Morphological and phylogenetic analyses reveal two new species of (Tubeufiales, Tubeufiaceae) from China.

is a genus of helicosporous hyphomycetes with the potential to produce bioactive secondary metabolites. During a survey of helicosporous fungi in Guizhou and Hainan provinces, southern China, four isolates were obtained from both freshwater and terrestrial habitats. Based on combined analyses of multigene phylogenetic data (ITS, LSU, 1-α, and 2) and morphological characteristics, two novel species, and , are proposed.

Potential risks of histone deacetylase inhibitors in cancer therapeutics and feasible combination therapeutic strategies.

Histone deacetylase inhibitors (HDACis), such as trichostatin A (TSA), have been recognized as promising anti-cancer agents due to their capacity to restore epigenetic regulation and reactivate tumor suppressor genes. However, emerging evidence indicates that unintended pro-metastatic effects may offset the therapeutic benefits of HDACis. Chen elucidate this paradox, demonstrating that TSA-induced hyperacetylation activates the BRD4/c-Myc/ER-stress axis, thereby promoting epithelial-mesenchymal transition and metastasis in esophageal squamous cell carcinoma (ESCC).

[Gene expression characteristics of lncRNAs and mRNAs in the sperm of asthenospermia patients].

Objective: To determine the differential expressions of long non-coding RNA (lncRNA) and messenger RNA (mRNA) in normal and asthenospermia (AS) men and analyze their biological significance in AS.

Methods: We isolated and extracted total RNAs from 9 normal and 9 AS sperm samples, determined the expressions of RNAs in the sperm using the DNBSEQ sequencing platform, and analyzed their relevant functions by gene ontology enrichment (GO) and Kyoto encyclopedia of genes and genomes pathway (KEGG) analyses.

Results: An average of 10.

The Mechanistic Investigation of Polycarbonate:Polystyrene and Poly(vinylidene fluoride):Polystyrene Micro-Nano Structures in Optimization Light Field Distribution and Viewing Angle Ratio of Organic Light-Emitting Diodes.

In this study, we utilize the phase separation phenomenon between polycarbonate (PC), poly(vinylidene fluoride) (PVDF), and polystyrene (PS) to fabricate two types of micro-nano structures, PC:PS, and PVDF:PS. We investigate the optimization mechanisms of two micro-nano structures in green phosphorescent organic light-emitting diodes (OLEDs) by using electroluminescence (EL), normalized viewing angle ratio tests, and finite-difference time-domain (FDTD) simulations. The results confirm that improvements in both the viewing angle ratio and light extraction efficiency are due to the optimized internal light field distribution.

Two new species of (Tubeufiaceae, Tubeufiales) from freshwater and terrestrial habitats in China.

species are a group of helicosporous hyphomycetes with the potential to produce novel bioactive natural compounds. During our investigation on helicosporous hyphomycetes, six isolates were collected from freshwater and terrestrial habitats in the tropical and subtropical regions of southern China. Based on multi-gene phylogenetic analyses (LSU-ITS-1-α-2) and morphological comparisons of taxa, two new species ( and ) are introduced.

Epidemiological and etiological investigation of a rare family cluster caused by severe fever with thrombocytopenia syndrome in Anhui Province in 2023.

Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease discovered in the 21st century. Human-to-human transmission of the disease has been documented, but the mechanisms of transmission require further investigation.

Methods: Epidemiological investigations and genetic analyses of the patients were conducted, and a retrospective cohort study was performed to analyze potential risk factors for person-to-person transmission.

TcEVdb: a database for T-cell-derived small extracellular vesicles from single-cell transcriptomes.

T-Cell-derived extracellular vesicles (TcEVs) play key roles in immune regulation and tumor microenvironment modulation. However, the heterogeneity of TcEV remains poorly understood due to technical limitations of EV analysis and the lack of comprehensive data. To address this, we constructed TcEVdb, a comprehensive database that explores the expression and cluster of TcEV by the SEVtras method from T-cell single-cell RNA sequencing data.

