Manganese-doped nickel-iron layered double hydroxides for enhanced peroxidase, oxidase, and catalase activities.

Nanozymes with multi-enzymatic activity in biomedical fields have gained significant attention. However, the effects of metal-doping elements on the structure-activity relationship of many nanomaterials remain insufficiently understood. Herein, we selected NiFe-LDH as the base material to systematically investigate how varying Mn doping ratios and specific Mn doping sites within the NiFe-LDH lattice influences peroxidase (POD), oxidase (OXD), and catalase (CAT) activities.

Manganese-Copper Co-Doped NiFe-LDH Nanosheets toward Multi-Enzymatic Activities and Cascaded Synergistic Anti-Liver Tumor Therapy.

Primary liver cancer remains a significant global health challenge, with the majority of patients diagnosed at an unresectable stage, further complicated by liver dysfunction due to cirrhosis. To address these clinical hurdles, nanozyme-based catalytic therapy has emerged as a promising strategy. However, its therapeutic efficacy is often limited by self-protective mechanisms associated with the tumor microenvironment (TME), particularly the overexpression of glutathione (GSH) and hypoxia-induced metabolic adaptation.