Early preschool wheeze trajectories are predominantly non-allergic with distinct biologic and microbiome traits.

Background: Disentangling preschool wheezing heterogeneity in terms of clinical traits, temporal patterns, and collective healthcare burden is critical for precise and effective interventions.

Objective: We aimed to collectively define contributions and distinct characteristics of respiratory phenotypes based on longitudinal wheeze and atopic sensitization patterns in the first 5 years of life.

Methods: Group-based trajectory analysis was performed in the CHILD Cohort study to identify distinct wheeze and allergic sensitization trajectories.

Regulatory Prospects for Stem Cell in Clinical Trials: UAE, US, and India.

Introduction: Stem cell therapies are advancing rapidly, requiring robust regulations to ensure safety and ethics. The UAE, with authorities like MOHAP, DOH, DHA, and DHCR, is actively involved in clinical research but faces regulatory inconsistencies across emirates. In contrast, the U.

Efficient activation of percarbonate by metal-free carbonylated activated carbon for green groundwater remediation: Performance, mechanism, applicability, and environmental implications.

Sodium percarbonate (SPC)-based advanced oxidation processes (AOPs) hold great promise for in-situ groundwater remediation. However, most existing studies have focused on the metal-carbon composite activation systems, facing the risk of secondary pollution from metal ion leaching. Herein, this study innovatively prepared metal-free carbonylated activated carbon (CAC) by regulating the conversion of oxygen-containing functional groups on carbon materials to activate SPC efficiently.

Science diplomacy and the 5th International Polar Year (IPY-5): planetary considerations across centuries.

The 5th International Polar Year (IPY-5) in 2032-2033 represents an important next step in the legacy of the oldest continuous climate research program created by humanity, which intentionally began during a Solar Maximum with IPY-1 in 1882-1883, following the Little Ice Age. Current IPY-5 planning by the International Arctic Science Committee (IASC) and Scientific Committee on Antarctic Research (SCAR) is "From IPY-4 to IPY-5" with scope since 2007-2008, considering relevant large-scale polar process, international activities and UN decades. Additionally, there are essential features to incorporate into IPY-5 planning with Indigenous knowledge as well as next-generation leadership along with international science connections across the United Nations, involving core integration of data system and Earth-Sun system research, which accelerated with the International Geophysical Year (IGY) in 1957-1958 that was renamed from IPY-3.

Efficient dye removal from aqueous solution using a hybrid GA@ZnO-AC nanocomposite.

Environmental damage caused by colored effluents poses a threat to the environment, as vast amounts of harmful water contamination are regularly discharged into water sources. The hybrid nanocomposite was successfully synthesized using hydrothermal and thermal treatment methods. A prepared hybrid nanostructure metal composite material, utilizing gallic acid (GA@ZnO-AC), was synthesized and employed for the treatment of methylene blue (MB) in an aqueous environment via adsorption.

Multifactorial influences on musical creativity: an integrated perspective on cognitive and social capital factors.

Introduction: Musical creativity is a crucial aspect of music education and innovation. This study has aimed to systematically examine its key determinants, with particular attention to cognitive and social capital mechanisms.

Methods: Grounded in the componential theory of creativity, social capital theory, social cognitive theory, this study has developed a conceptual framework incorporating five explanatory variables.

H Nuclear Magnetic Resonance (NMR) Metabolomics in Rodent Plasma: A Reproducible Framework for Preclinical Biomarker Discovery.

This protocol paper outlines a robust and reproducible framework for a H nuclear magnetic resonance (NMR) metabolomics analysis of rodent plasma, designed to facilitate preclinical biomarker discovery. The protocol details optimised steps for plasma collection in a preclinical rodent model, sample preparation, and NMR data acquisition using presaturation Carr-Purcell-Meiboom-Gill (PRESAT-CPMG) pulse sequences, ensuring high-quality spectral data and effective suppression of macromolecule signals. Comprehensive spectral processing and metabolite assignment are described, with guidance on multivariate and univariate statistical analyses to identify metabolic changes and potential biomarkers.

Driving sustainability in universities through carbon footprint analysis.

This research addresses the critical need to reduce carbon footprints in higher education institutions (HEIs). While many HEIs have adopted sustainability practices and embedded sustainability-related content into their curricula, assessing and mitigating their carbon emissions is equally essential. This study evaluates the sustainability of UCSI University Kuala Lumpur by measuring its total carbon footprint using the GHG Protocol as the framework.

