Manganese-Copper Co-Doped NiFe-LDH Nanosheets toward Multi-Enzymatic Activities and Cascaded Synergistic Anti-Liver Tumor Therapy.

Primary liver cancer remains a significant global health challenge, with the majority of patients diagnosed at an unresectable stage, further complicated by liver dysfunction due to cirrhosis. To address these clinical hurdles, nanozyme-based catalytic therapy has emerged as a promising strategy. However, its therapeutic efficacy is often limited by self-protective mechanisms associated with the tumor microenvironment (TME), particularly the overexpression of glutathione (GSH) and hypoxia-induced metabolic adaptation.

A synergistic strategy of Fe doping and anion protection enables efficient and robust seawater electrolysis.

Seawater electrolysis is a promising method for producing hydrogen, but the generation of corrosive chlorine species (, chloride and hypochlorite) at anodes remains a critical challenge. Herein, with the use of Ni foam (NF) as a catalyst support, we developed a FeNiP/MoO/NiMoO/NF as the anode for alkaline seawater oxidation. The incorporation of Fe enhances charge transfer and promotes the generation of active sites, and the generated PO and MoO species effectively repel Cl, thereby significantly enhancing the electrode's corrosion resistance.

Palladium-chloride ion coordination stabilizes NiFe layered double hydroxides for alkaline seawater oxidation at industrial current densities.

Seawater electrolysis represents a promising route for sustainable hydrogen production, offering substantial potential for large-scale energy conversion applications. However, ample chloride ions (Cl) in seawater promote competitive chlorine evolution reaction at the anode, compromising oxidation selectivity and significantly shortening electrode lifespan, particularly under industrial-level current densities (j). In this study, a self-supported Ni-foam electrode was synthesized by anchoring palladium (Pd) nanoparticles on NiFe layered double hydroxide (Pd@NiFe LDH/NF) to serve as a robust catalyst for alkaline seawater oxidation (ASO).

Engineered PW-polyoxometalate docked Fe sites on CoFe hydroxide anode for durable seawater electrolysis.

Seawater electrolysis driven by offshore renewable energy is a promising avenue for large-scale hydrogen production but faces challenges in designing robust anodes that suppress surface chlorine reactions and corrosion at high current densities. Here we report a strategy by selectively docking PW-polyoxometalate (PW-POM) onto Fe sites of CoFe hydroxide anode to modulate the electronic structure of adjacent Co active centers and regulate Cl⁻/OH⁻ adsorption for efficient alkaline seawater oxidation. Our CoFe-based anode achieves low overpotentials, high catalytic selectivity, and notable durability, with continuous operation at 1 A cm⁻² for over 1300 hours and at 2 A cm⁻² more than 600 hours.

Artificial intelligence-enabled analysis methods and their applications in food chemistry.

Food chemistry is a science that studies the composition, properties, and changes of food at the chemical and molecular levels, as well as their relationships to human health. With the rapid advancement of artificial intelligence (AI) technology, the field of food chemistry has undergone significant transformation, and new development opportunities have emerged. AI provides efficient, precise, and intelligent solutions for food analysis.

Research progress in high-throughput DNA synthesis and its applications.

In recent years, the development of high-throughput DNA synthesis technology has significantly advanced research in genomics and synthetic biology. Traditional DNA synthesis methods, such as first-generation DNA synthesizer and PCR-based approaches, have demonstrated excellent performance in many aspects. However, they exhibit notable limitations in synthesis of long-chain DNA and large-scale parallel synthesis.

High-Coverage Ce(OH)₃-Decorated NiFe Layered Double Hydroxide for Durable Seawater Oxidation at Ampere-Scale Current Densities.

Seawater electrolysis powered by offshore renewable energy, provides an attractive approach for green hydrogen production. Yet, the abundant chloride ions (Cl⁻) in seawater pose severe challenges to the long-term stability of anode materials, particularly under industrial current densities. Herein, a high-coverage Ce(OH)₃-decorated nickel-iron layered double hydroxide (NiFe LDH) electrocatalyst is reported, in which Ce(OH)₃ undergoes in situ transformation into CeO₂ during alkaline seawater oxidation (ASO), forming a robust protective layer that effectively repels Cl⁻.

Amorphous Phosphates Tailor Local Proton Supply for Alkaline Hydrogen Evolution Electrocatalysis.

