Education and development as factors inspiring nursing leaders: A qualitative study.

Background: Nursing leadership plays a crucial role in advancing healthcare, yet young nurses and nursing students face barriers to pursuing leadership roles, such as resource constraints and personal challenges.

Purpose: This study aimed to explore the perceptions of young nurses and nursing students regarding factors that influence their willingness to pursue leadership roles in nursing.

Methods: Qualitative descriptive exploratory design with interviews.

Two homeobox transcription factors CgrHtf1 and CgrAfh1 hierarchically regulate asexual sporulation and appressorium formation in the maize anthracnose fungus Colletotrichum graminicola.

Maize anthracnose, caused by the fungal pathogen Colletotrichum graminicola, is among the most devastating diseases affecting maize production. Homeobox transcription factors (HTFs) regulate key developmental and physiological processes in eukaryotes, including fungal pathogenesis. In this study, we identified two HTFs, CgrHtf1 and CgrAfh1, in C.

Tauroursodeoxycholic acid modulates neuroinflammation via STING/NF-κB inhibition after traumatic brain injury.

The incidence of traumatic brain injury (TBI) has demonstrated a marked escalation recently. Nevertheless, there remains a critical paucity of effective drug interventions targeting persistent neuroinflammation-induced damage following TBI. STING/NF-κB axis-induced pyroptosis emerges as a pivotal mechanism driving persistent neuroinflammation, providing it as a potential target for multi-pathway precision therapeutic in TBI.

Blueberry anthocyanins-functionalized hydrogel labels for smartphone-assisted real-time visual freshness monitoring of perishable proteins.

Given rising consumer demands for meat safety and quality assurance, developing an intuitive, cost-effective, and user-friendly sensor platform for real-time monitoring of perishable meat freshness is important. Herein, this study developed an innovative chitosan/agarose/blueberry anthocyanin (CS/AG/BA) hydrogel label system for visual real-time freshness tracking of perishable proteins through smartphone-assisted colorimetric analysis. Through systematic optimization of CS/AG compositional ratios (3:7-7:3) and pH conditions (2.

Marine organism-inspired tough and adhesive patch based on thermosensitive quaternized chitin for tissue sealing/repair and hemostasis.

Tissue adhesives have emerged as a promising alternative to conventional sutures and staplers in the management of hemostasis, tissue defect sealing, and wound repair. However, the efficacy of current bio-adhesives in clinical practice is compromised by the limitations, including poor wet adhesion, inadequate mechanical strength, vulnerability to gastrointestinal fluids, and insufficient hemostatic performance. Herein, a marine organism-inspired tough and adhesive patch (MOTAP) was developed to address these challenges.

A facile and stable single-system fluorescent sensor array for the quantification and discrimination of nitrofuran antibiotics.

The misuse of nitrofuran antibiotics (NFAs) poses serious risks to food safety and human health. Thus, it is urgent to establish a rapid and sensitive method for detecting NFAs. In this work, a dual-emission fluorescent material (TbUDPA) was developed by embedding Tb in a Zr-MOF for rapid and sensitive detection of four NFAs, and it successfully detected nitrofurazone (NFZ) residues in real food samples with high recovery rates.

Synergistically Enhanced NiCo(OH)@NiS Heterojunction Catalyst for High-Performance Ethanol Electrooxidation.

Coupling the ethanol electrooxidation reaction (EOR) with the hydrogen evolution reaction is an effective way to obtain green energy. Although Ni-based catalysts have the characteristics of low cost and good stability, meanwhile, the activity needs to be further improved. Here, we report a Ni-based heterojunction EOR catalyst, NiCo(OH)@NiS, composed by two phases of NiS and NiCo(OH).

β-Asaronol, the Neuroactive Component of : Mitigating Seizures with Minimal Developmental Risk in Dravet Syndrome.

Developmental epileptic encephalopathies (DEEs), including Dravet syndrome (DS), require antiseizure medications (ASMs) that balance efficacy with developmental safety. There is an urgent clinical need for novel therapeutic agents that combine potent anticonvulsant activity with developmental safety. β-Asarone, an active constituent of plants, has demonstrated antiepileptic potential, but its toxicities severely limit clinical application.

Use of shunt-side esCCO monitoring for hemodynamic management during hemodialysis as a novel approach for early detection of hypotension: a report of two cases.

