Novel photocatalytic SrTiO@TiO/SrSO heterojunction and its high performance in RhB degradation.

Building a heterogeneous structure is favorable for improving the performance of photocatalyst materials. In this study, we fabricated a ternary SrTiO@TiO/SrSO heterojunction material with a porous shell composite structure a simple one-step direct high-temperature treatment using the commercial strontium titanate and ZnSO. The effect of the synthesis temperature on the ZS-STO- products was investigated.

Binding of autotransporter adhesin CbpF to human CEACAM1 and CEACAM5: A Velcro model for bacterium adhesion.

In eukaryotic systems, three major types of cell junctions have been well characterized. While bacterial adhesion mechanisms also exhibit remarkable diversity, the molecular processes that regulate the dynamic modulation of binding strength between elongated bacterial cells and host cells remain poorly understood. () utilizes the surface adhesin CbpF to interact with the highly expressed host receptors CEACAM1 and CEACAM5 on cancer cells to facilitate tumor colonization.

Trace water-induced anomalous diffusion in chlorinated imidazolium ionic liquids.

Through molecular dynamics simulations of imidazolium-based ionic liquid-water mixtures, it was found that the trace water leads to an anomalous non-monotonic change in the diffusion coefficients of ionic liquid, characterized by an initial decrease followed by an increase. Hydrogen bond analysis revealed that this unusual trend is governed by the weighted hydrogen bond lifetime, reflecting the stability of the hydrogen-bond network, rather than simply the number or energy of hydrogen bonds.

Resolve and regulate: Alum nanoplatform coordinating STING availability and agonist delivery for enhanced anti-tumor immunotherapy.

The stimulator of interferon genes (STING) pathway represents a promising target in cancer immunotherapy. However, the clinical translation of cyclic dinucleotide (CDN)-based STING agonists remains hindered by insufficient formation of functional CDN-STING complexes. This critical bottleneck arises from two interdependent barriers: inefficient cytosolic CDN delivery and tumor-specific STING silencing via DNA methyltransferase-mediated promoter hypermethylation.

Exploitation of Biodiversity in Bioeconomy: Examples, Opportunities, and Challenges.

While bioprocesses using Escherichia coli, Corynebacterium glutamicum, various species of Bacillus, lactic acid bacteria, Clostridia, the yeasts Saccharomyces cerevisiae and Pichia pastoris, fungi such as Aspergillus niger, and Chinese hamster ovary cells are well established, the high level of microbial diversity has not yet been exploited industrially. However, the use of alternative organisms has the potential to significantly expand the process window of bioprocesses. These extensions include the use of alternative substrates (e.

Crystal structure of bis-(1-methyl-1-imidazole-κ )(5,10,15,20-tetra-phenyl-porphyrinato-κ )iron(II) toluene tris-olvate.

The title complex, [Fe(CHN)(CHN)]·3CH, possesses inversion symmetry with the iron(II) atom located on a center of symmetry. The metal atom is coordinated in a symmetric octa-hedral geometry by four pyrrole N atoms of the porphyrin ligand in the equatorial plane and two N atoms of 1-methyl-imidazole ligands in the axial sites; the complex crystallizes with three toluene solvent mol-ecules. The average Fe-N (N is a porphyrin N atom) bond length is 1.

Raman-based PAT for multi-attribute monitoring during VLP recovery by dual-stage CFF: attribute-specific spectral preprocessing for model transfer.

Spectroscopic soft sensors are developed by combining spectral data with chemometric modeling, and offer as Process Analytical Technology (PAT) tools powerful insights into biopharmaceutical processing. In this study, soft sensors based on Raman spectroscopy and linear or partial least squares (PLS) regression were developed and successfully transferred to a filtration-based recovery step of precipitated virus-like particles (VLPs). For near real-time monitoring of product accumulation and precipitant depletion, the dual-stage cross-flow filtration (CFF) set-up was equipped with an on-line loop in the second membrane stage.

Fused-ring isomerization dopant-free hole transport materials for high-performance inorganic perovskite solar cells.

We synthesized two linear dopant-free hole transport materials (HTMs), denoted as NT and iNT, by coupling methoxytriphenylamine donor unit with either naphtho[1,2-:5,6-']bis[1,2,5]thiadiazole or its isomeric counterparts naphtho[1,2-:5,6-']bis([1,2,3]thiadiazole) as acceptor units. The fused-ring isomerization structure of iNT endows it with a substantial dipole moment and well-aligned energy levels, which are highly favorable for efficient free-charge extraction. Compared to devices based on NT, CsPbI inorganic perovskite solar cells (IPSCs) employing iNT exhibited significantly enhanced performance, achieving a power conversion efficiency (PCE) of 18.