Hydrogen (H) is irreplaceable as a feedstock in varied industrial scenarios, and alkaline water electrolysis allows for H production without costly proton exchange membrane and noble metals with limited reserves. However, alkaline solution is devoid of directly available protons, leading to suboptimal electrochemical H-evolving kinetics even on catalysts with high intrinsic activities like CoP. On the other hand, high local acidity (i.

Hexafluorophosphate additive enables durable seawater oxidation at ampere-level current density.

Direct seawater electrolysis at ampere-level current densities, powered by coastal/offshore renewables, is an attractive avenue for sustainable hydrogen production but is undermined by chloride-induced anode degradation. Here we demonstrate the use of hexafluorophosphate (PF₆⁻) as an electrolyte additive to overcome this limitation, achieving prolonged operation for over 5,000 hours at 1 A cm and 2300 hours at 2 A cm using NiFe layered double hydroxide (LDH) as anode. Together with the experimental findings, PF₆⁻ can intercalate into LDH interlayers and adsorb onto the electrode surface under an applied electric field, blocking Cl⁻ and stabilizing Fe to prevent segregation.

Ultra-stable seawater oxidation at 1.5 A cm enabled by heptafluorotantalate intercalated NiFe layered double hydroxide.

Seawater electrolysis is a facile, economical, and ecologically friendly approach for large-scale hydrogen production. However, the presence of chloride ions (Cl) in seawater can cause severe anode corrosion, which hinders its further application. Herein, a heptafluorotantalate (TaF) intercalated NiFe layered double hydroxide on Ni foam (TF-NiFe LDH/NF) is proposed for efficient and durable alkaline seawater oxidation (ASO).

Zr-doped porous NiP nanoarray as a highly efficient electrocatalyst for hydrogen evolution reaction in alkaline seawater.

The utilization of seawater electrolysis is recognized as a promising method for generating hydrogen as a substitute for conventional technology. Herein, the electrodes were fabricated bygrowth of Zr-NiP arrays on a nickel foam substrate (Zr-NiP/NF) through a low-temperature hydrothermal and phosphating process. The Zr-NiP/NF can achieve efficient hydrogen evolution reaction (HER) performance in alkaline seawater electrolyte.

Apical Anchoring and Cofactor Customizing To Achieve Ultrahigh Active Nanoenzymes for Removing O Interference in Glucose Electro-oxidation.

Noble metal nanozymes (NMs) are promising alternatives to the fragile glucose oxidase (GOD), however, in all previously reported NMs, O consumes electrons from glucose by competing with electrodes, which remarkably limits the Faraday efficiency. The low NM utilization rate and sluggish mass transfer severely limit the electrocatalytic activity. Herein, we report the first Au nanozyme that can catalyze glucose electro-oxidation (GEO) via a distinctive O immune pathway with record-breaking mass activity based on apical anchoring and cofactor customization.

A hierarchical NiPO@NiFe LDH nanoarray for durable seawater oxidation.

Seawater electrolysis, benefiting from the closeness to coastal areas, is recognized as a promising alternative for hydrogen (H) production to replace conventional technologies. However, the effectiveness of this method is limited by anode catalysts that exhibit high energy consumption and short lifespans due to chloride-induced chemical corrosion. Herein, we propose a hierarchical Ni phosphate@NiFe layered double hydroxide on Ni foam (NiPO@NiFe LDH/NF) towards alkaline seawater oxidation (ASO).

Ultrasensitive Electrochemical Screening of Circulating Tumor Cells Over Single-Atom Nanozyme Integrated 3D Nanoarray.

Late-stage diagnosis is a major contributor to cancer mortality and thus leads to increased fatality, making early detection crucial for improving survival rates. Circulating tumor cells (CTC), detectable before primary tumors become clinically apparent, have emerged as vital biomarkers for the early identification of aggressive cancers. Here, develop a single-atom nanozyme integrated nanoarray as a 3D nano-biointerface for ultrasensitive electrochemical screening of CTCs from hepatocellular carcinoma.

Poly(Acid Yellow 17)-Modified CoFe-Layered Double Hydroxide Achieves Long-Term Alkaline Seawater Oxidation.

Seawater electrolysis powered by renewable energy is a promising technique for green hydrogen production. However, the high concentration of chloride ions (Cl) and their derivatives in seawater can severely corrode the anode catalyst, significantly challenging the lifespan of electrolyzers. Herein, we present a poly(acid yellow 17) (PAY) layer-modified CoFe-layered double hydroxide nanoarrays on nickel foam (CoFe LDH@PAY/NF), which serves as an efficient and stable electrocatalyst for alkaline seawater oxidation (ASO).

