LncSSBP1/FOXO3 axis modulates autophagy: a novel insight into bronchial epithelial cells defense against Talaromyces marneffei in-fection.

Background: While autophagy is pivotal in antimicrobial defense, its regulatory role in Talaromyces marneffei (TM) infected bronchial epithelium remains elusive.

Objective: To elucidate the impact of TM infection on autophagy in bronchial epithelial cells and to identify the key molecular regulators involved in this process.

Methods: Primary computational screening identified core autophagy modulators.

Protective Role of Bre1 in Mitochondrial Function and Energy Metabolism in Drosophila Models of Parkinson's disease.

Background: The second most common cause of autosomal recessive early-onset Parkinson's disease (PD) can be attributed to mutations in the PINK1 gene, malfunction of the mitochondria is the key pathological mechanism. Bre1 encodes an E3 ubiquitin ligase, with the discovery of Bre1's role in repairing mitochondrial damage, further investigation into its implications for PD is warranted.

Methods: We used the PINK1B9 drosophila melanogaster as the PD model.

Transcriptomic Analysis Reveals Key Regulatory Genes and Pathways Involved in Macrophage Inflammation Induced by Hypervirulent Klebsiella pneumoniae Infection.

Hypervirulent Klebsiella pneumoniae (hvKP) possesses multiple virulence factors and causes severe infections with elevated mortality rates. It induces a strong inflammatory response in the host, with macrophages playing a key role in defense and inflammation. However, the signaling pathways of macrophages involved in response to hvKP infection remain unclear.

Consensus statement on the multidisciplinary treatment of nasopharyngeal carcinoma with immune checkpoint inhibitors in China.

Introduction: This study aims to establish a multidisciplinary consensus on the treatment of nasopharyngeal carcinoma (NPC) in China, with a particular focus on the guidelines for the use of immune checkpoint inhibitors (ICIs) to ensure scientific and rational treatment protocols.

Methods: The consensus was formulated based on the 'guidelines for the diagnosis and treatment of NPC (2024 edition)' issued by the Chinese Society of Clinical Oncology. The Delphi method was used to collect and consolidate expert opinions.

Indobufen Versus Aspirin Plus Clopidogrel in Patients After Coronary Stenting in Patients With Diabetes: A Post Hoc Analysis of the OPTION Trial.

Background: Despite increased risk of ischemic events in diabetes, the optimal anti-thrombotic strategy for secondary prevention has not been defined. We aimed to assess the efficacy and safety of optimal antiplatelet agents such as indobufen-based dual antiplatelet therapy (DAPT) in patients with diabetes after coronary stenting.

Methods: OPTION trial was a randomized, open-label, noninferiority, and multicentric study in China.

Case Report: Congenital absence of the fifth metacarpal with polydactyly and syndactyly.

Congenital hand malformations encompass various types, with polydactyly and syndactyly being common. However, congenital absence of the metacarpal is rarely reported, and literature on this condition remains limited. To date, no cases of congenital absence of the fifth metacarpal combined with polydactyly and syndactyly have been documented.

CTRP3 mitigates sepsis-induced impairment of endothelial barrier function by suppressing pyroptosis in endothelial cells.

Acute lung injury significantly contributes to mortality in bacterial sepsis due to lung endothelial barrier destruction, leading to protein-rich lung edema, an influx of proinflammatory leukocytes, and persistent hypoxemia. CTRP3, an adipokine, reduces endothelial adhesion molecules Vcam-1 and Icam-1 and inhibits LPS-induced monocytic adhesion, highlighting its anti-inflammatory effects. This study investigates CTRP3's protective role in sepsis-induced acute lung injury, revealing reduced CTRP3 expression during sepsis, which worsens endothelial dysfunction.

Impact of Clonorchis sinensis infection on long-term survival after curative resection for hepatocellular carcinoma: A multicenter cohort study.

