Photocatalytic cyclization reaction of 2-vinylarylamines with CFSONa and arylaldehydes to access 3-(2,2,2-trifluoroethyl)-3-indoles.

A visible-light-catalyzed three-component cyclization reaction of 2-vinylarylamines with CFSONa and arylaldehydes is developed to build a series of 3-(2,2,2-trifluoroethyl)-3-indoles. This protocol features mild reaction conditions using an 18 W blue LED as the light source at room temperature. The desired 3-indole products can be successfully transformed into valuable tetrahydroindole scaffolds through either reduction or cross-coupling reactions.

Environmental impact analysis of the synergistic recycling process of waste three-way catalysts and waste LiCoO batteries.

Waste three-way catalysts (TWCs) and waste LiCoO batteries represent critical environmental challenges due to hazardous components yet contain high-value resources, and their recycling has garnered widespread attention. We propose a novel 'waste-to-waste' synergistic recycling where spent LiCoO batteries reconstruct mineral phases of waste TWCs, enabling co-recovery of platinum group metals and Li/Co without traditional oxidants. However, the environmental performance of this process still requires further analysis.

Electrically Conductive Hydrogels for Wound Healing.

Wound healing is a complex, tightly regulated process involving a range of enzymes, growth factors, and cytokines that coordinate cellular activities essential for tissue repair and wound closure. However, in cases of extensive or severe injury, the intrinsic repair mechanisms are often insufficient, underscoring the need for advanced therapeutic strategies to accelerate healing and minimize scar formation. Electrically conductive hydrogels (ECHs), combining the advantageous properties of hydrogels with the physiological and electrochemical characteristics of conductive materials, present a safer and more convenient alternative to traditional electrode-based electrical stimulation (ES) for treating chronic and nonhealing wounds.

Novel photocatalytic SrTiO@TiO/SrSO heterojunction and its high performance in RhB degradation.

Building a heterogeneous structure is favorable for improving the performance of photocatalyst materials. In this study, we fabricated a ternary SrTiO@TiO/SrSO heterojunction material with a porous shell composite structure a simple one-step direct high-temperature treatment using the commercial strontium titanate and ZnSO. The effect of the synthesis temperature on the ZS-STO- products was investigated.

Origin and mitigation of the imprint effect in hafnia-based ferroelectrics.

The potential of hafnia-based ferroelectric materials for Ferroelectric Random Access Memory (FeRAM) applications is limited by the imprint effect, which compromises readout reliability. Here, we systematically investigate the asymmetric imprint behavior in W/HfZrO/W ferroelectric capacitors, demonstrating that the imprint direction correlates directly with the ferroelectric polarization state. Notably, a pre-pulse of specific polarity can temporarily suppress the imprint effect.

Globular proteins as functional-mechanical materials: a multiscale perspective on design, processing, and applications.

Globular proteins, traditionally regarded as non-structural biomolecules due to the limited load-bearing capacity in their monomeric states, are increasingly recognized as valuable building blocks for functional-mechanical materials. Their inherent bioactivity, chemical versatility, and structural tunability enable the design of materials that combine biological functionality with tailored mechanical performance. This review highlights recent advances in engineering globular proteins-spanning natural systems (serum albumins, enzymes, milk globulins, silk sericin, and soy protein isolates) to recombinant architectures including tandem-repeat proteins-into functional-mechanical platforms.

Type-I Supramolecular Photosensitizer Enables GSH Depletion by Hydrogen Atom Transfer.

Photodynamic therapy (PDT) induces oxidative stress that triggers a compensatory upregulation of intracellular glutathione (GSH), thereby diminishing PDT efficacy. The simultaneous generation of reactive oxygen species and depletion of GSH holds promise for amplifying oxidative damage and enhancing therapeutic outcomes yet remains a challenge. In this work, we present a Type-I supramolecular photosensitizer designed to deplete GSH through a hydrogen atom transfer mechanism while concurrently generating superoxide radicals.

Discovery of Tricyclic Derivative as Novel and Potent Respiratory Syncytial Virus Fusion Glycoprotein Inhibitor with an Improved Pharmacokinetic Profile.

Respiratory syncytial virus (RSV) is a major pathogen causing acute respiratory infections, and the RSV fusion glycoprotein (F) has been identified as a key target for developing small-molecule inhibitors. Based on our prior identification of lonafarnib as an F protein inhibitor, medicinal chemistry efforts led to the development of , which exhibits significantly enhanced potency against both laboratory and clinical RSV isolates in cellular assays. Time-of-addition and SPR assays indicate that inhibits viral entry by targeting the RSV F protein, but has farnesyltransferase-independent antiviral efficacy.

