Neuro-Immuno-Stromal Context in Colorectal Cancer: An Enteric Glial Cell-Driven Prognostic Model via Machine Learning Predicts Survival, Recurrence, and Therapy Response.

Background: Enteric glial cells (EGCs) have been implicated in colorectal cancer (CRC) progression. This study aimed to develop and validate a prognostic model integrating EGC- and CRC-associated gene expression to predict patient survival, recurrence, metastasis, and therapy response.

Methods: Bulk and single-cell RNA sequencing data were analyzed, and a machine learning-based model was constructed using the RSF random forest algorithm.

Appraisal of Residual Tumor Burden on Survival Prognosis Following Neoadjuvant Chemotherapy in Locally Advanced Gastric Cancer: A Multicenter Cohort Study.

Background: The eighth edition American Joint Committee on Cancer (AJCC) guidelines introduced the postneoadjuvant therapy pathologic tumor, node, metastasis (ypTNM) staging system to assess gastric cancer prognosis postneoadjuvant chemotherapy; however, it overlooks other residual tumor burden aspects beyond tumor infiltration depth and positive lymph nodes.

Methods: Data from 537 locally advanced gastric cancer patients (cT2-4NanyM0) treated with neoadjuvant chemotherapy (2010-2021) across six tertiary centers were analyzed. Prognostic factors for overall survival (OS) and recurrence-free survival (RFS) were identified using Cox regression.

Origami Silicon Anodes: Geometric Design for Structural Elasticity and Connectivity.

Achieving stable cycling of high-capacity battery electrodes with large volume changes remains a significant challenge, with their mechanical failure and sluggish kinetics, primarily due to inadequate structural accommodation and inefficient transport pathways. Here, a magnesiothermic crystallization approach is presented to construct origami capsule (OC) architectures, imparting flexibility and conformability to inherently brittle silicon, featuring highly interconnected 2D silicon nanosheets (2.5 nm thickness) with built-in nanopores encapsulated within a pressure-tolerant conformal microshell.

Sieving pore design enables stable and fast alloying chemistry of silicon negative electrodes in Li-ion batteries.

Ideal silicon negative electrodes for high-energy lithium-ion batteries are expected to feature high capacity, minimal expansion, long lifespan, and fast charging. Yet, engineered silicon materials face a fundamental paradox associated with particle deformation and charge transfer, which hinders the industrial use of advanced silicon electrode materials. Here we show a sieving-pore design for carbon supports that overcomes these mechano-kinetic limitations to enable stable, fast (de)alloying chemistries of silicon negative electrodes.

Surgical and oncological outcomes of laparoscopic versus open gastrectomy after neoadjuvant chemotherapy in patients with locally advanced gastric cancer: A multicenter analysis.

Background: Evidence based on large-scale samples comparing the efficacy of laparoscopic gastrectomy (LG) and open gastrectomy (OG) in patients with locally advanced gastric cancer (LAGC) after neoadjuvant chemotherapy (NACT) remains limited. This multicenter study aimed to evaluate the short -term and oncological outcomes of LG and OG after NACT.

Methods: Data from a multicenter database of LAGC patients undergoing radical gastrectomy after NACT across 12 centers in China.

Optimal response population after neoadjuvant therapy for patients with locally advanced gastric cancer: A multicenter study.

Objective: Pathologic complete response (pCR) following neoadjuvant therapy (NAT) for gastric cancer (GC) is rare but associated with a favorable prognosis. This study aims to reassess the optimal response population (ORP) following NAT by evaluating the prognostic outcomes associated with various T and N stages, utilizing multicenter data from China.

Methods: Patients who underwent NAT following radical gastrectomy at 10 tertiary hospitals in China between 2008 and 2021 were included.

Patterns of Survival and Recurrence in Poor Responders to Neoadjuvant Therapy for Gastric Cancer: A Real-World Multicenter Study.

Background: Neoadjuvant therapy (NAT) is increasingly used in locally advanced gastric cancer (LAGC), but a significant proportion of patients respond poorly, causing adverse outcomes. Few studies have specifically examined the prognosis of this subgroup. This study aimed to analyze survival and recurrence in poor responders to guide follow-up and treatment strategies.

Facile synthesis of CsPbBr perovskite for improved stability and luminescence behavior in an aquatic environment.

CsPbBr (CPB) perovskite has demonstrated unique advantages as a photoelectric material. However, its stability and optoelectronic properties exhibit significantly susceptibility to environmental conditions during practical applications. Additionally, the synthesis of CPB often involves complex procedures and stringent requirements for the experimental environment, resulting in low yield.

Beyond Polymerization: In Situ Coupled Fluorination Enables More Stable Interfaces for Solid-State Lithium Batteries.

