Insights Into the Separate and Joint Effects of Cadmium and Cesium on the Risk of Circadian Syndrome and the Underlying Mechanism: An Integrated Epidemiological and Network Toxicological Study.

The uncharted effects of cadmium and cesium on circadian syndrome (CircS), an emerging circadian rhythm disorder drawing considerable attention, and underlying mechanisms warrant exigent elaboration. Data of 11141 subjects from National Health and Nutrition Examination Survey 2005-2018 were incorporated to investigate separate-, joint-/interaction-, and mixture-effects of urinary cadmium and cesium on prevalent CircS risk exploiting survey weight regression and quantile g-computation. The underlying mechanisms were probed by network toxicological analysis.

Lysine-polydopamine nanoparticles for ameliorating acidic microenvironment and neuroprotection in spinal cord injury repair.

Spinal cord injury (SCI) is exacerbated by the formation of an acidic microenvironment and extensive neuronal loss, both of which contribute to poor functional recovery. To address this, we developed lysine-polydopamine nanoparticles (Lys-PDA) as a multifunctional therapeutic platform for SCI. Lysine, a naturally occurring amino acid, possesses weak alkalinity and neuroprotective properties, but suffers from poor in vivo stability and non-specific distribution.

Addressing Frailty in Cardiology: Identifying Barriers Faced by Cardiologists and Health Care Professionals in Asia.

Background: Preventing frailty is crucial for improving outcomes in aging populations at heightened cardiovascular risk, yet implementation in real-world practice remains challenging. The authors previously reported low use of frailty strategies among cardiologists in Asia.

Objectives: The aim of this study was to explore the barriers to frailty implementation among cardiologists, other physicians, and nurses.

Epigenetic‑ncRNA crosstalk in atherosclerosis: Mechanisms, disease progression and therapeutic potential (Review).

Atherosclerosis is a chronic and progressive vascular disease involving the gradual accumulation of lipids, cholesterol, cellular debris, and fibrous elements within the arterial wall. This process leads to the thickening and hardening of arteries, resulting in restricted blood flow and reduced oxygen delivery to tissues. Over time, these pathological changes significantly elevate the risk of life‑threatening cardiovascular events, including myocardial infarction and ischemic stroke.

Early hyperferritinemia in polytrauma: a biomarker of systemic inflammation and mortality risk in a multicenter cohort study.

Background: Severe polytrauma is one of the leading causes of death and disability worldwide. Hyperferritinemia is increasingly recognized as a biomarker of critical illness, yet its prognostic significance in polytrauma remains underexplored. This multicenter study investigates the temporal dynamics of serum ferritin in polytrauma patients and its association with systemic inflammation, organ dysfunction, and mortality.

Applications and challenges of biomarker-based predictive models in proactive health management.

Digital technology and artificial intelligence have revolutionized predictive models based on clinical data, creating opportunities for proactive health management. This review systematically evaluates the role and effectiveness of biomarker-driven predictive models across disease detection, personalized intervention, and healthcare resource optimization. Critical challenges hindering their implementation include data heterogeneity, inconsistent standardization protocols, limited generalizability across populations, high implementation costs, and substantial barriers in clinical translation.

Propylparaben impairs muscle development in zebrafish via the PI3K-mTOR pathway.

Congenital myopathies are genetically inherited muscle disorders that impair muscle function and strength. While primarily linked to genetic mutations, emerging evidence suggests environmental toxins may exacerbate disease progression. Despite its widespread use as a preservative, the impact of propylparaben (PP) remains insufficiently characterized in current research.

Safety and clinical efficacy of immune checkpoint inhibitors in pediatric hepatocellular carcinoma: a case report and review of the literature.

Background: Pediatric hepatocellular carcinoma (HCC) is rare, with surgical resection and liver transplantation as primary treatments. No standard options exist for unresectable/metastatic disease. Although immune checkpoint inhibitors (ICIs) show efficacy in adults, their pediatric safety and efficacy remain unestablished.