Mitochondrial ClpX Inhibition Induces Ferroptosis and Blocks Pancreatic Cancer Cell Proliferation.

The ATPase caseinolytic protease X (ClpX), forming the ClpXP complex with caseinolytic protease P (ClpP), is essential for mitochondrial protein homeostasis. While ClpP targeting is a recognized anticancer strategy, the role of ClpX in cancer remains underexplored. In pancreatic ductal adenocarcinoma (PDAC), elevated CLPX expression correlates with poor prognosis, suggesting its oncogenic function.

Covalently Supported Phenazine for Electrochemical Capture of Low Concentration CO.

Electrochemical CO capture (eCC) excels in selectivity, reversibility, low-temperature operation, and reusability, yet liquid-phase systems struggle with mass transfer limitations. In this study, a phenazine-based capture agent was chemically grafted onto carboxylated carbon nanotubes, achieving an active loading of 4.4 wt %.

Long-Lived Charge-Transfer State and Interfacial Lock in Double-Cable Conjugated Polymers Enable Efficient and Stable Organic Solar Cells.

The donor/acceptor (D/A) interfaces in bulk heterojunction (BHJ) organic solar cells (OSCs) critically govern exciton dissociation and molecular diffusion, determining both efficiency and stability. Herein, we design a double-cable conjugated polymer, SC-1F, to insert into a physically-blended D/A system to optimize the interface. We have found that SC-1F spontaneously segregates to the interface through favorable miscibility and heterogeneous nucleation with the acceptor.

One-Pot Sequential Coordination-Covalent Construction of Symmetry-Broken MNO Catalytic Sites in Cobalt-Polyimide Polymers for Nitrate Electroreduction.

The metal-nitrogen chelated species, MN, have shown promise as efficient electrocatalysts for nitrate reduction, yet the symmetric arrangement of N atoms results in suboptimal adsorption affinity toward reaction substrates and intermediates. The current approaches to breaking the symmetry of MN suffer from inaccuracy and inhomogeneity because of the lack of strategies stemming from molecular design aspects. Herein, we report the construction of symmetry-broken MNO sites in coordination polymers via sequential coordination-covalent control in a one-pot reaction.

Temperature-Driven Conformational Switching of Binaphthalene-Based Tetraimidazolium Macrocycles to Enhance Sequence-Selective Recognition of Dinucleotides in Water.

Developing artificial hosts with temperature-driven conformational switching behaviors facilitates our understanding of the temperature-dependent allostery and adaptation mechanisms in natural recognition systems. Herein, we report the design and synthesis of three pairs of water-soluble, enantiomeric binaphthalene-based tetraimidazolium macrocycles (SS/RR-1•4Cl- - SS/RR-3•4Cl-) as artificial hosts for exploring sequence-selective recognition of dinucleotides in aqueous media. Owing to the reversible rotational conformation of axially chiral binaphthyl units, SS-1•4Cl- demonstrates the conformational switching, converting from cis-conformation (SS-1) to trans-conformation (SS-1) by increasing temperature, thereby causing the recognition cavity to transition from a closed to an open state.

Clinicopathological Features of Non-HPV-associated Common Differentiated Penile Squamous Cell Carcinoma: A Study of 55 Patients.

To investigate the clinicopathological characteristics of non-HPV-related common differentiated penile squamous cell carcinoma, and to observe and analyze the changes of TP53 gene and the expression and significance of TP53, P16, programmed death-ligand 1 (PD-L1), epidermal growth factor receptor (EGFR), androgen receptor (AR), human epidermal growth factor receptor-2 (HER2), and Ki67 proteins in tumor tissue. A total of 65 patients with penile squamous cell carcinoma diagnosed from May 2008 to May 2020 in Yantai Yuhuangding Hospital were retrospectively analyzed, and tumors were confirmed as non-HPV-associated common differentiated squamous cell carcinoma of the penis with negative HPV molecular tests in 55 patients. The relevant clinicopathological data of 55 patients were collected, and the TP53 gene mutation was detected by applying first-generation sequencing technology.

Long noncoding RNAs as molecular architects: Shaping plant functions and physiological plasticity.

Long noncoding RNAs (lncRNAs) are emerging as pivotal regulators in gene expression networks, characterized by their structural flexibility and functional versatility. In plants, lncRNAs have gained increasing attention due to accumulating evidence of their roles in modulating developmental plasticity and agronomic traits. In this review, we focus on the origin, classification, and mechanisms of action of plant lncRNAs, with a particular emphasis on their involvement in developmental processes.

A solo-LTR insertion in the CreTPS3a promoter enhances γ -terpinene biosynthesis and affects consumer preference for tangerine-like aroma in citrus fruits.