In situ polymerization strategies hold great promise for enhancing the physical interfacial stability in solid-state batteries, yet (electro)chemical degradation of polymerized interfaces, especially at high voltages, remains a critical challenge. Herein, we find interphase engineering is crucial for the polymerization process and polymer stability and pioneer an in situ polymerization-fluorination (Poly-FR) strategy to create durable interfaces with excellent physical and (electro)chemical stabilities, achieved by designing a bifunctional initiator for both polymerization and on-surface lithium donor reactions. The integrated in situ fluorination converts LiCO impurities on LiNiCoMnO (NCM811) surfaces into LiF-rich interphases, effectively inhibiting the aggressive (de)lithiation intermediates and protecting the interface from underlying chemical degradation, thereby surpassing the stability limitations of polymerization alone.

Reversing Surface Charge for Highly-Active Organic Photovoltaic Catalysts.

Organic photovoltaic materials typically exhibit low charge separation and transfer efficiency and severe exciton/carrier recombination due to high exciton binding energy and short exciton diffusion lengths, limiting the enhancement of photocatalytic hydrogen evolution performance. Here, we introduce a surface charge reversal strategy to regulate the charge character of organic photovoltaic catalyst (OPC). Compared to OPC nanoparticles (NPs) stabilized by an anionic surfactant ((-) NPs), NPs stabilized by a cationic surfactant ((+) NPs) exhibit a raised Fermi level, larger surface band bending and Schottky barrier, thereby enhancing charge separation and transfer efficiency while suppressing charge carrier recombination.

Effect of Adjuvant Chemotherapy Cycles on Patients with Node-Negative Gastric Cancer Following Neoadjuvant Chemotherapy: Multicenter Cohort Study.

Background: Research investigating the potential impact of postoperative adjuvant chemotherapy cycles on patients with lymph node-negative gastric cancer following neoadjuvant chemotherapy is currently sparse. This study aims to explore the effect of adjuvant chemotherapy cycles on the prognosis of this specific patient group.

Patients And Methods: We analyzed clinicopathological data from patients at four institutions between 2010 and 2020.

The value of amide proton transfer imaging in assessing brain damage in patients with obstructive sleep apnea.

Objective: To investigate the application value of amide proton transfer (APT) magnetic resonance imaging in evaluating brain damage in patients with obstructive sleep apnea (OSA).

Materials And Methods: 49 OSA patients and 25 healthy individuals matched for age and sex were included as case and control groups. All study participants underwent conventional 3D T1WI and APT imaging of the head.

Assessment of thermal power plant CO emissions quantification performance and uncertainty of measurements by ground-based remote sensing.

Thermal power plants serve as significant CO sources, and accurate monitoring of their emissions is crucial for improving the precision of global carbon emission estimates. In this study, a measurement method based on measuring point source plumes was employed in ground-based remote sensing experiments at the thermal power plant. By simulating CO plumes, we analyzed the impact of surrounding urban structures, the geometric relationship between measurement points and plumes, and the influence on measurement points selection.

MiR-653-5p drives osteoarthritis pathogenesis by modulating chondrocyte senescence.

Background: Due to the unclear pathogenesis of osteoarthritis (OA), effective treatment for this ailment is presently unavailable. Accumulating evidence points to chondrocyte senescence as a key driver in OA development. This study aims to identify OA-specific microRNAs (miRNAs) targeting chondrocyte senescence to alleviate OA progression.

Both Resilience and Adhesivity Define Solid Electrolyte Interphases for a High Performance Anode.

Solid electrolyte interphases (SEIs) are sought to protect high-capacity anodes, which suffer from severe volume changes and fast degradations. The previously proposed effective SEIs were of high strength yet abhesive, inducing a yolk-shell structure to decouple the rigid SEI from the anode for accommodating the volume change. Ambivalently, the interfacial void-evolved electro-chemo-mechanical vulnerabilities become inherent defects.

Consummating ion desolvation in hard carbon anodes for reversible sodium storage.

Hard carbons are emerging as the most viable anodes to support the commercialization of sodium-ion (Na-ion) batteries due to their competitive performance. However, the hard carbon anode suffers from low initial Coulombic efficiency (ICE), and the ambiguous Na-ion (Na) storage mechanism and interfacial chemistry fail to give a reasonable interpretation. Here, we have identified the time-dependent ion pre-desolvation on the nanopore of hard carbons, which significantly affects the Na storage efficiency by altering the solvation structure of electrolytes.

Weak-Interaction Environment in a Composite Electrolyte Enabling Ultralong-Cycling High-Voltage Solid-State Lithium Batteries.

