Manganese-doped nickel-iron layered double hydroxides for enhanced peroxidase, oxidase, and catalase activities.

Nanozymes with multi-enzymatic activity in biomedical fields have gained significant attention. However, the effects of metal-doping elements on the structure-activity relationship of many nanomaterials remain insufficiently understood. Herein, we selected NiFe-LDH as the base material to systematically investigate how varying Mn doping ratios and specific Mn doping sites within the NiFe-LDH lattice influences peroxidase (POD), oxidase (OXD), and catalase (CAT) activities.

Src Reduces Neutrophil Extracellular Traps Generation and Resolves Acute Organ Damage.

Neutrophil extracellular traps (NETs) are key factors mediating acute inflammatory injury. However, the underlying mechanisms and potential therapeutic targets remain unclear. Previous results suggest Src may be involved in regulating the NETs formation.

Transcutaneous electrotherapy of facial nerve injuries based on dissolvable conductive microneedles.

Local electrical stimulation (LES) is a widely used clinical method to treat peripheral nerve injury. However, existing plate electrodes (PE) usually suffer from low electronic transport efficiency, whereas acupuncture electrical stimulation may cause damage to normal tissues. There is an urgent need to develop an innovative LES technique with efficient electronic transport, minimal tissue injury and enhanced biosafety.

Manganese-Copper Co-Doped NiFe-LDH Nanosheets toward Multi-Enzymatic Activities and Cascaded Synergistic Anti-Liver Tumor Therapy.

Primary liver cancer remains a significant global health challenge, with the majority of patients diagnosed at an unresectable stage, further complicated by liver dysfunction due to cirrhosis. To address these clinical hurdles, nanozyme-based catalytic therapy has emerged as a promising strategy. However, its therapeutic efficacy is often limited by self-protective mechanisms associated with the tumor microenvironment (TME), particularly the overexpression of glutathione (GSH) and hypoxia-induced metabolic adaptation.

Single-cell RNA sequencing reveals a B cell-related immunosuppressive landscape and a potential suppressor in hepatocellular carcinoma.

Background: The sophisticated tumour microenvironment is responsible for the malignant progression and poor prognosis of hepatocellular carcinoma (HCC). Discovering new therapeutic targets is desired for the preferable treatment of HCC patients.

Methods: To characterize the HCC microenvironment, the single-cell transcriptomes of HCC tissues and corresponding noncancerous tissues were analysed.

Effects of Chaetomium globosum and Trichoderma asperellum on root configuration and growth of cucumber seedlings.

In order to investigate the effects of Acer truncatum endophytic fungi Chaetomium globosum and Trichoderma asperellum on root configuration and growth of cucumber seedlings, "Xinjin No. 4" was used as experimental material and pot experiment was conducted. The experiment was set up with four treatments: a blank control (CK), a treatment with Chaetomium globosum at 100% concentration (CG), a treatment with Trichoderma asperellum at 100% concentration (TA), and a mixed strain treatment combining 50% Chaetomium globosum and 50% Trichoderma asperellum administered via root irrigation (GA).

Tackling Traditional: Tamil Gender Ideologies and their Socioeconomic Correlates.

Modernization theory posed gender ideology as a unidimensional continuum ranging from "traditional" to egalitarian with egalitarianism increasing as societies progress. Recent research replaces a unidimensional view with multidimensionality, but other modernization remnants remain. We tackle such remnants by examining gender ideologies and their socioeconomic correlates in Tamil Nadu, an Indian context often labeled "traditional.

Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.

Background And Purpose: Lysosomal membrane permeabilization (LMP) is exacerbated following spinal cord injury (SCI), leading to increased neuronal cell death. Ubiquitination may affect LMP by regulating the stability and functionality of lysosomal membranes. Semax, a synthetic heptapeptide, comprising the ACTH (4-7) fragment and a C-terminal Pro-Gly-Pro tripeptide, exhibits neuroprotective properties and improves cognitive function.

Molecular characterization and expression of in testes of the sterile male cattle-yak.

The male hybrid of cattle and yak is sterile, while the female is fertile. This is caused by aberrations with the process of spermatogenesis. SPATA22 plays a critical role in the pairing of homologous chromosomes, synapsis, DNA repair, and meiotic recombination; dysregulation of which can disrupt these processes, resulting in meiotic arrest and male sterility in mammals.

IBS May Have a Causal Effect on Increased Tryptophan Metabolites Levels: Insights from a Bidirectional Two-Sample Mendelian Randomization Study.

Background: Irritable Bowel Syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by abdominal pain and altered bowel habits. Tryptophan, an essential amino acid derived from dietary proteins, can be metabolized into various compounds by the gut microbiome. Emerging evidence suggests that tryptophan metabolites play a role in functional gastrointestinal disorders.

Oleuropein Regulates Bile Acid Metabolism via Modulating the Gut Microbiota, Thereby Alleviating DSS-Induced Ulcerative Colitis in Mice.