Spatial and Temporal Analysis of Severe Fever with Thrombocytopenia Syndrome in Anhui Province from 2011 to 2023.

Objective: To analyze the spatial autocorrelation and spatiotemporal clustering characteristics of severe fever with thrombocytopenia syndrome(SFTS) in Anhui Province from 2011 to 2023.

Methods: Data of SFTS in Anhui Province from 2011 to 2023 were collected. Spatial autocorrelation analysis was conducted using GeoDa software, while spatiotemporal scanning was performed using SaTScan 10.

Perturbations in gut and respiratory microbiota in COVID-19 and influenza patients: a systematic review and meta-analysis.

Objectives: Coronavirus disease-19 (COVID-19)/influenza poses unprecedented challenges to the global economy and healthcare services. Numerous studies have described alterations in the microbiome of COVID-19/influenza patients, but further investigation is needed to understand the relationship between the microbiome and these diseases. Herein, through systematic comparison between COVID-19 patients, long COVID-19 patients, influenza patients, no COVID-19/influenza controls and no COVID-19/influenza patients, we conducted a comprehensive review to describe the microbial change of respiratory tract/digestive tract in COVID-19/influenza patients.

[Separation, characterization, and antiviral activity of colloidal phase state of Maxing Shigan Decoction].

This study focused on the separation, characterization, content determination, and antiviral efficacy research on colloidal particles with different sizes in Maxing Shigan Decoction(MXSG). The mixed colloidal phase of MXSG was initially separated into small colloidal particle segment(S), medium colloidal particle segment(M), and big colloidal particle segment(B) using ultrafiltration. Further fine separation was performed using size-exclusion chromatography.

TRAF3/STAT6 axis regulates macrophage polarization and tumor progression.

Converting tumor-associated macrophages (TAMs) from the M2 to the M1 phenotype is considered an effective strategy for cancer therapy. TRAF3 is known to regulate NF-κB signaling. However, the role of TRAF3 in TAM polarization has not yet been completely elucidated.

Insomnia and circadian rhythm: a bibliometrics study and visualization analysis CiteSpace.

Objective: The present study aimed to use CiteSpace to analyze the status of insomnia and circadian rhythm, identify the hot spots and trends, and provide a basis for future study.

Method: The Web of Science database was searched for studies related to insomnia and circadian from its inception to 14 April 2023. CiteSpace was used to generate online maps of collaboration between countries and authors and revealed hot spots and frontiers in insomnia and circadian rhythm.

Clinical guideline on magnetically controlled capsule gastroscopy (2021 edition).

With the development and generalization of endoscopic technology and screening, clinical application of magnetically controlled capsule gastroscopy (MCCG) has been increasing. In recent years, various types of MCCG are used globally. Therefore, establishing relevant guidelines on MCCG is of great significance.

-Opioid Receptor Agonist U50448H Protects Against Acute Lung Injury in Rats with Cardiopulmonary Bypass via the CAP-NLRP3 Signaling Pathway.

Objective: Acute lung injury (ALI) is one of the common and severe complications of cardiopulmonary bypass (CPB), which is the primary cause of death in intensive care units. Nevertheless, there is a lack of effective treatment for ALI secondary to CPB. -Opioid receptor (KOR) agonists have been demonstrated to improve lung function after pulmonary hypertension.

Design, synthesis and evaluation of novel curcumin analog as potential anti-lung cancer agent.

Curcumin is a polyphenolic compound derived from the plant turmeric and the structural instability of which limits its further clinical applications. In this study, 11 curcumin analogs with more stable scaffold were prepared and evaluated. The results indicated that the optimal compound exhibited the strongest antiproliferative activities against lung cancer cells including H460 and H1650.

[Research on the Effects of NOX-Mediated Oxidative Stress and Hearing Loss].

Hearing loss is one of the most common chronic developmental diseases.The available studies have demonstrated that the occurrence and development of hearing loss is closely related to oxidative damage caused by oxidative stress.Nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase,NOX) contribute to the production of reactive oxygen and are classified into seven subtypes (NOX1,NOX2,NOX3,NOX4,NOX5,DUOX1,and DUOX2).

