Construction of medical scientific data repositories in China: analysis of survey and recommendations.

Background: In the context of global open science trends, medical open-access repositories (OARs) promote transparency in research and facilitate the sharing of scientific data. The increase in scientific output necessitates a robust infrastructure to enhance OARs in China.

Objectives: This study aimed to evaluate medical open-access repositories (OARs) in China that are indexed in re3data.

Mechanistic Insights into Rh-Catalyzed Regio- and Enantioselective Hydroformylation of Cyclopropyl-Functionalized Trisubstituted Alkenes.

Asymmetric hydroformylation (AHF) is a valuable method to convert cheaper feedstock alkenes into value-added products. In view of the contemporary importance of these reactions, we have examined the mechanism of AHF of cyclopropyl-functionalized trisubstituted alkenes by using syngas (CO and H) catalyzed by [Rh(,)-Yanphos], offering high regio- and enantioselectivities by deploying a combination of computational, kinetic, and spectroscopic tools. Our comprehensive density functional calculations suggest that the regio- and enantioselectivities originate from the irreversible alkene insertion step, where the branched pathway exhibits a notable energetic advantage of 4.

Suppressed Intermolecular Interaction Between Organic Spacers for High-Performance p-i-n and n-i-p Perovskite Solar Cells.

Ammonium cations are widely used for defect passivation in perovskite solar cells (PSCs), effectively reducing defect density and improving photovoltaic performance. However, ammonium cations tend to form 2D phases on the surface or at the grain boundaries of 3D perovskites, hindering charge transport across interfaces and between grains. Here, cyclohexylmethylammonium (CHMA), a low-polarity and low-rigidity alicyclic ammonium cation, is introduced to reduce intermolecular interactions among ammonium cations and improve their coordination with defect centers.

Combined model-driven and dual-cycle interactive strategy few-shot learning scheme for predicting breast cancer molecular subtypes based on DCE-MRI.

Background And Objective: Deep learning has achieved significant success in solving classification problems in the medical field, which has, in turn, facilitated the development of continuous and real-time health monitoring systems. Yet medical images have extremely low data regimes, unlike natural images with a large amount of data. Hence, to classify medical images with a few per-class data samples is a challenging problem.

The Application of N-Aryl Glycines and Their Analogues in Visible-Light-Promoted Photoredox Catalysis.

The aminomethylation reaction, a fundamental and versatile organic transformation is extensively utilized to incorporate an aminomethyl group into target molecules and plays a significant role in the synthesis of natural products and functional molecules. In recent years, N-Aryl glycines and their analogues have been widely explored in visible-light-promoted photoredox reactions to install an aminomethyl moiety or construct various N-heterocycles under mild conditions. Their key reaction intermediates are α-aminoalkyl radicals, imines, or iminium ions.

Ceiba flower-derived hard carbon with multi-dimensional self-supported structures and its ZnInS-based composites: long-term stable anode materials for sodium-ion batteries.

Biomass-derived functional carbon materials have attracted increasing research attention due to their cost-effectiveness, environmental friendliness, and easy adjustability of compositions and structures. Especially, for sodium-ion batteries (SIBs), which are widely recognized as a promising alternative to lithium-ion batteries, biomass-derived hard carbon holds the greatest potential as an anode material for commercialization in the near future. In this paper, through a facile carbonization process, a multi-dimensional structured N-doped hard carbon with rational pores and defects has been successfully synthesized from an abundant and easy-accessible biomass precursor of ceiba flower, which delivers a remarkable initial coulombic efficiency of 83.

A Luminescent Zirconium-Pentacarboxylate Framework with 10-Connected Zr Clusters for Dichromate Detection.

Zirconium-based metal-organic frameworks (Zr-MOFs) have received great attention due to their abundant structural diversity and controllable functionalizations. However, pentacarboxylic acid-based Zr-MOFs are less studied. Herein, we report a new pentacarboxylic acid-based organic linker, 4″,4‴″,4‴‴″-((4-(4,5-bis(4-carboxyphenyl)-1-imidazol-2-yl)phenyl)methanetriyl)tris(([1,1':4',1″-terphenyl]-4-carboxylic acid)), which has been successfully employed to construct a Zr-MOF, HIAM-4055 (HIAM = Hoffmann Institute of Advanced Materials).

GraphGIM: rethinking molecular graph contrastive learning via geometry image modeling.