Aroma differentiation is a key trait distinguishing citrus and other horticultural crops from staple crops. However, the mechanisms and sensory features by which distinctive and various citrus-like aroma in citrus remain poorly understood. In this study, we demonstrated that γ-terpinene determines tangerine-like aroma, affects consumer preference, and has pest-repellent properties.

SlBES1-mediated brassinosteroid signaling suppresses flavonoid biosynthesis in tomato fruit.

With the improvement of living standards, consumers' demands for color diversity and nutritional quality of tomato products have increased. Flavonoid is a considerable index of peel color and nutritional quality in tomato fruit, where flavonoid biosynthesis is controlled by various phytohormones, including brassinosteroids (BRs). However, the underlying mechanism by which BR regulates flavonoid biosynthesis is still unknown.

Visible-Light-Induced Cascade Annulation of -Cyanamide Alkenes with Unsaturated α-Halogenocarbonyls.

A visible-light-induced cascade annulation of -cyanamide alkenes with unsaturated α-halogenocarbonyls for the facile synthesis of piperidino-quinazolinone derivatives has been developed. This transformation simultaneously constructs three C-C bonds, one C-N bond, and three cyclic structures through a cascade process involving alkyl radical addition to alkene followed by three radical annulations. The reaction proceeds under mild conditions and demonstrates a high bond-forming efficiency.

A Reaction-Diffusion-Coupled Strategy for Ampere-Level Electrocatalytic Nitrate Reduction to Ammonia.

Ampere-level electrocatalytic nitrate reduction to ammonia (eNRA) offers a carbon-neutral alternative to the Haber-Bosch process. However, its energy efficiency is critically hampered by the inherent conflict between the reaction and diffusion. Herein, we propose a reaction-diffusion-coupled strategy implemented on a well-tailored CuCoNiRuPt high-entropy alloy aerogel (HEAA) to simultaneously realize energy barrier homogenization and accelerate mass transport, endowing ampere-level eNRA with a high energy efficiency.

Design, Synthesis, Insecticidal Activities, and Structure-Activity Relationship of Phenylpyrazole Derivatives Incorporating 1,2,4-Oxadiazole Moiety.

The ryanodine receptors (RyRs) represent an optimal target for insecticide development. To explore novel structures of RyRs agonists, a series of compounds containing 1,2,4-oxadiazole were designed and synthesized based on the RyRs structure. The compounds were confirmed by H and C nuclear magnetic resonance as well as high-resolution mass spectrometry.

Highly Sensitive Determination of Bacillus subtilis by Microchip Electrophoresis Combining With A Dual Nucleic Acid Recycling Amplification.

In dairy products, Bacillus subtilis (B. subtilis) is considered a harmful spoilage bacterium. Consequently, it is imperative to establish highly sensitive and selective approaches for detecting B.

Organoids in Genetic Disorders: from Disease Modeling to Translational Applications.

The emergence of organoid models has significantly bridged the gap between traditional cell cultures/animal models and authentic human disease states, particularly for genetic disorders, where their inherent genetic fidelity enables more biologically relevant research directions and enhances translational validity. This review systematically analyzes established organoid models of genetic diseases across organs (e.g.

MRI-based radiomics signatures for predicting the efficacy of targeted therapy with lenvatinib in hepatocellular carcinoma: a retrospective cohort study.

Purpose: Targeted therapy with lenvatinib is a preferred option for advanced hepatocellular carcinoma, however, predicting its efficacy remains challenging. This study aimed to build a nomogram integrating clinicoradiological indicators and radiomics features to predict the response to lenvatinib in patients with hepatocellular carcinoma.

Methods: This study included 211 patients with hepatocellular carcinoma from two centers, who were allocated into the training (107 patients), internal test (46 patients) and external test set(58 patients).

Scalable Photothermal Superhydrophobic Deicing Coating with Mechanochemical-Thermal Robustness.

Developing scalable and robust deicing coatings is essential for real-world applications, yet current coatings either suffer from intrinsic fragility or low thermal conductivity, limiting sustainability and deicing effectiveness. Here, we report a scalable and durable photothermal superhydrophobic coating coupling with enhanced thermal conductivity, engineered by embedding carbon nanotubes within a perfluoroalkoxy polymer matrix. Our design achieved 97.

Activating the Oxygen Evolution Performance of NiCuFe by Phosphorus Doping.

The oxygen evolution reaction (OER), a critical yet kinetically sluggish process in electrochemical water splitting, severely limits efficient hydrogen production. Herein, a simple one-step dynamic hydrogen bubble templated electrodeposition technique is used to prepare a self-supported 3D porous NiCuFeP catalyst with outstanding OER performance. In 1.