Nanoformulation-based drug delivery systems for the treatment of gastric cancer: recent developments and future prospects.

Gastric cancer (GC) is one of the leading causes of cancer-related mortality worldwide. Despite significant efforts and recent advances in GC treatment, therapeutic efficacy remains suboptimal. In recent years, emerging nanomaterials have demonstrated considerable potential for cancer therapy, primarily due to their ability to function as drug carriers that enable targeted and precise delivery of therapeutic agents to tumour tissues.

Interfacial Li Diffusion Booster Accelerated by Enhanced Metal-Organic Framework Sieving and Wettability for High-Voltage Solid-State Lithium Metal Batteries.

Solid-state lithium metal batteries (SSLMBs) are promising for realizing higher energy density. However, the poor interfacial Li transport kinetics and Li dendrite growth inhibit SSLMBs, leading to sluggish interfacial ion diffusion and depressive lifespan, which is attributed to high barriers blocked by anions or interface space in solid-state electrolytes. Herein, a flexible solid-state polymer skeleton employed with ionic liquid and metal-organic frameworks (PIM) electrolyte is proposed to strengthen interfacial Li ion exchange by improving the Li sieving effect and interfacial wettability.

Advances in immunoPET/SPECT imaging: The role of Fab and F(ab') fragments in theranostics.

With the advent of precision medicine and personalized treatment, targeted therapies have become pivotal in oncology. Noninvasive molecular imaging, especially immunoPET/SPECT, plays a crucial role in refining cancer diagnostics and treatment monitoring by visualizing biological processes at the molecular level. This review explores the dynamic field of immunoPET/SPECT imaging using Fab and F(ab') fragments, characterized by advantageous pharmacokinetics and swift clearance from the bloodstream, making them suitable for same-day imaging procedures.

Integrated co-cultivation and subsequent esterification: Harnessing Saccharomyces cerevisiae and Clostridium tyrobutyricum for streamlined ester production.

The rising demand for natural products is accelerating research into sustainable methods for producing bio-based flavourings like ethyl butyrate. In this study, ethyl butyrate was successfully produced through the enzymatic esterification of butyric acid and ethanol, which were derived from the co-cultivation of Clostridium tyrobutyricum and Saccharomyces cerevisiae. Initial monoculture experiments with both strains were performed to investigate compromised fermentation conditions for co-cultivation.

sp. nov., isolated from mouse faeces.

An extracellular polysaccharide-producing strain labelled GBG-M4 was isolated from the faeces of a C57BL/6 J mouse model with ulcerative colitis prognosis. Using a polyphasic approach, the taxonomy of this novel species was characterized. The strain was Gram-negative, non-motile, non-spore-forming, non-pigmented and rod-shaped.

Soil restoration in rare earth tailings: Synergistic effects of coal gangue-based silicon fertilizers.

The growing demand for rare earth elements has intensified environmental concerns in mining areas, particularly with respect to soil contamination by heavy metals and nutrient imbalances. This study investigated the potential of coal gangue-based silicon fertilizers (CG-SF) for the remediation of ion-type rare earth tailings soil (RETS). CG-SF was applied at various concentrations in controlled pot experiments, with ryegrass cultivation used as a bioindicator of soil health.

Selenized neural stem cell-derived exosomes: A neotype therapeutic agent for traumatic injuries of the central nervous system.

Oxidative damage and neuroinflammation are the key features of central nervous system (CNS) injury. Inspired by the neuroprotective properties of neural stem cell-derived exosomes (NExo) and the reactive oxygen species (ROS) scavenging ability of selenium, we develop an advanced NExo bearing ultrasmall nano-selenium (∼3.5 nm) via lipid-mediated nucleation (SeNExo).

Engineering silica-stabilized Pickering emulsions as versatile protein carriers.

Oil-in-water (o/w) Pickering emulsions (PEs), featuring multi-leveled structures and particle-assembled interfaces, have emerged as promising platforms for biomedical applications, due to their superior stability and biocompatibility compared to conventional surfactant-stabilized emulsions. In this study, silica nanoparticles (SNPs) with tunable sizes, surface charges, and morphologies were synthesized and utilized as stabilizers for o/w PEs. Bovine serum albumin and varicella-zoster virus glycoprotein E were selected as model proteins to evaluate the feasibility of SNP-stabilized PEs as protein carriers.

Magnetic Field-Driven Interface Hydroxylation via the Vibrational Stark Effect Boosts Alkaline Hydrogen Evolution Reaction.

