Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Disentangling preschool wheezing heterogeneity in terms of clinical traits, temporal patterns, and collective healthcare burden is critical for precise and effective interventions.
Objective: We aimed to collectively define contributions and distinct characteristics of respiratory phenotypes based on longitudinal wheeze and atopic sensitization patterns in the first 5 years of life.
Methods: Group-based trajectory analysis was performed in the CHILD Cohort study to identify distinct wheeze and allergic sensitization trajectories. Trajectories were evaluated for associated risk factors, healthcare utilization, biological determinants, and clinical outcomes. Stool samples for shotgun metagenomic sequencing profiles from infant microbiomes collected at 3-months and 1-year were assessed for phenotype-specific biomarkers.
Results: Six distinct respiratory phenotypes were identified from 2902 children that differed by temporal wheeze and allergic sensitization patterns. While allergic wheeze phenotypes (11·6% of participants) carried the highest asthma diagnosis risk, the more common non-allergic phenotypes (88·3% of participants) contributed to the majority of 5-year asthma diagnoses (61·4% of diagnoses). Most importantly, non-allergic phenotypes accounted for over 2/3 of healthcare utilization in this age group. Phenotypes differed by lung function, blood eosinophils, allergic comorbidities and weight-for-age z-score. Moreover, microbiome profiles from 1439 infants revealed largely non-overlapping microbial signatures at 1 year were associated with each phenotype.
Conclusion: We identified novel early childhood respiratory phenotypes to disentangle non-overlapping paths to preschool wheezing. Our findings highlight the continued clinical relevance of non-atopic wheeze phenotypes, which remain undertreated despite accounting for a substantial proportion of healthcare utilization and asthma diagnoses.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jaci.2025.07.034 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Protective Role of Bre1 in Mitochondrial Function and Energy Metabolism in Drosophila Models of Parkinson's disease.
Free Radic Biol Med
September 2025
Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases, The First Affiliated Hospital of Guangxi Medical University,Nanning, Guangxi 530021, China; Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education,
Background: The second most common cause of autosomal recessive early-onset Parkinson's disease (PD) can be attributed to mutations in the PINK1 gene, malfunction of the mitochondria is the key pathological mechanism. Bre1 encodes an E3 ubiquitin ligase, with the discovery of Bre1's role in repairing mitochondrial damage, further investigation into its implications for PD is warranted.
Methods: We used the PINK1B9 drosophila melanogaster as the PD model.
Mitochondrial Complex Member VdNuo1 Recruits Superoxide Dismutases VdSOD2/4 to Maintain Superoxide Anion Homeostasis During Pathogenesis in Verticillium dahliae.
Mol Plant Pathol
September 2025
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.
During oxidative phosphorylation, the leaked electrons generate superoxide anions to attack the mitochondrial inner membrane and impair mitochondrial activity. Three superoxide dismutases (SODs) are secreted to degrade host superoxide anions in Verticillium dahliae. However, the roles of mitochondrial SODs (mtSODs) in superoxide anion detoxification and in virulence are unknown in this fungus.
View Article and Find Full Text PDFAcute Respiratory Distress Syndrome Phenotypes After Stem Cell Transplantation: A Latent Class Analysis.
Crit Care Explor
September 2025
Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN.
Objective: To identify distinct phenotypes of acute respiratory distress syndrome (ARDS) developing after hematopoietic cell transplantation (HCT), using routinely available clinical data at ICU admission.
Design: Multicenter retrospective cohort study using latent class analysis.
Setting: ICUs across three Mayo Clinic campuses (Minnesota, Florida, and Arizona).
Integrative blood transcriptomic and metabolomic profiling reveals biomarkers of natural heat tolerance in Holstein cows.
J Dairy Sci
September 2025
Key Laboratory of Animal Genetics & Breeding and Molecular Design of Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu 225009, China. Electronic address:
Heat stress poses a major threat to dairy cattle productivity, particularly in high-producing Holstein cows. To identify robust biomarkers of thermotolerance, we employed an integrative strategy combining physiological phenotyping, blood metabolite profiling, and transcriptomic analysis. A total of 120 lactating Holstein cows were evaluated under natural summer heat conditions using rectal temperature, respiratory rate, salivation index, serum HSP70, cortisol, potassium levels, and milk production.
View Article and Find Full Text PDFEarly preschool wheeze trajectories are predominantly non-allergic with distinct biologic and microbiome traits.
J Allergy Clin Immunol
September 2025
Department of Pediatrics, and Translational Medicine, SickKids Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:
Background: Disentangling preschool wheezing heterogeneity in terms of clinical traits, temporal patterns, and collective healthcare burden is critical for precise and effective interventions.
Objective: We aimed to collectively define contributions and distinct characteristics of respiratory phenotypes based on longitudinal wheeze and atopic sensitization patterns in the first 5 years of life.
Methods: Group-based trajectory analysis was performed in the CHILD Cohort study to identify distinct wheeze and allergic sensitization trajectories.