Mechanistic Insights into Aflatoxin B and M Degradation by HNGD-Mq02 from Wheat Koji and Its Application in Food Detoxification.

Aflatoxin B (AFB), the most toxic and prevalent mycotoxin in food and feed, and its hydroxylated metabolite aflatoxin M (AFM), common in dairy products, pose serious health risks. Effective degradation of these toxins is thus a key goal in food safety. In this study, HNGD-Mq02 was isolated and assessed for its ability to degrade AFB and AFM.

Superpath is Superior to Posterolateral Approach for Hemiarthroplasty in Geriatric Patients with High Risk for Dislocation.

Background: Dislocation following hemiarthroplasty (HA) for femoral neck fractures in the elderly was a rare but severe complication. Tissue-sparing SuperPATH approach for HA had been described with promising results in terms of function recovery, transfusion and dislocation rate. The aim of the present study was to investigate the clinical outcomes, perioperative complications, and mortality rate through SuperPATH (SP) and posterolateral (PL) approach in geriatric patients with high dislocation risk.

Hydrochemistry and water quality assessment of the Kashi River Basin, China.

The Kashi River is an important source of daily water for local residents and provides irrigation water for the areas along its banks to support agricultural development. Meanwhile, the natural scenery of the river basin is also an important driving force for the development of regional tourism. Therefore, studying the water quality of river basins has significant practical significance for the sustainable development and utilization of local water resources and the protection of the ecological environment.

Comparative Analysis of Directional Snare vs Cutting Seton for High Anal Fistula Treatment.

BACKGROUND The cutting seton (CS) method uses a suture knot placed in the track of an anal fistula around the anal sphincter, which is tied using tension. This study aimed to compare outcomes in 60 patients with high anal fistula treated with a disposable directional snare or CS method. MATERIAL AND METHODS Sixty patients with high anal fistula were selected and randomly divided into 2 groups, with 30 patients in each group.

Obtuse-angled separation of chiral resonances with planar asymmetry-induced tunability of quality factors.

Photonic crystal (PhC) supports Bloch resonances that confine electromagnetic energy within the subwavelength thickness and enable polarization modulation through their intrinsic mode states. If a PhC generates chiral resonances, then it can selectively enhance or suppress specific circular polarizations, making it ideal for chiral optics. Here, we devise a design strategy to realize chiral resonant modes with large angular divergence and tunable quality factors ( factors) by introducing planar structural perturbations.

Contribution of dietary methionine to gut health and its related diseases: implications for precision nutrition.

Gut health is intricately linked to energy homeostasis, stress resistance, inflammation, and longevity. Methionine (Met) intake significantly influences gut health, with both supplementation and restriction showing distinct effects. While appropriate Met supplementation offers benefits, excessive intake can be harmful, whereas Met restriction appears to improve overall health of the body, especially the gut.

Corrigendum to "Nitric oxide synergizes Minoxidil delivered by transdermal hyaluronic acid liposomes for multimodal androgenetic-alopecia therapy" [Bioact. Mater. 32 (2024) 190-205].

[This corrects the article DOI: 10.1016/j.bioactmat.

Unraveling the Efficacy of AR Antagonists Bearing -(4-(Benzyloxy)phenyl)piperidine-1-sulfonamide Scaffold in Prostate Cancer Therapy by Targeting LBP Mutations.

Point mutations in the androgen receptor (AR) are significant drivers of resistance in prostate cancer (PCa), posing a great challenge to the development of effective treatment strategies. Building on our previous discovery of the suboptimal AR antagonist , we developed , which contains an -(4-(benzyloxy)phenyl)piperidine-1-sulfonamide scaffold through structural optimization and comprehensive screening against T878A-mutated AR. outperformed existing antiandrogens by fully antagonizing clinical AR mutations and effectively suppressing castration- and enzalutamide-resistant LNCaP cells proliferation .

The effect of clonal hematopoiesis on long-term outcomes in patients undergoing coronary artery bypass grafting.

Background: Clonal hematopoiesis of indeterminate potential (CHIP), characterized by age-related somatic mutations in hematopoietic stem and progenitor cells, has been identified as a potential risk factor for cardiovascular events and mortality. However, the significance of CHIP in the context of coronary artery bypass grafting (CABG) remains unexplored. We aim to investigate the potential impact of CHIP on long-term outcomes of patients who underwent CABG.

Dietary methionine restriction ameliorates atherosclerosis by remodeling the gut microbiota in apolipoprotein E-knockout mice.