Nanobodies targeting cytokines for the amelioration of autoimmune diseases.

Autoimmune diseases are driven by dysregulated cytokine networks, where excessive cytokines such as TNF-α, IL-6, IL-17, and IL-23 promote chronic inflammation and tissue damage. While monoclonal antibodies effectively neutralise these cytokines, they face limitations including high production costs, glycosylation requirements, limited tissue penetration, and immunogenicity. Nanobodies; small, single-domain antibodies derived from camelids, offer a promising alternative due to their high stability, solubility, microbial expression, and low immunogenicity.

Risk for Sleep-Disordered Breathing Among Children and Adolescents With Perinatal Stroke and the Impact on Mental Health, Quality of Life, and Caregivers.

Background: Perinatal stroke is a leading cause of cerebral palsy and lifelong neurological disability and a potential risk factor for sleep-disordered breathing (SDB).

Methods: We examined the risk for SDB and associated psychosocial outcomes among 77 children with perinatal stroke. Caregivers completed validated questionnaires evaluating their children's sleep (Pediatric Sleep Questionnaire), mental health (Behavior Assessment System for Children, Third Edition [BASC-3]), and quality of life (Pediatric Quality of Life Inventory [PedsQL]) as well as the psychosocial impact on themselves (Parental Outcome Measure [POM]).

How big data analytics improves hospital environmental performance through supply chain innovation, decision quality, and risk taking.

Despite big data analytics (BDA) capabilities have been increasingly recognized for their potential to improve sustainability, the underlying mechanisms by which BDA capabilities influence hospital environmental performance in the context of healthcare supply chains are not well understood. This paper aims to bridge this significant empirical void by examining the mediating effect of supply chain innovation, decision-making quality and risk-taking on the links between BDA capabilities and environmental performance for Chinese hospitals. Based on Stimulus-Organism-Response theory, the theoretical model depicts BDA capability as a key stimulus factor affecting the hospital sustainability outcomes.

Bioinformatics mining and experimental validation of prognostic biomarkers in colorectal cancer.

Colorectal cancer (CRC) is a prevalent condition with increasing incidence and mortality rates. The identification of robust prognostic gene signatures remains an unmet clinical need in CRC treatment. In this study, data from the GEO and TCGA databases were utilized to identify 2,779 upregulated and 2,629 downregulated genes in CRC tissues compared to adjacent normal tissues.

Scrutinizing the impact of two self-regulation policies on unhealthy food marketing in children's popular television in Malaysia: a multiple-year repeated evaluation using a harmonized protocol.

Background: Regulating unhealthy food marketing is critical as it is a recognized driver of childhood obesity. Two voluntary self-regulatory policies governing food advertising in the media were introduced in Malaysia in 2008 and 2013.

Objectives: To assess food advertising on Malaysian children's popular television channels across a decade using the standardized INFORMAS protocol.

From leadership to action: How green inclusive leadership drives pro-environmental behaviour.

BackgroundOrganizations face increasing pressure to respond to environmental concerns, yet fostering pro-environmental behaviour among employees remains a persistent challenge. Leadership, particularly green inclusive leadership, is considered vital in promoting such behaviours, but the underlying mechanisms remain insufficiently explored.ObjectiveThis study investigates how green inclusive leadership influences employees' pro-environmental behaviour by examining the mediating roles of environmental passion and green self-efficacy.

Improved cognition and memory via PLGA nanoparticle-mediated delivery of curcumin and piperine in an in vivo Alzheimer's disease model.

Alzheimer's disease (AD) is a multifactorial neurodegenerative disease that causes dementia, impaired cognitive function, and disorientation. Studies have revealed that curcumin and piperine were found to be neuroprotective for patients with dementia. Nevertheless, both compounds are known for their poor solubility.

Association between chrononutrition, sleep behaviours, and glycaemic outcomes in individuals with prediabetes: Findings from the Chrono-DM study.

Little is known about the associations between chrononutrition and sleep behaviours with glycaemic responses. Hence, this study aimed to examine the associations between chrononutrition, sleep behaviours and glycaemic outcomes among adults with prediabetes. This was a cross-sectional study within a prospective longitudinal study in Malaysia.

