Primary hepatic neuroendocrine neoplasms: a case series of 10 patients and literature review.

The clinical data of 10 patients with pathologically confirmed primary hepatic neuroendocrine neoplasms from Ningbo medical institutions between 2012 and 2024 were retrospectively analyzed. The cohort included 8 males and 2 females, with a median age of 63 years. None presented with carcinoid syndrome.

Improving the functionality of wireless sensor networks through the use of reinforcement learning and metaheuristic based energy efficient system.

To improve the routing and data transmission of wireless sensor networks, this study recommends utilising a new clustering mechanism that is energy efficient and intelligent. First, the positions of the sensor nodes in the network and energy values are acquired. Harris hawks optimization, a meta-heuristic that considers the distance, dispersion, and energy balance of sensors, is then used to do energy-aware clustering.

Interaction between DRD4 and MAOA genetic polymorphisms on static and dynamic regional coherence in the prefrontal cortex of drug-naive children with ADHD.

Objectives: The aim of this study was to explore the genetic association between DRD4 and MAOA genotypes and local functional connectivity in drug-naive children with ADHD.

Methods: We investigated the effects of individual genotypes and gene × gene interactions between DRD4 and MAOA variants on local functional connectivity in 94 children with ADHD, using both the mean static regional homogeneity (sReHo) and the coefficient of variation (CV) of dynamic ReHo (dReHo). Additionally, correlation and mediation analyses were conducted to explore the relationships between dopamine-related genes, regional brain function, and neurocognitive alterations.

Dual Active Site Engineering of Nickel Selenides by a Substrate Effect for Alkaline Hydrogen Evolution.

Developing efficient catalysts for alkaline hydrogen evolution reaction (HER) requires rapid water/hydrogen adsorption/dissociation kinetics. However, challenges remain in reducing energy barriers by simultaneously activating the anionic and cationic sites in a single compound. In this article, a heterogeneous substrate (NiS-NiS) regulatory strategy is developed to construct dual active sites in NiSe toward the HER.

Coexistence of head and face Merkel cell and squamous cell carcinomas in the elderly population - a case report and literature review.

Merkel cell carcinoma (MCC) is a rare and highly aggressive neuroendocrine cancer type that predominantly impacts sun-exposed skin areas in the elderly, particularly the head and neck (41-50%), followed by the limbs (32-38%). There is likely an association between MCC and other cutaneous malignancies, such as cutaneous squamous cell carcinoma (CSCC), Bowen's disease, and basal cell carcinoma. Cutaneous squamous cell carcinoma is the most common concurrent tumor with MCC, especially in sun-exposed regions of the skin.

Energy efficient multi hop clustering using Artificial Bee Colony metaheuristic in WSN.

Wireless sensor networks (WSNs) have garnered considerable interest for their ability to gather and transmit data in applications including environmental monitoring, industrial automation, and military surveillance. The constrained energy supply of sensors, frequently dependent on non-rechargeable batteries, presents a significant issue in the design and efficacy of these networks. This paper introduces EEM-LEACH-ABC, a novel energy-efficient clustering and routing protocol for WSNs using the Artificial Bee Colony (ABC) algorithm.

Ultra-wide time-dependent phosphorescence color of carbon dots a synergistic strategy of dual confinement structures constructing multiple luminescent centers.

Phosphorescent materials with time-dependent phosphorescent color (TDPC) output have significant potential for applications in advanced optical information encryption. However, the effective construction of TDPC composites compatible with multiple phosphorescent emission centers to achieve wider phosphorescent colors evolving over time in a single material system remains a huge challenge. Here, ultra-wide TDPC composites with time-dependent color evolution were realized for the first time in a single system by exploiting the synergistic effect of a doubly confined structure.

Nobiletin alleviates hypoxia-induced pulmonary hypertension by inhibiting calcium-sensing receptor.

