The source and thermal driver of young (<3.0 Ga) lunar volcanism.

The thermal mechanism that drives the prolonged volcanism on the Moon, especially after the major pulse of Imbrian-aged eruptions, remains unknown. Here, we present a petrological and geochemical study of two types of young farside mare basalts, the ~2.8-billion year (Ga) low-Ti and ~2.

Optimizing multilevel interactions of paper straws using modified cellulose nanocrystal-based coatings to enhance PLA crystallization and microplastic capture efficiency.

Disposable plastics make up 80 % of marine waste, threatening aquatic ecosystems. Over time, these plastics decompose into harmful microplastics (MPs), which can potentially enter the human body. This study presents a novel PLA-CO coating (where 'x' represents the concentration of cellulose nanocrystals and organically modified montmorillonite (CNC-OMMT)), designed to enhance the performance of paper straws by mimicking Chinese candle dip molding.

The Clinical Spectrum of Rare Inherited Ichthyosis in China: A Review of Thirty-five Cases.

Inherited ichthyosis comprises a spectrum of genetic disorders related to over 50 pathogenic genes. However, there are limited data summarizing the clinical and molecular characteristics of Chinese patients. To broaden the knowledge of clinical and genetic characteristics of inherited ichthyosis and to optimize disease diagnosis and therapies, cases diagnosed with inherited ichthyosis in 1 tertiary centre from 2019 to 2023 were collected, excluding ichthyosis vulgaris and X-linked recessive ichthyosis, genomic sequencing was then performed, and clinical details of the patients were assessed.

A deep intronic founder variant in the SERPINB7 gene causing aberrant splicing is a potential therapeutic target for Nagashima-type palmoplantar keratoderma.

Background: Nagashima-type palmoplantar keratoderma (NPPK), caused by biallelic SERPINB7 loss-of-function variants, lacks effective treatments. Intriguingly, monoallelic exonic variants are observed in some patients with NPPK, suggesting additional genetic variants.

Objective: To characterize a deep intronic SERPINB7 variant's pathogenicity, elucidate its splicing dysregulation, and evaluate antisense oligonucleotide (ASO) therapy.

The gray matter microstructure and psychological resilience in patients with depression: A preliminary study using DSI/NODDI imaging.

Background: Psychological resilience serves as a crucial protective factor against depression, yet its microstructural neuroimaging correlates remain poorly understood. This study aimed to investigate gray matter microstructural features associated with psychological resilience levels in patients with depression.

Methods: Sixty-four patients with depression underwent diffusion spectrum imaging (DSI) and neurite orientation dispersion and density imaging (NODDI).

Discovery of a Potent, Selective, and Multiple His435 Mutation-Sensitive Thyroid Hormone Receptor β Agonist.

Beyond selectivity concerns for thyroid hormone receptor β (THR-β) agonists, intolerance to the His435 mutation remains a challenge. Following our previous study, we performed detailed modifications on the 7-position of isoquinoline, specifically targeting the hydrophobic region of the THR-β ligand-binding pocket (LBP). This led to the identification of compound , which showed potent THR-β agonistic activity (EC: 3.

Covalent Bridges in Bi Loaded BiVO Enabling Rapid Charge Transfer for Efficient Photocatalytic Water Oxidation.

Bismuth vanadate (BiVO) is known as one of the most potential candidates in photocatalytic water oxidation for supplying oxygen in extreme environment. However, its photocatalytic oxygen evolution is hindered by the rapid photogenerated charge carrier separation efficiency. Herein, plasmonic bismuth (Bi) nanoparticles loaded BiVO is prepared for photocatalytic water oxidation.

Dynamic early recruitment of GAK-Hsc70 regulates coated pit maturation.

Clathrin-mediated endocytosis (CME) begins with the assembly of clathrin onto the plasma membrane. These structures grow and stabilize to form clathrin-coated pits (CCPs), which invaginate and accumulate cargo. Finally, through membrane fission, CCPs detach to form clathrin-coated vesicles (CCVs).

Safety and efficacy of topical simvastatin plus cholesterol cream versus topical simvastatin cream alone for porokeratosis ptychotropica: A randomized, single-blind, split-body, placebo-controlled, investigator-initiated trial.

Background: Porokeratosis ptychotropica (PP) is a severe inherited skin disorder resistant to traditional treatments. Topical statins are being explored as a potential alternative.

Objective: To evaluate the efficacy and safety of topical simvastatin and simvastatin/cholesterol in treating PP.

Multi-omics analysis of the mechanisms of abundant theacrine and EGCG3"Me in tea (Camellia sinensis).

Theacrine and epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me) are notable secondary metabolites in tea (Camellia sinensis), celebrated for their unique flavors and significant health effects. Theacrine has a mild effect on nerve stimulation, while EGCG3"Me exhibits better stability, higher oral bioavailability and stronger biological activity. However, tea plant varieties naturally rich in both theacrine and EGCG3"Me are rare.

Cutaneous Nontuberculous Mycobacteria Infections Following Cosmetic Procedures: A Retrospective Study.

Background: Reports of skin infections associated with nontuberculous mycobacteria (NTM) following cosmetic procedures are increasing. The diagnosis and treatment of these infections remain a significant challenge for clinicians.

Objective: We examined the clinical characteristics, microbiology, histopathology, and treatment strategies of NTM infections following cosmetic procedures, including botulinum toxin injection, lipolysis injection, hyaluronic acid injection, mesotherapy, autologous fat grafting, and other related procedures.

Global, regional, and national burden of fracture of sternum and/or fracture of one or more ribs: a systematic analysis of incidence, YLDs with projections to 2030.