The pathogenesis of ulcerative colitis (UC) involves genetic, immunological, and environmental factors as well as gut microbiota dysbiosis. As a natural antioxidant with various pharmacological activities widely present in Oleaceae plants, oleuropein (OLE) exhibits anti-inflammatory, anti-tumor, antiviral, hypoglycemic, and cardioprotective effects. It has been validated that OLE extracted from olive oil can ameliorate UC.

Colorectal cancer risk in ulcerative colitis: an updated population-based systematic review and meta-analysis.

Background: Patients with ulcerative colitis (UC) face a heightened risk of colorectal cancer (CRC), though the estimated risk levels differ across UC populations. This study aims to provide updated, population-based estimates of CRC incidence, standardised incidence ratios (SIR), and prevalence in patients with UC.

Methods: We searched PubMed, Embase, and Cochrane Library to April 12, 2025, for population-based studies on patients with UC reporting CRC risk.

Effect of perioperative probiotic intervention on postoperative cognitive dysfunction in elderly patients: a randomized double- blinded and placebo-controlled trial.

Background: Postoperative cognitive dysfunction (POCD) may last for days, months or even years, leading to prolonged hospitalization and increased costs, increased mortality, and poor quality of life. Although POCD is an important clinical problem, its prevention, treatment strategies and effects are still limited. Therefore, this study aims to investigate the preventive effect of perioperative probiotic intervention on POCD in elderly patients, and further explore the mechanism of probiotics in improving postoperative cognitive function.

Polyclonal plasma cell (PolyPC) signature as a key indicator for predicting the progression of MGUS to multiple myeloma.

BackgroundMultiple myeloma (MM) is virtually always preceded by monoclonal gammopathy of undetermined significance (MGUS). Elevated serum markers are used to classify MGUS patients into clinical risk categories. Previous research has indicated that the absence of a normal plasma cell signature in MGUS is linked to early progression.

Specific distinguishing between miRNA and pre-miRNA by blocker displacement SMOS-qPCR.

MicroRNAs (miRNAs) play crucial roles in various biological processes, and their dysregulation is associated with numerous diseases. Accurate quantification of mature miRNAs is essential for their use as biomarkers. However, distinguishing between mature miRNAs and pre-miRNAs remains challenging.

Harnessing RGDS peptides to regulate bacterial-host interfaces for targeted antimicrobial therapy.

Refractory infections caused by pathogenic bacteria, particularly multidrug-resistant bacteria, pose a significant threat to global human health. Emerging host-directed antimicrobial strategies have the potential to prolong the effectiveness of existing treatments or eliminate the development of antibiotic resistance, representing a promising avenue for addressing infections caused by resistant bacteria. Here, we propose a mechanobiology-based host-directed antimicrobial strategy that utilizes an inhibitory fibronectin (Fn) peptide, Arg-Gly-Asp-Ser (RGDS), to regulate bacterial-host interfacial adhesion forces and thereby effectively combat multidrug-resistant bacterial infections.

Prognostic Impact of the Pathologic Response of Patients with Hepatocellular Carcinoma After Preoperative Treatments.

Background: Hepatocellular carcinoma (HCC) exhibits varying degrees of tumor regression after preoperative treatments. However, the relationship between a tumor residual and its impact on recurrence-free survival (RFS) remains poorly defined. This study aimed to assess the effect of pathologic response on RFS in HCC patients undergoing preoperative treatments.

[Characteristics of soil organic carbon components across a chronosequence of plantations in Rainy Area of Western China].

Soil organic carbon (SOC) components are crucial indicators of soil fertility and carbon sequestration capacity, playing a pivotal role in maintaining global carbon balance. However, the dynamics of SOC components across plantations with different stand ages remain poorly understood. In this study, we collected soil samples (0-15 cm and 15-30 cm) from 7, 13, 24, 33 and 53 years stands of plantations in the Rainy Area of Western China to quantify the contents of different SOC components, including particulate organic carbon (POC), easily oxidized organic carbon (EOC), light fraction organic carbon (LFOC), heavy fraction organic carbon (HFOC), labile organic carbon (LOC), and inert organic carbon (IOC).

Predicting the immune therapy response of advanced non-small cell lung cancer based on primary tumor and lymph node radiomics features.

Objective: To identify imaging biomarkers of primary tumors and lymph nodes in patients with stage III-IV non-small cell lung cancer (NSCLC) and assess their predictive ability for treatment response (response vs. non-response) to immune checkpoint inhibitors (ICIs) after 6 months.

Methods: Retrospective analysis of 83 NSCLC patients treated with ICIs.

Effects of vegetation restoration on soil microbial necromass carbon and organic carbon in grazed and degraded sandy land.

Vegetation restoration effectively enhances carbon (C) sequestration and supports the sustainable management of degraded ecosystems. However, its impact on the accumulation of microbial necromass C (NC) and soil organic C (SOC) in degraded and grazed sandy land remains unclear. This study evaluated six restoration types-grazing plot (control), grassland, scrubland, and forestland of Populus alba, Pinus tabuliformis, and Robinia pseudoacacia-to analyze microbial NC and SOC accumulation and identify the factors influencing these changes from the perspectives of soil nutrients, microbial structure, diversity, and activity.