Pulmonary hypertension is a disease characterized by complex diagnosis, challenging treatment, and a shortage of clinical medications. Among them, Group III pulmonary hypertension, which is caused by lung diseases and/or hypoxia, has the second-largest number of patients. Currently, there are extremely few clinically guided medications for Group III pulmonary hypertension, and their efficacy is limited.

A neutral-atom Hubbard quantum simulator in the cryogenic regime.

Ultracold fermionic atoms in optical lattices offer pristine realizations of Hubbard models, which are fundamental to modern condensed-matter physics. Despite notable advancements, the accessible temperatures in these optical lattice material analogues are still too high to address many open problems. Here we demonstrate a several-fold reduction in temperature, bringing large-scale quantum simulations of the Hubbard model into an entirely new regime.

The Effect of Supply Gas Pressure on the Atomization Characteristics of Medical Air-Compression Nebulizers.

In treating respiratory diseases, medical air-compression nebulizers play a crucial role in the noninvasive targeted delivery of medications. Alterations in the operating parameters of the nebulizer can cause significant changes in its atomization characteristics, directly affecting the drug delivery efficiency and therapeutic effect. This study examined the impact of the supply gas pressure on the atomization characteristics of medical air-compression nebulizers.

Structural Heterogeneity of MgSiO_{3} Liquid and Its Connection with Dynamical Properties.

Silicate melts not only govern key processes in the Earth's early evolution, but also significantly influence its interior dynamics today. MgSiO_{3}, a primary component of silicate melts, undergoes significant structural changes and exhibits complex macroscopic properties from the Earth's surface to the core-mantle boundary. Despite extensive studies, the atomic structure, densification mechanisms, and their connection to dynamics remain unclear.

Orf132: a critical gene for LSDV replication and its role in Er stress-related apoptosis.

Lumpy skin disease (LSD), caused by the lumpy skin disease virus (LSDV), is an emerging infectious disease in China that primarily affects cattle. LSDV and goatpox virus (GTPV) belong to the Capripoxvirus genus and exhibit high genomic homology, enabling cross-immunogenicity. Comparative genome analysis revealed that LSDV contains a unique gene, Orf132, whose function remains uncharacterized.

Wafer-scale synthesis of transition metal dichalcogenides and van der Waals heterojunctions.

Two-dimensional materials, as a promising class of emerging materials, are expected to overcome the technical bottlenecks of silicon-based device miniaturization and enable the continuation of 'Moore's Law' due to their unique physical and chemical properties. Notably, transition metal dichalcogenides (TMDs) and heterojunctions have demonstrated unprecedented potential applications in novel electronic and optoelectronic devices. In recent years, breakthroughs have been continuously made in the preparation techniques and growth strategies of wafer-scale TMDs and heterostructures.

Research Progress on Data-Driven Industrial Fault Diagnosis Methods.

With the advent of Industry 5.0, fault diagnosis is playing an increasingly important role in routine equipment maintenance and condition monitoring. From the perspective of industrial big data, this paper systematically reviews the current mainstream industrial fault diagnosis methods.

Is leader innovation a challenge or a burden for employees? The perspective of affective events.

The importance of innovation has lit scholars' passion to figure out how to encourage innovative behavior, while its outcomes have been largely overlooked. Meanwhile, prior studies have focused on employees as the innovator and ignored that leaders are even more responsible to innovate. To understand employees' emotional and behavioral reactions to leader innovative behavior, this study drew on the affective events theory and regulatory focus theory and constructed a dual pathway model to illustrate the double-edge sword effects of leader innovation.

Pd-catalyzed efficient synthesis of 3-formylindole derivatives with diaziridinone.

This work describes an efficient Pd-catalyzed annulation process of acetal alkynes, aryl iodides, and di--butyldiaziridinone to afford a variety of 3-formylindoles and their derivatives. The reaction likely proceeds through a regioselective Heck reaction followed by aryl C-H activation to form a pallada(II)cycle, which is bisaminated with diaziridinone a pallada(IV)cycle. The utility of the current reaction process is demonstrated by the facile synthesis of bioactive indoles.

