Association analysis-based screening strategy for quality markers of Tengdan capsule in the treatment of hypertensive renal disease.

Background And Aim: Hypertensive Renal Disease (HRD) is a chronic and progressive condition driven by sustained high blood pressure, which leads to renal fibrosis and, eventually, end-stage kidney failure. Tengdan Capsule (TDC), a traditional Chinese medicinal formulation, has shown therapeutic potential for managing HRD. However, the specific quality markers (Q-markers) responsible for its efficacy and the underlying molecular mechanisms remain insufficiently understood.

Polysaccharides Mitigate Alzheimer's Disease Progression by Dynamic Regulation of Gut Microbiota Composition and Metabolites.

polysaccharides (CDPS) exhibit a range of pharmacological activities, most notably in immune modulation, anti-oxidation, and gut microbiota regulation. Emerging evidence suggests that restoring gut microbial and metabolic homeostasis may decelerate the progression of Alzheimer's disease (AD). However, the specific effects and underlying mechanisms of CDPS in the context of AD remain incompletely understood.

Co-resistance and plasmid-mediated co-dissemination of florfenicol and azithromycin resistance in non-O157 Shiga toxin-producing Escherichia coli from cattle in Xinjiang, China.

Background: Florfenicol is a critical antibiotic used in cattle to manage respiratory infections, while azithromycin is recommended for treating early-stage Shiga toxin-producing Escherichia coli (STEC) infections. This study focused on examining the co-resistance and mechanisms of co-dissemination of resistance to florfenicol and azithromycin in 367 non-O157 STEC strains isolated from cattle in Xinjiang between 2015 and 2023.

Results: Among these isolates, 16.

Early prediction of parotid glands secretory function based on ADC variations during radiotherapy for nasopharyngeal carcinoma: a phase II prospective study.

Objectives: This study aimed to quantify dynamic changes in the Apparent Diffusion Coefficient (ADC) values of the parotid glands during radiotherapy and explore their correlation with early-stage gland dysfunction.

Methods: Nasopharyngeal carcinoma patients receiving definitive chemoradiotherapy were prospectively enrolled. Magnetic Resonance Diffusion-Weighted Imaging (MR-DWI) was performed at pre-radiotherapy (pre-RT), the 5th, 15th fractions, and end of radiotherapy.

Comparative efficacy of pharmacological and non-pharmacological interventions on pain intensity of primary dysmenorrhoea: protocol for systematic review and network meta-analysis.

Introduction: Primary dysmenorrhoea (PD) is the most common gynaecological condition among young women and is associated with significant socioeconomic repercussions. It is unclear which works best for pain relief when pharmacological and non-pharmacological interventions are compared. This systematic review and network meta-analysis (NMA) will aim to compare and rank the effects of pharmacological and non-pharmacological interventions in patients with PD.

Prevalence of Serotype 4,[5],12:i:- from Human Sources: Antimicrobial Resistance, Genotypic Diversity and Emergence of Carbapenem Resistance - China, 2017-2023.

Introduction: 4,[5],12:i:-, a globally emerging pathogen with multidrug resistance (MDR), is spreading in China. Nationwide data on the antimicrobial resistance (AMR) and genomic characteristics of 4,[5],12:i:- from human sources in China are scarce. This study aimed to characterize the prevalence, genetic diversity, and AMR profiles of 4,[5],12:i:- in China.

Steady-state pharmacokinetics, efficacy, and safety of bictegravir in Chinese patients with HIV: an observational study.

Background: This study aimed to evaluate the steady-state plasma concentration, efficacy, and safety of bictegravir (BIC) in Chinese people with HIV (PWH) receiving BIC-based therapy for at least 6 months.

Research Design And Methods: PWH on BIC-based regimens for at least 6 months were enrolled. Plasma BIC concentrations, viral loads, CD4 T cell counts, weight, renal and hepatic function, and adverse reactions were assessed.