Background: Learning molecular representations is crucial for accurate drug discovery. Using graphs to represent molecules is a popular solution, and many researchers have used contrastive learning to improve the generalization of molecular graph representations.

Results: In this work, we revisit existing graph-based contrastive methods and find that these methods have limited diversity in the constructed sample pairs, resulting in insufficient performance gains.

Investigation of joint formation in aluminum wire and nickel-coated copper terminals using ultrasonic welding.

The presence of intermetallic compounds (IMC) can significantly degrade the mechanical properties of joints, leading to premature failure. This paper presents a detailed investigation into the mechanical manufacturing and forming quality of ultrasonically welded joints between aluminum wire, copper terminals and nickel-coated copper terminals. The electroplated nickel coating enhances the corrosion resistance and operating temperature tolerance of copper substrate.

A methodology for designing accurate, modifiable and reproducible scientific graphics in environmental studies using GPT4Designer.

The integration of text-to-image generation capabilities within GPT-4 allows for the convenient creation of various graphics. However, the proficiency of GPT-4 in crafting challenging scientific visuals remains largely unexplored. In this study, we conduct systematic experiments by employing multiple prompt engineering techniques with various supplementary materials to generate complex scientific illustrations for environmental studies.

ER-related E2-E3 ubiquitin enzyme pair regulates ethylene response by modulating the turnover of ethylene receptors.

Gaseous phytohormone ethylene regulates various aspects of plant development. Ethylene is perceived by ER membrane-localized receptors, which are inactivated upon binding with ethylene molecules, thereby initiating ethylene signal transduction. Here, we report that a novel E3 ligase RING finger for Ethylene receptor Degradation (RED) and its E2 partner UBC32 ubiquitinate ethylene-bound receptors for degradation through an ER associated degradation (ERAD) pathway in both Rosa hybrida and Solanum lycopersicum.

Strain relaxation in halide perovskites via 2D/3D perovskite heterojunction formation.

Applying mechanical strain and strain engineering to halide perovskites has endowed them with intriguing properties. However, an in-depth understanding of mechanical strain, including residual strain in halide perovskites, remains incomplete, coupled with the critical challenge of decoupling strain effects from other interferences. Here, we examine the relaxation of residual tensile strain in three-dimensional (3D) halide perovskites through 2D/3D perovskite heterojunction formation.

IRF8 and RUNX1 cooperatively regulate the senescence and damage of urine-derived renal progenitor cells by upregulating LINC01806.

Urine-derived renal progenitor cells (UdRPCs) from healthy individuals have been identified as having the potential to repair kidney damage. However, it remains uncertain whether UdRPCs retain their functionality in chronic kidney disease (CKD) patients. In this study, UdRPCs were isolated from healthy individuals and CKD patients.

Eternal-MAML: a meta-learning framework for cross-domain defect recognition.

Defect recognition tasks for industrial product suffer from a serious lack of samples, greatly limiting the generalizability of deep learning models. Addressing the imbalance of defective samples often involves leveraging pre-trained models for transfer learning. However, when these models, pre-trained on natural image datasets, are transferred to pixel-level defect recognition tasks, they frequently suffer from overfitting due to data scarcity.

Phenotypic Characterization and Marker-Trait Association Analysis Using SCoT Markers in Chrysanthemum ( Ramat.) Germplasm.

Unlabelled: Chrysanthemum is an economically important ornamental species whose genetic diversity assessment forms the foundation for effective breeding programs.

Methods: Phenotypic characterization of 12 traits (7 quantitative and 5 qualitative traits) was conducted alongside SCoT marker analysis to assess genetic diversity and perform marker-trait association analysis in 65 chrysanthemum accessions.

Results: Quantitative traits showed 14.

Novel 4H-SiC Double-Trench MOSFETs with Integrated Schottky Barrier and MOS-Channel Diodes for Enhanced Breakdown Voltage and Switching Characteristics.

In this study, a novel silicon carbide (SiC) double-trench MOSFET (DT-MOS) combined Schottky barrier diode (SBD) and MOS-channel diode (MCD) is proposed and investigated using TCAD simulations. The integrated MCD helps inactivate the parasitic body diode when the device is utilized as a freewheeling diode, eliminating bipolar degradation. The adjustment of SBD position provides an alternative path for reverse conduction and mitigates the electric field distribution near the bottom source trench region.

A Multi-Domain Feature Fusion CNN for Myocardial Infarction Detection and Localization.

