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http://dx.doi.org/10.1245/s10434-025-17537-w | DOI Listing |
J Antimicrob Chemother
September 2025
Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan.
Front Pharmacol
August 2025
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, China.
Connective tissue growth factor (CTGF) is notably upregulated in scar tissue, making it a promising target for therapeutic intervention. Here, we have designed and screened an antisense oligonucleotide (ASO) that binds specifically to the exon five sequence of CTGF, with particular emphasis on the use of 2'-O-methoxyethyl (MOE) and locked nucleic acid (LNA) modifications to enhance stability and specificity. experiments demonstrated that both MOE-ASO#1 and LNA-ASO#1 significantly inhibited fibroblast proliferation and extracellular matrix protein expression.
View Article and Find Full Text PDFAnn Surg Oncol
September 2025
St. Paul's Hospital, The University of British Columbia, Vancouver, Canada.
Ann Surg Oncol
September 2025
Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Tokyo, Japan.
Ann Surg Oncol
September 2025
Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, USA.