Dietary methionine restriction (MR) has been shown to reduce the risk of atherosclerosis, but the specific regulatory effects and mechanisms remain unclear. This research intends to investigate the effects of MR on atherosclerosis in apolipoprotein E-knockout (ApoE) mice fed a high-fat, high-cholesterol, high-choline diet and their mechanisms. ApoE mice were fed a normal diet (0.

Myriocin Restores Metabolic Homeostasis in dAGE-Exposed Mice via AMPK-PGC1α-Mediated Mitochondrial Activation and Systemic Lipid/Glucose Regulation.

: Diet-derived advanced glycation end products (dAGEs) are closely associated with obesity and metabolic disorders. This study investigates the therapeutic potential of myriocin (Myr), a sphingolipid synthesis inhibitor, in counteracting dAGE-induced obesity and its underlying mechanisms. : Male C57BL/6J wild-type mice were randomly assigned to receive either a low-AGE diet or a high-AGE diet with or without the administration of myriocin for a duration of 24 weeks.

DON-Apt19S bioactive scaffold transplantation promotes spinal cord repair in rats with transected spinal cord injury by effectively recruiting endogenous neural stem cells and mesenchymal stem cells.

The spinal cord's limited regeneration is attributed to the scarcity of endogenous stem cells and a poor post-injury microenvironment in adult mammals. To overcome these challenges, we transplanted a DNA aptamer 19S (Apt19S) sustained-release decellularized optic nerve (DON) scaffold (DON-A) into completely transected spinal cord injury (SCI) site in rats and investigated its effect on endogenous stem cell recruitment and differentiation, which subsequently contributed to SCI repair. It has been demonstrated that Apt19S specifically binds to the membrane receptor alkaline phosphatase highly expressed on neural stem cells (NSCs) and mesenchymal stem cells (MSCs), and our study further proved that Apt19S can simultaneously recruit endogenous NSCs and MSCs to the lesion of SCI.

[Clinical study of reverse total shoulder arthroplasty versus open reduction and internal plate fixation for treatment of Neer three/four-part proximal humeral fractures in elderly].

Objective: To compare the effectiveness and shoulder function of reverse total shoulder arthroplasty (RTSA) and open reduction and internal fixation (ORIF) in the treatment of Neer three/four-part proximal humeral fractures in the elderly.

Methods: Randomized controlled analysis was conducted on 68 patients over 70 years old with Neer three/four-part proximal humeral fractures treated with RTSA or ORIF between January 2020 and June 2022. The patients were randomly divided into RTSA group ( =32) and ORIF group ( =36).

Decoding the Role of Molecular Orientation in Conjugated Self-Assembled Monolayers for High-Performance Binary Organic Photovoltaics Approaching 20% Efficiency.

Molecular orientation stands as the quintessential hallmark of conjugated self-assembled monolayers (SAMs), which have recently catalyzed noteworthy advancements in organic photovoltaics (OPVs). Nevertheless, an unambiguous understanding of these directional arrangements and their impact on optoelectronic properties remains elusive. To address this issue, herein three SAMs with representative orientations, i.

Preoperative three-dimensional simulation and clinical evaluation of bone harvesting in anterior cervical discectomy and fusion surgery.

Background: The supplemental harvesting of bone obtained from cervical vertebrae as cage-filling material in anterior cervical discectomy and fusion (ACDF) results in a good fusion outcome. This study aimed to further quantitatively evaluate the obtainable bone volume and clinical outcomes of cervical autogenous bone grafting based on a three-dimensional (3D) preoperative simulation.

Methods: This study included 78 patients who underwent single-level ACDF.

Association between Triglyceride-Glucose Index and Prognosis in Critically Ill Patients with Acute Coronary Syndrome: Evidence from the MIMIC Database.

This study aimed to investigate the association between triglyceride-glucose (TyG) index and prognosis in critically ill patients with acute coronary syndrome (ACS), exploring potential heterogeneity of the association among patient subgroups with different characteristics. Records of patients with ACS were extracted from the MIMIC-IV database. The association between TyG index and mortality was analyzed using Cox proportional-hazard regression model, while potential non-linear associations were assessed using restricted cubic spline (RCS) regression.

Hyaluronic acid-liposomes hybridized with HucMSC exosomes for enhanced exosomes transdermal delivery and acute skin photodamage repair.

Long-term exposure to ultraviolet (UV) radiation can damage human skin, resulting in photodamage. Repairing photodamaged skin has been a major focus of research in recent years. Extensive research has shown that human umbilical cord mesenchymal stem cell-derived exosomes (Exo) possess anti-inflammatory, pro-angiogenic, and wound healing properties, holding great potential for treating skin damage.