Background: Hepatocellular carcinoma (HCC) prognosis is poor in East Asia. The impact of Clonorchis sinensis (C.sinensis) infection, a known carcinogen for cholangiocarcinoma, on HCC prognosis after curative resection in co-endemic regions is unclear.

A comparative study of dexmedetomidine combined with esketamine and sufentanil for sedation and analgesia in patients undergoing microwave ablation of lung tumors: A prospective single-center randomized double-blind clinical trial.

Background: This study evaluated the efficacy and safety of esketamine plus dexmedetomidine for sedation and analgesia during computed tomography (CT)-guided lung tumor percutaneous microwave ablation (MWA).

Methods: Patients undergoing CT-guided percutaneous MWA of lung tumors were randomly divided into two groups: esketamine plus dexmedetomidine (Group E) and sufentanil plus dexmedetomidine (Group S). The patients' general information, mean arterial pressure (MAP), heart rate (HR), peripheral oxygen saturation, respiratory rate (RR), partial pressure of end-tidal carbon dioxide, bispectral index, and Ramsay sedation score were recorded before anesthesia administration (T0), after dexmedetomidine loading dose (T1), during percutaneous puncture (T2), during ablation (T3), at the end of surgery (T4), and during recovery of consciousness (T5).

Improvement and application of supine position components for lung tumor microwave ablation.

Objective: This study aimed to evaluate the safety and efficacy of improved supine positioning components for lung tumor microwave ablation (MWA), with the goal of enhancing surgical efficiency, reducing complications, and improving patient experience.

Materials And Methods: One hundred patients undergoing MWA for lung tumors were randomly divided into two groups (n = 50 each): experimental (using improved components) and control (using traditional components). The improved positioning system included a high-density memory foam head pillow, lumbar and leg pillows, and adjustable fixing bands tailored to individual patient needs.

Recent Advancement in MRI-Based Nanotheranostic Agents for Tumor Diagnosis and Therapy Integration.

Cancer remains one of the leading causes of mortality worldwide. Although conventional treatment strategies such as chemotherapy, radiotherapy, and surgery have demonstrated therapeutic potential, their clinical effectiveness is often limited by poor targeting specificity, systemic toxicity, and inadequate treatment monitoring. Magnetic resonance imaging (MRI) has emerged as a powerful diagnostic modality owing to its non-invasive nature, high spatial resolution, deep tissue penetration, and real-time imaging capabilities, making it particularly suitable for guiding and evaluating cancer therapies.

Elevated THOC5 expression in liver cancer and its implications for tumor progression and therapeutic response.

Purpose: Cancer remains a major global cause of death, with rising incidence influenced by environmental factors. The THOC5 gene, part of the THO complex, has emerged as a potential regulator in cancer biology. This study investigates THOC5 expression across various cancers, its role in prognosis, and its potential therapeutic implications, particularly in liver hepatocellular carcinoma (LIHC).

Prognostic role of Ki-67 in colorectal carcinoma: Development and evaluation of machine learning prediction models.

Background: Ki-67 is a routine test item in clinical pathology departments. However, its prognostic value requires further investigation, especially in the context of research using machine learning (ML), which remains relatively underdeveloped.

Aim: To investigate the prognostic value of Ki-67 in cases of colorectal carcinoma (CRC) and explore the potential application of ML algorithms to predict the Ki-67 index.

Identification of exosome-related genes in Alzheimer's disease: Evidence from transcriptomic and Mendelian randomization analyses.

BackgroundEmerging evidence implicates exosomes in the pathogenesis of Alzheimer's disease (AD).ObjectiveThis study aimed to investigate the role of exosome-related genes in AD pathogenesis and evaluate their potential as diagnostic biomarkers.MethodsWe analyzed AD transcriptomic datasets (GSE5281, GSE138260, GSE29378) from the Gene Expression Omnibus database.

CFHR2 Supplementation Mitigates Pathologies of Neuromyelitis Optica by Regulating Complement Activation.

