Merging mirror-coupled bound states in the continuum at THz frequency.

We achieve merging mirror-coupled bound states in the continuum (BICs) at THz frequency in the metasurface consisting of Si block arrays on an Au mirror with SiO as a spacer. Compared with the conventional mirror-coupled BIC, the merging BIC exhibits a higher Q-factor and local field enhancement at the same in-plane wavevector . Further, merging mirror-coupled BICs can combine the advantage of mirror-coupled BICs without breaking the symmetry of the nanostructure and the superiority of merging BICs, which is robust to imperfections of the nanostructure.

FAHD1-mediated pyruvate metabolism in hepatocellular carcinoma: Multi-omics and causal genetic evidence.

Hepatocellular carcinoma (HCC) progression is driven by metabolic reprogramming in the tumor microenvironment (TME), yet the causal regulators of pyruvate metabolism and their spatial interplay remain elusive. Here, we integrate single-cell transcriptomics, spatial mapping, and genetic causal inference to identify a pyruvate-hyperactive epithelial subpopulation (PyHighEpi) in HCC, characterized by enhanced stemness, proliferation, and metastatic traits. Spatial analyses reveal metabolic zonation, with pyruvate activity concentrated in tumor cores and associated with aggressive clones.

Asymmetrically Trifluoromethylated Non-fused Electron Acceptor for High-Efficiency and Stable Organic Solar Cells.

Fused-ring electron acceptors (FREAs) have advanced significantly in organic solar cells (OSCs) but suffer from complex synthesis and high production costs. As a cost-effective alternative, nonfused-ring electron acceptors (NFREAs) offer structural simplicity and easier synthesis, though typically at the expense of device performance. In this work, two asymmetric NFREAs, 3TT-CF and 3TT-BCF, were synthesized via a modular strategy and applied in high-efficiency OSCs.

Deubiquitinase-associated mRNA signature model predicts prognosis and influences the immune microenvironment in patients with hepatocellular carcinoma: An observational study.

Liver hepatocellular carcinoma (LIHC) represents a category of malignant neoplasms that present a considerable risk to public health. Recent studies have increasingly focused on the biological roles of messenger RNAs (mRNAs) linked to deubiquitinating enzymes in the context of LIHC. These deubiquitinating enzyme-associated mRNAs have been utilized to construct a prognostic model for this type of cancer.

Comprehensive pan-cancer multi-omics analysis of ATAD2 in human cancers.

Background: ATAD2, a member of the AAA + ATPase family and a known cancer/testicular antigen, has demonstrated oncogenic properties in various cancers. Despite its established role in cancer progression, a comprehensive pan-cancer analysis of its prognostic significance, therapeutic predictive potential, and immunological associations has not been conducted.

Methods: We performed a pan-cancer analysis of ATAD2 using data from The Cancer Genome Atlas (TCGA), assessing its expression profiles across different tumor types.

Revealing electron transport connectivity as an important factor influencing stability of organic solar cells.

In the pursuit of advancing the commercialization of organic solar cells (OSCs), stability emerges as a paramount challenge. Herein, we show that the electron transport connectivity is a key factor determining the electron transport and device stability of OSCs. When compared to small molecular acceptors (SMAs), the larger-size polymeric acceptors (PAs) are likely to establish an electron transport network with superior connectivity.

NSUN3-Mediated ROS Accumulation Promotes Hepatocellular Carcinoma Proliferation and Activates PI3K/AKT Pathway.

NSUN3 (NOP2/Sun RNA methyltransferase family member 3) is a gene encoding an RNA methyltransferase primarily responsible for specific methylation modifications on mitochondrial tRNA. Recent studies have indicated that aberrant expression of NSUN3 may be associated with the development of a range of tumors. UALCAN and GEPIA2 were utilized for bioinformatics analyses, while lentiviral vectors and small interfering RNA techniques were employed to create cell lines with either overexpression or silencing of NSUN3.

Evaluated NSUN3 in reticulocytes from HbH-CS disease that reflects cellular stress in erythroblasts.

Hemoglobin H Disease-Constant Spring (HbH-CS) represents a severe variant of α-thalassemia characterized by a fundamental pathological mechanism involving inadequate synthesis of α-globin chains. This deficiency results in the formation of unstable Hemoglobin H (HbH) due to the aggregation of free β-globin chains, which subsequently induces an imbalance in oxidative stress within erythrocytes. This imbalance leads to an abnormal accumulation of reactive oxygen species (ROS), which in turn promotes lipid peroxidation, culminating in the production of malondialdehyde (MDA) and a significant depletion of glutathione (GSH).