Post marketing safety assessment of the novel postpartum depression drug, Zuranolone: evidence from real-world pharmacovigilance analysis based on the FDA adverse event reporting system.

Objective: Zuranolone, the latest oral medication for postpartum depression, was approved in the United States in August 2023. Due to its pharmacokinetic characteristics and rapid onset of action, it is hailed as a breakthrough and enhanced version of the drug. However, there is limited information on adverse drug reactions associated with its use.

Characteristics and Related Factors of Chinese Herbal Medicine Use in Middle-Aged and Older Patients with Cardiovascular Disease in China: A Cross-Sectional Study.

Background: Cardiovascular disease (CVD) poses a significant health burden in middle-aged and older Chinese populations, with Chinese herbal medicine (CHM) often used as a complementary therapy. This study aimed to analyze the characteristics of CHM use and its influencing factors in middle-aged and older Chinese patients with CVD.

Methods: This was a cross-sectional study based on data from the 2018 China Health and Aging Longitudinal Study (CHARLS).

Circulatory extracellular vesicles transport complement C1q for promoting neuronal amyloid-β production in Alzheimer's disease.

Unlabelled: Alzheimer’s disease (AD) is the most common type of dementia. A major pathological feature of AD is the aggregation of amyloid-β (Aβ), primarily driven by β-secretase (BACE1) activity. However, the mechanisms underlying continuous Aβ accumulation remain unclear.

Advances in bone organoids research and future perspectives.

Skeletal diseases pose a significant threat to both physical and mental health, emerging as a critical global issue. A thorough understanding of bone physiology and the development of effective clinical interventions necessitate robust research methodologies. Recently, organoids have gained widespread attention as three-dimensionalmodels capable of recapitulating complexenvironments, addressing key limitations of traditional two-dimensional cell cultures and animal models.

Crosstalk between hypoxia-inducible factor (HIF) and lncRNAs in digestive tumors: from molecular mechanisms to clinical translation.

Hypoxia is a characteristic feature of the tumor microenvironment that significantly influences cancer progression and treatment responses. Hypoxia-inducible factor (HIF), a key regulator of hypoxic adaptation, has been demonstrated to modulate hypoxic gene expression profiles and signaling networks, thereby serving as a potential therapeutic target. Long-stranded non-coding RNAs (lncRNAs), defined as non-coding RNAs exceeding 200 nucleotides in length, regulate various cellular processes by modulating gene expression at transcriptional, post-transcriptional, and epigenetic levels.

Tamarixetin Suppresses Colorectal Cancer Progression by Targeting DPP7-Mediated WNT3A/β-Catenin Signalling Pathway.

Colorectal cancer (CRC) patients have had limited benefits from conventional chemotherapy, highlighting the need for improved therapeutic strategies. Natural compounds have emerged as promising alternatives due to their potent anti-cancer properties and reduced side effects. Tamarixetin is an O-methylated flavonol derived from Azadirachta indica, but its potential and clinical utility to suppress CRC progression remain unknown.

Estrogen receptor 1 (ESR1) promotes Di-butyl phthalate (DBP)-induced hypospadias by regulating mitophagy through PINK1-Parkin axis to inhibit ferroptosis.

This study reveals how Di-butyl phthalate (DBP), an estrogen-mimicking environmental pollutant, induces hypospadias by inhibiting ferroptosis through ESR1 activation and PINK1-Parkin-dependent mitophagy. Utilizing a prenatal DBP-exposed fetal rat hypospadias model, we observed significant downregulation of pro-ferroptotic ACSL4 and upregulation of anti-ferroptotic GPX4/SLC7A11 in urethral tissues, alongside elevated oxidative stress markers (MDA, Fe²⁺) and reduced glutathione (GSH). In vitro experiments using rat urethral plate fibroblasts (RUPFs) demonstrated that DBP enhanced ferroptosis resistance and promoted proliferation at concentrations below 200 μM.

Tegoprazan-based versus esomeprazole-based triple therapy plus bismuth for first-line Helicobacter pylori eradication: A nationwide, multicenter, double-blind, double-dummy, randomized controlled trial.