Graph neural network-based drug-drug interaction prediction.

With the growing variety of pharmacological compounds and the increasing need for polypharmacy, accurately predicting drug-drug interactions (DDIs) is essential to ensure both treatment efficacy and patient safety. Beneficial DDIs can enhance therapeutic outcomes. In contrast, adverse interactions may result in toxicity, reduced efficacy, or even fatality.

Predicting EGFR mutation status in non-small cell lung cancer patients with brain metastases based on MRI radiomics: A systematic review and meta-analysis.

Introduction: This study evaluates the quality and diagnostic accuracy of Magnetic Resonance Imaging (MRI) radiomics-based prediction of epidermal growth factor receptor (EGFR) mutation status in non-small cell lung cancer (NSCLC) patients with brain metastasis.

Methods: Six databases (PubMed, Embase, Web of Science, Cochrane Library, Scopus, and IEEE Xplore) were systematically searched up to June 2025. Quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool and Radiomics Quality Score (RQS).

Binding interactions between ar-turmerone and human serum albumin: mechanistic and biophysical insights.

Ar-turmerone, a major bioactive compound in , has been reported to exhibit anti-inflammatory, antiproliferative, antifungal, antioxidant, and anticancer properties. This study investigated its interaction with human serum albumin (HSA) using spectroscopic, microscopic, and computational approaches to characterize its binding properties, which are crucial for its distribution and transport in the bloodstream. Fluorescence spectroscopy showed a 34% decrease in HSA fluorescence intensity at 90 μM ar-turmerone, accompanied by a 2 nm blue shift, suggesting a transition of the protein's fluorophores' microenvironment to a slightly nonpolar state.

Medical cannabis: Regulatory review in United States, European Union and United Kingdom.

Cannabis contains compounds like delta-9-tetrahydrocannabinol and cannabidiol, which are commonly used for epilepsy, anxiety and chronic pain. Medical marijuana involves the utilization of cannabis for therapeutic objectives, such as the management of various ailments. Given the vast array of potential pharmacological and medicinal applications of cannabis and its by-products, there has been a surge of interest in developing cannabis-related products.

Advancements in antibody-drug conjugates as cancer therapeutics.

Antibody-drug conjugates (ADCs) represent a promising approach in targeted cancer therapy, combining the targeted precision of antibodies with the potency of cytotoxic payloads to selectively target tumour cell whilst minimising off-target effects. This review provides a comprehensive analysis of ADCs, encompassing their structural components, mechanisms of action, and clinical applications. It also examines recent technological advancements, particularly in antibody engineering and linker design, aimed at enhancing therapeutic efficacy and safety.

Multi-omics profiling reveals PLEKHA6 as a modulator of β-catenin signaling and therapeutic vulnerability in lung adenocarcinoma.

Lung adenocarcinoma (LUAD) remains the most prevalent and lethal subtype of lung cancer, largely due to late diagnosis and therapeutic resistance. In this study, we conducted a comprehensive multi-omics analysis to characterize the pleckstrin homology domain-containing (PLEKHA) family gene in LUAD. Among the eight members, PLEKHA6 was uniquely overexpressed in LUAD tissues and significantly associated with poor prognosis.

Parents' Sharenting Behaviours: A Systematic Review of Motivations, Attitudes, Perceptions, and Impression Management Perspectives.

Introduction: Sharenting involves parents sharing photos, videos, or other information about their children on their social media profiles via online platforms. Research indicated the rising prevalence of parental sharenting behaviour among various countries.

Objective: The main aim of this article was to explore the role of motivations, perceptions, attitudes, and impression management on parental sharenting behaviours.

Microglia-Mediated Neuroinflammation Through Phosphatidylinositol 3-Kinase Signaling Causes Cognitive Dysfunction.

Microglia, as the immune guardians of the central nervous system (CNS), have the ability to maintain neural homeostasis, respond to environmental changes, and remodel the synaptic landscape. However, persistent microglial activation can lead to chronic neuroinflammation, which can alter neuronal signaling pathways, resulting in accelerated cognitive decline. Phosphoinositol 3-kinase (PI3K) has emerged as a critical driver, connecting inflammation to neurodegeneration, serving as the nexus of numerous intracellular processes that govern microglial activation.