Phylogeographic History of Tomato Chlorosis Virus.

Tomato chlorosis virus (ToCV), first reported in Florida, USA, in 1998, has since emerged in multiple regions worldwide, posing a significant threat to global tomato production. However, its origin, migration patterns, and evolutionary history remain poorly understood. In this study, we used Bayesian phylogeographic analysis of coat protein gene sequences from 155 ToCV isolates to reconstruct its phylogeographic history.

Fabrication and Performance of Aluminum-Based Composite Wicks Using a Two-Step Laser-Sintering Process.

The evolution of 5G technology necessitates effective thermal management strategies for compact, high-power devices. The potential of aluminum-based vapor chambers (VCs) as thermal management solutions is recognized, yet the heat transfer performance is limited by the capillary constraints of the wick structures. This study proposes a laser-sintered composite wick to address this limitation.

Multi-Trait Genomic Prediction of Meat Yield in Pacific Whiteleg Shrimp ().

The meat yield (MY) is a key economic trait in Pacific whiteleg shrimp () breeding, necessitating accurate genomic prediction for efficient genetic improvement. In this study, we investigated single-trait (STGMs) and multi-trait genomic models (MTGMs) for predicting MY and related traits, using two cross-validation strategies reflecting different data-availability scenarios. A total of 899 individuals from 63 full-sibling families were phenotyped for MY, net meat weight (MW), body weight (BW), body length (BL), and abdominal segment length (AL).

Integration of Flow Cytometry and Single-Cell RNA Sequencing Analysis to Explore the Fibroblast Subpopulations in Keloid that Correlate with Recurrence.

Fibroblasts (FBs) are the cytological basis of keloid (KD) formation. This study aimed to identify the key pathogenic target cell subpopulation involved in KD recurrence. Single-cell RNA sequencing data were retrieved from public databases, revealing distinct gene expression patterns in FB subpopulations.

Broad-spectrum antibody against thiazides and degraded salamide and immunoassay establishment for simultaneous detection.

The illegal additive thiazides and degraded salamide in food supplements poses significant health risks and regulatory challenges. However, the structural differences between thiazides and salamide complicate the hapten design for immunoassay detection. In this study, we first outlined the common skeleton of thiazides and their shared epitopes with salamide through molecular overlap and atomic charge distribution analysis.

Controllable Growth of Wafer-Scale TeSe Thin Films Based on Selenium Phase Change-Induced Strategy for Single-Pixel Imaging.

Recently, TeSe films have shown significant potential for infrared detection. However, the conventional deposition process of TeSe films typically requires a cooled substrate, which results in the formation of poorly crystallized materials. Achieving controlled synthesis of large-area TeSe films remains a major challenge.

A Practical Approach for Polarity and Quantity Controlled Assembly of Membrane Proteins into Nanoliposomes.

Biological membranes achieve selectivity and permeability through protein transporters and channels. The design of artificial compartments with permeable membranes is essential to facilitate substrate and product transfer in enzymatic reactions. In this study, an E.

Unified Variational Approach Description of Ground-State Phases of the Two-Dimensional Electron Gas.

The two-dimensional electron gas (2DEG) is a fundamental model, which is drawing increasing interest because of recent advances in experimental and theoretical studies of 2D materials. Current understanding of the ground state of the 2DEG relies on quantum Monte Carlo calculations, based on variational comparisons of different Ansätze for different phases. We use a single variational ansatz, a general backflow-type wave function using a message-passing neural quantum state architecture, for a unified description across the entire density range.

Ferromagnetic Semimetal and Charge-Density Wave Phases of Interacting Electrons in a Honeycomb Moiré Potential.

The exploration of quantum phases in moiré systems has drawn intense experimental and theoretical efforts. The realization of honeycomb symmetry has been a recent focus. The combination of strong interaction and honeycomb symmetry can lead to exotic electronic states such as fractional Chern insulator, unconventional superconductor, and quantum spin liquid.