Sagittal Classification of Calcified Lumbar Disc Herniation and Therapeutic Analysis of Percutaneous Endoscopic Interlaminar Discectomy.

Background: Calcified lumbar disc herniation (CLDH) is one specific type of lumbar disc herniation (LDH). Currently, there are no uniform classification standards for different calcification degrees of herniated lumbar disc tissue. Percutaneous endoscopic interlaminar discectomy (PEID) has been proved to exhibit great efficacy in treating LDH, but whether it can achieve satisfactory results in treating CLDH with different calcification remains unclear.

Whole-genome sequencing reveals three follicular lymphoma subtypes with distinct cell of origin and patient outcomes.

Follicular lymphoma (FL) is characterized by clinical, phenotypic, and genetic heterogeneity. Here, we conduct whole-genome sequencing on 131 Chinese FL samples and identify three clinically relevant genetic subtypes. These include C1, associated with favorable prognoses and enriched for BCL6-related translocations and mutations in the NOTCH/nuclear factor κB (NF-κB)/immune evasion pathways; C2, characterized by BCL2-IGH translocations and mutations in chromatin modifiers; and C3, associated with poorer prognosis, lacking BCL2-IGH/BCL6-related translocations but exhibiting more copy number variations.

Targeted metabolomics in PCOS mice identifies hippuric acid as a therapeutic metabolite.

Polycystic ovary syndrome (PCOS) represents a complex endocrine disorder with profound detrimental effects on women's reproductive and metabolic health, yet the absence of specific pharmacotherapeutic interventions has resulted in a significant therapeutic gap. To elucidate the metabolic alterations in PCOS, we conducted a comprehensive targeted metabolomics analysis of plasma samples from healthy control mice and PCOS model mice, examining a panel of 197 metabolites spanning diverse metabolic classes. Our analysis revealed substantial metabolic differences between the groups, with organic acids, amino acids, and fatty acids emerging as the most abundant metabolite classes in both cohorts.

Liu Wei Di Huang Decoction Alleviates Renal Fibrosis by Inhibiting Endothelial Mesenchymal Transitions via Upregulating Sirt1 Expression and Inhibiting the Wnt/β-Catenin Signaling Pathway.

Background: Renal fibrosis (RF) is the final outcome of chronic kidney disease (CKD), which can be triggered by various factors. Liuwei Dihuang Decoction (LWDHD) has been clinically established as an effective treatment for CKD, demonstrating anti-inflammatory, antioxidant, and antifibrotic effects. However, the specific molecular mechanisms underlying the therapeutic effectiveness of LWDHD remain unknown.

Stable n-Type Conducting Elastomer with High Stretchability and Electrical Conductivity.

Stretchable n-type conducting polymers are crucial for advancing high-performance optoelectronic and bioelectronic devices, yet their development lags significantly behind that of p-type counterparts due to the intrinsic challenge of harmonizing electrical conductivity with mechanical compliance. Herein, a novel strategy is reported to engineer a high-performance n-type conductive elastomer by synergistically blending the n-type polymer poly(benzodifurandione) (PBFDO) with thermoplastic polyurethane (TPU) and modulating phase separation via the ionic liquid (IL) 1-butyl-3-methylimidazolium tetrafluoroborate. The resulting PBFDO/TPU/IL composites (PBTI) achieve an unprecedented combination of n-type electrical conductivity exceeding 200 S cm¹, fracture elongation surpassing 200%, and robust operational stability, outperforming existing stretchable n-type conductive polymers.

A case of nevoid basal cell carcinoma syndrome associated with optic nerve coloboma and epiretinal membrane.

Purpose: To report the first case of nevoid basal cell carcinoma syndrome associated with optic nerve coloboma and epiretinal membrane in Chinese patient.

Observations: A 12-year-old female presented with bilateral visual decline. Examination revealed a porcelain-white optic nerve coloboma and epiretinal membrane in the right eye.

Effects of Void Characteristics on the Mechanical Properties of Carbon Fiber Reinforced Polyetheretherketone Composites: Micromechanical Modeling and Analysis.

This study proposes a novel algorithm for generating representative volume elements which mitigate microstructural inhomogeneities in fiber-reinforced composites. The algorithm integrates void characteristics obtained from micro-computed tomography to more accurate microstructure models. Based on these models, the effects of void content, spatial distribution, and void diameter on the mechanical behavior of CF/PEEK composites are systematically evaluated using finite element analysis and experimental validation.

Risk Stratification for Diffuse Large B-Cell Lymphoma by Integrating Interim F-FDG PET-CT Analysis and the NCCN-IPI: A Multicenter Retrospective Study.