Poly(vinylidene fluoride) (PVDF)-based solid electrolytes with a Li salt-polymer-little residual solvent configuration are promising candidates for solid-state batteries. Herein, we clarify the microstructure of PVDF-based composite electrolyte at the atomic level and demonstrate that the Li-interaction environment determines both interfacial stability and ion-transport capability. The polymer works as a "solid diluent" and the filler realizes a uniform solvent distribution.

Changes in physiology, antioxidant system, and gene expression in Microcystis aeruginosa under fenoxaprop-p-ethyl stress.

Fenoxaprop-p-ethyl (FE) is one of the typical aryloxyphenoxypropionate herbicides. FE has been widely applied in agriculture in recent years. Human health and aquatic ecosystems are threatened by the cyanobacteria blooms caused by Microcystis aeruginosa, which is one of the most common cyanobacteria responsible for freshwater blooming.

Prognostic impact of age in advanced non-small cell lung cancer patients undergoing first-line checkpoint inhibitor immunotherapy and chemotherapy treatment.

Background: Research on the association between age and clinical outcome in patients with non-small cell lung cancer (NSCLC) treated with immunotherapy combined with chemotherapy as first-line setting is limited. The aim of study is to determine the influence of age on the progress-free survival (PFS) and overall survival (OS) in those patients after adjusting for potential confounders.

Methods: A total of 207 advanced NSCLC patients treated with immunotherapy combined with chemotherapy in the first-line treatment in Guangxi Medical University Cancer Hospital from March 10, 2019, to December 31, 2022, was retrospectively analyzed.

SM22α deficiency: promoting vascular fibrosis via SRF-SMAD3-mediated activation of transcription following arterial injury.

Vascular fibrosis, characterized by increased Type I collagen expression, significantly contributes to vascular remodeling. Our previous studies show that disrupting the expression of SM22α (aka SM22, Tagln) induces extensive vascular remodeling following arterial injury, involving oxidative stress, inflammation, and chondrogenesis within the vessel wall. This study aims to investigate the molecular mechanisms underlying the transcription of , a key fibrotic extracellular matrix marker.

Enhanced SSD framework for detecting defects in cigarette appearance using variational Bayesian inference under limited sample conditions.

In high-speed cigarette manufacturing industries, occasional minor cosmetic cigarette defects and a scarcity of samples significantly hinder the rapid and accurate detection of defects. To tackle this challenge, we propose an enhanced single-shot multibox detector (SSD) model that uses variational Bayesian inference for improved detection of tiny defects given sporadic occurrences and limited samples. The enhanced SSD model incorporates a bounded intersection over union (BIoU) loss function to reduce sensitivity to minor deviations and uses exponential linear unit (ELU) and leaky rectified linear unit (ReLU) activation functions to mitigate vanishing gradients and neuron death in deep neural networks.

Ubiquitylation-independent cotranslational degradation of dihydrofolate reductase and ubiquitin.

Nascent proteins are degraded during or immediately after synthesis, a process called cotranslational protein degradation (CTPD). Although CTPD was observed decades ago, it has never been fully explored mechanistically and functionally. We show here that dihydrofolate reductase (DHFR) and ubiquitin (Ub), two stable proteins widely used in protein degradation studies, are actually subject to CTPD.

Fluorinating All Interfaces Enables Super-Stable Solid-State Lithium Batteries by In Situ Conversion of Detrimental Surface LiCO.

Li-stuffed battery materials intrinsically have surface impurities, typically LiCO, which introduce severe kinetic barriers and electrochemical decay for a cycling battery. For energy-dense solid-state lithium batteries (SSLBs), mitigating detrimental LiCO from both cathode and electrolyte materials is required, while the direct removal approaches hardly avoid LiCO regeneration. Here, a decarbonization-fluorination strategy to construct ultrastable LiF-rich interphases throughout the SSLBs by in situ reacting LiCO with LiPF at 60 °C is reported.

Insights into elastic fiber fragmentation: Mechanisms and treatment of aortic aneurysm in Marfan syndrome.

Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder caused by mutations in fibrillin 1 (FBN1) gene. These mutations result in defects in the skeletal, ocular, and cardiovascular systems. Aortic aneurysm is the leading cause of premature mortality in untreated MFS patients.

Step-by-step desolvation enables high-rate and ultra-stable sodium storage in hard carbon anodes.

Hard carbon is regarded as the most promising anode material for sodium-ion (Na-ion) batteries, owing to its advantages of high abundance, low cost, and low operating potential. However, the rate capability and cycle life span of hard carbon anodes are far from satisfactory, severely hindering its industrial applications. Here, we demonstrate that the desolvation process defines the Na-ion diffusion kinetics and the formation of a solid electrolyte interface (SEI).