Background: Sternal and/or rib fractures represent a growing global health challenge. Despite their significant clinical and public health implications, epidemiological studies on these injuries remain limited. Utilizing the Global Burden of Disease 2019 (GBD2019) database, this study evaluates the worldwide burden of sternal and/or rib fractures and projects trends through 2030 to inform policy development.

Data-driven discovery of biaxially strained single atoms array for hydrogen production.

The structure-performance relationship for single atom catalysts has remained unclear due to the averaged coordination information obtained from most single-atom catalysts. Periodic array of single atoms may provide a platform to tackle this inaccuracy. Here, we develop a data-driven approach by incorporating high-throughput density functional theory computations and machine learning to screen candidates based on a library of 1248 sites from single atoms array anchored on biaxial-strained transition metal dichalcogenides.

A novel LSS variant leading to hypotrichosis with pseudoainhum.

Congenital alopecia/hypotrichosis constitutes a spectrum of rare inherited hair disorders characterized by partial to complete alopecia and possible structural hair shaft defects. The lanosterol synthase (LSS) gene, implicated in cholesterol biosynthesis, has emerged as a novel genetic determinant of congenital hypotrichosis. This article describes a 43-year-old female with congenital lanugo-like scalp hair and absence of eyebrows who later developed painful fibrotic constrictive bands on her fingers, culminating in pseudoainhum, but without manifestations of typical palmoplantar keratoderma (PPK).

An antibody-dependent cellular phagocytosis-related gene signature predicts survival and response to immunotherapy in stomach adenocarcinoma.

Antibody-dependent cellular phagocytosis (ADCP) is an immune biological process and plays a biological role in the clearance of tumor cells and the response to immune checkpoint inhibitors. However, the effects of ADCP on stomach adenocarcinoma (STAD) remain unclear. Clinical and genomic data were extracted from multiple datasets.

Tumor-specific CXCR6 positive precursor CD8 T cells mediate tumor control in metastatic melanoma.

Background: Adoptive cell therapy (ACT) mediates durable and complete regression of various cancers. However, its efficacy is limited by the long-term persistence of cytotoxic T lymphocytes, given their irreversible dysfunction within the tumor microenvironment. Herein, we aimed to establish an artificial lung metastasis model to examine T-lymphocyte subsets, in order to identify potential effective cell subsets for ACT.

A Dual-Response DNA Origami Platform for Imaging and Treatment of Sepsis-Associated Acute Kidney Injury.

Current diagnostics for sepsis-associated acute kidney injury (SA-AKI) detect kidney damage only at advanced stages, limiting opportunities for timely intervention. A DNA origami-based nanoplatform is developed for the early diagnosis and treatment of SA-AKI. Modified with a fluorophore (Cy5) and quencher (BHQ3), the DNA origami remains nonfluorescent under normal conditions.

Vegetation types shape the soil micro-food web compositions and soil multifunctionality in Loess Plateau.

Introduction: Vegetation degradation and soil erosion are severe problems in the Loess hilly region, rendering it one of the most ecologically vulnerable areas in China and globally. Vegetation restoration has been recognized as an effective approach to amending the fragile ecological environment and restoring degraded ecosystems.

Methods: The effects of different vegetation types: Carrière, L.

Combining virtual endoscopy and postmortem computed tomography to identify airway obstruction by a peritonsillar abscess as the cause of an asphyxia death.

Peritonsillar abscess (PTA) is the most common deep neck infection, with well-known complications such as airway stenosis and aspiration pneumonia. However, death due to asphyxia caused by PTA is extremely rare in forensic research reports. Traditionally, the autopsy is the standard diagnostic method for pharyngeal lesions in forensic practice.

Three-Channel Wavefront Shaping Using Non-Interleaved Spin-Multiplexed Plasmonic Metasurfaces.

Metasurfaces have garnered significant attention for their ability to manipulate light waves with multifunctional capabilities. Integrating independent wavefront controls within a single metasurface is essential to meet the growing demand for high-capacity, flat photonic devices. In this work, a versatile non-interleaved plasmonic metasurface platform utilizing quarter-wave plate meta-atoms for independent and simultaneous phase modulation of both co- and cross-polarized circularly polarized waves with subwavelength pixels, achieved by merging resonance and Pancharatnam-Berry phases is presented.

Reconfigurable Inverter Based on Ferroelectric-Gating MoS Field-Effect Transistors toward In-Memory Logic Operations.

With the advancement of information technology in contemporary society, there is an increasing demand for the rapid processing of large amounts of data. Concurrently, traditional silicon-based integrated circuits have reached their performance limits due to the exacerbation of non-ideal effects. This necessitates further multifunctionalities and miniaturization of modern integrated circuits.

Crippled Hepatocarcinogenesis Inhibition of Quercetin in Glycolysis Pathway with Hepatic Farnesoid X Receptor Deficiency.

Aim: Quercetin, a bioactive flavonoid extracted from traditional Chinese medicine, has antihepatocellular carcinoma effects. Farnesoid X receptor (FXR), a nuclear receptor highly expressed in the liver, plays important roles in maintaining hepatic glucose homeostasis, anti-inflammation, liver regeneration, and anti-cancer properties. Whether quercetin regulates the glycolysis/glycolysis pathway through FXR signaling remains unknown.

Alginate-based hydrogel beads for ultrasensitive detection and effective adsorption of terbium and europium in water.

Developing sustainable difunctional materials that allow for selective visual detection and efficient removal of rare earth elements ions (REE) is crucial for fostering an eco-friendly economy and protecting the environment. However, achieving both dual functionalities represents a significant challenge. In this work, we fabricated a unique hydrogel bead (DPA/GB) characterized by a high density of carboxyl groups and pyridine nitrogen atoms, through the hybridization of dipicolinic acid (DPA) and sodium alginate (SA) with calcium as a cross-linker.