Heterogeneity-optimized method for predicting immune checkpoint blockade response.

Interpatient tumor heterogeneity manifests as multimodal distributions across genomic, transcriptomic, and microenvironmental profiles. This fundamentally violates the unimodal assumption of conventional machine learning models, impairing immune checkpoint blockade (ICB) response prediction. To resolve this limitation, we propose a heterogeneity-optimized framework that applies K-means clustering to stratify patients into biologically distinct hot-tumor and cold-tumor subgroups, demonstrating superiority over hierarchical/DBSCAN clustering.

Correction: Research progress on nanomaterial-empowered electrochemical biosensors for the detection of cardiac troponin I.

[This corrects the article DOI: 10.1039/D5RA04555J.].

Light-cured millineedle platform delivers "nano-pomegranate" for combinatorial electrodynamic therapy and cuproptosis against oral carcinoma.

Monomodal therapies often fail to eradicate tumors due to the complexity of tumorigenesis and microenvironmental resistance. Electrodynamic therapy (EDT) and cuproptosis as emerging antitumor therapies have attracted widespread attention and become the promising strategies for tumor treatment due to their unique advantages. Here, we first time present a light-cured millineedle as a tool for co-delivering a nano-pomegranate (N-PG) platform and Cu by integrating EDT and cuproptosis induction for combined oral cancer treatment.

Configuration analysis on servitisation transformation of sporting goods manufacturing enterprises: The case study of 33 listed companies of China.

This study explores the multifactorial and complex causal relationships affecting the performance of sporting goods manufacturing enterprises during service transformation. A fuzzy set qualitative comparative analysis method was applied using 33 sporting goods manufacturing enterprises listed on the Shanghai and Shenzhen A-shares and the New Third Board in China. The study developed a model using the Technology-Organization-Environment(TOE) theoretical framework, to analyse the factors driving the servitisation transformation of China's sporting goods manufacturers.

Preparation and Properties of Flexible Multilayered Transparent Conductive Films on Substrate with High Surface Roughness.

The flexible transparent conductive films (TCFs) of a ZnS/Cu/Ag/TiO multilayered structure were deposited on a flexible PET substrate with high surface roughness using magnetic sputtering, and the effects of structural characteristics on the performance of the films were analyzed. The TCFs with TiO/Cu/Ag/TiO and ZnS/Cu/Ag/ZnS symmetric structures were also prepared for comparison. The TCF samples were deposited using ZnS, TiO, Cu and Ag targets, and they were analyzed using scanning electronic microscopy, atomic force microscopy, grazing incidence X-ray diffraction, spectrophotometry and a four-probe tester.

Research progress on nanomaterial-empowered electrochemical biosensors for the detection of cardiac troponin I.

Acute myocardial infarction (AMI) is a prevalent and high-risk type of cardiovascular disease (CVD) and a major threat to global human health. Rapid and accurate diagnosis of CVD is important to protect life and health. Cardiac troponin (cTnI) is considered the best biomarker for diagnosing AMI because of its high specificity and sensitivity to acute cardiomyocyte injury.

Multiple Dynamic Anticounterfeiting Using Photochromic Luminescence Organic Cocrystals.

Photochromic and luminescent complexes are easy to imitate due to their single-signal output, resulting in a low encryption and anticounterfeiting level. Photochromic luminescence (PCL) complexes exhibit fluorescence and color-changing dual output, which provides additional safety and greatly improves anticounterfeiting security. However, it is challenging to overcome the competition between luminescence and the quenching effect of the photoinduced electron transfer (PET) process.

Recent Advances in Monitoring Technologies for Cardiac Troponin I: A Pivotal Biomarker in Cardiovascular Diseases.

Cardiovascular diseases (CVDs) are among the leading causes of morbidity and mortality rates globally, presenting a severe threat to human health and life. Acute myocardial infarction (AMI) is one of the most common and extremely severe disorders within CVDs, causing an estimated 17.5 million deaths each year.

CMedRAGBot: A Chinese Medical Chatbot Based on Graph RAG and Large Language Models.

