Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Patients with ulcerative colitis (UC) face a heightened risk of colorectal cancer (CRC), though the estimated risk levels differ across UC populations. This study aims to provide updated, population-based estimates of CRC incidence, standardised incidence ratios (SIR), and prevalence in patients with UC.
Methods: We searched PubMed, Embase, and Cochrane Library to April 12, 2025, for population-based studies on patients with UC reporting CRC risk. Study quality was assessed using the Newcastle-Ottawa Scale. The primary outcome was CRC risk in UC, evaluated through incidence, SIR, and prevalence. A random-effects model was used for meta-analysis, and meta-regression evaluated the impact of study characteristics. Publication bias was assessed using funnel plots and statistical tests. PROSPERO: CRD42025634800.
Findings: From 7991 records, 13 population-based studies involving 161,157 patients with UC were included. Most studies were conducted in Europe, with others from North America and Asia. All studies were of good quality, with scores greater than 5 on the NOS quality assessment scale. The pooled CRC incidence was 1.47 per 1000 person-years (95% CI 1.30-1.67; I = 66.2%), the SIR was 2.48 (95% CI 1.64-3.76; I = 91.7%), and the prevalence was 1.54% (95% CI 1.14-1.99; I = 96.1%). Subgroup analyses revealed similar CRC risk in male (SIR 2.14, 95% CI 0.85-5.38) and female (SIR 2.20, 95% CI 1.52-3.19) patients and an increased risk with extensive colitis, with an SIR of 3.95 (95% CI 2.56-6.09).
Interpretation: This systematic review and meta-analysis provides population-based estimates of CRC risk in patients with UC, based on high-quality studies with rigorous methodology. The results offer reliable reference values for incidence, SIR, and prevalence, which are applicable to the broader UC population and relevant to clinical decision-making and public health planning. Nonetheless, substantial heterogeneity across studies and limited geographic representation-particularly from Asia, South America, Africa, and Oceania-highlight the need for additional population-based research in underrepresented regions to improve the global applicability of CRC risk estimates in UC.
Funding: This study was supported by State key Laboratory of Digestive Health.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150054 | PMC |
| http://dx.doi.org/10.1016/j.eclinm.2025.103269 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neuro-Immuno-Stromal Context in Colorectal Cancer: An Enteric Glial Cell-Driven Prognostic Model via Machine Learning Predicts Survival, Recurrence, and Therapy Response.
Exp Cell Res
September 2025
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Gastrointestinal Cancer Center, Peking University Cancer Hospital and Institute, Beijing, China. Electronic address:
Background: Enteric glial cells (EGCs) have been implicated in colorectal cancer (CRC) progression. This study aimed to develop and validate a prognostic model integrating EGC- and CRC-associated gene expression to predict patient survival, recurrence, metastasis, and therapy response.
Methods: Bulk and single-cell RNA sequencing data were analyzed, and a machine learning-based model was constructed using the RSF random forest algorithm.
The role of CT Colonography in the assessment of inflammatory bowel Diseases patients.
Eur J Radiol
August 2025
Unità Operativa di Radiologia, ASST Fatebenefratelli Sacco, L. Sacco University Hospital, Milan, Italy. Electronic address:
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and Ulcerative Colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract, and its long-standing course significantly elevates the risk of colorectal cancer (CRC), primarily arising from dysplastic lesions. While regular surveillance by colonoscopy is well established for UC patients, guidelines for CD remain uncertain. Computed Tomographic Colonography (CTC) offers a minimally invasive alternative for evaluating the colon, particularly in cases where colonoscopy is incomplete or contraindicated.
View Article and Find Full Text PDFPrognostic Value of CRP-Albumin-Lymphocyte (CALLY) Index in Colorectal Cancer Survival: A Multicenter Retrospective Cohort Study.
J Gastrointest Cancer
September 2025
Firoozabadi Clinical Research Development Unit (F A CRD U), Iran , University of Medical Sciences (IUMS), Tehran, Iran.
Background: Colorectal cancer (CRC) has become one of the major health burdens in the world with high mortality rates, especially at the advanced stages. The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is a novel multidimensional biomarker combining systemic inflammation, nutritional status, and immune function. This study evaluated the association between the CALLY index and overall survival (OS) as well as recurrence-free survival (RFS) in colorectal cancer (CRC) patients.
View Article and Find Full Text PDFDeep Learning Based Multiomics Model for Risk Stratification of Postoperative Distant Metastasis in Colorectal Cancer.
Acad Radiol
September 2025
Department of Radiology, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang Province, China (S.D., X.N., L.Y., W.A.); Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, Zhejiang Province, China (W.A.). Electronic address:
Rationale And Objectives: To develop deep learning-based multiomics models for predicting postoperative distant metastasis (DM) and evaluating survival prognosis in colorectal cancer (CRC) patients.
Materials And Methods: This retrospective study included 521 CRC patients who underwent curative surgery at two centers. Preoperative CT and postoperative hematoxylin-eosin (HE) stained slides were collected.
Epidemiology of Early-onset Colorectal Cancer in a Safety-net Hospital System in Texas.
J Clin Gastroenterol
October 2025
Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine.
Goals: We aimed to characterize risk factors for early versus advanced-stage early-onset colorectal cancer (eoCRC) at our safety-net hospital system.
Background: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in the United States. Rates of CRC diagnosis in young adults (age below 50) have been rising despite an overall decrease in CRC.