Neuromyelitis Optica spectrum disorder (NMOSD) is a relapsing autoimmune disease primarily affecting the optic nerves and spinal cord. While the pathogenesis of NMO involves Aquaporin-4 antibodies (AQP4-IgG) and complement-mediated damage, the specific roles of the complement pathway remain to be fully elucidated. In this study, we found that complement factor H-related protein 2 (CFHR2), a regulator that inhibits the complement C3 alternative pathway, was significantly decreased in the serum of NMO patients and was negatively correlated with the Expanded Disability Status Scale (EDSS) score.

Lumbar spondylolysis: A bibliometric analysis and visualization research from 2000 to 2023.

Objective: To conduct a bibliometric analysis of lumbar spondylolysis research in the Web of Science database over the past 23 years. This analysis aimeds to determine the field's knowledge graph and explore the development trends, research focus, and frontiers in lumbar spondylolysis.

Methods: We conducted a study of lumbar spondylolysis research papers obtained from the WOS Core Collection.

Sirolimus Plus Low-Exposure Calcineurin Inhibitors as an Alternative Graft-Versus-Host Disease Prophylaxis in Calcineurin Inhibitor-Intolerant Recipients: A Retrospective Study.

Background: Graft-versus-host disease (GvHD) remains a major barrier to long-term survival after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although calcineurin inhibitors (CNIs) are the cornerstone of GvHD prophylaxis, some patients cannot tolerate them, creating a critical need for alternative strategies.

Objective: To evaluate the efficacy and safety of sirolimus plus low-exposure CNIs as an alternative GvHD prophylaxis in CNI-intolerant recipients undergoing allo-HSCT.

Fatty acid-binding proteins as potential biomarkers for human cancer prognosis.

Fatty acid-binding proteins (FABPs) play a pivotal role in the malignant progression of numerous human cancers. However, the precise functions of FABP family genes in different cancer types remain incompletely elucidated. The data used in this study were acquired from The Cancer Genome Atlas (TCGA).

Potential prognostic value and immune landscape of lactylation and liquid-liquid phase separation related genes in acute myeloid leukemia.

Objectives: Lactylation- and liquid-liquid phase separation-related differentially expressed genes (LLRDEGs) have been implicated in cancer. However, their role in acute myeloid leukemia (AML) remains largely unexplored.

Methods: LLRDEGs associated with AML prognosis were identified using Cox regression and LASSO analyzes.

Beyond ISS staging: the prognostic value of the Inflammation Prognostic Score Index (IPSI) in multiple myeloma.

Objectives: To establish a novel Inflammation Prognostic Score Index (IPSI) and evaluate its prognostic value and complementary role to the International Staging System (ISS) in newly diagnosed multiple myeloma (MM).

Methods: This retrospective study analyzed 98 newly diagnosed MM patients. ROC-derived cutoffs stratified patients by RDW, PLT, NMLR, SII, and SIRI.

Sea cucumber polypeptide ameliorates aging properties via the brain-gut axis in naturally aging mice.

Background: Sea cucumber has been recognized as a traditional nutraceutical in Chinese medicine for millennia, with its derived polypeptide (SCP) demonstrating diverse bioactive properties. Nevertheless, the molecular mechanisms underlying SCP's potential geroprotective effects remain insufficiently characterized.

Methods: We systematically evaluated SCP's impact on neuromotor function and cognitive performance in physiologically aged C57BL/6 J mice models using a behavioral test battery comprising open field, Y-maze, and Barnes maze paradigms.

Heterogeneity of diabetes and disease progression with a tree-like representation: findings from the China Cardiometabolic Disease and Cancer Cohort (4C) study.

Aims/hypothesis: Diabetes heterogeneity has been modelled as a continuum in European populations, but its phenotypes and long-term comorbidity risks remain unclear in Chinese individuals. This study aimed to identify distinct phenotypes and evaluate their links to future cardiometabolic risks in a large Chinese cohort.

Methods: The discriminative dimensionality reduction with trees (DDRTree) algorithm was used to develop a tree structure based on nine clinical variables.