn//MnO batteries show great potential for large-scale energy storage due to their affordability, eco-friendliness and high safety. However, their practical application is hindered by capacity losses due to incomplete MnO dissolution. Herein, we propose the strategy by coupling a 1,4-benzoquinone (1,4-BQ)/hydroquinone (HQ) redox mediator pair with modulation of MnO electronic structure through electrolyte engineering to facilitate rapid and complete MnO dissolution.

The Application of Microfluidic Chips in Primary Urological Cancer: Recent Advances and Future Perspectives.

The research of primary urological cancers, including bladder cancer (BCa), prostate cancer (PCa), and renal cancer (RCa), has developed rapidly. Microfluidic technology provides a good variety of benefits compared to the heterogeneity of animal models and potential ethical issues of human study. Microfluidic technology and its application with cell culture (e.

Crosstalk between kidney and bones: New perspective for modulating osteoporosis.

Growing evidence indicates an interesting interplay between kidney and bone. The pathophysiological condition of the skeletal system is intricately associated with the normal functioning of the kidneys. This relationship is modulated by various factors, including calcium and phosphate, 1-α-hydroxylase, erythropoietin (EPO), klotho, fibroblast growth factor 23 (FGF23), bone morphogenetic protein-7 (BMP-7), and extracellular vesicles (EVs).

Isoliquiritigenin Alleviates Periodontitis by Suppressing Inflammation via NF-κB Signaling Pathway of Immune Cell.

Background: Periodontitis, a chronic infectious disease, presents significant treatment challenges due to antibiotic resistance and high recurrence rates, necessitating novel therapeutics.

Methods: Network pharmacology identified ISL's potential targets in periodontitis, focusing on NF-κB signaling pathway. Toxicity was assessed via MTT assay and long-term toxicity studies in vivo.

Efficacy and safety of PD-1/PD-L1 inhibitor monotherapy or combination therapy versus platinum-based chemotherapy as a first-line treatment of advanced urothelial cancer: A systematic review and meta-analysis.

Background: Recent clinical trials have shown that inhibitors targeting programmed cell death protein 1 (PD-1) or its ligand (programmed cell death-ligand 1 [PD-L1]) provide significant efficacy and clinical benefit in the treatment of advanced or metastatic urothelial carcinoma (UC). This systematic review and meta-analysis aimed to compare the effectiveness and safety of PD-1/PD-L1 inhibitors in combination with chemotherapy or PD-1/PD-L1 inhibitor monotherapy versus platinum-based chemotherapy as a first-line treatment for advanced UC.

Materials And Methods: From the beginning of the database construction to February 4, 2024, a combination of medical subject headings and free-text words was searched using the Population Intervention Comparison Outcome Study design framework.

Machine learning for grading prediction and survival analysis in high grade glioma.

We developed and validated a magnetic resonance imaging (MRI)-based radiomics model for the classification of high-grade glioma (HGG) and determined the optimal machine learning (ML) approach. This retrospective analysis included 184 patients (59 grade III lesions and 125 grade IV lesions). Radiomics features were extracted from MRI with T1-weighted imaging (T1WI).

Size-matching effects in quantitative detection of PS nanoplastics using controllable and reusable Ag nanoarrays SERS substrates.

This study proposes a strategy for the highly sensitive detection of polystyrene nanoplastics (PS NPs) with varying particle sizes. Ag nanoarrays (AgNAs) with different inter-column spacings and heights are fabricated via thermal deposition of Ag in anodized aluminum oxide (AAO) templates. The size-matching effects between PS NPs and the parameters of the AgNAs (inter-column spacing and height) are investigated.

Status and influencing factors of balance in middle-aged and older adults with Parkinson's disease: a national longitudinal study.

Background: To examine the current status and influencing factors of balance in middle-aged and older adults with Parkinson's disease (PD) and explore the correlations of these factors with balance.

Methods: The China Health and Retirement Longitudinal Study (CHARLS) Database in 2015, 2018 and 2020 were utilized as the data source, from which the missing value samples were excluded and 1,390 participants aged ≥45 years were recruited. Using the chi-square test, balance comparisons were made among middle-aged and older adults PD patients under different indicators.

Effects of Spartina alterniflora invasion on carbon fixation and sulfate reduction in a subtropical marine mangrove ecosystem.

Mangrove sediments host diverse microbial communities that are crucial for carbon fixation, but their functions and pathways in subtropical ecosystems-particularly under Spartina alterniflora invasion and across varying sediment depths-remain unclear. This study employed metagenomic and qPCR analyses to explore microbial carbon fixation in Rhizophora stylosa, S. alterniflora, and bare beach habitats.

The novel biochar-based organic semiconductor toward broadband and direct radicals transfer enhanced photocatalytic degradations.

Organic semiconductor materials manifest themselves as fascinating light absorbers and high-speed carrier transport for applications in photocatalytic degradation and solar energy harvesting. The essential challenges lie in harvesting the complex synthesis processes and poor recyclability. To this end, a synergistic deposition strategy utilizing organic semiconductor materials extracted from discarded solar cells and natural adsorbent biochar has been proposed to mitigate these two challenges.

Regulation of elevated expression of Mcl-1 in hepatocellular carcinoma - a review.

Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors worldwide. Mcl-1 (myeloid cell leukemia-1) is highly expressed in HCC cells and plays a critical role in chemotherapy resistance and is a major contributor to chemotherapy failure in HCC. The purpose of this study is to review the recent research progress that explores the key factors in regulating Mcl-1 overexpression in HCC cells, contributing to chemotherapy resistance.

Research on an Online Intelligent Monitoring System for Resistance Spot Welding Based on Wireless Communication.

Resistance spot welding (RSW) faces critical monitoring challenges in industrial applications due to nonlinear coupling characteristics and production line disturbances. This study developed a Zigbee-enabled real-time monitoring system to address the precision limitations of conventional methods in tracking RSW parameters. Using DP780/DP590 dual-phase steel specimens with thickness variations, we implemented a dedicated data acquisition system capturing welding current, voltage, and barometric pressure dynamics.