Solid-State Alder-Ene Reaction of 1-Hexene under High Pressure.

The Alder-ene reaction is a chemical reaction between an alkene with an allylic hydrogen, and it provides an efficient method to construct the C-C bond. Traditionally, this reaction requires catalysts, high temperatures, or photocatalysis. In this study, we reported a high-pressure-induced solid-state Alder-ene reaction of 1-hexene at room temperature without a catalyst.

Molecular Control of the Donor/Acceptor Interface Suppresses Charge Recombination Enabling High-Efficiency Single-Component Organic Solar Cells.

Single-component organic solar cells based on double cable polymers have achieved remarkable performance, with DCPY2 reaching a high efficiency of over 13%. In this study, DCPY2 is further optimized with an efficiency of 13.85%, maintaining a high fill factor (FF) without compromising the short circuit current.

NMR Studies of the Interactions between Sialyllactoses and the Polysialytransferase Domain for Polysialylation Inhibition.

It is known that sialyllactose (SL) in mammalians is a major source of sialic acid (Sia), which can further form cytidine monophosphate sialic acid (CMP-Sia), and the final product is polysialic acid (polySia) using polysialyltransferases (polySTs) on the neural cell adhesion molecule (NCAM). This process is called NCAM polysialylation. The overexpression of polysialylation is strongly related to cancer cell migration, invasion, and metastasis.

The Bifunctional Effects of Lactoferrin (LFcinB11) in Inhibiting Neural Cell Adhesive Molecule (NCAM) Polysialylation and the Release of Neutrophil Extracellular Traps (NETs).

The expression of polysialic acid (polySia) on the neuronal cell adhesion molecule (NCAM) is called NCAM-polysialylation, which is strongly related to the migration and invasion of tumor cells and aggressive clinical status. Thus, it is important to select a proper drug to block tumor cell migration during clinical treatment. In this study, we proposed that lactoferrin (LFcinB11) may be a better candidate for inhibiting NCAM polysialylation when compared with CMP and low-molecular-weight heparin (LMWH), which were determined based on our NMR studies.

Dimerized Nonfused Electron Acceptor Based on a Thieno[3,4-]pyrrole-4,6-dione Core for Organic Solar Cells.

In this work, the first dimerized nonfused electron acceptor (NFEA), based on thieno[3,4-]pyrrole-4,6-dione as the core, has been designed and synthesized. The dimerized acceptor and its single counterpart exhibit similar energy levels but different absorption spectra due to their distinct aggregation behavior. The dimerized acceptor-based organic solar cells (OSCs) demonstrate a higher power conversion efficiency of 11.

Enhancing bighead carp cutting: Chilled storage insights and machine vision-based segmentation algorithm development.

To enhance market demand and fish utilization, cutting processing is essential for fish. Bighead carp were cut into four primary cuts: head, dorsal, belly, and tail, collectively accounting for 77.03% of the fish's total weight.

Safety and immunogenicity of homologous prime-boost CoronaVac vaccine in people living with HIV in China: A multicenter prospective cohort study.

People living with HIV (PLWH) are particularly vulnerable to SARS-CoV-2. This multicentre prospective cohort study evaluated the long-term immunogenicity and safety of a third homologous dose of Sinovac CoronaVac in PLWH in China. A total of 228 PLWH and 127 HIV-negative controls were finally included and followed up for 6 months.

A comprehensive review on 3D tissue models: Biofabrication technologies and preclinical applications.

The limitations of traditional two-dimensional (2D) cultures and animal testing, when it comes to precisely foreseeing the toxicity and clinical effectiveness of potential drug candidates, have resulted in a notable increase in the rate of failure during the process of drug discovery and development. Three-dimensional (3D) in-vitro models have arisen as substitute platforms with the capacity to accurately depict in-vivo conditions and increasing the predictivity of clinical effects and toxicity of drug candidates. It has been found that 3D models can accurately represent complex tissue structure of human body and can be used for a wide range of disease modeling purposes.

A Pyrene-Fused Dimerized Acceptor for Ternary Organic Solar Cells with 19% Efficiency and High Thermal Stability.

A pyrene-fused dimerized electron acceptor has been successfully synthesized and subsequently incorporated as the third component in ternary organic solar cells (OSCs). Diverging from the traditional dimerized acceptors with a linear configuration, this novel electron acceptor displays a distinctive "butterfly-like" structure, comprising two Y-acceptors as wings fused with a pyrene-based backbone. The extended π-conjugated backbone and the electron-donating nature of pyrene enable the new acceptor to show low solubility, elevated glass transition temperature (T ), and low-lying frontier energy levels.