The oxacillinase variant, OXA-1152, in contributes to discrepancies in carbapenem resistance.

species are emerging multidrug-resistant pathogens with inconsistent carbapenem susceptibility, being resistant to meropenem but susceptible to imipenem, which complicates treatment. Here, we identified a previously uncharacterized oxacillinase gene, , in 12 strains from Wuhan, China. Deleting reduced meropenem and imipenem minimal inhibitory concentrations (MICs) by 64- and 4-fold, respectively, while reintroducing it into and restored resistance.

Impact of a Scarcity Mindset on Proactive and Reactive Cognitive Control: The Role of Motivation and Cognitive Ability.

Resource scarcity has been demonstrated to potentially induce a scarcity mindset in individuals, leading to a reduction in cognitive control. However, the specific facets of cognitive control affected by a scarcity mindset and the underlying mechanisms driving this effect remain not fully understood. Based on the dual mechanisms of control framework, this study examines the effects of a scarcity mindset on both proactive and reactive control (Experiment 1) and explores the underlying mechanisms (Experiment 2).

Stability study of recombinant 9-valent human papillomavirus vaccine based on expression system.

This study reports on the long-term stability of a recombinant 9-valent HPV vaccine, addressing a gap in the literature as previous research did not extend beyond 72 months. The vaccine targets HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58 and was produced using an expression system. We optimized soluble HPV L1 protein expression by truncating the - and C-termini, resulting in HPV L1 virus-like particles (VLPs).

Characterization of Strains Isolated from Adult Patients with Diarrhea and Aquatic Environments - Beijing Municipality, China, 2016-2022.

Introduction: is widely distributed in aquatic environments. This study describes the pathogenic characteristics of isolated from adult diarrhea patients and aquatic environments in Beijing, China.

Methods: isolates from patients with diarrhea and river water samples were assessed using whole-genome sequencing (WGS) and antibiotic resistance profiling.

Removal of dissolved organic matter in road runoff with sludge-based filters from the drinking water treatment plant.

Road runoff underwent treatment using a filter filled with sludge from drinking water treatment plants to assess its capacity for removing dissolved organic matter (DOM). This evaluation utilized resin fractionation, gel permeation chromatography, three-dimensional excitation-emission matrix fluorescence spectroscopy, and UV-Visible spectroscopy. The filter demonstrated enhanced efficiency in removing dissolved organic carbon, achieving removal rates between 70 and 80%.

The accumulation process of pollutants in deposited particles of different sizes on different roads in Beijing, China.

Road-Deposited Sediments (RDS) samples were collected from four different roads in Beijing, and the distribution of pollutants in RDS with various particle sizes was compared. In this study, the cumulative mass of RDS exhibited a positive correlation with the number of dry days, and the RDS load below 75 μm was also influenced by road traffic volume. As traffic volume escalated, there was a corresponding increase in the load of these smaller RDS.

Traditional Mongolian medicine Wu-Lan thirteen-flavor decoction protects rat from hypertension-induced renal injury via aryl hydrocarbon receptor-mediated pathway.

Background: Wu-Lan Thirteen-Flavour decoction (WLTd), a traditional Mongolian medicine, has been used for treating hypertension in clinical practice, but the chemical basis and underlying mechanisms remain unknown.

Methods: The main components of WLTd were identified and quantified using HPLC and UPLC-MS/MS techniques. A compound-target-disease network was constructed using network pharmacology analysis to forecast the potential anti-hypertension targets.

PARP7i Clinical Candidate RBN-2397 Exerts Antiviral Activity by Modulating Interferon-β Associated Innate Immune Response in Macrophages.

Polyadenosine diphosphate-ribose polymerase 7 (PARP7) acts as a suppressor of the type I interferon (IFN) signaling pathway via suppressing TANK-binding protein 1 (TBK1). Research study indicates that inhibition of PARP7 could potentially regulate tumor immunity. However, the effect of PARP7 inhibition on innate antiviral immunity in macrophages as well as the underlying mechanism have not been demonstrated else well.

and variants are the underlying cause of Perrault-like syndrome and cardiac anomalies in a patient.