Our study aimed to assess the prognostic significance of the interim National Comprehensive Cancer Network International Prognostic Index and PET-CT-related parameters for predicting patient outcomes and achieving precise risk stratification for diffuse large B-cell lymphoma (DLBCL) patients. We retrospectively analyzed the clinicopathological and PET-CT data of 498 patients diagnosed with DLBCL across three medical centers in China. 418 patients were eligible for subsequent analysis after excluding those with incomplete data and 70% of which were randomly selected as the discovery cohort, whereas the remaining 30% constituted the validation cohort.

Natural cycle versus hormone replacement therapy as endometrial preparation in ovulatory women undergoing frozen-thawed embryo transfer: The compete open-label randomized controlled trial.

Background: Different endometrial preparation protocols are used prior to frozen-thawed embryo transfer (FET). Optimization of endometrial preparation protocols is mandatory to improve live birth rate and obstetric and perinatal outcomes. In the Comparison of Endometrial Preparation Protocols for Frozen Embryo Transfer (COMPETE) trial, our primary objective is to evaluate whether natural cycles (NCs) lead to a higher live birth rate after the first FET cycle compared to hormone replacement therapy (HRT) cycles in women with a regular ovulatory cycle.

A cell-interacting and multi-correcting method for automatic circulating tumor cells detection.

Sensitive detection of circulating tumor cells (CTCs) from peripheral blood can serve as an effective tool in the early diagnosis and prognosis of cancer. Many methods based on modern object detectors were proposed in recent years for automatic abnormal cells detection in slide images. Although the modes of these methods can also be applied to the CTCs detection, several practical difficulties lead to suboptimal performance of them, such as accurate capture of CTCs in a large number of mixed cells and identification of CTCs and CTC-like cells with similar visual characteristics.

Clinical Features and Outcomes of Primary Cutaneous Peripheral T-Cell Lymphoma, Not Otherwise Specified, Treated with CHOP-Based Regimens.

Primary cutaneous peripheral T-cell lymphoma, not otherwise specified (pcPTCL-NOS), is a rare and aggressive form of lymphoma. Its characteristics and treatment outcomes remain poorly understood. We identified 15 patients who were diagnosed with pcPTCL-NOS between January 2014 and August 2024 at Tianjin Medical University Cancer Institute and Hospital (TMUCIH) in this retrospective study.

Comparison of robotic AI-assisted and manual pedicle screw fixation for treating thoracolumbar fractures: a retrospective controlled trial.

Objective: To compare the clinical efficacy and screw placement accuracy of robot artificial intelligence (AI)-assisted percutaneous screw fixation and conventional C-arm-assisted percutaneous screw fixation (manual placement) in the treatment of thoracolumbar single-segment fractures without neurological symptoms.

Methods: This study is a single-center retrospective analysis involving patients with thoracolumbar single-segment fractures without neurological symptoms. Patients were divided into Group A (robotic AI-assisted placement) and Group B (manual placement).

Molecular landscape of distinct follicular lymphoma histologic grades: insights from genomic and transcriptome analyses.

The 2022 World Health Organization Classification of Haematolymphoid tumours classifies follicular lymphoma grades 1-2 (FL1-2) and grade 3A (FL3A) as classic follicular lymphoma (cFL) and reclassifies grade 3B (FL3B) as follicular large B-cell lymphoma (FLBL), without addressing cases of patients with concurrent FL and diffuse large B-cell lymphoma (FL/DLBCL). However, genetic information on FL histologic grading remains limited, and the latest classification lacks sufficient evidence to resolve whether these subgroups represent single or multiple distinct biological entities. This study analyzed clinical data from 831 patients, whole-exome sequencing (WES) from 149 patients, and transcriptome sequencing from 63 patients to explore differences among FL1-2, FL3A, FL3B, and FL/DLBCL.

Thyroid nodule classification in ultrasound imaging using deep transfer learning.

Background: The accurate diagnosis of thyroid nodules represents a critical and frequently encountered challenge in clinical practice, necessitating enhanced precision in diagnostic methodologies. In this study, we investigate the predictive efficacy of distinguishing between benign and malignant thyroid nodules by employing traditional machine learning algorithms and a deep transfer learning model, aiming to advance the diagnostic paradigm in this field.

Methods: In this retrospective study, ITK-Snap software was utilized for image preprocessing and feature extraction from thyroid nodules.

Research on the Chinese capital culture perception based on Weibo big data.

Ancient capital culture, red culture, Beijing-style culture, and innovation culture together constitute the capital's cultural system of China and support Beijing's position as the Chinese cultural center. In order to better help the cultural construction of the capital, Beijing, and to find some common and reasonable ways to reconcile the complex urban cultural system, this paper is based on the Weibo data of Beijing in 2019, takes the BERT pre-training model and the newer topic model "BERTopic" as the tools, combines the text content, spatial layout, and sentiment analysis methods, and explores the public perception of four types of capital culture in Beijing. The results reveal that: (1) Although the perception level of Dongcheng, Xicheng, Haidian and Chaoyang core areas is much higher than that of remote areas, the sentiment feedback of remote areas is better than that of the former; (2) A type of culture actively introduces other cultural types or even foreign cultural elements in the system, which helps it form a unique cultural attraction.