Early recognition of the signs of hypotension may lead to prompt intervention by medical professionals, reducing the risk of intradialytic hypotension. The study included two patients on dialysis, one with stable hemodynamics (Case 1) and one who developed hypotensive shock (Case 2), in whom noninvasive continuous hemodynamic monitoring using shunt-side estimated continuous cardiac output (esCCO) was performed. Noninvasive blood pressure (BP), heart rate, esCCO, estimated stroke volume, systemic vascular resistance, and decrease in blood volume of each patient before and after dialysis were evaluated in chronological order.

Potential risks of histone deacetylase inhibitors in cancer therapeutics and feasible combination therapeutic strategies.

Histone deacetylase inhibitors (HDACis), such as trichostatin A (TSA), have been recognized as promising anti-cancer agents due to their capacity to restore epigenetic regulation and reactivate tumor suppressor genes. However, emerging evidence indicates that unintended pro-metastatic effects may offset the therapeutic benefits of HDACis. Chen elucidate this paradox, demonstrating that TSA-induced hyperacetylation activates the BRD4/c-Myc/ER-stress axis, thereby promoting epithelial-mesenchymal transition and metastasis in esophageal squamous cell carcinoma (ESCC).

Reclassification of Ming . 2012 as a later heterotypic synonym of (Nakamura 1987) Shida . 1997.

In this study, the taxonomic relationship between and was reassessed utilizing a polyphasic taxonomic approach. Molecular identification through 16S rRNA gene sequence analysis demonstrated that DSM 5050 exhibited the highest sequence similarities with LMG 31458 (99.57%), LMG 31460 (99.

Proposal of (Artamonova and Krassilnikov 1960) Pridham 1970 (Approved Lists 1980) as a later heterotypic synonym of (Rossi Doria 1891) Waksman 1953 (Approved Lists 1980) and an emended description of .

The taxonomic relationship between and was re-evaluated using comparative genome analysis. The 16S rRNA gene sequence analysis indicated that the type strains of and shared 100% sequence similarity. Phylogenetic trees based on 16S rRNA gene sequences indicated that JCM 4387 was clustered together with CGMCC 4.

Time-series transcriptomic analysis of Nile tilapia reveals the crucial roles of long non-coding RNA and transcription factor in response to Aeromonas veronii infection.

Nile tilapia (Oreochromis niloticus) is a vital aquaculture species worldwide, prized for its rapid growth and high productivity. However, the increasing prevalence of Aeromonas veronii infections has led to significant economic losses in the Nile tilapia industry. To elucidate the molecular mechanisms underlying the host immune response, we performed transcriptome sequencing of Nile tilapia spleen tissues at 3, 7, and 10 days post-infection.

Genomic Investigation of a Bacillus subtilis Strain Sourced from Commercially Available Milk Powder in China Reveals Potential Risk Factors.

Background: Milk powder is a key food source, especially for infants and vulnerable groups. However, Bacillus contamination during production, storage, or handling can cause spoilage, quality issues, or health risks. This study identified and isolated from commercially available Chinese milk powder.

Multi-omics identification of quantitative trait loci associated with vascular pathogenesis and diagnostic potential in chronic venous disease.

Chronic venous disease (CVD) is a prevalent vascular disorder with a poorly characterized genetic basis. In this study, we employed an integrative omics strategy combining genome-wide association studies (GWAS), expression quantitative trait loci (eQTL) mapping, endothelial cell functional assays, and transcriptomic correlation analysis to elucidate the molecular architecture of CVD. A GWAS conducted in a Taiwanese population identified two CVD-associated single nucleotide polymorphisms: VSTM2L rs1998049 and DPYSL2 rs1442887.

Biodegradation of Zearalenone by a Novel Strain X13 Isolated from Volcanic Rock Soil Using the Mycotoxin as the Sole Carbon Source.

Zearalenone (ZEN) is a widespread estrogenic mycotoxin that poses serious health risks to both humans and animals through the contamination of cereals and feeds. In this study, a novel strain X13 was isolated from volcanic rock soil and demonstrated the unique ability to utilize ZEN as the sole carbon source for growth and metabolism. Under optimized conditions (37 °C, pH 8.

From Natriuretic Peptides to microRNAs: Multi-Analyte Liquid Biopsy Horizons in Heart Failure.