In the domain of Chinese clinical medical question-answering (QA), traditional Large Language Models (LLMs) encounter challenges such as hallucinations and difficulties in updating knowledge for knowledge-intensive tasks. To address these issues, this research presents a Chinese clinical medical QA model that integrates Retrieval-Augmented Generation (RAG) and a medical knowledge graph, named CMedRAGBot. First, a Chinese medical knowledge graph encompassing multiple entity types-including diseases, medications, and symptoms-is constructed.

Adaptive crayfish optimization algorithm for multi-objective scheduling optimization in distributed production workshops.

The increasing demand for wind turbines and cost pressures in the wind energy industry have made the Wind Turbine Pultruded Panels Production Scheduling Problem (WTPP-PSP) a critical challenge. To address the production scheduling requirements of WTPP-PSP, an intelligent platform is proposed for wind turbine pultruded panel production systems, leveraging intelligent decision-making to tackle the problem. A multi-objective model based on mixed-integer linear programming is developed, considering sequence-dependent completion and setup time constraints.

Development of Wearable Wireless Multichannel f-NIRS System to Evaluate Activities.

Functional near-infrared spectroscopy is a noninvasive neuroimaging technique that uses optical signals to monitor subtle changes in hemoglobin concentrations within the superficial tissue of the human body. This technology has widespread applications in long-term brain-computer interface monitoring within both traditional medical domains and, increasingly, domestic settings. The popularity of this approach lies in the fact that new single-channel brain oxygen sensors can be used in a variety of scenarios.

Research Progress on Micromachining Technologies Used to Fabricate Terahertz Micro-Metallic Rectangular Cavity Structures.

Terahertz metal rectangular cavity structures are widely used in terahertz devices due to their performance advantages, and various microfabrication techniques have been applied to the manufacturing of their high performance. In this paper, several typical application fields of terahertz technology and the reasons for its application in these fields are elaborated in detail. Several typical terahertz devices with terahertz metal rectangular cavity structures are introduced in detail.

Remediation of sulfonamide antibiotic-containing wastewater by constructed wetlands: Importance and action mechanism of plants.

Constructed wetlands (CWs) have been proved to be effective in treating sulfonamide antibiotics (SAs) wastewater. Nevertheless, as an essential element in CWs, the significance of plants, continues to be a topic of controversy. In this study, CWs with two different plant species were taken as the research object to investigate their treatment performance, in order to understand the impact of plants on the treatment of SAs wastewater in CWs and to discover the underlying action mechanisms.

Optimization of energy management strategies for multi-mode hybrid electric vehicles driven by travelling road condition data.

The fuel efficiency of plug-in hybrid electric vehicle is influenced by various factors, including working conditions, driving style, and environmental variables, with the design of their energy management strategy (EMS) serving as the core and critical technology. In order to adapt to traffic environment, it is of great significance to construct driving cycles that align with driving characteristics, providing data support for the optimization of the EMS. This paper carried out research on the EMS optimization for multi-mode hybrid electric vehicle (MMHEV).

IDDNet: Infrared Object Detection Network Based on Multi-Scale Fusion Dehazing.

In foggy environments, infrared images suffer from reduced contrast, degraded details, and blurred objects, which impair detection accuracy and real-time performance. To tackle these issues, we propose IDDNet, a lightweight infrared object detection network that integrates multi-scale fusion dehazing. IDDNet includes a multi-scale fusion dehazing (MSFD) module, which uses multi-scale feature fusion to eliminate haze interference while preserving key object details.

Solvothermal Synthesis of Magnetic CoFeO/Carbon Nanocomposites with Superior Visible Light Photocatalysis.

In order to enhance the photocatalytic performance of CoFeO, carbon (C) was exploited to modify it through developing a CoFeO/C heterojunction photocatalyst. CoFeO/C nanocomposites with varying C contents were fabricated through a simple one-pot solvothermal approach by adjusting the dosage of glucose. The photocatalytic capabilities of the as-prepared CoFeO/C nanocomposites were evaluated by the reduction of Cr(VI) under visible light exposure.

The evolutionary characteristics and neighbourhood mechanisms of urban innovation networks: The case of China's sports industry.