The age-adjusted international prognostic index 2 (A-FLIPI2) for elderly patients with follicular lymphoma.

Follicular lymphoma (FL) is a common B-cell lymphoma and typically affects the elderly population. It is urgently required to enhance our comprehension of disease-specific outcomes in elderly FL patients and identify a reliable predictive indicator to assess patient risk and guide treatment options for them. Therefore, we retrospectively analysed clinical data of 128 elderly patients (aged 60 years or older) with FL treated at Tianjin Medical University Cancer Institute & Hospital from 2002 to 2020.

"Disguise strategy" to bacteria: A multifunctional hydrogel with bacteria-targeting and photothermal conversion properties for the repair of infectious bone defects.

Addressing the challenge of eliminating bacteria and stimulating osteogenesis in infectious bone defects, where cells and bacteria coexist within the microenvironment, presents a significant hurdle. In this study, a strategy of targeting bacteria is proposed to address this challenge. For this purpose, a methacrylated gelatin composite hydrogel containing zinc ion and D-type cysteine-modified polydopamine nanoparticles (PZC) is developed.

Programmed Transformation of Osteogenesis Microenvironment by a Multifunctional Hydrogel to Enhance Repair of Infectious Bone Defects.

Repair of infectious bone defects remains a serious problem in clinical practice owing to the high risk of infection and excessive reactive oxygen species (ROS) during the early stage, and the residual bacteria and delayed Osseo integrated interface in the later stage, which jointly creates a complex and dynamic microenvironment and leads to bone non-union. The melatonin carbon dots (MCDs) possess antibacterial and osteogenesis abilities, greatly simplifying the composition of a multifunctional material. Therefore, a multifunctional hydrogel containing MCDs (GH-MCD) is developed to meet the multi-stage and complex repair needs of infectious bone injury in this study.

Validation and the role of PDK4 relevant to ferroptosis in degenerative lumbar disc disease.

Background: Ferroptosis was involved in the pathogenesis of intervertebral disc degeneration (IVDD). However, the exact mechanism of IVDD associated with ferroptosis still required deeper studies.

Method: The differentially expressed genes (DEGs) in rat lumbar disc tissue between the control and IVDD group treated with IL-1β were detected by RNA sequencing (RNA-seq).

DFCL: Dual-pathway fusion contrastive learning for blind single-image visible watermark removal.

Digital image watermarking is a prevalent method for image copyright protection. As watermark embedding techniques evolve, research in copyright protection has increasingly extended into watermark removal. Recent advancements in deep learning and generative technologies have led to the development of public watermark removal solutions, addressing issues such as plagiarized, illegal, or outdated watermarks while driving significant improvements in robust watermark embedding.

Correlation Between Bone Metabolism Indices and Osteoporotic Thoracolumbar Vertebrae Fracture in Postmenopausal Women.

Background: This study aims to explore the correlation between bone metabolism indices and osteoporotic thoracolumbar vertebrae fracture (OTVF) in postmenopausal women.

Methods: A total of 447 female patients with postmenopause and underwent OTVF in our hospital were selected as group A. Three hundred eighty-seven out-patients without fractures were selected as group B.

Pathological mechanisms and related markers of steroid-induced osteonecrosis of the femoral head.

Background: Osteonecrosis of the femoral head (ONFH) is a refractory orthopedic disease with a high disability rate. Long-term administration of steroids is the most common pathogenic factor for non-traumatic ONFH. Early diagnosis of steroid-induced osteonecrosis of the femoral head (SONFH) is difficult and mainly depends on imaging.

Biomimetic periosteum-bone scaffolds with codelivery of BMP-2 and PDGF-BB for skull repair.

Tissue engineering employs the use of bioactive materials to facilitate the filling and acceleration of bone defect healing, thereby introducing novel concepts to the field of in situ bone repair. Some studies have shown that periosteum plays an important role in bone regeneration and repair. In this study, biomimetic periosteum-bone scaffolds were prepared by depositing poly-L-lactic acid (PLLA) electrospun fibers on the surface of the gelatin/chitosan cryogel to mimic the bone and periosteum structure, respectively.

Revolutionizing spinal interventions: a systematic review of artificial intelligence technology applications in contemporary surgery.

Leveraging its ability to handle large and complex datasets, artificial intelligence can uncover subtle patterns and correlations that human observation may overlook. This is particularly valuable for understanding the intricate dynamics of spinal surgery and its multifaceted impacts on patient prognosis. This review aims to delineate the role of artificial intelligence in spinal surgery.