Adaptive Resistance of to Cefquinome Sulfate in an In Vitro Pharmacokinetic Model with Transcriptomic Insights.

Cefquinome sulfate has a strong killing effect against (), but bacterial resistance has become increasingly widespread. Experiments were conducted to investigate the pattern of adaptive resistance of to cefquinome sulfate under different dosage regimens by using pharmacokinetic-pharmacodynamics (PK-PD) modeling, and the adaptive-resistant bacteria in different states were screened and subjected to transcriptomic sequencing. The results showed that the minimum inhibitory concentration of Staphylococcus aureus under the action of cefquinome sulfate was 0.

Assessing hemorrhagic risks in combination therapy: implications of angiogenesis inhibitors and immune checkpoint inhibitors.

Objective: This study aims to evaluate the hemorrhage risk in solid tumor patients receiving angiogenesis inhibitors (AGIs), immune checkpoint inhibitors (ICIs), and their combination using the FDA Adverse Event Reporting System (FAERS) database.

Methods: Data from Q1 2011 to Q4 2023 were extracted from the FAERS database for solid tumor patients treated with AGIs, ICIs, or their combination. A disproportionality analysis was conducted by calculating the reporting odds ratio (ROR) and corresponding 95% confidence interval (CI), as well as the Proportional Reporting Ratio (PRR), to identify potential safety signals.

Modeling heat transfer and chemical reactions during pyrolysis of a single PCB particle.

Pyrolysis is a promising approach for recovering both metal and non-metal components from waste printed circuit boards (PCBs). The behavior of a single PCB particle is fundamental to all practical applications. This study develops a pyrolysis model that integrates heat transfer and reaction kinetics for a single PCB particle.

Etchless InSe Cavities Based on Bound States in the Continuum for Enhanced Exciton-Mediated Emission.

Recently, fervent research interest is sparked to indium selenide (γ-InSe) due to its dazzling optical and electronic properties. The direct bandgap in the near-infrared (NIR) range ensures efficient carrier recombination in InSe, promoting impressive competency for lavish NIR applications. Nevertheless, the photoluminescence (PL) efficiency of InSe is significantly limited by out-of-plane (OP) excitons, adverse to practical devices.

Near-infrared light-triggered nitric oxide-releasing hyaluronic acid hydrogel for precision transdermal therapy of androgenic alopecia.

Progressive follicle and vascular atrophy, insufficient nutrient supply, and hormonal imbalance are direct causes of androgenic alopecia (AGA), limiting treatment options. Nitric oxide (NO) has demonstrated significant advantages in cell proliferation, vascular repair, and inflammation regulation. However, precise control of NO concentration and efficient utilization limit its clinical application for AGA treatment.

Clinical value of aortic arch morphology in transfemoral TAVR: artificial intelligence evaluation.

Background: The impact of aortic arch (AA) morphology on the management of the procedural details and the clinical outcomes of the transfemoral artery (TF)-transcatheter aortic valve replacement (TAVR) has not been evaluated. The goal of this study was to evaluate the AA morphology of patients who had TF-TAVR using an artificial intelligence algorithm and then to evaluate its predictive value for clinical outcomes.

Materials And Methods: A total of 1480 consecutive patients undergoing TF-TAVR using a new-generation transcatheter heart valve at 12 institutes were included in this retrospective study.

Optimized Photochromic Performance of Spiropyran through Incorporation into Hydrogen-Bonded Organic Frameworks and Applications in Anticounterfeiting and Information Encryption.

Photostimulus-responsive fluorescent materials are promising for anticounterfeiting and UV printing due to rapid response and simple preparation. In this paper, we propose a novel strategy to prepare photostimulus-responsive materials SP@HOF-olefin by integrating the photochromic molecule spiropyran (SP) with postsynthetic modified hydrogen-bonded organic frameworks (HOF-olefin). Compared to SP@HOF, the composites SP@HOF-olefin exhibit enhanced photochromic properties, such as a fast response speed, pronounced color contrast, and exceptional fatigue resistance.

Deciphering key nano-bio interface descriptors to predict nanoparticle-induced lung fibrosis.

Background: The advancement of nanotechnology underscores the imperative need for establishing in silico predictive models to assess safety, particularly in the context of chronic respiratory afflictions such as lung fibrosis, a pathogenic transformation that is irreversible. While the compilation of predictive descriptors is pivotal for in silico model development, key features specifically tailored for predicting lung fibrosis remain elusive. This study aimed to uncover the essential predictive descriptors governing nanoparticle-induced pulmonary fibrosis.