Taking the patents granted from 2006 to 2023 and the applicants located in different cities in China as data samples, with the help of UCINET 6.0 software and according to the timeline, we visualise the cooperation and innovation network of the sports industry during the period of the "11th Five-Year Plan" to the "14th Five-Year Plan". QAP multiple regression analysis was used to explore the impact of geographical, cognitive, institutional, economic, and technological proximity on the collaborative innovation performance of the sports industry at different stages.

Association between social media use, physical activity level, and depression and anxiety among college students: a cross-cultural comparative study.

This article examined the interaction of social media use and physical activity with mental health outcomes in a cultural and regional perspective among university students in China. Among 1,500 students from ten universities across different regions of China, stratified random sampling was used to complete the validated measures of social media use, physical activity, depression, anxiety, sleep quality, and cultural values. Significantly positive associations were revealed between the use of social media and both depressive symptoms, r = .

DFT Study of the ORR Catalytic Activity of As-Doped and As-N Co-Doped Graphene Substrates.

This study employs first-principles methods to investigate the ORR catalytic activity of As-doped and AsN co-doped graphene. As atoms, as catalytic active sites, exhibit excellent catalytic activity. Due to the strong interaction between As and N, the stability of the As-N co-doped substrate is enhanced.

Theoretical Study on the Excitation Energy Transfer Dynamics in the Phycoerythrin PE555 Light-Harvesting Complex.

Photosynthesis in nature begins with light harvesting. The special pigment-protein complex converts sunlight into electron excitation that is transmitted to the reaction center, which triggers charge separation. Evidence shows that quantum coherence between electron excited states is important in the excitation energy transfer process.

Microstructure and properties of joint of Al/Cu welded by resistance element welding with an auxiliary gasket of Ni.

A rivet of aluminum and auxiliary gasket of nickel were adopted to weld A1060 aluminum plate and T2 copper plate using resistance element welding. The interfacial microstructure was analyzed and the tensile shear load of the joint was tested. A layer of AlCu and the eutectic structure of AlCu and (Al) were formed in the interfacial zone of Al/Cu.

Overseas residency rights of Chinese listed firms' controllers: Impacts on R&D and public welfare donations.

By developing an intertemporal decision-making model, this paper investigates the impact of the acquisition of overseas residency by a firm's beneficial owner on the firm's intertemporal decision-making. By incorporating a discount rate in the model, the paper finds that obtaining foreign residency alters the temporal distributional characteristics of the utility of the beneficial owner, weakening its preference for intertemporal investment behaviors such as R&D and donations. We then conduct an empirical analysis using the propensity score matching method for Chinese listed firms.

Sodium-Ion Storage in NaVMn(PO)/C Porous Nanorods Electrode.

NaVMn(PO) (NVMP) is a prospective cathode for sodium-ion batteries (SIBs) due to its low cost and extraordinary structural stability. However, poor conductivity restricts the electrochemical performance of NVMP, which limits its development and application. Herein, carbon-encapsulated NVMP porous nanorods are prepared via a convenient electrospinning method.

Density Functional Theory Study on Screening and Key Metrics for Non-Metallic Oxygen Reduction Catalysts.

This study systematically investigates the oxygen reduction reaction (ORR) catalytic activity of graphene doped with various non-metallic impurities. The non-metal elements include boron (B), silicon (Si), nitrogen (N), phosphorus (P), arsenic (As), oxygen (O), sulfur (S), selenium (Se), tellurium (Te), fluorine (F), chlorine (Cl), bromine (Br), and iodine (I). We found that adsorbates tend to adsorb on positively charged impurity atoms.

Evaluation Methods and Coupled Optimization at Macro- and Micro-Scales for Profiled Ring Rolling of Inconel718 Alloy.

The forming quality of profiled ring rolling not only encompasses macroscopic accuracy but also emphasizes the microstructure. Due to the multiple process parameters and complex metal flow during profiled ring rolling, the various forming defects are difficult to control and difficult to study theoretically. The objective of this study is to establish a comprehensive method for evaluating the forming quality of profiled rings, which considers both the macroscopic forming accuracy and the microstructure.