Study on differentially expressed genes and pattern recognition receptors in osteoporosis based on bioinformatics analysis.

Osteoporosis is a common skeletal disorder characterized by low bone mass and structural deterioration, leading to an increased risk of fractures. This study aimed to explore the molecular mechanisms underlying osteoporosis using bioinformatics approaches, with a focus on pattern recognition receptor-related differentially expressed genes (PRR-related DEGs). Two gene expression datasets (GSE7429 and GSE56815) were retrieved from the GEO database, comprising 30 osteoporosis samples and 30 matched controls.

Columbianadin Ameliorate Osteoporosis Against Glucocorticoid Induced Osteoporosis in Rats via Alteration of RANK/RANKL/OPG Signaling Pathway.

Background: Osteoporosis is a condition in where bones gradually become thin and weak, making them more susceptible to fractures. Columbianadin has showed potential anti-inflammatory and antioxidant effect. In this experimental study, anti-osteoporosis effect of Columbianadin against glucocorticoid induced osteoporosis in rats.

Artificial intelligence in neurodegenerative diseases research: a bibliometric analysis since 2000.

This bibliometric review examines the evolving landscape of artificial intelligence (AI) in neurodegenerative diseases research from 2000 to March 16, 2025, utilizing data from 1,402 publications (1,159 articles, 243 reviews) indexed in the Web of Science Core Collection. Through advanced tools - VOSviewer, CiteSpace, and Bibliometrix R - the study maps collaboration networks, keyword trends, and knowledge trajectories. Results reveal exponential growth post-2017, driven by advancements in deep learning and multimodal data integration.

Liu Wei Di Huang Decoction Alleviates Renal Fibrosis by Inhibiting Endothelial Mesenchymal Transitions via Upregulating Sirt1 Expression and Inhibiting the Wnt/β-Catenin Signaling Pathway.

Background: Renal fibrosis (RF) is the final outcome of chronic kidney disease (CKD), which can be triggered by various factors. Liuwei Dihuang Decoction (LWDHD) has been clinically established as an effective treatment for CKD, demonstrating anti-inflammatory, antioxidant, and antifibrotic effects. However, the specific molecular mechanisms underlying the therapeutic effectiveness of LWDHD remain unknown.

Apoptotic and anti-metastatic effect of chrysin on CD44 cancer stem cells from SW480 colorectal cancer cell line.

Introduction: Cancer stem cells (CSCs) are very important for colorectal cancer (CRC) because they help the cancer start, spread, and metastasise. This makes them a key target for making better cancer treatments. This study explores the effects of chrysin on the CSCs in the SW480 cell line to examine its potential impact on key signalling pathways involved in cell survival and proliferation, shedding light on its therapeutic potential in colon cancer.

Insulin resistance and Alzheimer's disease: Exploring research hotspots and frontiers from a bibliometric and visual analysis (2005-2024).

Background: Alzheimer's disease (AD) and insulin resistance (IR) share intersecting pathological pathways, with IR increasingly implicated in AD pathogenesis. Systematic bibliometric analyses mapping the evolution of this interdisciplinary field remain limited.

Objective: To quantify global research trends, collaboration networks, knowledge structures, and emerging frontiers in IR-AD research from 2005-2024.

CircYAP1 inhibits osteosarcoma progression through the miR-135b-5p/FRK axis.

Circular RNAs (circRNAs) are implicated in the progression of various malignancies, including osteosarcoma. However, little is known about the role of circYAP1 in osteosarcoma. In the present study, the expression of circYAP1 was found to be downregulated in osteosarcoma tissues relative to adjacent normal tissues.

Decomposition analysis of public health service utilization and health disparities among urban and rural older adult migrants in China.

Background: In the context of China's aging population and increasing internal migration, "old age" and "mobility" are the special dual attributes of the older adult migrants, and their utilization of basic public health services and health protection is also a major public health issue. Against the backdrop of growing urban-rural development disparities in China, this study aims to examine the differences in public health service utilization and health status between urban and rural older adult migrants and quantify the contribution of relevant influencing factors.