Heart failure (HF) is a leading cause of morbidity and mortality worldwide, underscoring the need for improved diagnostic, prognostic, and therapeutic strategies. Circulating microRNAs (c-miRNAs) have emerged as promising non-invasive biomarkers due to their stability, tissue specificity, and regulatory roles in cardiac pathophysiology. This review highlights the potential of c-miRNAs in enhancing HF diagnosis, risk stratification, and therapeutic monitoring, particularly when integrated with conventional biomarkers such as natriuretic peptides, galectin-3, soluble ST2, and high-sensitivity troponins.

Screening of cellulose-degrading bacteria and its degradation and growth-promoting applications.

More than one billion tons of chaff waste are generated globally every year, but traditional recycling methods face the dual challenges of inefficiency and environmental risks, to solve this problem, this study innovatively achieves the dual functions of lignocellulosic synergistic degradation and plant promotion by constructing synthetic microbial communities. Firstly, a cellulose-degrading bacterium cmk-7 (Chromobacterium violaceum) was screened from soil based on Congo red staining method, and the maximum values of CMCase enzyme activity and FPase enzyme activity were 289.12 U/mL and 332.

Axial modulation of Fe sites for boosted electrochemical oxidation.

Fe/NC single-atom catalysts have attracted extensive attention due to their maximal atomic utilization and tunable coordination environments. However, the structure-activity relationship of Fe single atoms in electrooxidation remains unclear. Herein, we report a defect engineering strategy to fine-tune the charge configuration of FeN sites by introducing an axial N ligand and constructing FeN-Fe/NC.

Bioorthogonal reaction mediated size transformation clustered nanosystems for potentiating bioimaging and drug delivery.

Continuous advances have been witnessed in the booming of size variable nanosystems for molecular imaging and therapy. These nanosystems usually exhibit size transformation, which promotes optimized biodistribution, retention and penetration in lesions. Bioorthogonal reactions have been introduced as a useful tool to develop size variable nanosystems.

Dual T/NK cell engagement via B7-H6-targeted bispecific antibodies and IL-15 eradicates chemo-resistant solid tumors.

Introduction: B7-H6, a tumor-specific immune checkpoint molecule within the B7 family, represents a promising therapeutic target due to its selective overexpression in malignancies and negligible expression in normal tissues.

Method: Here, we developed bispecific antibodies (BsAbs) targeting B7-H6 to redirect T and NK cells against solid tumors. Through phage display, 15 high-affinity B7-H6 monoclonal antibodies were generated.

[pLM4ACP: a model for predicting anticancer peptides based on machine learning and protein language models].

Cancer is a serious global health problem and a major cause of human death. Conventional cancer treatments often run the risk of impairing vital organ functions. Anticancer peptides (ACPs) are considered to be one of the most promising therapeutic agents against common human cancers due to their small sizes, high specificity, and low toxicity.

Amycolatopsis cyclosori sp. nov., isolated from the rhizosphere soil of Cyclosorus parasiticus.

A novel actinomycete strain, cg5, was isolated from the rhizosphere soil of Cyclosorus parasiticus, collected from Xiangtan City, Hunan province, China. Strain cg5 contained meso-diaminopimelic acid as a diagnostic amino acid. Whole-cell sugars of strain cg5 included arabinose, galactose, ribose, and rhamnose.

Molecular Insight into the Binding of Heme to β-Lactoglobulin: Effect on the Intestinal Iron Absorption and Microbiota.

Heme is widely recognized as an effective iron supplement. In vitro experiments suggested a relatively low bioaccessibility of free heme due to its strong hydrophobicity. The study prepared a β-lactoglobulin-heme nanocomplex (β-Lg-He) to improve the bioaccessibility of heme.

Opposing mechanisms by which miRNAs mediate distinct Nrf1 and Nrf2 regulation of epithelial-mesenchymal transition in hepatocellular carcinoma.

Accumulation of various genetics and epigenetics alterations are accepted to result in the initiation and progression of hepatocellular carcinoma (HCC), and its high metastasis is viewed as a critical bottleneck leading to its treatment failure. Amongst them, the microRNAs arising from the lack of the antioxidant transcription factor Nrf2 lead to cancer metastasis. However, much less is known about the regulation of microRNAs by Nrf1, even though it acts as an essential determinon of cell homoeostasis by governing the transcriptional expression of those driver genes contributing to the EMT involved in its metastasis.