Oncogenic TRIB2 interacts with and regulates PKM2 to promote aerobic glycolysis and lung cancer cell procession.

PKM2 is an important regulator of the aerobic glycolysis that plays a vital role in cancer cell metabolic reprogramming. In general, Trib2 is considered as a "pseudokinase", contributing to different kinds of cancer. However, the detailed roles of TRIB2 in regulating cancer metabolism by PKM2 remain unclear.

[Bone tunnel positions in anterior cruciate ligament reconstruction evaluated by three-dimensional CT reconstruction based on Mimics software:modified transtibial versus anteromedial portal technique].

Objective: To compare the femoral and tibial tunnel positions of anterior cruciate ligament reconstruction using the modified transtibial (MTT) technique and anteromedial (AM) portal technique.

Methods: Between January 2017 and September 2020, 78 patients with anterior cruciate ligament rupture underwent single-bundle reconstruction with the modified transtibial technique in 39 cases (group MTT) and through anteromedial approach in 39 cases (group AM). There were 25 males and 14 females in group MTT, with an average age of (37.

Qi-Regulating and Blood Circulation-Promoting Therapy Improves Health Status of Stable Angina Pectoris Patients with Depressive Symptoms.

Depressive symptoms have been found to be highly prevalent among patients with coronary heart disease (CHD) and seriously affect the patients' quality of life. However, most psychotropic drugs have warnings about potential side effects. Accordingly, safer effective alternatives are urgently demanded.

Observation of the effect of one-to-one education on high-risk cases of diabetic foot.

Background: Diabetes is a common chronic disease, and its global incidence is on the rise. The disease is directly attributed to insufficient insulin efficacy/secretion, and patients are often accompanied by multiple complications. Diabetic foot is one of the most common complications of diabetes.

The establishment of rat model in myocardial ischemia with psychological stress.

Background: Psychological stress can provoke and aggravate myocardial ischemia, and this stress can even trigger acute coronary syndromes or sudden cardiac death. Therefore, for the first time, this study aimed to investigate the method for establishing a rat model of myocardial ischemia with psychological stress and its evaluation.

Methods: Forty male Wistar rats were randomly divided into the sham (S, n=10), myocardial infarct (MI, n=10), psychological stress (MODEL, n=10), and myocardial infarct with psychological stress (MI + MODEL, n=10) groups.

Three-dimensional architecture of a mechanoreceptor in the brown planthopper, Nilaparvata lugens, revealed by FIB-SEM.

Trichoid sensilla are the most common mechanoreceptors in insects; depending on their distribution, they can act as either exteroceptors or proprioceptors. In this study, the internal structure of the trichoid sensillum from Nilaparvata lugens was studied, using focused ion beam scanning electron microscopy (FIB-SEM). We reconstructed a three-dimensional (3D) model derived from the FIB-SEM data set.

Postconditioning with Calreticulin Attenuates Myocardial Ischemia/Reperfusion Injury and Improves Autophagic Flux.

Background: Impaired autophagic flux contributes to cardiomyocyte death in ischemia/reperfusion (I/R) injury. Restoring the impaired autophagic flux by using agents may be a promising strategy that alleviates myocardial I/R injury. The present study aimed to evaluate the effect of exogenous calreticulin (CRT) postconditioning on impaired autophagic flux induced by hypoxia/reoxygenation (H/R) injury in H9c2 cells.

Protective Effect of Nicotinamide Adenine Dinucleotide Phosphate on Renal Ischemia-Reperfusion Injury.

Background/aims: Renal ischemia-reperfusion injury (IRI) is a common consequence of acute kidney injury. Nicotinamide adenine dinucleotide phosphate (NADPH), which is derived from the pentose phosphate pathway, is essential for the proper functioning of essential redox and antioxidant defense systems. Previous studies have indicated that NADPH is responsible for protecting the brain from ischemic injury.