Transition Metal-Coordinated Polymer Achieves Stable Seawater Oxidation over NiFe Layered Double Hydroxide.

Seawater electrolysis has emerged as a promising approach for the generation of hydrogen energy, but the production of deleterious chlorine derivatives (e.g., chloride and hypochlorite) presents a significant challenge due to the severe corrosion at the anode.

Advances in Electrochemical Nitrite Reduction toward Nitric Oxide Synthesis for Biomedical Applications.

Nitric oxide (NO) is an essential molecule in biomedicine, recognized for its antibacterial properties, neuronal modulation, and use in inhalation therapies. The effectiveness of NO-based treatments relies on precise control of NO concentrations tailored to specific therapeutic needs. Electrochemical generation of NO (E-NOgen) via nitrite (NO ) reduction offers a scalable and efficient route for controlled NO production, while also addressing environmental concerns by reducing NO pollution and maintaining nitrogen cycle balance.

Polycalmagite Coating Enables Long-Term Alkaline Seawater Oxidation Over NiFe Layered Double Hydroxide.

Renewable energy-powered seawater electrolysis is a green and attractive technique for producing high-purity hydrogen. However, severe chlorideions (Cl) and their derivatives tend to corrode anodic catalysts at ampere-level current densities and hinder the application of seawater-to-H systems. Herein, a polycalmagite (PCM)-coated NiFe layered double hydroxide is presented on Ni foam (NiFe LDH@PCM/NF) that exhibits exceptional stability in alkaline seawater.

NiFe-based arrays with manganese dioxide enhance chloride blocking for durable alkaline seawater oxidation.

Seawater splitting is increasingly recognized as a promising technique for hydrogen production, while the lack of good electrocatalysts and detrimental chlorine chemistry may hinder further development of this technology. Here, the interfacial engineering of manganese dioxide nanoparticles decorated on NiFe layered double hydroxide supported on nickel foam (MnO@NiFe LDH/NF) is reported, which works as a robust catalyst for alkaline seawater oxidation. Density functional theory calculations and experiment findings reveal that MnO@NiFe LDH/NF can selectively enrich OH and repel Cl in oxygen evolution reaction (OER).

Expanded Negative Electrostatic Network-Assisted Seawater Oxidation and High-Salinity Seawater Reutilization.

Coastal/offshore renewable energy sources combined with seawater splitting offer an attractive means for large-scale H electrosynthesis in the future. However, designing anodes proves rather challenging, as surface chlorine chemistry must be blocked, particularly at high current densities (). Additionally, waste seawater with increased salinity produced after long-term electrolysis would impair the whole process sustainability.

Advances in nanozymes with peroxidase-like activity for biosensing and disease therapy applications.

Natural enzymes are crucial in biological systems and widely used in biomedicine, but their disadvantages, such as insufficient stability and high cost, have limited their widespread application. Since discovering the enzyme-like activity of FeO nanoparticles, extensive research progress in diverse nanozymes has been made with their in-depth investigation, resulting in rapid development of related nanotechnologies. Nanozymes can compensate for the defects of natural enzymes and show higher stability with lower costs.

Ultrastable Seawater Oxidation at Ampere-level Current Densities with Corrosion-resistant CoCO/CoFe Layered Double Hydroxide Electrocatalyst.

Hydrogen is an essential energy resource, playing a pivotal role in advancing a sustainable future. Electrolysis of seawater shows great potential for large-scale hydrogen production but encounters challenges such as electrode corrosion caused by chlorine evolution. Herein, a durable CoCO/CoFe layered double hydroxide (LDH) electrocatalyst is presented for alkaline seawater oxidation, showcasing resistance to corrosion and stable operation exceeding 1,000 h at a high current density of 1 A cm.

Nebulized inhalation drug delivery: clinical applications and advancements in research.

Nebulized inhalation administration refers to the dispersion of drugs into small droplets suspended in the gas through a nebulized device, which are deposited in the respiratory tract by inhalation, to achieve the local therapeutic effect of the respiratory tract. Compared with other drug delivery methods, nebulized inhalation has the advantages of fast effect, high local drug concentration, less dosage, convenient application and less systemic adverse reactions, and has become one of the main drug delivery methods for the treatment of respiratory diseases. In this review, we first discuss the characteristics of nebulized inhalation, including its principles and influencing factors.