Myocardial infarction (MI) is a critical cardiovascular disease characterized by extensive myocardial necrosis occurring within a short timeframe. Traditional MI detection and localization techniques predominantly utilize single-domain features as input. However, relying solely on single-domain features of the electrocardiogram (ECG) proves challenging for accurate MI detection and localization due to the inability of these features to fully capture the complexity and variability in cardiac electrical activity.

Machine learning photodynamics reveal intersystem-crossing-driven ladderdiene ring opening.

Photochemical ring-opening reactions have become an essential tool for chemical syntheses under mild conditions with high atom economy. We propose a near-visible light-induced electrocyclic ring-opening reaction to afford cyclooctatetraene (COT) using carbonyl-functionalized tricyclooctadiene (1) based on our machine learning (ML) accelerated photodynamics simulations. Our CAM-B3LYP/cc-pVDZ calculations show that carbonyl group reduce the S-energy of 1 to 3.

Photoinduced Iron-Catalyzed Decarboxylative Radical Alkylation/Cyclization of -Alkenyl Quinazolin-4(3)-ones.

A visible-light-driven, iron-catalyzed decarboxylative radical alkylation/cyclization strategy for synthesizing alkyl-substituted ring-fused quinazolin-4(3)-ones has been developed. This method employs secondary and tertiary aliphatic carboxylic acids as alkyl radical precursors under mild conditions achieving moderate to excellent yields (up to 95%) across 35 diverse substrates.This protocol offers a practical and versatile route to access polycyclic quinazolinones with high atom economy and operational simplicity.

Association of Serum Uric Acid With Relative Muscle Loss: A US Population-Based Cross-Sectional Study.

Background: Evidence regarding serum uric acid (SUA) and sarcopenia remains insufficient and controversial. Muscle mass is a basic and objective component of sarcopenia, and relative muscle loss has been used to define sarcopenia in some studies. We sought to investigate the association of SUA levels with relative muscle loss in the National Health and Nutrition Examination Survey (NHANES) 2011-2018.

Regulation of Structural Flexibility and CH Selectivity of Interpenetrated Isoreticular Metal-Organic Frameworks.

Interpenetrated pillar-layered metal-organic frameworks (MOFs), distinguished by their readily tunable pore architectures and functionalities, hold particular promise for separating molecules with similar physicochemical characteristics. Here, we report two isoreticular interpenetrated pillar-layered MOFs, designated as M-PTTB-BPY (M = Zn, Co). They exhibit the same connectivity with slightly different linker distortion.

Electrochemical Cross-Dehydrogenative Coupling of P(O)-H/P-H Bonds with Heteroatom Nucleophiles: Access to P(O)-N and P(S)-X Compounds.

A unified electrochemical cross-dehydrogenative coupling (CDC) of heteroatom nucleophiles with H-phosphine oxides, H-phosphinates, H-phosphites, and in situ-formed H-phosphine sulfides has been developed for the synthesis of -aryl phosphamides, phosphoramidates, thiophosphamides, phosphinodithioates, and phosphinothioates. This electrochemical reaction exhibited good function tolerance and high atomic economy under metal-, light-, base-, and oxidant-free conditions with releasing molecular hydrogen as the sole and nontoxic byproduct.

Flexible Metal-Organic Frameworks for Adsorptive Separation of Liquid Hydrocarbons.

ConspectusThe separation and purification of liquid hydrocarbons are vital for producing various petrochemical feedstocks. However, the structural and chemical similarities among these hydrocarbons make conventional separation methods such as distillation and extraction both challenging and energy intensive. Adsorptive separation using porous solid adsorbents presents a promising and energy-efficient alternative.

NINJ1 regulates plasma membrane fragility under mechanical strain.

The integrity of the plasma membrane is vital for nearly all aspects of cell functioning. Mechanical forces can cause plasma membrane damage, but it is unclear whether there are large molecules that regulate the integrity of the plasma membrane under mechanical strain. Here we constructed a 384-well cellular-stretch system that delivers precise, reproducible strain to cultured cells.

Pulsed Electrolysis Promotes CO Reduction on Tin Oxide Catalyst.

The performance of electrochemical CO reduction reaction (CORR) is determined by multiple factors, including the optimization of catalysts and electrolyser, along with the electrolysis technique. Recently, pulsed electrolysis has been found to tailor the selectivity and prolong the stability of CORR on a variety of catalysts, with the most focus on Cu-based materials. The investigation of pulsed electrolysis on Sn-based materials remains at early stage.