Recent studies have established an association between variants and Perrault syndrome. In this case report, we present a female patient with Perrault syndrome and cardiomyopathy, resulting from variants in and , respectively.

Lanthanum chloride exerts therapeutic potential for chronic kidney disease by suppressing nanohydroxyapatite-induced mitophagy and mitochondria-mediated apoptosis.

Objective: To investigate the protective effect of lanthanum chloride on kidney injury in chronic kidney disease and its mechanism.

Methods: 1. Patients with CKD stage 2-5 were selected to analyze the effect of lanthanum-containing preparations on CKD.

Development and Validation of a High-Performance Liquid Chromatography Coupled With Ultraviolet Detection Method for Quantification of Bictegravir in Human Plasma.

Background: To establish a method for determining the bictegravir (BIC) concentration in human plasma using high-performance liquid chromatography coupled with ultraviolet detection.

Methods: The analysis was performed on a CLC-octadecylsilane column (150 × 6.0 mm, 5 μm) using a mixture of phosphate buffer and acetonitrile (62:38, v/v) as the mobile phase at the flow rate of 1.

Novel Bifunctional Conjugates Targeting PD-L1/PARP7 as Dual Immunotherapy for Potential Cancer Treatment.

Bifunctional conjugates targeting PD-L1/PARP7 were designed, synthesized, and evaluated for the first time. Compounds and showed potent activity against PD-1/PD-L1 interaction (IC = 0.426 and 0.

Perioperative management of a patient with unexpectedly detected early-stage ovarian mucinous carcinoma combined with progressive bulbar paralysis: a case report and literature review.

Background: Giant ovarian cysts (GOCs)complicated with progressive bulbar paralysis (PBP) are very rare, and no such literature about these cases have been reported. Through the diagnosis and treatment of this case, the perioperative related treatment of such patients was analyzed in detail, and early-stage ovarian mucinous carcinoma was unexpectedly found during the treatment, which provided reference for clinical diagnosis and treatment of this kind of diseases.

Case Presentation: In this article, we reported a 38-year-old female patient.

The first clinical validation of whole-genome screening on standard trophectoderm biopsies of preimplantation embryos.

Objective: To validate the performance of our laboratory-developed whole-genome screening assay within clinical preimplantation genetic testing environments.

Design: Perform a laboratory-developed whole-genome assay on both cell lines and trophectoderm biopsies, subsequently employing the next-generation sequencing procedure to reach a sequencing depth of 30X. Adhere to the Genome Analysis Toolkit best practices for accuracy, sensitivity, specificity, and precision calculations by comparing samples with references.

Rejection Sensitivity and Reactive Aggression in Early Adults: The Mediating Role of Loneliness and Maladaptive Coping.

Reactive aggression is an aggressive response to a perceived threat or provocation. It has detrimental effects on individuals and society. Rejection sensitivity, a disposition that one tends to anxiously expect, readily perceive, and intensely react to social rejection, has been associated with reactive aggression.

A preliminary study on plasma concentration, short-term efficacy, and safety profile of dolutegravir in Chinese people with HIV.

Background: This study examined the plasma concentration, clinical efficacy, and safety of dolutegravir (DTG) in Chinese people with HIV (PWH).

Methods: In this observational study, HIV-positive individuals on DTG-based regimens for at least 6 months were included. Plasma DTG concentrations were measured 1 month after initiating treatment.

Binding capacity and co-migration potential of Pb(II), Cu(II), and Cd(II) on colloids in road runoff.

To evaluate the co-migration potential between heavy metal ions and road runoff colloids, the influence of contact time, temperature, initial concentration of metal ions, pH, humic acid (HA), and polymetallic coexistence on the binding capacity of heavy metals onto runoff colloids were investigated. The adsorption of heavy metals by runoff colloids was extremely rapid, approximately 80% of the equilibrium adsorption capacity was achieved in the first 30 min. The binding capacity exhibited an increasing trend with the initial concentration of metal ions increasing, and the maximum adsorption capacities of Pb(II), Cu(II), and Cd(II) achieved 159.