Tuning interfacial water structures is a fundamental yet underexplored strategy for advancing the hydrogen evolution reaction (HER) and broader electrocatalytic processes. Here, we demonstrate a universal and scalable catalytic optimization strategy via the magnetic field-driven reconfiguration of interfacial water at the molecular level. Unlike conventional magnetohydrodynamic (MHD) strategies focusing on mass transport, this work pioneers a molecular-level interfacial water structure modulation via the vibrational Stark effect (VSE), achieving intrinsic catalytic enhancement for HER.

PD-1-Ab therapeutic hypothyroidism associated with decreased of peripheral blood CD4 T cells and addressed prophylactic medication of thyroxine administration.

Immune checkpoint inhibitor PD-1 antibody (PD-1-Ab) has arisen the increasing clinical prevalence of immune-related adverse events (irAEs) such as hypothyroidism. Hypothyroidism is the common irAEs but the mechanism of such immunological pathogenesis was still unclear. We have developed an unique hypothyroidism mice model induced by mimicking clinical exposure to PD-1-Ab.

Enhanced therapeutic efficacy of cationic liposome-delivered nerve growth factor antisense oligonucleotide for interstitial cystitis/bladder pain syndrome.

The pathogenesis of interstitial cystitis/bladder pain syndrome (IC/BPS) remains unclear, and there is no definitive treatment for this condition. Studies have shown that antisense oligonucleotide (asODN) targeting nerve growth factor (NGF) can downregulate the level of NGF in the bladder, however, the uptake of NGF asODN by the body is limited. Therefore, this study constructed cationic liposomes (CLs) as a delivery system to carry NGF asODN and evaluated its functional efficacy on the bladder.

Boosting Electrochemical CO Reduction to Formate over La-Doped SnO via Pinning Effect and Water Activation.

Electrochemical reduction of CO to formate over Sn-based catalysts offers an effective carbon-neutral approach for chemical production and renewable energy storage. However, poor selectivity under high current densities persists, primarily due to the instability of Sn-O active sites and slow water dissociation. In this work, a La-doped SnO catalyst is synthesized for efficient CO conversion to formate.

Automated exo-glycosidase-based glycan sequencing on a digital microfluidic system with integrated electrochemical detection of monosaccharides.

Glycans are one of the most important biomacromolecules and are essential to nearly all known life forms. However, their structural complexity makes structural analysis more challenging than nucleic acids or proteins, significantly limiting the opportunities for investigating their structure-function relationship. Here, we proposed a novel glycan sequencing strategy in which a suite of specific non-reducing-end exoglycosidases was integrated with electrochemical detection of monosaccharides in a digital microfluidic (DMF) chip.

[An electrostatically coupled polypeptide affinity multimodal chromatography medium for the purification of antibodies and their separation efficiency].

As the need for antibody production rises, there is an urgent need to lower the costs and enhance the efficiency of the separation process. Currently, the chromatographic media used for antibody separation and purification often focus on individual properties of antibodies, such as affinity, hydrophobicity, and charge, leading to issues like low purification efficiency or inadequate adsorption capacity. To address this, an electrostatically coupled polypeptide affinity medium (FD7-3, 5-diaminobenzoic acid n-sepharose, FD7-DA-Sepharose) was developed for rapid purification of antibodies from cell culture supernatant.

A dual-domain regularization method for ring artifact removal of X-ray CT.

Background: Photon-counting detectors (PCDs) offer improved spatial resolution and dose efficiency. However, as a new X-ray detection device, PCD faces technical challenges, particularly the non-uniformity among detector units, which can lead to ring artifacts in reconstructed CT images.

Purpose: To address this challenge, we propose a dual-domain regularization model to effectively remove ring artifacts while maintaining the integrity of the original CT image.

Biosynthesis of melanin from lignin hydrolysates by metabolically engineered Cupriavidus necator.

Melanin is an advanced polymer with exceptional properties, widely used across cosmetics, pharmaceuticals, environmental applications, and more. However, its broader use is constrained by high production costs and limited availability. Lignin, the most abundant and renewable aromatic compound in nature, presents a promising alternative for synthesizing melanin.

Efficient capture and conversion of HS into H and sulfur in guanidinium ionic liquid-NaOH aqueous solution.

Electrochemistry allows for the simultaneous conversion of hydrogen sulfide (HS) to hydrogen (H) and sulfur, achieving atomic economy, and is a sustainable and cost-effective method. At the same time, an electrolyte with high conductivity and HS absorption that can effectively capture HS in an electrochemical process is essential. An ionic liquid electrolyte system for the absorption and electrolysis of HS was constructed using the guanidine salt ionic liquid with amine-based functional groups as the carrier electrolyte, water as the solvent, and NaOH as the HS absorber.