Methods: This study utilized data from the 2018 China Migrants Dynamic Survey (CMDS).

Adding Clip Before Endoscopic Cyanoacrylate Injection Decreases Ectopic Embolisms in Gastric Varices: A Randomized Controlled Trial.

Introduction: Ectopic embolism caused by cyanoacrylate migration is a severe complication. We aimed to test the hypothesis that prior clipping can reduce ectopic embolism secondary to endoscopic cyanoacrylate injection (ECI) in gastric varices with a gastrorenal shunt.

Methods: In this multicenter, open-label, parallel, randomized controlled trial, patients with fundal gastric varices and gastrorenal shunts from 10 tertiary hospitals were randomly assigned to clip-assisted ECI (Clip-ECI, n = 35) and conventional ECI groups (Con-ECI, n = 35).

Analysis of key factors and equity in influenza vaccination among Chinese adults-evidence from a large national cross-sectional survey.

Introduction: Influenza is prevalent globally, leading to severe morbidity and mortality. Vaccination remains a critical strategy for influenza prevention. Although previous studies in China have primarily focused on influenza vaccination among children, limited research has addressed the key determinants and equity issues concerning adult influenza vaccination.

Mechanistic Exploration of Shugan Jianpi Formula for Treating Triple-Negative Breast Cancer Under Chronic Stress: A Network Pharmacology-Guided Experimental Study.

Purpose: This study aimed to investigate the pharmacological mechanisms of Shugan Jianpi Formula (SGJPF) in treating TNBC using network pharmacology and molecular biology approaches.

Methods: HPLC/MS identified the key compounds in SGJPF. In vitro assays were performed on norepinephrine (NE)-stimulated MDA-MB-231 and SUM159PT cells to mimic triple-negative breast cancer (TNBC) under chronic psychological stress (CPS) and evaluate SGJPF's effects on cell proliferation, apoptosis, cell cycle, migration, and invasion.

Comparative Efficacy and Safety of Antibiotic Regimens in Sepsis-Induced Acute Kidney Injury: A Retrospective Cohort Study.

Purpose: Acute kidney injury (AKI) is a prevalent and serious complication in septic patients, potentially exacerbated by certain medications, which significantly affects morbidity and mortality rates. This study aims to evaluate the comparative efficacy and safety of different antibiotic regimens for treating sepsis-induced AKI.

Methods: This retrospective cohort study analyzed adult patients with AKI resulting from sepsis between 2022 and 2024.

A Rare Case of Breast Abscess Caused by Facklamia hominis Following COVID-19 Infection.

Purpose: Facklamia hominis is an infrequent opportunistic pathogen. This case report describes a ​young immunocompetent female who developed ​recurrent abscesses after a COVID-19 infection, highlighting the potential link between post-COVID-19 immune dysfunction and opportunistic infections.

Methods: A comprehensive review of the patient's clinical course, relevant laboratory tests, treatment, and post-treatment outcomes was conducted.

Asian consensus statement of experts on thermal ablation for secondary hyperparathyroidism in chronic kidney disease.

Secondary hyperparathyroidism (SHPT) is characterized by parathyroid hyperplasia, persistently elevated parathyroid hormone levels, and disturbances in mineral metabolism. Currently, a considerable amount of literature has consistently shown that thermal ablation is effective in maintaining parathyroid hormone levels within an appropriate range, normalizing calcium and phosphorus levels, improving clinical symptoms, and reducing the volume of parathyroid glands. However, there are currently no established guidelines regarding its utilization.

Liver resection versus interventional treatments for hepatocellular carcinoma patients with hypohepatia: a multicenter study.

Background: Hypohepatia limits the feasibility of therapeutic options for hepatocellular carcinoma (HCC), negatively affecting patient prognosis. Established guidelines for the treatment strategies of HCC patients with hypohepatia are lacking. This study was performed to evaluate therapeutic benefits between liver resection (LR) and interventional treatments using ablation or transarterial chemoembolization (TACE) in such population.

Mendelian randomization analysis identifies ERAP1 and IL23R as potential drug targets for ankylosing spondylitis.

Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the spine and pelvis, leading to ankylosis, stiffness, and reduced quality of life. Despite therapeutic advances, identifying novel drug targets remains critical.

Methods: This Mendelian randomization (MR) study leveraged proteome-wide analysis, utilizing data from five genome-wide association studies (GWAS) for proteomics exposure.

Water Transport-Modulated Highly Compressive Hydrogel for Total Biomimetic Sensing Intervertebral Disc.

Degenerative disc disease (DDD) affects millions globally, with artificial total disc replacement (A-TDR) emerging as a key surgical intervention to restore spinal function and mobility. Current implantable prostheses incorporating multi-component architectures to replicate the functional heterogeneity of natural intervertebral discs (IVD) face challenges in achieving mechanical and physiological compatibility. Inspired by the natural IVD's structure, where a soft nucleus pulposus (NP) is encased by a tough annulus fibrosus (AF), a water transport-modulated directional annealing casting (DAC) approach has been developed to construct bulk hydrogels with tunable mechanical properties (up to ≈36.

Hypoxia-Driven Neurovascular Impairment Underlies Structural-Functional Dissociation in Diabetic Sudomotor Dysfunction.

Sudomotor dysfunction in diabetic patients increases the risk of fissures, infections, and diabetic foot ulcers (DFUs), thereby reducing the quality of life. Despite its clinical importance, the mechanisms underlying this dysfunction remain inadequately elucidated. This study addresses this gap by demonstrating that despite structural integrity, sweat glands (SGs) in diabetic individuals with DFUs, and a murine model of diabetic neuropathy (DN), exhibit functional impairments, as confirmed by histological and functional assays.

Polysaccharide from Atractylodes macrocephala Koidz. alleviates pyrotinib-induced diarrhea through regulating cAMP/LKB1/AMPK/CFTR pathway and restoring gut microbiota and metabolites.

Polysaccharide from Atractylodes macrocephala Koidz. (PAMK), a bioactive component of Atractylodes macrocephala Koidz. (AMK), demonstrates a wide range of pharmacological activities, including the enhancement of gastrointestinal function and regulation of internal homeostasis.

Comparable survival outcomes in HLA-Matched and haploidentical hematopoietic stem cell transplantation for severe aplastic anemia patients aged 40-50: A CBMTR Registry-based propensity score matching analysis over the last decade.

Our study includes 278 patients aged between 40 and 50 years from 29 centers who received allogeneic hematopoietic stem cell transplantation (allo-HSCT) from matched sibling donors (MSDs) (n = 106) and haploidentical donors (HIDs) (n = 172) over the last decade. Univariate analysis revealed that HID recipients was associated with more serious disease severity, a delayed allo-HSCT after diagnosis, a higher pretransplant transfusion burden and poor performance status pre-transplant than MSD recipients in clinical settings. After these pretransplant clinical factors were well balanced following propensity score-matching (PSM), 80 matched pairs were selected for further analysis.

Mechanism of Atractylenolide Ⅲ alleviating pyrotinib-induced diarrhea by regulating AMPK/CFTR pathway through metabolite of gut microbiota.

Atractylenolide III, a sesquiterpene extracted from the rhizome of Atractylodes macrocephala (Asteraceae), exhibits pharmacological effects, including improvement of gastrointestinal function, regulation of immune function, anti-inflammatory and antibacterial properties. Pyrotinib, a representative TKI originally developed in China, is classified as a Class 1.1 novel drug, exhibits superior efficacy compared to similar drugs.

Chinese Expert Consensus on Preventing and Managing Chyle Fistula in Cervical Lymph Node Dissection for Thyroid Cancer (2024).

Background: The prevalence of thyroid carcinoma is on the rise, with cervical lymph node metastasis being a frequent occurrence necessitating surgical intervention. Chyle fistula, a significant postoperative complication, can have a substantial impact on recovery.

Objective: To reduce the incidence of chyle fistula, enhance the effectiveness of postoperative treatment, and assist thyroid surgeons in performing cervical lymph node dissection, the consensus was compiled in a standardized and secure manner.