Chinese herbal medicine combined with cognitive-behavioural therapy for avoidant paruresis: a controlled trial.

Background: Avoidant paruresis is a common clinical condition in urology and psychosomatic medicine. However, it has limited treatment options that are safe and effective with few side effects.

Aims: Our study aimed to investigate the effectiveness and safety of the Chinese herbal Yangxin Tongquan decoction combined with cognitive-behavioural therapy (CBT) for avoidant paruresis.

Incorporating Naphthalene and Halogen into Near-Infrared Double-Cable Conjugated Polymers for Single-Component Organic Solar Cells with Low-Voltage Losses.

The invention of near-infrared pedant-based double-cable conjugated polymers has demonstrated remarkable efficacy in single-component organic solar cells (SCOSCs). This work focuses on the innovative double-cable conjugated polymers aimed at attaining good absorption and suitable energy levels. Specifically, in the aromatic side units, the electron-donating (D) part is designed using a thieno[3,4-]pyrrole-4,6-dione (TPD) as a core unit, flanked by two cyclopentadithiophene groups on either side.

Willingness of people living with HIV to receive a second COVID-19 booster dose: a multicenter cross-sectional study in China.

Background: The coronavirus disease 2019 (COVID-19) pandemic has significantly affected the global population, with People Living with HIV (PLWH) being particularly vulnerable due to their compromised immune systems. Although vaccination is a crucial preventative measure against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, little is understood about the willingness of PLWH to receive a second COVID-19 booster dose and the factors that may influence this decision. This study investigates the willingness of PLWH in China to receive a second COVID-19 booster dose and its influencing factors, comparing these with a group of healthy individuals.

The NMR studies of CMP inhibition of polysialylation.

The overexpression of polysialic acid (polySia) on neural cell adhesion molecules (NCAM) promotes hypersialylation, and thus benefits cancer cell migration and invasion. It has been proposed that the binding between the polysialyltransferase domain (PSTD) and CMP-Sia needs to be inhibited in order to block the effects of hypersialylation. In this study, CMP was confirmed to be a competitive inhibitor of polysialyltransferases (polySTs) in the presence of CMP-Sia and triSia (oligosialic acid trimer) based on the interactional features between molecules.

The safety and immunogenicity of a two-dose schedule of CoronaVac, and the immune persistence of vaccination for six months, in people living with HIV: A multicenter prospective cohort study.

Background: People living with HIV (PLWH) are more vulnerable to SARS-CoV-2. However, evidence on the immunogenicity of coronavirus disease 2019 (COVID-19) vaccines in this population is insufficient. The objective of this study is to assess the immunogenicity and safety of the two-dose schedule of Sinovac CoronaVac for 6 months postvaccination in PLWH.

Electrically Tunable Lenses for Imaging and Light Manipulation.

Optofluidics seamlessly combines optics and microfluidics together to construct novel devices for microsystems, providing flexible reconfigurability and high compatibility. By taking advantage of mature electronic fabrication techniques and flexible regulation of microfluidics, electrically actuated optofluidics has achieved fantastic optical functions. Generally, the optical function is achieved by electrically modulating the interfaces or movements of microdroplets inside a small chamber.

13% Single-Component Organic Solar Cells based on Double-Cable Conjugated Polymers with Pendent Y-Series Acceptors.

Double-cable conjugated polymers with pendent electron acceptors, including fullerene, rylene diimides, and nonfused acceptors, have been developed for application in single-component organic solar cells (SCOSCs) with efficiencies approaching 10%. In this work, Y-series electron acceptors have been firstly incorporated into double-cable polymers in order to further improve the efficiencies of SCOSCs. A highly crystalline Y-series acceptor based on quinoxaline core and the random copolymerized strategy are used to optimize the ambipolar charge transport and the nanophase separation of the double-cable polymers.

Double-Cable Conjugated Polymers with Pendent Near-Infrared Electron Acceptors for Single-Component Organic Solar Cells.

Double-cable conjugated polymers with near-infrared (NIR) electron acceptors are synthesized for use in single-component organic solar cells (SCOSCs). Through the development of a judicious synthetic pathway, the highly sensitive nature of the 2-(3-oxo-2,3-dihydroinden-1-ylidene)malononitrile (IC)-based electron acceptors in basic and protonic solvents is overcome. In addition, an asymmetric design motif is adopted to optimize the packing of donor and acceptor segments, enhancing charge separation efficiency.