Background: Although triple therapy plus bismuth (TTPB), comprising a proton pump inhibitor (PPI), two antibiotics, and bismuth, is widely used to eradicate Helicobacter pylori (H. pylori), eradication rates have been suboptimal. Potassium-competitive acid blockers (P-CABs) offer stronger and more stable gastric acid inhibition compared to PPIs.

Comparison of Subxiphoid and Intercostal Uniportal Video-Assisted Thoracoscopic Surgery for Early Thymoma, Lung Cancer, and Pneumothorax: A Retrospective Single-Center Study.

Background: Video-assisted thoracoscopic surgery (VATS) is a minimally invasive technique for early thymoma, early-stage non-small cell lung cancer (NSCLC), and primary spontaneous pneumothorax (PSP). The subxiphoid uniportal VATS (SU-VATS) approach offers potential advantages over the intercostal uniportal VATS (IU-VATS) by reducing nerve injury and postoperative pain.

Methods: A single-center retrospective study at The Fifth Hospital of Ganzhou included 756 patients who underwent SU-VATS or IU-VATS between January 2018 and September 2024.

KIAA1429 Silencing ameliorates osteosarcoma progression through promoting ferroptosis via Nrf2/NQO1 axis.

Background: Osteosarcoma (OS) is the most common primary malignant bone tumor. Recent insights into ferroptosis have opened new avenues for OS therapy. However, the role of KIAA1429 in regulating ferroptosis and its underlying mechanisms in OS remain unclear.

Advances in the study of the relationship between and various diseases.

The relationship between the imbalance of flora and the development of various diseases is one of the hotspots of research in recent years. A number of studies have confirmed that () is strongly associated with the progression of periodontal disease, oral cancer, esophageal carcinoma, colorectal carcinoma, pancreatic cancer, Alzheimer's disease, rheumatoid arthritis and other diseases. These diseases have a great impact on human health.

Dual-functional Anti-hPSMA nanocapsules for targeted inhibition of prostate tumor growth.

Addressing prostate cancer, particularly in its aggressive forms, poses challenges that call for innovative treatment modalities. Our research focuses on developing a nanotechnological solution to enhance targeted cancer therapy. We have synthesized advanced nanocapsules embedded with indocyanine green (ICG) and conjugated with the Anti-hPSMA to improve specificity towards prostate cancer cells.

Efficacy and Safety of Firsekibart Compared to Etoricoxib for Gout Flares: A Phase 2, Multicenter, Open-label, Active-controlled, Randomized Non-inferiority Trial.

Introduction: Firsekibart, an anti-interleukin (IL)-1β monoclonal antibody, has demonstrated more sustained control of gout flares compared with compound betamethasone in previous clinical studies. This study evaluated the efficacy and safety of firsekibart versus etoricoxib for the treatment of frequent gout flares.

Methods: In this phase 2, randomized, open-label, active-controlled, multicenter study (NCT05936268), adults with gout according to American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) 2015 criteria experiencing frequent flares (≥ 2 flares within 12 months pre-screening) were randomized (1:1) to receive either a single subcutaneous injection of firsekibart 200 mg, or once-daily oral etoricoxib 120 mg administered until pain remission or treatment intolerance for up to 8 days.

The Protective Activity of Apigenin Against Bone and Cartilage Diseases.

Bone and cartilage diseases have become the leading causes of joint disability due to the destruction of bone and cartilage. No effective drugs are available to cure bone and cartilage diseases. Exploring natural compounds as therapeutic alternatives shows promise.

Prospects and Challenges of Different Delivery Systems in Breast Tumors Therapy.

Breast cancer (BC) is the most prevalent malignancy in women. The emergence of targeted therapies and advancements in comprehensive treatment protocols have significantly improved survival outcomes for patients with early-stage BC. However, individuals with refractory BC, particularly those who have received multiple lines of therapy or presented with distant metastases at diagnosis, continue to face challenges due to the limitations of conventional antibodies and cytotoxic agents in meeting therapeutic needs.